Abstract:
BACKGROUND:The diagnostic pathway for prostate cancer (PCa) is advancing towards an imaging-driven approach. Multiparametric magnetic resonance imaging, although increasingly used, has not shown sufficient accuracy to replace biopsy for now. The introduction of new ultrasound (US) modalities, such as quantitative contrast-enhanced US (CEUS) and shear wave elastography (SWE), shows promise but is not evidenced by sufficient high quality studies, especially for the combination of different US modalities. The primary objective of this study is to determine the individual and complementary diagnostic performance of greyscale US (GS), SWE, CEUS and their combination, multiparametric ultrasound (mpUS), for the detection and localization of PCa by comparison with corresponding histopathology. METHODS/DESIGN:In this prospective clinical trial, US imaging consisting of GS, SWE and CEUS with quantitative mapping on 3 prostate imaging planes (base, mid and apex) will be performed in 50 patients with biopsy-proven PCa before planned radical prostatectomy using a clinical ultrasound scanner. All US imaging will be evaluated by US readers, scoring the four quadrants of each imaging plane for the likelihood of significant PCa based on a 1 to 5 Likert Scale. Following resection, PCa tumour foci will be identified, graded and attributed to the imaging-derived quadrants in each prostate plane for all prostatectomy specimens. Primary outcome measure will be the sensitivity, specificity, negative predictive value and positive predictive value of each US modality and mpUS to detect and localize significant PCa evaluated for different Likert Scale thresholds using receiver operating characteristics curve analyses. DISCUSSION:In the evaluation of new PCa imaging modalities, a structured comparison with gold standard radical prostatectomy specimens is essential as first step. This trial is the first to combine the most promising ultrasound modalities into mpUS. It complies with the IDEAL stage 2b recommendations and will be an important step towards the evaluation of mpUS as a possible option for accurate detection and localization of PCa. TRIAL REGISTRATION:The study protocol for multiparametric ultrasound was prospectively registered on Clinicaltrials.gov on 14 March 2017 with the registry name 'Multiparametric Ultrasound-Study for the Detection of Prostate Cancer' and trial registration number NCT03091231.
journal_name
BMC Uroljournal_title
BMC urologyauthors
Mannaerts CK,Wildeboer RR,Postema AW,Hagemann J,Budäus L,Tilki D,Mischi M,Wijkstra H,Salomon Gdoi
10.1186/s12894-018-0409-5subject
Has Abstractpub_date
2018-11-08 00:00:00pages
98issue
1issn
1471-2490pii
10.1186/s12894-018-0409-5journal_volume
18pub_type
临床试验,杂志文章相关文献
BMC Urology文献大全abstract:BACKGROUND:The core question of the study was whether adequately achieved HD affected the sexual dysfunction in women on hemodialysis (HD) with chronic renal failure (CRF). METHODS:Thirty-seven female patients on HD, including 18 women with adequate HD and 19 women with non-adequate HD, and 36 healthy controls were in...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-14-4
更新日期:2014-01-08 00:00:00
abstract:BACKGROUND:Schwannomas are tumours arising from Schwann cells, which sheath the peripheral nerves. Here, we report a rare case of left intrascrotal, extratesticular schwannoma. Although rare, scrotal localisation of schwannomas has been reported in male children, adult men, and elderly men. They are usually asymptomati...
journal_title:BMC urology
pub_type: 杂志文章,评审
doi:10.1186/1471-2490-14-32
更新日期:2014-04-28 00:00:00
abstract:BACKGROUND:Recently, the Expanded Prostate Cancer Index Composite 26-item version (EPIC-26) was recommended for the assessment of adverse effects after the treatment of prostate cancer without clear reasons. This decision encouraged us to review the questionnaire development from the UCLA Prostate Cancer Index (UCLA-PC...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-017-0302-7
更新日期:2017-12-02 00:00:00
abstract:BACKGROUND:There is an increased incidence of renal cell carcinoma (RCC) in patients with metabolic syndrome who usually have high levels of serum triglyceride (TG) and low high-density lipoprotein-cholesterol (HDL-C). Plasma atherogenic index (PAI) is the logarithmic ratio of serum TG level to HDL-C and related to car...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-019-0514-0
更新日期:2019-09-13 00:00:00
abstract:BACKGROUND:It is well recognized that the presence of positive surgical margins (PSM) after radical prostatectomy (RP) adversely affects cancer specific outcomes and recent evidence from randomized trials supports the use of adjuvant radiotherapy in these cases. However, not all of the patients with PSM develop disease...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-14-79
更新日期:2014-10-02 00:00:00
abstract:BACKGROUND:Obstetric fistula although virtually eliminated in high income countries, still remains a prevalent and debilitating condition in many parts of the developing world. It occurs in areas where access to care at childbirth is limited, or of poor quality and where few hospitals offer the necessary corrective sur...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-11-23
更新日期:2011-12-07 00:00:00
abstract:BACKGROUND:To establish and internally validate an innovative R.I.R.S. scoring system that allows urologists to preoperatively estimate the stone-free rate (SFR) after retrograde intrarenal surgery (RIRS). METHODS:This study included 382 eligible samples from a total 573 patients who underwent RIRS from January 2014 t...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-017-0297-0
更新日期:2017-11-21 00:00:00
abstract:BACKGROUND:Emerging evidence has noted the important participation of microRNAs (miRNAs) in several human diseases including cancer. This research was launched to probe the function of miR-381 in bladder cancer (BCa) progression. METHODS:Twenty-eight patients with primary BCa were included in this study. Cancer tissue...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-020-00775-3
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Jackstone is a bladder stone that has a similar appearance to toy jacks. However review of the English language medical literature revealed only a few previous reports of jackstone calculus. CASE PRESENTATION:We report a case in which a large jackstone calculus was incidentally detected during the evaluatio...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-017-0230-6
更新日期:2017-06-05 00:00:00
abstract:BACKGROUD:To evaluate the relationship between omentin-1 and benign prostatic hyperplasia (BPH). BPH is the most common urological disease in elderly men worldwide. Lower serum omentin-1 levels were reported to be negatively associated with the incidence of inflammation, diabetes, obesity and metabolic syndrome, which ...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-020-00623-4
更新日期:2020-05-06 00:00:00
abstract:BACKGROUND:Primary renal carcinoid is extremely rare and there are few reports on the natural history of the disease. CASE PRESENTATION:A 68-year-old male with a right renal mass who lost to follow-up for ten years has been presented. His only complaint was a mild flank pain. Upon admission to the hospital for his ren...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-2-1
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Osteoporosis is a common consequence of androgen deprivation therapy (ADT) for prostate cancer. Up to 20 % of men on ADT have suffered from fractures within 5 years. The WHO Fracture Risk Assessment Tool (FRAX) has been utilized to predict the 10-year probability of major osteoporotic and hip fracture. Howev...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-016-0151-9
更新日期:2016-06-17 00:00:00
abstract:BACKGROUND:The tumor draining lymph node concept was first described in penile cancer for staging. Immunohistochemistry and histopathology evaluations are routinely used in clinical practice to examine lymph nodes for metastasis. However, these methods are time-consuming with low diagnostic accuracy and micro-metastase...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-018-0399-3
更新日期:2018-10-05 00:00:00
abstract:BACKGROUND:More and more frequently stress urinary incontinence affects young healthy women. Hence, early implementation of effective preventive strategies in nulliparous continent women is essential, including pelvic floor muscle training. An initial evaluation based on the bioelectrical activity of the pelvic floor m...
journal_title:BMC urology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12894-015-0103-9
更新日期:2015-10-24 00:00:00
abstract:BACKGROUND:In patients with neurogenic bladder (NB), elevated intravesical pressures can be transmitted to the upper urinary tract, causing hydronephrosis (HN) and ureteral dilation (UD), which are referred to as upper urinary tract dilation (UUTD). Ureteral obstruction at the bladder wall is another cause for UUTD, bu...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-14-38
更新日期:2014-05-22 00:00:00
abstract:BACKGROUND:Wilms tumor is the most common renal tumor of childhood. Duplication of the inferior vena cava is an uncommon anomaly. In the present study, we present a case of Wilms tumor with the inferior vena cava duplication, which has not been reported previously. CASE PRESENTATION:A 14-month-old female presented wit...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-018-0401-0
更新日期:2018-10-19 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy. METHODS:We carried out a retrospective analysis of clinical and pathological data from 576...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-8-14
更新日期:2008-11-10 00:00:00
abstract:BACKGROUND:Sacral neuromodulation operations have usually been performed based on 2D fluoro images. However, sacral nerve stimulation lead implantation may be challenging when the normal anatomy is confused by obesity or congenital anomalies. Thus the surgical navigation and intraoperative imaging methods could be help...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-13-48
更新日期:2013-10-16 00:00:00
abstract:BACKGROUND:Stauffer Syndrome (SS) is a paraneoplastic disorder associated with renal cell carcinoma (RCC). First described by Herbert Maurice Stauffer in 1961, it is characterized by hepatic dysfunction in the absence of metastasis, and elevated alkaline phosphatase, aminotransferases and prolonged prothrombin time. In...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-020-00671-w
更新日期:2020-07-20 00:00:00
abstract:BACKGROUND:Urologists frequently encounter malignant ureteral obstruction (MUO) caused by advanced urological or non-urological malignant disease, but the treatment policy is unclear. The present study examined the risk factors for predicting ureteral stent failure in patients with MUO after ureteral stent insertion an...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-018-0346-3
更新日期:2018-05-08 00:00:00
abstract:BACKGROUND:To investigate the factor structure, dimensionality and construct validity of the (5-item) PRAFAB questionnaire score in women with stress urinary incontinence (stress UI). METHODS:A cross validation study design was used in a cohort of 279 patients who were randomly divided into Sample A or B. Sample A was...
journal_title:BMC urology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2490-8-1
更新日期:2008-01-24 00:00:00
abstract:BACKGROUND:Caveolae play a significant role in disease phenotypes such as cancer, diabetes, bladder dysfunction, and muscular dystrophy. The aim of this study was to elucidate the caveolin-1 (CAV1) protein expression in renal cell cancer (RCC) and to determine its potential prognostic relevance. METHODS:289 clear cell...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-11-25
更新日期:2011-12-07 00:00:00
abstract:BACKGROUND:Reduced clinical exposure to urology at the undergraduate or internship level is the main explanation for the marked decrease in applicants to urology residencies. This manuscript was to access the application rate for urology specialty compared with that of other specialties and to investigate the relations...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-018-0375-y
更新日期:2018-07-24 00:00:00
abstract:BACKGROUND:To assess the prognostic value of the extent of positive surgical margins (PSM) following radical prostatectomy (RP) on biochemical recurrence (BR) with long-term follow-up. METHODS:This retrospective study analyzed 1275 RPs performed between January 1992 and December 2013 in two university centers in Marse...
journal_title:BMC urology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12894-019-0470-8
更新日期:2019-05-15 00:00:00
abstract:BACKGROUND:Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a rare hereditary kidney cancer syndrome in which affected individuals are at risk of skin and uterine leiomyomatosis and kidney cancer. HLRCC-associated kidney cancer is a lethal disease with a highly aggressive behavior, and there is no standard...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-019-0484-2
更新日期:2019-06-10 00:00:00
abstract:BACKGROUND:To explore the additive effect of urinary incontinence, in people with comorbid depression, on health related quality of life. METHODS:Males and females, 15 to 95 years (n = 3010, response rate 70.2%) were interviewed face to face in the 1998 Autumn South Australian Health Omnibus Survey. RESULTS:Self-repo...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-13-11
更新日期:2013-02-16 00:00:00
abstract:BACKGROUND:Due to the lack of strong evidence to identify the relationship between antihypertensive drugs use and the risk of prostate cancer, it was needed to do a systematic review to go into the subject. METHODS:We systematically searched PubMed, Web of Science and Embase to identify studies published, through May ...
journal_title:BMC urology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12894-018-0318-7
更新日期:2018-03-07 00:00:00
abstract::This review summarizes recent literature on advances regarding renal and ureteral calculi, with particular focus in areas of recent advances in the overall field of urolithiasis. Clinical management in everyday practice requires a complete understanding of the issues regarding metabolic evaluation and subgrouping of s...
journal_title:BMC urology
pub_type: 杂志文章,评审
doi:10.1186/1471-2490-13-10
更新日期:2013-02-16 00:00:00
abstract:BACKGROUND:The objective of this population-based study was to assess patient, physician and tumour determinants associated with positive surgical margins after prostatectomy, and to assess the effects of positive surgical margins on prostate cancer-specific survival. METHODS:We included 1'254 prostate cancer patients...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-14-86
更新日期:2014-11-05 00:00:00
abstract:BACKGROUND:The route of local and metastatic spread of testicular seminoma is well recognised and accepted. The spread is via lymphatics to the paraaortic nodes. CASE PRESENTATION:We present a case report of testicular seminoma in a 56 year old man with previously unreported histological findings. In this case seminom...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-6-5
更新日期:2006-03-01 00:00:00