当前位置： SCI文献检索 > BMJ Open期刊下所有文献 > Young adolescent girls are at high risk for adverse pregnancy outcomes in sub-Saharan Africa: an observational multicountry study.

Young adolescent girls are at high risk for adverse pregnancy outcomes in sub-Saharan Africa: an observational multicountry study.

Abstract：

OBJECTIVES:One of Africa's most important challenges is to improve maternal and neonatal health. The identification of groups at highest risk for adverse pregnancy outcomes is important for developing and implementing targeted prevention programmes. This study assessed whether young adolescent girls constitute a group at increased risk for adverse birth outcomes among pregnant women in sub-Saharan Africa. SETTING:Data were collected prospectively as part of a large randomised controlled clinical trial evaluating intermittent preventive treatment of malaria in pregnancy (NCT00811421-Clinical Trials.gov), conducted between September 2009 and December 2013 in Benin, Gabon, Mozambique and Tanzania. PARTICIPANTS:Of 4749 participants, pregnancy outcomes were collected for 4388 deliveries with 4183 live births including 83 multiple gestations. Of 4100 mothers with a singleton live birth delivery, 24% (975/4100) were adolescents (≤19 years of age) and 6% (248/4100) were aged ≤16 years. PRIMARY AND SECONDARY OUTCOME MEASURES:Primary outcomes of this predefined analysis were preterm delivery and low birth weight. RESULTS:The overall prevalence of low birthweight infants and preterm delivery was 10% (371/3851) and 4% (159/3862), respectively. Mothers aged ≤16 years showed higher risk for the delivery of a low birthweight infant (OR: 1.96; 95% CI 1.35 to 2.83). Similarly, preterm delivery was associated with young maternal age (≤16 years; OR: 2.62; 95% CI 1.59 to 4.30). In a subanalysis restricted to primiparous women: preterm delivery, OR 4.28; 95% CI 2.05 to 8.93; low birth weight, OR: 1.29; 95% CI 0.82 to 2.01. CONCLUSIONS:Young maternal age increases the risk for adverse pregnancy outcomes and it is a stronger predictor for low birth weight and preterm delivery than other established risk factors in sub-Saharan Africa. This finding highlights the need to improve adolescent reproductive health in sub-Saharan Africa. TRIAL REGISTRATION NUMBER:NCT00811421; Post-results.

journal_name

BMJ Open

journal_title

BMJ open

authors

Mombo-Ngoma G,Mackanga JR,González R,Ouedraogo S,Kakolwa MA,Manego RZ,Basra A,Rupérez M,Cot M,Kabanywany AM,Matsiegui PB,Agnandji ST,Vala A,Massougbodji A,Abdulla S,Adegnika AA,Sevene E,Macete E,Yazdanbakhsh M,Krems

doi

10.1136/bmjopen-2016-011783

subject

Has Abstract

pub_date

2016-06-29 00:00:00

pages

e011783

issue

6

issn

2044-6055

pii

bmjopen-2016-011783

journal_volume

6

pub_type

杂志文章,多中心研究,随机对照试验

相关文献

BMJ Open文献大全