Protocol for a prospective magnetic resonance imaging study on supraspinal lower urinary tract control in healthy subjects and spinal cord injury patients undergoing intradetrusor onabotulinumtoxinA injections for treating neurogenic detrusor overactivity

Abstract:

BACKGROUND:The control of the lower urinary tract is a complex, multilevel process involving both the peripheral and central nervous system. Due to lesions of the neuraxis, most spinal cord injury patients suffer from neurogenic lower urinary tract dysfunction, which may jeopardise upper urinary tract function and has a negative impact on health-related quality of life. However, the alterations to the nervous system following spinal cord injury causing neurogenic lower urinary tract dysfunction and potential effects of treatments such as intradetrusor onabotulinumtoxinA injections on lower urinary tract control are poorly understood. METHODS/DESIGN:This is a prospective structural and functional magnetic resonance imaging study investigating the supraspinal lower urinary tract control in healthy subjects and spinal cord injury patients undergoing intradetrusor onabotulinumtoxinA injections for treating neurogenic detrusor overactivity.Neuroimaging data will include structural magnetic resonance imaging (T1-weighted imaging and diffusion tensor imaging) as well as functional, i.e. blood oxygen level-dependent sensitive magnetic resonance imaging using a 3 T magnetic resonance scanner. The functional magnetic resonance imaging will be performed simultaneously to three different bladder stimulation paradigms using an automated magnetic resonance compatible and synchronised pump system.All subjects will undergo two consecutive and identical magnetic resonance imaging measurements. Healthy subjects will not undergo any intervention between measurements but spinal cord injury patients will receive intradetrusor onabotulinumtoxinA injections for treating neurogenic detrusor overactivity.Parameters of the clinical assessment including bladder diary, urinalysis, medical history, neuro-urological examination, urodynamic investigation as well as standardised questionnaires regarding lower urinary tract function and quality of life will serve as co-variates in the magnetic resonance imaging analysis. DISCUSSION:This study will identify structural and functional alterations in supraspinal networks of lower urinary tract control in spinal cord injury patients with neurogenic detrusor overactivity compared to healthy controls. Post-treatment magnetic resonance imaging measurements in spinal cord injury patients will provide further insights into the mechanism of action of treatments such as intradetrusor onabotulinumtoxinA injections and the effect on supraspinal lower urinary tract control. TRIAL REGISTRATION:ClinicalTrials.gov NCT01768910.

journal_name

BMC Urol

journal_title

BMC urology

authors

Leitner L,Walter M,Freund P,Mehnert U,Michels L,Kollias S,Kessler TM

doi

10.1186/1471-2490-14-68

subject

Has Abstract

pub_date

2014-08-18 00:00:00

pages

68

issn

1471-2490

pii

1471-2490-14-68

journal_volume

14

pub_type

杂志文章
  • Relationship between plasma Atherogenic index and final pathology of Bosniak III-IV renal masses: a retrospective, single-center study.

    abstract:BACKGROUND:There is an increased incidence of renal cell carcinoma (RCC) in patients with metabolic syndrome who usually have high levels of serum triglyceride (TG) and low high-density lipoprotein-cholesterol (HDL-C). Plasma atherogenic index (PAI) is the logarithmic ratio of serum TG level to HDL-C and related to car...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-019-0514-0

    authors: Karabay E,Karsiyakali N,Duvar S,Tosun C,Aslan AR,Yucebas OE

    更新日期:2019-09-13 00:00:00

  • Urothelial carcinoma of the upper urinary tract diagnosed via FGFR3 mutation detection in urine: a case report.

    abstract:BACKGROUND:Upper urinary tract cancer is typically diagnosed with urine cytology and imaging techniques. These assays can be limited by sensitivity, specificity, or technical issues making some diagnoses difficult. CASE PRESENTATION:A 73-year old man presented to the clinic with a right renal pelvis filling defect tha...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/1471-2490-12-20

    authors: Silverberg DM

    更新日期:2012-08-08 00:00:00

  • A rare diaphragmatic ureteral herniation case report: endoscopic and open reconstructive management.

    abstract:BACKGROUND:Ureteral herniations are a rare occurrence, generally found incidentally on cross sectional imaging or during surgical intervention for unrelated processes. Several locations of ureteral herniations can occur including the inguinal, femoral, sciatic, obturator, and thoracic regions. While few reports of uret...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-017-0207-5

    authors: Lin FC,Lin JS,Kim S,Walker JR

    更新日期:2017-04-05 00:00:00

  • Clinical relevance of aortic calcification in urolithiasis patients.

    abstract:BACKGROUND:The aim of the present study is to investigate the clinical relevance of aortic calcification in urolithiasis patients. METHODS:Between January 2010 and September 2014, 1221 patients with urolithiasis were treated in Oyokyo Kidney Research Institute and Hirosaki University Hospital. Among these, 287 patient...

    journal_title:BMC urology

    pub_type: 临床试验,杂志文章

    doi:10.1186/s12894-017-0218-2

    authors: Tanaka T,Hatakeyama S,Yamamoto H,Narita T,Hamano I,Matsumoto T,Soma O,Tobisawa Y,Yoneyama T,Yoneyama T,Hashimoto Y,Koie T,Takahashi I,Nakaji S,Terayama Y,Funyu T,Ohyama C

    更新日期:2017-04-04 00:00:00

  • Prognostic significance of epidermal growth factor receptor (EGFR) over expression in urothelial carcinoma of urinary bladder.

    abstract:BACKGROUND:Epidermal growth factor receptor (EGFR) has been shown to have abnormal expression in many human cancers and is considered as a marker of poor prognosis. Frequency of over expression in bladder cancer has not been studied in our population; therefore we aimed to evaluate the frequency and prognostic signific...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-018-0373-0

    authors: Hashmi AA,Hussain ZF,Irfan M,Khan EY,Faridi N,Naqvi H,Khan A,Edhi MM

    更新日期:2018-06-07 00:00:00

  • Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis.

    abstract:BACKGROUND:Given that a deubiquitinating enzyme, ubiquitin-specific protease 2a (USP2a), regulates ubiquitination, trafficking, and degradation of EGFR, which plays a critical role in bladder cancer, in this study, we aimed to quantify the USP2a gene expression, and to determine the possibility that USP2a can be used f...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-015-0074-x

    authors: Jeong P,Ha YS,Yun SJ,Yoon HY,Freeman MR,Kim J,Kim WJ

    更新日期:2015-08-07 00:00:00

  • A meta-ethnography to understand the experience of living with urinary incontinence: 'is it just part and parcel of life?'

    abstract:BACKGROUND:Urinary incontinence (UI) is highly prevalent and affects the lives of many men and women. We aimed to conduct a qualitative evidence synthesis (QES) to explore the experience of living with UI and to develop a conceptual model that can help us to understand this experience, and the potential barriers to app...

    journal_title:BMC urology

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12894-019-0555-4

    authors: Toye F,Barker KL

    更新日期:2020-01-16 00:00:00

  • Efficacy analysis of self-help position therapy after holmium laser lithotripsy via flexible ureteroscopy.

    abstract:BACKGROUND:To observe the efficacy of self-help position therapy (SHPT) after holmium laser lithotripsy via flexible ureteroscopy (FURS). METHODS:From January 2010 to November 2015, 736 nephrolithiasis patients who had received FURS lithotripsy were analyzed retrospectively. In position group, 220 cases accepted SHPT ...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-018-0348-1

    authors: Yang J,Tao RZ,Lu P,Chen MX,Huang XK,Chen KL,Huang YH,He XR,Wan LD,Wang J,Tang X,Zhang W

    更新日期:2018-05-08 00:00:00

  • Anti-TNF agents and potential effects on male fertility: are men being counseled?

    abstract:BACKGROUND:Adult men with autoimmune conditions are commonly prescribed anti-tumor necrosis factor (anti-TNF) agents; however, there is a paucity of quality evidence as to their effect on male fertility (e.g. semen parameters and sperm quality). Our objective was to determine if men with autoimmune conditions are being...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-020-00658-7

    authors: Cooley LF,Wren J,Keeter MK,Lam I,Bennett N,Brannigan RE

    更新日期:2020-07-27 00:00:00

  • Primary renal carcinoid natural history of the disease for ten years: case report.

    abstract:BACKGROUND:Primary renal carcinoid is extremely rare and there are few reports on the natural history of the disease. CASE PRESENTATION:A 68-year-old male with a right renal mass who lost to follow-up for ten years has been presented. His only complaint was a mild flank pain. Upon admission to the hospital for his ren...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/1471-2490-2-1

    authors: Gunes A,Yilmaz U,Ugras M,Mizrak B

    更新日期:2002-01-01 00:00:00

  • Sperm parameters and anti-Müllerian hormone remain stable with Helicobacter pylori infection: a cross-sectional study.

    abstract:BACKGROUND AND AIMS:It has been reported that Helicobacter pylori (HP) infection was more prevalent in infertile populations. HP infection could lead to decreased sperm parameters, and treating the HP infection could improve the quality of sperm. However, studies investigating the relationship between infertility and H...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-020-00725-z

    authors: Feng C,Lv PP,Huang CC,Yang SQ,Yao QP,Shen JM,Jin M

    更新日期:2020-11-26 00:00:00

  • Penile metastasis from recurrent sarcoma in a teenager: a case report.

    abstract:BACKGROUND:Metastatic tumors of the penis are uncommon, and fewer than 500 cases have been reported since 1870. Most penile secondary tumors originate in organs of the genitourinary tract, followed by the gastrointestinal tract. Primary tumors of sarcoma origin are extremely rare. Herein, we present a teenager who had ...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-019-0511-3

    authors: Chen CF,Tang TY,Chen M,Chen LC

    更新日期:2019-09-02 00:00:00

  • A pilot randomized trial of conventional versus advanced pelvic floor exercises to treat urinary incontinence after radical prostatectomy: a study protocol.

    abstract:BACKGROUND:Radical prostatectomy is the most common and effective treatment for localized prostate cancer. Unfortunately, radical prostatectomy is associated with urinary incontinence and has a significant negative impact on quality of life. Pelvic floor exercises are the most common non-invasive management strategy fo...

    journal_title:BMC urology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12894-015-0088-4

    authors: Santa Mina D,Au D,Alibhai SM,Jamnicky L,Faghani N,Hilton WJ,Stefanyk LE,Ritvo P,Jones J,Elterman D,Fleshner NE,Finelli A,Singal RK,Trachtenberg J,Matthew AG

    更新日期:2015-09-16 00:00:00

  • Treatment patterns and characteristics of European patients with castration-resistant prostate cancer.

    abstract:BACKGROUND:European treatment guidelines recommend the use of hormonal therapy for the treatment of advanced prostate cancer, including castration-resistant prostate cancer (CRPC), but there is little understanding of how common practices in prostate cancer treatment compare across Europe. The aim of this analysis was ...

    journal_title:BMC urology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2490-13-58

    authors: Sternberg CN,Baskin-Bey ES,Watson M,Worsfold A,Rider A,Tombal B

    更新日期:2013-11-09 00:00:00

  • Multiparametric ultrasound: evaluation of greyscale, shear wave elastography and contrast-enhanced ultrasound for prostate cancer detection and localization in correlation to radical prostatectomy specimens.

    abstract:BACKGROUND:The diagnostic pathway for prostate cancer (PCa) is advancing towards an imaging-driven approach. Multiparametric magnetic resonance imaging, although increasingly used, has not shown sufficient accuracy to replace biopsy for now. The introduction of new ultrasound (US) modalities, such as quantitative contr...

    journal_title:BMC urology

    pub_type: 临床试验,杂志文章

    doi:10.1186/s12894-018-0409-5

    authors: Mannaerts CK,Wildeboer RR,Postema AW,Hagemann J,Budäus L,Tilki D,Mischi M,Wijkstra H,Salomon G

    更新日期:2018-11-08 00:00:00

  • Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2α contributes to human bladder cancer cell survival.

    abstract:BACKGROUND:Survival rate for patients presenting muscle invasive bladder cancer is very low, and useful therapeutic target has not been identified yet. In the present study, new COX2 downstream signals involved in urothelial carcinoma cell survival were investigated in vitro and in vivo. METHODS:COX2 gene was silenced...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/1471-2490-11-8

    authors: Shimada K,Anai S,Marco DA,Fujimoto K,Konishi N

    更新日期:2011-05-18 00:00:00

  • The diagnostic accuracy of urine-based tests for bladder cancer varies greatly by patient.

    abstract:BACKGROUND:Spectrum effects refer to the phenomenon that test performance varies across subgroups of a population. When spectrum effects occur during diagnostic testing for cancer, difficult patient misdiagnoses can occur. Our objective was to evaluate the effect of test indication, age, gender, race, and smoking statu...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-016-0147-5

    authors: Gopalakrishna A,Longo TA,Fantony JJ,Owusu R,Foo WC,Dash R,Inman BA

    更新日期:2016-06-13 00:00:00

  • Antihypertensive drugs use and the risk of prostate cancer: a meta-analysis of 21 observational studies.

    abstract:BACKGROUND:Due to the lack of strong evidence to identify the relationship between antihypertensive drugs use and the risk of prostate cancer, it was needed to do a systematic review to go into the subject. METHODS:We systematically searched PubMed, Web of Science and Embase to identify studies published, through May ...

    journal_title:BMC urology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12894-018-0318-7

    authors: Cao L,Zhang S,Jia CM,He W,Wu LT,Li YQ,Wang W,Li Z,Ma J

    更新日期:2018-03-07 00:00:00

  • Multivariate analysis of early surgical management factors affecting posttraumatic penoscrotal avulsion injury: a level I trauma center study.

    abstract:BACKGROUND:To conduct an accurate evaluation of patients presenting with posttraumatic penoscrotal injuries, and to formulate a treatment algorithm based on this assessment. METHODS:We conducted a retrospective chart review study. Patients with penoscrotal defects admitted to our level I trauma center from 2017 to 201...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-020-00763-7

    authors: Kim MJ,Lee DH,Park DH,Lee IJ

    更新日期:2021-01-07 00:00:00

  • Characterization of prostate cancer detected at repeat biopsy.

    abstract:BACKGROUND:The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy. METHODS:We carried out a retrospective analysis of clinical and pathological data from 576...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/1471-2490-8-14

    authors: Yuasa T,Tsuchiya N,Kumazawa T,Inoue T,Narita S,Saito M,Horikawa Y,Satoh S,Habuchi T

    更新日期:2008-11-10 00:00:00

  • Mannitol reduces nephron loss after warm renal ischemia in a porcine model.

    abstract:BACKGROUND:Mannitol has been employed to ameliorate renal warm ischemia damage during partial nephrectomy, however, there is limited scientific evidence to support the use of mannitol during partial nephrectomy. The objective of the present study was to investigate the glomerular number after renal warm ischemia, with ...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-018-0328-5

    authors: Damasceno-Ferreira JA,Abreu LAS,Bechara GR,Costa WS,Pereira-Sampaio MA,Sampaio FJB,De Souza DB

    更新日期:2018-03-06 00:00:00

  • LithoVue™ for renal stone therapy - a perfect fit for high volume academic centers; a retrospective evaluation of 108 cases.

    abstract:BACKGROUND:Over the last few years the number of flexible ureterorenoscopies, used for renal stone treatment, has risen steadily. This was associated with an increase in costs for maintenance and repair of the fragile ureterorenoscopes used. To overcome this problem single-use devices have been introduced to the market...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-020-00624-3

    authors: Pallauf M,Sevcenco S,Steiner C,Drerup M,Mitterberger M,Colleselli D,Lusuardi L,Kunit T

    更新日期:2020-05-18 00:00:00

  • miR-185 inhibits prostate cancer angiogenesis induced by the nodal/ALK4 pathway.

    abstract:BACKGROUND:Inhibition of angiogenesis in prostatic cancer could be a brand-new method to suppress tumour progression. Nodal/ALK4 has been associated with vascularization in many cancers. However, the relationship between and role of Nodal/ALK4 and miR-185 in human prostatic cancer is still unknown. METHODS:Prostatic c...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-020-00617-2

    authors: Li Y,Zhong W,Zhu M,Li M,Yang Z

    更新日期:2020-05-04 00:00:00

  • Unilateral pedal lymphangiography plus computed tomography angiography for location of persistent idiopathic chyle leakage not detectable by ordinary contrast computed tomography.

    abstract:BACKGROUND:To identify the value of unilateral pedal lymphangiography (LPG) plus computed tomography angiography (CTA) in accurate depiction of persistent idiopathic chyluria undetectable by ordinary contrast CT. METHODS:Eighteen patients 44-63 years of age with persistent idiopathic chyluria who failed conservative m...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-018-0323-x

    authors: Liu D,Liu B,Xia W,Tang Q,Wang H,Wang J,Zhou Y,Yu J,Li W,Wang M,Zhou W,Hu S,Shao Y

    更新日期:2018-02-06 00:00:00

  • Which anthropometric measurements including visceral fat, subcutaneous fat, body mass index, and waist circumference could predict the urinary stone composition most?

    abstract:BACKGROUND:Although there is growing evidence of relationship between obesity and some specific stone compositions, results were inconsistent. Due to a greater relationship between metabolic syndrome and some specific stone type, obesity measured by body mass index (BMI) has limitation in determining relationship betwe...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-015-0013-x

    authors: Kim JH,Doo SW,Cho KS,Yang WJ,Song YS,Hwang J,Hong SS,Kwon SS

    更新日期:2015-03-14 00:00:00

  • Development of a high-precision bladder hyperthermic intracavitary chemotherapy device for bladder cancer and pharmacokinetic study.

    abstract:BACKGROUND:Bladder hyperthermic intracavitary chemotherapy (HIVEC) has good effectiveness for bladder cancer, but conventional HIVEC systems lack precision and convenient application. To test the safety of a new HIVEC device (BR-TRG-II-type) in pigs and to perform a preliminary clinical trial in patients with bladder c...

    journal_title:BMC urology

    pub_type: 临床试验,杂志文章

    doi:10.1186/s12894-019-0543-8

    authors: Ba M,Cui S,Long H,Gong Y,Wu Y,Lin K,Tu Y,Zhang B,Wu W

    更新日期:2019-12-03 00:00:00

  • Psychometric properties of the expanded prostate cancer index composite - 26 instrument in a cohort of radical prostatectomy patients: theoretical and practical examinations.

    abstract:BACKGROUND:Recently, the Expanded Prostate Cancer Index Composite 26-item version (EPIC-26) was recommended for the assessment of adverse effects after the treatment of prostate cancer without clear reasons. This decision encouraged us to review the questionnaire development from the UCLA Prostate Cancer Index (UCLA-PC...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-017-0302-7

    authors: Axcrona K,Nilsson R,Brennhovd B,Sørebø Ø,Fosså SD,Dahl AA

    更新日期:2017-12-02 00:00:00

  • Vasitis: a rare diagnosis mimicking inguinal hernia: a case report.

    abstract:BACKGROUND:Vasitis or inflammation of the vas deferens is a rare condition, and few case reports with computed tomography images have been published since 1980. CASE PRESENTATION:A 50-year-old man presented with severe right inguinal and lower abdominal pain. Initial diagnosis at the emergency department was incarcera...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-019-0460-x

    authors: Chen CW,Lee CH,Huang TY,Wang YM

    更新日期:2019-04-29 00:00:00

  • Five testicles in the genital area of a thirteen-month-old baby: a case report.

    abstract:BACKGROUND:Polyorchidism is a congenital anomaly of the urogenital system and means more than two testes. It is a rare phenomenon, where there are no more than 200 reported cases in the literature. In this case, we report a 13-month year's old case with five testicles. CASE PRESENTATION:We report a rare five testicles...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-020-00681-8

    authors: Zahirian Moghadam T,Mohseni Rad H,Zandian H,Hosseinkhani A

    更新日期:2020-08-20 00:00:00

  • Efficacy of commercialised extracorporeal shock wave lithotripsy service: a review of 589 renal stones.

    abstract:BACKGROUND:Extracorporeal shockwave lithotripsy (ESWL) is the management of choice for renal stones 20 mm or smaller, with a stone clearance rate of up to 89%. The purpose of the present is to investigate the efficacy of a commercialised ESWL service, being performed as an outsourced treatment using a mobile lithotrips...

    journal_title:BMC urology

    pub_type: 杂志文章

    doi:10.1186/s12894-017-0249-8

    authors: Nielsen TK,Jensen JB

    更新日期:2017-07-27 00:00:00