Abstract:
:In this month's issue of Critical Care, Determann and colleagues report the results of a randomized controlled trial comparing the effects of mechanical ventilation (MV) with two tidal volumes (6 versus 10 ml/kg predicted body weight) on cytokine levels in lung lavage fluid and plasma as a surrogate for early identification of acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). The study was stopped early after an interim analysis - when 150 patients were enrolled - showing that the incidence of ALI/ARDS according to the current definition was 10.9% higher in the 10 ml/kg group, although duration of MV and mortality was similar in both groups. We examine these interesting results after providing a brief historical perspective and discuss the limitations and implications of the study.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Villar J,Slutsky ASdoi
10.1186/cc8842subject
Has Abstractpub_date
2010-01-01 00:00:00pages
120issue
1eissn
1364-8535issn
1466-609Xpii
cc8842journal_volume
14pub_type
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