Bench-to-bedside review: Therapeutic options and issues in the management of ventilator-associated bacterial pneumonia.

abstract：INTRODUCTION:The pathophysiology of postoperative delirium remains poorly understood. The purpose of this study was to examine the relationship between serum cortisol level and occurrence of early postoperative delirium in patients undergoing coronary artery bypass graft (CABG) surgery. METHODS:A total of 243 patients...

journal_title：Critical care (London, England)

authors： Mu DL,Wang DX,Li LH,Shan GJ,Li J,Yu QJ,Shi CX

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:In patients with severe sepsis and septic shock as cause of Intensive Care Unit (ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy initiated before ICU admission. METHODS:We conducted a prospective observational study enrolling patients admitted to the ICU with severe se...

journal_title：Critical care (London, England)

authors： Garnacho-Montero J,Gutiérrez-Pizarraya A,Escoresca-Ortega A,Fernández-Delgado E,López-Sánchez JM

更新日期：2015-08-27 00:00:00

abstract：INTRODUCTION:Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP) hepatotoxicity. Kupffer cells (KC) play important roles in inflammation, and KC depletion confers protection at early time points after APAP treatment but can lead to more severe injury at a later time point. It is possib...

journal_title：Critical care (London, England)

authors： Yang R,Zou X,Koskinen ML,Tenhunen J

更新日期：2012-01-16 00:00:00

abstract：BACKGROUND:Omega-3 (ω-3) fatty acid (FA)-containing parenteral nutrition (PN) is associated with significant improvements in patient outcomes compared with standard PN regimens without ω-3 FA lipid emulsions. Here, we evaluate the impact of ω-3 FA-containing PN versus standard PN on clinical outcomes and costs in adult...

journal_title：Critical care (London, England)

authors： Pradelli L,Klek S,Mayer K,Omar Alsaleh AJ,Rosenthal MD,Heller AR,Muscaritoli M

更新日期：2020-11-03 00:00:00

abstract：:Primary or secondary infection of necrotized areas by enteral bacteria is considered a primary cause of mortality in patients with severe acute pancreatitis (SAP). Indeed, 20-30% of patients die during the course of the disease from multiple organ dysfunction after infection. This is why strategies such as antibiotic ...

journal_title：Critical care (London, England)

authors： Gerlach H

更新日期：2004-12-01 00:00:00

abstract：:In a group of postoperative patients, Taniguchi and coworkers compared the effect of a computerized system for weaning against 'manual care'. The computerized system involved automatic adjustments to the level of pressure support to achieve a target respiratory rate. Manual care involved adjustments to the level of pr...

journal_title：Critical care (London, England)

authors： Adigüzel N,Güngör G,Tobin MJ

更新日期：2009-01-01 00:00:00

abstract：:The early detection and treatment of sepsis are the most important factors in improving the outcome of patients with this condition. However, many patients admitted to hospital experience a long delay in the diagnosis of sepsis. Furthermore, it is not uncommon for febrile patients to be sent home from the Emergency De...

journal_title：Critical care (London, England)

authors： Marik PE

更新日期：2014-09-27 00:00:00

abstract：BACKGROUND:Esophageal pressure (Pes) can provide information to guide mechanical ventilation in acute respiratory failure. However, both relative changes and absolute values of Pes can be affected by inappropriate filling of the esophageal balloon and by the elastance of the esophagus wall. We evaluated the feasibility...

journal_title：Critical care (London, England)

authors： Mojoli F,Iotti GA,Torriglia F,Pozzi M,Volta CA,Bianzina S,Braschi A,Brochard L

更新日期：2016-04-11 00:00:00

abstract：INTRODUCTION:The endothelial specific angiopoietin (Ang)-Tie2 ligand-receptor system has been identified as a non-redundant mediator of endothelial activation in experimental sepsis. Binding of circulating Ang-1 to the Tie2 receptor protects the vasculature from inflammation and leakage, whereas binding of Ang-2 antago...

journal_title：Critical care (London, England)

authors： Kümpers P,Lukasz A,David S,Horn R,Hafer C,Faulhaber-Walter R,Fliser D,Haller H,Kielstein JT

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Pulmonary embolism (PE) is one of the greatest diagnostic challenges in prehospital emergency setting. Most patients with suspected PE have a positive D-dimer and undergo diagnostic testing. Excluding PE with additional non-invasive tests would reduce the need for further imaging tests. We aimed to determi...

journal_title：Critical care (London, England)

authors： Rumpf TH,Krizmaric M,Grmec S

更新日期：2009-01-01 00:00:00

abstract：:Over the last years, there was an increase in the number and severity of Clostridium difficile infections (CDI) in all medical settings, including the intensive care unit (ICU). The current prevalence of CDI among ICU patients is estimated at 0.4-4% and has severe impact on morbidity and mortality. An estimated 10-20%...

journal_title：Critical care (London, England)

authors： Prechter F,Katzer K,Bauer M,Stallmach A

更新日期：2017-10-22 00:00:00

abstract：:Mechanically ventilated, intubated patients are at increased risk for tracheal colonization with bacterial pathogens that may progress to heavy bacterial colonization, ventilator-associated tracheobronchitis (VAT), and/or ventilator-associated pneumonia (VAP). Previous studies report that 10 to 30 % of patients with V...

journal_title：Critical care (London, England)

authors： Craven DE,Hudcova J,Lei Y,Craven KA,Waqas A

更新日期：2016-09-29 00:00:00

abstract：INTRODUCTION:Enteral nutrition (EN) with eicosapentaenoic acid (EPA)/γ-linolenic acid (GLA) is recommended for mechanically ventilated patients with severe lung injury. EPA/GLA has anti-inflammatory benefits, as evidenced by its association with reduction in pulmonary inflammation, improvement in oxygenation and improv...

journal_title：Critical care (London, England)

authors： Pontes-Arruda A,Martins LF,de Lima SM,Isola AM,Toledo D,Rezende E,Maia M,Magnan GB,Investigating Nutritional Therapy with EPA, GLA and Antioxidants Role in Sepsis Treatment (INTERSEPT) Study Group.

更新日期：2011-06-09 00:00:00

abstract：INTRODUCTION:It has been unclear if mechanical cardiopulmonary resuscitation (CPR) is a viable alternative to manual CPR. We aimed to compare resuscitation outcomes before and after switching from manual CPR to load-distributing band (LDB) CPR in a multi-center emergency department (ED) trial. METHODS:We conducted a p...

journal_title：Critical care (London, England)

authors： Hock Ong ME,Fook-Chong S,Annathurai A,Ang SH,Tiah L,Yong KL,Koh ZX,Yap S,Sultana P

更新日期：2012-08-03 00:00:00

abstract：BACKGROUND:ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been shown to protect against such illness-induced muscle wasting and weakness. Here, we hypothesized that this protection was due to increased lipid and ket...

journal_title：Critical care (London, England)

authors： Goossens C,Weckx R,Derde S,Dufour T,Vander Perre S,Pauwels L,Thiessen SE,Van Veldhoven PP,Van den Berghe G,Langouche L

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The dysregulated host immune response that defines sepsis varies as a function of both the immune status of the host and the distinct nature of the pathogen. The degree to which immunocompromising comorbidities or immunosuppressive medications affect the immune response to infection is poorly understood beca...

journal_title：Critical care (London, England)

authors： Greenberg JA,Hrusch CL,Jaffery MR,David MZ,Daum RS,Hall JB,Kress JP,Sperling AI,Verhoef PA

更新日期：2018-04-25 00:00:00

abstract：INTRODUCTION:Fractalkine is a chemokine implicated as a mediator in a variety of inflammatory conditions. Knowledge of fractalkine release in patients presenting with infection to the Intensive Care Unit (ICU) is highly limited. The primary objective of this study was to establish whether plasma fractalkine levels are ...

journal_title：Critical care (London, England)

authors： Hoogendijk AJ,Wiewel MA,van Vught LA,Scicluna BP,Belkasim-Bohoudi H,Horn J,Zwinderman AH,Klein Klouwenberg PM,Cremer OL,Bonten MJ,Schultz MJ,van der Poll T,MARS consortium.

更新日期：2015-11-25 00:00:00

abstract：INTRODUCTION:Lowering of hyperglycemia in the intensive care unit (ICU) is widely practiced. We investigated in which way glucose regulation, defined as mean glucose concentration during admission, is associated with ICU mortality in a medical and a surgical cohort. METHODS:Retrospective database cohort study includin...

journal_title：Critical care (London, England)

authors： Siegelaar SE,Hermanides J,Oudemans-van Straaten HM,van der Voort PH,Bosman RJ,Zandstra DF,DeVries JH

更新日期：2010-01-01 00:00:00

abstract：:A new randomised controlled trial suggested that plasma exchange hastened removal from the ventilator in mechanically ventilated children with Guillain-Barré syndrome compared with intravenous immunoglobulin. Two larger trials in adults showed the opposite result. ...

journal_title：Critical care (London, England)

authors： Hughes RA

更新日期：2011-07-28 00:00:00

abstract：:Characteristic patterns of variation over time, namely rhythms, represent a defining feature of complex systems, one that is synonymous with life. Despite the intrinsic dynamic, interdependent and nonlinear relationships of their parts, complex biological systems exhibit robust systemic stability. Applied to critical ...

journal_title：Critical care (London, England)

authors： Seely AJ,Macklem PT

更新日期：2004-12-01 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available ...

journal_title：Critical care (London, England)

authors： Bassetti M,Bandera A,Gori A

更新日期：2020-03-24 00:00:00

abstract：BACKGROUND:Simvastatin therapy for patients with acute respiratory distress syndrome (ARDS) has been shown to be safe and associated with minimal adverse effects, but it does not improve clinical outcomes. The aim of this research was to report on mortality and cost-effectiveness of simvastatin in patients with ARDS at...

journal_title：Critical care (London, England)

authors： Agus A,Hulme C,Verghis RM,McDowell C,Jackson C,O'Kane CM,Laffey JG,McAuley DF

更新日期：2017-05-17 00:00:00

abstract：INTRODUCTION:The analysis of flow and pressure waveforms generated by ventilators can be useful in the optimization of patient-ventilator interactions, notably in chronic obstructive pulmonary disease (COPD) patients. To date, however, a real clinical benefit of this approach has not been proven. METHODS:The aim of th...

journal_title：Critical care (London, England)

authors： Di Marco F,Centanni S,Bellone A,Messinesi G,Pesci A,Scala R,Perren A,Nava S

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Our aim was to evaluate the role of B-type natriuretic peptide (BNP) percentage variations at 24 hours and at discharge compared to its value at admission in order to demonstrate its predictive value for outcomes in patients with acute decompensated heart failure (ADHF). METHODS:This was a multicenter Ita...

journal_title：Critical care (London, England)

authors： Di Somma S,Magrini L,Pittoni V,Marino R,Mastrantuono A,Ferri E,Ballarino P,Semplicini A,Bertazzoni G,Carpinteri G,Mulè P,Pazzaglia M,Shah K,Maisel A,Clopton P

更新日期：2010-01-01 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum.com/series/annualupdate2015. Further information about the Annual Update in Intensive Care a...

journal_title：Critical care (London, England)

authors： Pepe PE,Roppolo LP,Fowler RL

更新日期：2015-03-16 00:00:00

abstract：:Acute pancreatitis results from a sequence of events that involve the systemic inflammatory response. Activated C has multiple anti-inflammatory activities and may attenuate the degree of pancreatic injury and systemic organ dysfunction when infused early in pancreatitis. ...

journal_title：Critical care (London, England)

authors： Kirschenbaum L,Astiz M

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:Prevalence of iron deficiency (ID) at intensive care (ICU) admission is around 25 to 40%. Blood losses are important during ICU stay, leading to iron losses, but prevalence of ID at ICU discharge is unknown. ID has been associated with fatigue and muscular weakness, and may thus impair post-ICU rehabilitat...

journal_title：Critical care (London, England)

authors： Lasocki S,Chudeau N,Papet T,Tartiere D,Roquilly A,Carlier L,Mimoz O,Seguin P,Malledant Y,Asehnoune K,Hamel JF,AtlanREA group.

更新日期：2014-09-30 00:00:00

abstract：:The past 25 years have witnessed the development of improved tools with which to predict short-term and long-term outcomes after critical illness. The general paradigm for constructing the best known tools has been the logistic regression model. Recently, a variety of alternative tools, such as artificial neural netwo...

journal_title：Critical care (London, England)

authors： Clermont G

更新日期：2005-04-01 00:00:00

abstract：INTRODUCTION:Hemorrhagic shock induced O2 deficit triggers inflammation and multiple organ failure (MOF). Endogenous H2S has been proposed to be involved in MOF since plasma H2S concentration appears to increase in various types of shocks and to predict mortality. We tested the hypothesis that H2S increases during hemo...

journal_title：Critical care (London, England)

authors： Van de Louw A,Haouzi P

更新日期：2012-10-02 00:00:00

abstract：BACKGROUND:Despite quick implementation of reperfusion therapies, a few patients with high-risk, acute, massive, pulmonary embolism (PE) remain highly hemodynamically unstable. Others have absolute contraindication to receive reperfusion therapies. Venoarterial-extracorporeal membrane oxygenation (VA-ECMO) might lower ...

journal_title：Critical care (London, England)

authors： Corsi F,Lebreton G,Bréchot N,Hekimian G,Nieszkowska A,Trouillet JL,Luyt CE,Leprince P,Chastre J,Combes A,Schmidt M

更新日期：2017-03-28 00:00:00