Statistics review 2: samples and populations.

abstract：:Over the last years, there was an increase in the number and severity of Clostridium difficile infections (CDI) in all medical settings, including the intensive care unit (ICU). The current prevalence of CDI among ICU patients is estimated at 0.4-4% and has severe impact on morbidity and mortality. An estimated 10-20%...

journal_title：Critical care (London, England)

authors： Prechter F,Katzer K,Bauer M,Stallmach A

更新日期：2017-10-22 00:00:00

abstract：INTRODUCTION:Dextrose may be used during cardiac arrest resuscitation to prevent or reverse hypoglycemia. However, the incidence of dextrose administration during cardiac arrest and the association of dextrose administration with survival and other outcomes are unknown. METHODS:We used the Get With The Guidelines®-Res...

journal_title：Critical care (London, England)

authors： Peng TJ,Andersen LW,Saindon BZ,Giberson TA,Kim WY,Berg K,Novack V,Donnino MW,American Heart Association’s Get With The Guidelines®-Resuscitation Investigators.

更新日期：2015-04-10 00:00:00

abstract：INTRODUCTION:Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal. Until now no controlled studies have been conducted to compare their effectiveness, even though the Brain Trauma Foundation Guidelines recommend that such studies be undertaken. The ...

journal_title：Critical care (London, England)

authors： Pérez-Bárcena J,Llompart-Pou JA,Homar J,Abadal JM,Raurich JM,Frontera G,Brell M,Ibáñez J,Ibáñez J

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:N-acetylcysteine (NAC) has been shown to improve splanchnic blood flow in experimental studies. This report evaluates the effects of NAC on liver perfusion and lactate signal intensities in the liver tissue of septic shock patients using proton magnetic resonance imaging and spectroscopy. Furthermore, the mo...

journal_title：Critical care (London, England)

authors： Hein OV,Ohring R,Schilling A,Oellerich M,Armstrong VW,Kox WJ,Spies C

更新日期：2004-04-01 00:00:00

abstract：INTRODUCTION:Critically ill patients and families rely upon physicians to provide estimates of prognosis and recommendations for care. Little is known about patient and clinician factors which influence these predictions. The association between these predictions and recommendations for continued aggressive care is als...

journal_title：Critical care (London, England)

authors： O'Brien JM Jr,Aberegg SK,Ali NA,Diette GB,Lemeshow S

更新日期：2009-01-01 00:00:00

abstract：:Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance. The pathophysiology is complex and includes dysregulation of vasodilatory and vasoconstrictive properties of smooth vascular muscle cells. Specific bypas...

journal_title：Critical care (London, England)

authors： Busse LW,Barker N,Petersen C

更新日期：2020-02-04 00:00:00

abstract：INTRODUCTION:Subarachnoid haemorrhage (SAH) may damage the hypothalamo-pituitary-adrenal gland (HPA) axis and disturb cortisol metabolism. There are no available data that relates to the response of the HPA axis in the acute phase of SAH. We aimed to characterise the behavior of serum adrenocorticotropic hormone (ACTH)...

journal_title：Critical care (London, England)

authors： Bendel S,Koivisto T,Ruokonen E,Rinne J,Romppanen J,Vauhkonen I,Kiviniemi V,Uusaro A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:In hospitalised patients, anaemia increases the risk of developing acute kidney injury (AKI). Our aim was to determine whether anaemia also has an impact on the risk of progression from early AKI to more severe AKI in critically ill patients. METHODS:We retrospectively analysed the data of patients admitted...

journal_title：Critical care (London, England)

authors： Powell-Tuck J,Crichton S,Raimundo M,Camporota L,Wyncoll D,Ostermann M

更新日期：2016-03-08 00:00:00

abstract：INTRODUCTION:Currently, little is known about the immunological characteristics of patients with avian influenza A (H7N9) virus infection. METHODS:The numbers and percentages of peripheral blood immune cells were measured in 27 patients with laboratory-confirmed H7N9 virus infection and 30 healthy controls (HCs). The ...

journal_title：Critical care (London, England)

authors： Wu W,Shi Y,Gao H,Liang W,Sheng J,Li L

更新日期：2014-03-24 00:00:00

abstract：INTRODUCTION:Dehydroepiandrosterone (DHEA) improves survival after trauma and sepsis, while mechanisms of action are not yet fully understood. Therefore, we investigated the influence of DHEA on local cytokine expression in a two-hit model. METHODS:Male NMRI mice were subjected to femur fracture/hemorrhagic shock and ...

journal_title：Critical care (London, England)

authors： Barkhausen T,Hildebrand F,Krettek C,van Griensven M

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The goal of personalised medicine in the intensive care unit (ICU) is to predict which diagnostic tests, monitoring interventions and treatments translate to improved outcomes given the variation between patients. Unfortunately, processes such as gene transcription and drug metabolism are dynamic in the cr...

journal_title：Critical care (London, England)

authors： Celi LA,Hinske LC,Alterovitz G,Szolovits P

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Calcium release-activated calcium (CRAC) channel inhibitors stabilize the pulmonary endothelium and block proinflammatory cytokine release, potentially mitigating respiratory complications observed in patients with COVID-19. This study aimed to investigate the safety and efficacy of Auxora, a novel, intraven...

journal_title：Critical care (London, England)

authors： Miller J,Bruen C,Schnaus M,Zhang J,Ali S,Lind A,Stoecker Z,Stauderman K,Hebbar S

更新日期：2020-08-14 00:00:00

abstract：INTRODUCTION:The anaesthetic agent propofol (2,6-diisopropylphenol) has been shown to be an effective neuroprotective agent in different in vitro models of brain injury induced by oxygen and glucose deprivation. We examined its neuroprotective properties in an in vitro model of traumatic brain injury. METHODS:In this ...

journal_title：Critical care (London, England)

authors： Rossaint J,Rossaint R,Weis J,Fries M,Rex S,Coburn M

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Manifestations of sepsis are sensitive but are poorly specific of infection. Our aim was to assess the value of daily measurements of C-reactive protein (CRP), temperature and white cell count (WCC) in the early identification of intensive care unit (ICU)-acquired infections. METHODS:We undertook a prospe...

journal_title：Critical care (London, England)

authors： Póvoa P,Coelho L,Almeida E,Fernandes A,Mealha R,Moreira P,Sabino H

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Mottling around the knee, reflecting a reduced skin blood flow, is predictive of mortality in patients with septic shock. However, the causative pathophysiology of mottling remains unknown. We hypothesized that the cutaneous hypoperfusion observed in the mottled area is related to regional endothelial dysfun...

journal_title：Critical care (London, England)

authors： Bourcier S,Joffre J,Dubée V,Preda G,Baudel JL,Bigé N,Leblanc G,Levy BI,Guidet B,Maury E,Ait-Oufella H

更新日期：2017-06-23 00:00:00

abstract：:In this month's issue of Critical Care, Determann and colleagues report the results of a randomized controlled trial comparing the effects of mechanical ventilation (MV) with two tidal volumes (6 versus 10 ml/kg predicted body weight) on cytokine levels in lung lavage fluid and plasma as a surrogate for early identifi...

journal_title：Critical care (London, England)

authors： Villar J,Slutsky AS

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Blood transfusion in the perioperative period has frequently been associated with an excess of nosocomial infections. Whilst transfused whole blood induces specific host immune alteration that may predispose to nosocomial infections, the immunomodulating properties associated with leukodepleted blood remai...

journal_title：Critical care (London, England)

authors： Fragkou PC,Torrance HD,Pearse RM,Ackland GL,Prowle JR,Owen HC,Hinds CJ,O'Dwyer MJ

更新日期：2014-10-01 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available ...

journal_title：Critical care (London, England)

authors： Jonkman AH,de Vries HJ,Heunks LMA

更新日期：2020-03-24 00:00:00

abstract：INTRODUCTION:To determine whether subjecting patients to 100 ml of additional dead space after a 120-minute weaning trial could predict readiness for extubation. METHODS:This was a prospective, non-randomised pilot study in an intensive care unit at a university hospital with 14 beds. It included all non-tracheostomis...

journal_title：Critical care (London, England)

authors： Solsona JF,Díaz Y,Vázquez A,Pilar Gracia M,Zapatero A,Marrugat J

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The choice of invasive systemic haemodynamic monitoring in critically ill patients remains controversial as no multicentre comparative clinical data exist. Accordingly, we sought to study and compare the features and outcomes of patients who receive haemodynamic monitoring with either the pulmonary artery ...

journal_title：Critical care (London, England)

authors： Uchino S,Bellomo R,Morimatsu H,Sugihara M,French C,Stephens D,Wendon J,Honore P,Mulder J,Turner A,PAC\/PiCCO Use and Likelihood of Success Evaluation PULSE Study Group.

更新日期：2006-01-01 00:00:00

abstract：:Adverse events affect approximately 3% to 12% of hospitalized patients. At least a third, but as many as half, of such events are considered preventable. Detection of these events requires investments of time and money. A report in a recent issue of Critical Care used the medical emergency team activation as a trigger...

journal_title：Critical care (London, England)

authors： Amaral AC,Shojania KG

更新日期：2009-01-01 00:00:00

abstract：:This commentary on a paper by Bendel and colleagues in the previous issue of Critical Care describes the difficulty in assessing the sufficiency of adrenal responses to endogenous, stress-induced adrenocorticotropic hormone (ACTH) release by the pituitary or to exogenous ACTH administration in the critically ill patie...

journal_title：Critical care (London, England)

authors： Groeneveld AB,Beishuizen A,Molenaar N

更新日期：2009-01-01 00:00:00

abstract：IMPORTANCE:The optimal approach to airway management during in-hospital cardiac arrest is unknown. OBJECTIVE:To describe hospital-level variation in endotracheal intubation during cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest and the association between hospital use of endotracheal intubation and ...

journal_title：Critical care (London, England)

authors： Bradley SM,Zhou Y,Ramachandran SK,Engoren M,Donnino M,Girotra S

更新日期：2019-05-06 00:00:00

abstract：BACKGROUND:The incidence of seizures in intensive care units ranges from 3.3% to 34%. It is therefore often necessary to initiate or continue anticonvulsant drugs in this setting. When a new anticonvulsant is initiated, drug factors, such as onset of action and side effects, and patient factors, such as age, renal, and...

journal_title：Critical care (London, England)

authors： Farrokh S,Tahsili-Fahadan P,Ritzl EK,Lewin JJ 3rd,Mirski MA

更新日期：2018-06-07 00:00:00

abstract：:Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known a...

journal_title：Critical care (London, England)

authors： Souza-Fonseca-Guimaraes F,Cavaillon JM,Adib-Conquy M

更新日期：2013-08-27 00:00:00

abstract：:Despite progress in the diagnosis, prevention and therapy for hospital-acquired infections, ventilator-associated pneumonia (VAP) continues to complicate the course of a significant proportion of patients receiving mechanical ventilation. Mortality rates among patients with VAP have been reported to be as high as 72%,...

journal_title：Critical care (London, England)

authors： Rello J

更新日期：2005-06-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) has a substantial mortality rate and annually affects more than 140,000 people in the USA alone. Standard management includes lung protective ventilation but this impairs carbon dioxide clearance and may lead to right heart dysfunction or increased intracranial pressure. Extr...

journal_title：Critical care (London, England)

authors： Cove ME,MacLaren G,Federspiel WJ,Kellum JA

更新日期：2012-09-21 00:00:00

abstract：:Three pulse contour systems for monitoring cardiac output - LiDCO Plus™, PiCCO Plus™ and FloTrac™ - were compared in postcardiac surgery patients. None of the three methods demonstrated good trending ability according to concordance analysis. Pulse contour systems remain unreliable in the haemodynamically unstable pat...

journal_title：Critical care (London, England)

authors： Critchley LA

更新日期：2011-01-19 00:00:00

abstract：INTRODUCTION:Delayed patient admission to the intensive care unit (ICU) due to lack of bed availability is a common problem, but the effect on patient outcome is not fully known. METHODS:A retrospective study was performed using departmental computerised records to determine the effect of delayed ICU admission and tem...

journal_title：Critical care (London, England)

authors： O'Callaghan DJ,Jayia P,Vaughan-Huxley E,Gribbon M,Templeton M,Skipworth JR,Gordon AC

更新日期：2012-10-01 00:00:00

abstract：:This narrative review summarizes the role of vitamin C in mitigating oxidative injury-induced microcirculatory impairment and associated organ failure in ischemia/reperfusion or sepsis. Preclinical studies show that high-dose vitamin C can prevent or restore microcirculatory flow impairment by inhibiting activation of...

journal_title：Critical care (London, England)

authors： Oudemans-van Straaten HM,Spoelstra-de Man AM,de Waard MC

更新日期：2014-08-06 00:00:00