Abstract:
UNLABELLED:The WARM study is a longitudinal cohort study following infants of mothers with schizophrenia, bipolar disorder, depression and control from pregnancy to infant 1 year of age. BACKGROUND:Children of parents diagnosed with complex mental health problems including schizophrenia, bipolar disorder and depression, are at increased risk of developing mental health problems compared to the general population. Little is known regarding the early developmental trajectories of infants who are at ultra-high risk and in particular the balance of risk and protective factors expressed in the quality of early caregiver-interaction. METHODS/DESIGN:We are establishing a cohort of pregnant women with a lifetime diagnosis of schizophrenia, bipolar disorder, major depressive disorder and a non-psychiatric control group. Factors in the parents, the infant and the social environment will be evaluated at 1, 4, 16 and 52 weeks in terms of evolution of very early indicators of developmental risk and resilience focusing on three possible environmental transmission mechanisms: stress, maternal caregiver representation, and caregiver-infant interaction. DISCUSSION:The study will provide data on very early risk developmental status and associated psychosocial risk factors, which will be important for developing targeted preventive interventions for infants of parents with severe mental disorder. TRIAL REGISTRATION:NCT02306551, date of registration November 12, 2014.
journal_name
BMC Psychiatryjournal_title
BMC psychiatryauthors
Harder S,Davidsen K,MacBeth A,Lange T,Minnis H,Andersen MS,Simonsen E,Lundy JM,Nyström-Hansen M,Trier CH,Røhder K,Gumley Adoi
10.1186/s12888-015-0692-6subject
Has Abstractpub_date
2015-12-09 00:00:00pages
310issn
1471-244Xpii
10.1186/s12888-015-0692-6journal_volume
15pub_type
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