当前位置： SCI文献检索 > BMC Psychiatry期刊下所有文献 > The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment.

The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment.

Abstract：

BACKGROUND:Depression is associated with immunological responses as reflected by altered levels of circulating cytokines. Alcohol use and trauma may modulate immune activity, and few studies have investigated these factors in depressed patients. We aimed to explore the association between circulating peripheral cytokine levels and degree of depressive symptoms, taking trauma and alcohol into account. METHODS:The study was a cross-sectional assessment of patients at admission to a specialized psychiatric center in Norway. A total of 128 patients were included. Information was gathered using the self-administered questionnaires Beck Depression Inventory-II (BDI-II) and the Alcohol Use Disorders Identification Test (AUDIT), in addition to clinical interviews recording childhood or adult life trauma. Serum levels of the cytokines Interleukin-1β (IL-1β), Interleukin-1 Receptor Antagonist (IL-1RA), Tumor Necrosis Factor-α (TNF-α) and the chemokine Monocyte Chemoattractant Protein-1 (MCP-1) were assessed. A Luminex bead-based multiplex assay was used for cytokine measurements. Patient cytokine levels were compared to those of healthy volunteers by the Mann-Whitney U test. RESULTS:Levels of cytokines did not differ across patients with mild, moderate and severe depression. AUDIT score was not related to cytokine levels, but to level of depression. A history of trauma was related to higher levels of IL-1RA and TNF-α (p = 0.048 and p = 0.033, respectively), especially among the severely depressed. Serum levels of MCP-1 and TNF-α were significantly higher among psychiatric patients than in healthy volunteers. CONCLUSIONS:Findings indicate that depression was not related to levels of circulating cytokines among patients in treatment, but that traumatized patients had higher levels of IL-1RA and TNF-α than patients without trauma experience. The lack of relationship between cytokine level and depression was evident both in those without and with trauma.

journal_name

BMC Psychiatry

journal_title

BMC psychiatry

authors

Toft H,Neupane SP,Bramness JG,Tilden T,Wampold BE,Lien L

doi

10.1186/s12888-018-1677-z

subject

Has Abstract

pub_date

2018-04-10 00:00:00

pages

issue

issn

1471-244X

pii

10.1186/s12888-018-1677-z

journal_volume

pub_type

杂志文章

在线工具

The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment.