Abstract:
BACKGROUND:Epidermal growth factor receptor (EGFR) has been shown to have abnormal expression in many human cancers and is considered as a marker of poor prognosis. Frequency of over expression in bladder cancer has not been studied in our population; therefore we aimed to evaluate the frequency and prognostic significance of EGFR immunohistochemical expression in locoregional population. METHODS:We performed EGFR immunohistochemistry on 126 cases of bladder cancer and association of EGFR expression with tumor grade, lamina propria invasion, deep muscle invasion and recurrence of disease was evaluated. RESULTS:High EGFR expression was noted in 26.2% (33 cases), 15.1% (19 cases) and 58.7% (74 cases) revealed low and no EGFR expression respectively. Significant association of EGFR expression was noted with tumor grade, lamina propria invasion, deep muscle invasion and recurrence status while no significant association was seen with age, gender and overall survival. Kaplan- Meier curves revealed significant association of EGFR expression with recurrence while no significant association was seen with overall survival. CONCLUSION:Significant association of EGFR overexpression with tumor grade, muscularis propria invasion and recurrence signifies its prognostic value; therefore EGFR can be used as a prognostic biomarker in Urothelial bladder carcinoma.
journal_name
BMC Uroljournal_title
BMC urologyauthors
Hashmi AA,Hussain ZF,Irfan M,Khan EY,Faridi N,Naqvi H,Khan A,Edhi MMdoi
10.1186/s12894-018-0373-0subject
Has Abstractpub_date
2018-06-07 00:00:00pages
59issue
1issn
1471-2490pii
10.1186/s12894-018-0373-0journal_volume
18pub_type
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