当前位置： SCI文献检索 > BMC Urology期刊下所有文献 > Treatment patterns and characteristics of European patients with castration-resistant prostate cancer.

Treatment patterns and characteristics of European patients with castration-resistant prostate cancer.

Abstract：

BACKGROUND:European treatment guidelines recommend the use of hormonal therapy for the treatment of advanced prostate cancer, including castration-resistant prostate cancer (CRPC), but there is little understanding of how common practices in prostate cancer treatment compare across Europe. The aim of this analysis was to evaluate the management of CRPC patients across five European countries (France, Germany, Italy, Spain and the UK). METHODS:Data were drawn from the Adelphi Real World Prostate Cancer Disease Specific Programme (DSP), a cross-sectional survey of patients undertaken between December 2009 and May 2010. The study is based on physician interviews, physician-completed detailed patient record forms, and a patient-completed questionnaire. RESULTS:A total of 348 physicians (191 urologists and 157 oncologists) reported on 3477 patients with prostate cancer. Of the 3477 patients, 1405 (40%) were categorised as having CRPC, and 1119 of these had metastatic CRPC. Bone metastases were the most common (78%), followed by liver (37%) and lung (30%). The mean age of CRPC patients was 71 years, 35% were current or ex-smokers and 10% had a family history of prostate cancer. CRPC patients had a mean of 1.8 comorbidities; 66% had hypertension and 32% had diabetes. Most physicians estimated their patients would stop responding to initial hormone therapy after 19-24 months. Overall, addition of an anti-androgen to a luteinising-hormone-releasing hormone (LHRH) agonist was the most commonly prescribed therapy when patients failed initial LHRH agonist therapy, although there were considerable variations between countries. While 72% of physicians in Europe would choose chemotherapy as the next treatment option after diagnosis of CRPC, 31% of this group would initially prescribe this without an LHRH agonist. CONCLUSIONS:Results from this analysis highlight inconsistencies in common hormonal therapy treatment patterns for CRPC and hormonal therapy across the EU.

journal_name

BMC Urol

journal_title

BMC urology

authors

Sternberg CN,Baskin-Bey ES,Watson M,Worsfold A,Rider A,Tombal B

doi

10.1186/1471-2490-13-58

subject

Has Abstract

pub_date

2013-11-09 00:00:00

pages

58

issn

1471-2490

pii

1471-2490-13-58

journal_volume

13

pub_type

杂志文章,多中心研究

相关文献

BMC Urology文献大全
  • Little effects of insulin-like Growth Factor-I on testicular atrophy induced by hypoxia.

    abstract：BACKGROUND:Insulin-like Growth Factor-I (IGF-I) supplementation restores testicular atrophy associated with advanced liver cirrhosis that is a condition of IGF-I deficiency. The aim of this work was to evaluate the effect of IGF-I in rats with ischemia-induced testicular atrophy (AT) without liver disease and consequen...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/1471-2490-6-4

    authors： Diez-Caballero F,Castilla-Cortázar I,Garcia-Fernandez M,Puche JE,Diaz-Sanchez M,Casares AD,Aliaga-Montilla MA,Rodriguez-Borrajo C,Gonzalez-Barón S

    更新日期：2006-02-21 00:00:00

  • Efficacy of commercialised extracorporeal shock wave lithotripsy service: a review of 589 renal stones.

    abstract：BACKGROUND:Extracorporeal shockwave lithotripsy (ESWL) is the management of choice for renal stones 20 mm or smaller, with a stone clearance rate of up to 89%. The purpose of the present is to investigate the efficacy of a commercialised ESWL service, being performed as an outsourced treatment using a mobile lithotrips...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-017-0249-8

    authors： Nielsen TK,Jensen JB

    更新日期：2017-07-27 00:00:00

  • Scrotal extratesticular schwannoma: a case report and review of the literature.

    abstract：BACKGROUND:Schwannomas are tumours arising from Schwann cells, which sheath the peripheral nerves. Here, we report a rare case of left intrascrotal, extratesticular schwannoma. Although rare, scrotal localisation of schwannomas has been reported in male children, adult men, and elderly men. They are usually asymptomati...

    journal_title：BMC urology

    pub_type： 杂志文章,评审

    doi：10.1186/1471-2490-14-32

    authors： Palleschi G,Carbone A,Cacciotti J,Manfredonia G,Porta N,Fuschi A,de Nunzio C,Petrozza V,Pastore AL

    更新日期：2014-04-28 00:00:00

  • The impact of fellowship training on pathological outcomes following radical prostatectomy: a population based analysis.

    abstract：BACKGROUND:Radical prostatectomy (RP) is a common treatment for prostate cancer (PCa). Morbidity, mortality and pathological outcomes may be superior in academic institutions. One explanation may be the involvement of oncology fellowship trained urologists within academic institutions. The literature examining patholog...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/1471-2490-14-82

    authors： Nayak JG,Drachenberg DE,Mau E,Suderman D,Bucher O,Lambert P,Quon H

    更新日期：2014-10-23 00:00:00

  • Role of microRNA-381 in bladder cancer growth and metastasis with the involvement of BMI1 and the Rho/ROCK axis.

    abstract：BACKGROUND:Emerging evidence has noted the important participation of microRNAs (miRNAs) in several human diseases including cancer. This research was launched to probe the function of miR-381 in bladder cancer (BCa) progression. METHODS:Twenty-eight patients with primary BCa were included in this study. Cancer tissue...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-020-00775-3

    authors： Chen D,Cheng L,Cao H,Liu W

    更新日期：2021-01-06 00:00:00

  • Development of a high-precision bladder hyperthermic intracavitary chemotherapy device for bladder cancer and pharmacokinetic study.

    abstract：BACKGROUND:Bladder hyperthermic intracavitary chemotherapy (HIVEC) has good effectiveness for bladder cancer, but conventional HIVEC systems lack precision and convenient application. To test the safety of a new HIVEC device (BR-TRG-II-type) in pigs and to perform a preliminary clinical trial in patients with bladder c...

    journal_title：BMC urology

    pub_type： 临床试验,杂志文章

    doi：10.1186/s12894-019-0543-8

    authors： Ba M,Cui S,Long H,Gong Y,Wu Y,Lin K,Tu Y,Zhang B,Wu W

    更新日期：2019-12-03 00:00:00

  • The comparison of the effect of phenylephrine and epinephrine on penile spongy tissue in rats after experimental hypospadias surgery: a quantitative stereological study.

    abstract：BACKGROUND:Many factors including vasoconstrictor agents can interfere with wound healing process. This study aimed to compare the histopathological outcome of injection of two sympathomimetic drugs used during urologic surgery, including phenylephrine and epinephrine, on the structure of spongy tissue and urethra in a...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-019-0483-3

    authors： Shirazi M,Rajabalian MB,Noorafshan A,Karbalay-Doust S,Jahanabadi Z,Ahmed F

    更新日期：2019-06-20 00:00:00

  • Impact of bilateral biopsy-detected prostate cancer on an active surveillance population.

    abstract：BACKGROUND:To assess factors that can predict active surveillance (AS) failure on serial transrectal ultrasound guided biopsies in patients with low-risk prostate cancer. METHODS:We evaluated the records of 144 consecutive patients enrolled in AS between 2007 and 2014 at a single academic institution. Low risk inclusi...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-019-0452-x

    authors： Wang JH,Sierra P,Richards KA,Abel EJ,Allen GO,Downs TM,Jarrard DF

    更新日期：2019-04-23 00:00:00

  • Clinical, molecular and cytogenetic analysis of 46, XX testicular disorder of sex development with SRY-positive.

    abstract：BACKGROUND:To review the possible mechanisms proposed to explain the etiology of 46, XX sex reversal by investigating the clinical characteristics and their relationships with chromosomal karyotype and the SRY(sex-determining region Y)gene. METHODS:Five untreated 46, XX patients with SRY-positive were referred for inf...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/1471-2490-14-70

    authors： Wu QY,Li N,Li WW,Li TF,Zhang C,Cui YX,Xia XY,Zhai JS

    更新日期：2014-08-28 00:00:00

  • Mannitol reduces nephron loss after warm renal ischemia in a porcine model.

    abstract：BACKGROUND:Mannitol has been employed to ameliorate renal warm ischemia damage during partial nephrectomy, however, there is limited scientific evidence to support the use of mannitol during partial nephrectomy. The objective of the present study was to investigate the glomerular number after renal warm ischemia, with ...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-018-0328-5

    authors： Damasceno-Ferreira JA,Abreu LAS,Bechara GR,Costa WS,Pereira-Sampaio MA,Sampaio FJB,De Souza DB

    更新日期：2018-03-06 00:00:00

  • Detection of micro-metastases by flow cytometry in lymph nodes from patients with penile cancer.

    abstract：BACKGROUND:The tumor draining lymph node concept was first described in penile cancer for staging. Immunohistochemistry and histopathology evaluations are routinely used in clinical practice to examine lymph nodes for metastasis. However, these methods are time-consuming with low diagnostic accuracy and micro-metastase...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-018-0399-3

    authors： Zhang L,Hu J,Ali Zirakzadeh A,Rosvall J,Hedlund M,Hu PS,P A Wallin R,Sherif A,Winqvist O

    更新日期：2018-10-05 00:00:00

  • Partial segmental thrombosis of the corpus cavernosum (PSTCC) diagnosed by contrast-enhanced ultrasound: a case report.

    abstract：BACKGROUND:Partial segmental thrombosis of the corpus cavernosum (PSTCC) is a rare disease predominantly occurring in young men. Cardinal symptoms are pain and perineal swelling. Although several risk factors are described in the literature, the exact etiology of penile thrombosis remains unclear in most cases. MRI or ...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/1471-2490-14-100

    authors： Sauer S,Goltz JP,Gassenmaier T,Kunz AS,Bley TA,Klein D,Petritsch B

    更新日期：2014-12-17 00:00:00

  • Spontaneous bilateral renal pelvis rupture during CT in the absence of urinary tract obstruction: case report.

    abstract：BACKGROUND:Atraumatic renal pelvis rupture without pre-existing renal or ureteric pathology is an uncommon event. It is reported in the setting of acute urinary tract obstruction, most often secondary to ureteric calculi. Typical symptoms include acute flank pain and nausea, mimicking pyelonephritis or other causes of ...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-020-00669-4

    authors： Li Z,Beh JCY

    更新日期：2020-07-13 00:00:00

  • Severe paraneoplastic hypereosinophilia in metastatic renal cell carcinoma.

    abstract：BACKGROUND:Renal cell carcinoma can cause various paraneoplastic syndromes including metabolic and hematologic disturbances. Paraneoplastic hypereosinophilia has been reported in a variety of hematologic and solid tumors. We present the first case in the literature of severe paraneoplastic hypereosinophilia in a patien...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/1471-2490-12-7

    authors： Todenhöfer T,Wirths S,von Weyhern CH,Heckl S,Horger M,Hennenlotter J,Stenzl A,Kanz L,Schwentner C

    更新日期：2012-03-21 00:00:00

  • Recent finding and new technologies in nephrolitiasis: a review of the recent literature.

    abstract：:This review summarizes recent literature on advances regarding renal and ureteral calculi, with particular focus in areas of recent advances in the overall field of urolithiasis. Clinical management in everyday practice requires a complete understanding of the issues regarding metabolic evaluation and subgrouping of s...

    journal_title：BMC urology

    pub_type： 杂志文章,评审

    doi：10.1186/1471-2490-13-10

    authors： Rosa M,Usai P,Miano R,Kim FJ,Finazzi Agrò E,Bove P,Micali S,International Translational Research in Uro-Sciences Team (ITRUST).

    更新日期：2013-02-16 00:00:00

  • Oncologic outcomes in men with metastasis to the prostatic anterior fat pad lymph nodes: a multi-institution international study.

    abstract：BACKGROUND:The presence of lymph nodes (LN) within the prostatic anterior fat pad (PAFP) has been reported in several recent reports. These PAFP LNs rarely harbor metastatic disease, and the characteristics of patients with PAFP LN metastasis are not well-described in the literature. Our previous study suggested that m...

    journal_title：BMC urology

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s12894-015-0070-1

    authors： Kwon YS,Ha YS,Modi PK,Salmasi A,Parihar JS,Patel N,Faiena I,May M,Lee DI,Llukani E,Patrick T,Rha KH,Ahlering T,Skarecky D,Ahn H,Choi SK,Park S,Jeon SS,Ou YC,Eun D,Manucha V,Albala D,Badani K,Yuh B,Ruel N,

    更新日期：2015-08-01 00:00:00

  • Five testicles in the genital area of a thirteen-month-old baby: a case report.

    abstract：BACKGROUND:Polyorchidism is a congenital anomaly of the urogenital system and means more than two testes. It is a rare phenomenon, where there are no more than 200 reported cases in the literature. In this case, we report a 13-month year's old case with five testicles. CASE PRESENTATION:We report a rare five testicles...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-020-00681-8

    authors： Zahirian Moghadam T,Mohseni Rad H,Zandian H,Hosseinkhani A

    更新日期：2020-08-20 00:00:00

  • Metachronous renal cell carcinoma with metastasis to the urinary bladder, and distant organs, 28 years after radical nephrectomy: a case report.

    abstract：BACKGROUND:Metachronous renal cell carcinoma after radical nephrectomy is extremely rare. Renal cell carcinoma commonly metastasizes to distant organs. However, metastasis to the urinary bladder is very uncommon. CASE PRESENTATION:Herein, we report a case of metachronous renal cell carcinoma with metastasis to the uri...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-019-0521-1

    authors： Babar M,Hamdani S,Liu C,Vedula J,Schnapp DS

    更新日期：2019-12-27 00:00:00

  • Penile metastasis from recurrent sarcoma in a teenager: a case report.

    abstract：BACKGROUND:Metastatic tumors of the penis are uncommon, and fewer than 500 cases have been reported since 1870. Most penile secondary tumors originate in organs of the genitourinary tract, followed by the gastrointestinal tract. Primary tumors of sarcoma origin are extremely rare. Herein, we present a teenager who had ...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-019-0511-3

    authors： Chen CF,Tang TY,Chen M,Chen LC

    更新日期：2019-09-02 00:00:00

  • Multi-tract percutaneous nephrolithotomy combined with EMS lithotripsy for bilateral complex renal stones: our experience.

    abstract：BACKGROUND:The treatment of bilateral complex renal stones is a tough challenge for urologists. This study aimed to evaluate the efficiency and safety of bilateral ultrasonography-guided multi-tract percutaneous nephrolithotomy (PCNL) combined with EMS lithotripsy for the treatment of such cases. METHODS:Twenty-seven ...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-017-0205-7

    authors： Liang T,Zhao C,Wu G,Tang B,Luo X,Lu S,Dong Y,Yang H

    更新日期：2017-02-28 00:00:00

  • Antihypertensive drugs use and the risk of prostate cancer: a meta-analysis of 21 observational studies.

    abstract：BACKGROUND:Due to the lack of strong evidence to identify the relationship between antihypertensive drugs use and the risk of prostate cancer, it was needed to do a systematic review to go into the subject. METHODS:We systematically searched PubMed, Web of Science and Embase to identify studies published, through May ...

    journal_title：BMC urology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1186/s12894-018-0318-7

    authors： Cao L,Zhang S,Jia CM,He W,Wu LT,Li YQ,Wang W,Li Z,Ma J

    更新日期：2018-03-07 00:00:00

  • Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis.

    abstract：BACKGROUND:Given that a deubiquitinating enzyme, ubiquitin-specific protease 2a (USP2a), regulates ubiquitination, trafficking, and degradation of EGFR, which plays a critical role in bladder cancer, in this study, we aimed to quantify the USP2a gene expression, and to determine the possibility that USP2a can be used f...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-015-0074-x

    authors： Jeong P,Ha YS,Yun SJ,Yoon HY,Freeman MR,Kim J,Kim WJ

    更新日期：2015-08-07 00:00:00

  • miR-199a-5p suppresses human bladder cancer cell metastasis by targeting CCR7.

    abstract：BACKGROUND:C-C chemokine receptor type 7 (CCR7) overexpression correlated with lymphatic metastasis and poor prognosis is a major obstacle to bladder cancer treatment. Recent studies have revealed that miR-199a-5p was significantly abnormal expressed in several solid tumors and functioned as oncogene or tumor suppresso...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-016-0181-3

    authors： Zhou M,Wang S,Hu L,Liu F,Zhang Q,Zhang D

    更新日期：2016-11-04 00:00:00

  • Which anthropometric measurements including visceral fat, subcutaneous fat, body mass index, and waist circumference could predict the urinary stone composition most?

    abstract：BACKGROUND:Although there is growing evidence of relationship between obesity and some specific stone compositions, results were inconsistent. Due to a greater relationship between metabolic syndrome and some specific stone type, obesity measured by body mass index (BMI) has limitation in determining relationship betwe...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-015-0013-x

    authors： Kim JH,Doo SW,Cho KS,Yang WJ,Song YS,Hwang J,Hong SS,Kwon SS

    更新日期：2015-03-14 00:00:00

  • Clinical relevance of aortic calcification in urolithiasis patients.

    abstract：BACKGROUND:The aim of the present study is to investigate the clinical relevance of aortic calcification in urolithiasis patients. METHODS:Between January 2010 and September 2014, 1221 patients with urolithiasis were treated in Oyokyo Kidney Research Institute and Hirosaki University Hospital. Among these, 287 patient...

    journal_title：BMC urology

    pub_type： 临床试验,杂志文章

    doi：10.1186/s12894-017-0218-2

    authors： Tanaka T,Hatakeyama S,Yamamoto H,Narita T,Hamano I,Matsumoto T,Soma O,Tobisawa Y,Yoneyama T,Yoneyama T,Hashimoto Y,Koie T,Takahashi I,Nakaji S,Terayama Y,Funyu T,Ohyama C

    更新日期：2017-04-04 00:00:00

  • Long-term outcomes of total ureterectomy with ileal-ureteral substitution treatment for ureteral cancer: a single-center experience.

    abstract：BACKGROUND:To explore the feasibility and long-term outcomes of renal preservation in a retrospective cohort of patients with ureteral urothelial carcinoma undergoing total ureterectomy with ileal-ureteral substitution. METHODS:A retrospective review of the data from patients treated with total ureterectomy with ileal...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-018-0389-5

    authors： Ou YC,Hu CY,Cheng HL,Yang WH

    更新日期：2018-08-31 00:00:00

  • Unbiased data mining identifies cell cycle transcripts that predict non-indolent Gleason score 7 prostate cancer.

    abstract：BACKGROUND:Patients with newly diagnosed non-metastatic prostate adenocarcinoma are typically classified as at low, intermediate, or high risk of disease progression using blood prostate-specific antigen concentration, tumour T category, and tumour pathological Gleason score. Classification is used to both predict clin...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-018-0433-5

    authors： Johnston WL,Catton CN,Swallow CJ

    更新日期：2019-01-07 00:00:00

  • The risk factors of Urethrocutaneous fistula after hypospadias surgery in the youth population.

    abstract：BACKGROUND:The current research aims to evaluate the risk factors of urethrocutaneous fistula after hypospadias surgery among the youth in China. METHODS:One hundred twenty hypospadias patients were enrolled in our study. All of them were defined as Tanner 4 or 5. The information collected from the participants includ...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-018-0366-z

    authors： Sheng X,Xu D,Wu Y,Yu Y,Chen J,Qi J

    更新日期：2018-07-24 00:00:00

  • Supernumerary kidneys: a clinical and radiological analysis of nine cases.

    abstract：BACKGROUND:A supernumerary kidney (SK) is an additional kidney with its own capsule and blood supply that is not fused with the ipsilateral kidney (IK). Because individual case reports indicate a high morbidity rate, the aim of this retrospective study was a detailed analysis of this rare anatomical variant. METHODS:O...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/s12894-019-0522-0

    authors： Rehder P,Rehwald R,Böhm JM,Grams AE,Loizides A,Pedrini M,Stühmeier J,Glodny B

    更新日期：2019-10-17 00:00:00

  • Treatment of upper urinary tract stones with extracorporeal shock wave lithotripsy (ESWL) Sonolith vision.

    abstract：BACKGROUND:The aim was to retrospectively assess the results of treatment of upper urinary tract stones with the Sonolith vision manufactured by EDAP, and purchased in 2004. METHODS:The subjects were 226 Japanese patients who underwent extracorporeal shock wave lithotripsy (ESWL) alone as an initial treatment and coul...

    journal_title：BMC urology

    pub_type： 杂志文章

    doi：10.1186/1471-2490-11-26

    authors： Nakamura K,Tobiume M,Narushima M,Yoshizawa T,Nishikawa G,Kato Y,Katsuda R,Zennami K,Aoki S,Yamada Y,Honda N,Sumitomo M

    更新日期：2011-12-12 00:00:00