Abstract：
BACKGROUND:Annona muricata (A. muricata) is widely distributed in Asia, Africa and South America. Different parts of this plant are used to treat several diseases in Cameroon. The aim of this study is to determine the in vitro anti-proliferative effects and apoptotic events of A. muricata extracts on HL-60 cells as well as to quantify its phenols content. METHODS:The cell viability was measured by using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay while the changes in morphology of HL-60 cells, membrane mitochondrial potential (MMP) and the cell cycle were used for assessment apoptosis induction. RESULTS:The results show that the concentration of phenols, flavonoids and flavonols in the extracts varied depending on the part of the plant. All the extracts tested inhibited the proliferation of HL-60 cells in a concentration dependent manner with IC50 varied from 6-49 μg/mL. The growth inhibition of the cells by extracts was associated with the disruption of MMP, reactive oxygen species (ROS) generation and the G0/G1 cell arrest. CONCLUSION:These findings suggest that the extracts from A. muricata have strong antiproliferation potential and can induce apoptosis through loss of MMP and G0/G1 phase cell arrest.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Pieme CA,Kumar SG,Dongmo MS,Moukette BM,Boyoum FF,Ngogang JY,Saxena AKdoi
10.1186/1472-6882-14-516subject
Has Abstractpub_date
2014-12-24 00:00:00pages
516issn
1472-6882pii
1472-6882-14-516journal_volume
14pub_type
杂志文章abstract：BACKGROUND:Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to dengue pathogenesis such as nonstructural protein 1 (NS1) production and viremia level have never been highlighted ...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-018-2390-7
更新日期：2018-12-05 00:00:00
abstract：BACKGROUND:Cancer-related fatigue is one of the most common symptoms experienced by cancer patients, and it diminishes their quality of life. However, there is currently no confirmed standard treatment for cancer-related fatigue, and thus, many patients who suffer cancer-related fatigue seek complementary and alternati...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/s12906-017-1856-3
更新日期：2017-07-05 00:00:00
abstract：BACKGROUND:Endophytes, which reside in plant tissues, have the potential to produce novel metabolites with immense benefits for health industry. Cytotoxic and antimicrobial activities of endophytic fungi isolated from Bacopa monnieri (L.) Pennell were investigated. METHODS:Endophytic fungi were isolated from the Bacop...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-14-52
更新日期：2014-02-11 00:00:00
abstract：BACKGROUND:During recent years the market for homeopathic education media has increasingly diversified with old (books, seminars) and new media (video-seminars, pc-programs, homeo-wiki and internet-courses). However, little is known about homeopaths' preferences in using educational media and their requirements of this...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-12-95
更新日期：2012-07-13 00:00:00
abstract：BACKGROUND:In traditional Chinese medicine, green tea is considered to have a life-prolonging effect, possibly as a result of its rich content of antioxidant tea polyphenols, and hence has the potential to prevent cancer. This study investigated the role of the major tea secondary plant compound epigallocatechin gallat...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-12-258
更新日期：2012-12-18 00:00:00
abstract：BACKGROUND:The use of CAM by pregnant women is very popular in developed countries. The trend is increasing globally and lack of evidence of safety particularly when used during pregnancy may lead to complications. Pregnancy is a vulnerable period especially during the first trimester. There is scarcity of empirical ev...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-017-1689-0
更新日期：2017-04-04 00:00:00
abstract：BACKGROUND:Saliva is fundamental to our oral health and our well-being. Many factors can impair saliva secretion, such as adverse effects of prescribed medication, auto-immune diseases (for example Sjögren's syndrome) and radiotherapy for head and neck cancers. Several studies have suggested a positive effect of acupun...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,评审
doi：10.1186/s12906-018-2124-x
更新日期：2018-02-13 00:00:00
abstract：BACKGROUND:Suo Quan Wan (SQW) is a Chinese traditional prescription that has been used in clinical treatment of lower urinary tract symptoms for centuries. However, scientific basis of SQW efficacy and mechanism is still needed. This study investigated the effect of SQW on bladder function and transient receptor potent...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-015-0898-7
更新日期：2015-12-01 00:00:00
abstract：:Following publication of the original article [1], the author reported that Tables 3 and 4 were incorrect due to a production error. ...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,已发布勘误
doi：10.1186/s12906-019-2658-6
更新日期：2019-11-07 00:00:00
abstract：BACKGROUND:Medical students have consistently expressed interest in learning about alternative healing modalities, especially herbal and natural products. To fill this void in medical education at our institution, a novel elective was developed and implemented for fourth year medical students. This herbal/natural produ...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-12-57
更新日期：2012-05-22 00:00:00
abstract：BACKGROUND:In China, demands for disease prevention and health care and the prevalence of chronic non-communicable diseases have increased. TCM and general hospitals are increasingly utilizing TCM strategies for chronic non-communicable disease care and prevention. This study aimed to investigate health care profession...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-018-2273-y
更新日期：2018-07-06 00:00:00
abstract：BACKGROUND:The aims of this study were to evaluate the effect and mechanism of a traditional Chinese medicine formula: Tongxieyaofang (TXYF) on Rats with Post Infectious Irritable Bowel Syndrome (PI-IBS). METHODS:SD male rats in adult were used to model PI-IBS and treated with TXYF at three dosage for 14 consecutive d...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-13-246
更新日期：2013-10-02 00:00:00
abstract：BACKGROUND:Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we inves...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-019-2611-8
更新日期：2019-08-09 00:00:00
abstract：BACKGROUND:Tinospora cordifolia (Guduchi or Amrita) is an important drug of Ayurvedic System of Medicine and found mention in various classical texts for the treatment of diseases such as jaundice, fever, diabetes, cancer and skin disease etc. In view of its traditional claims, antioxidant and anti-proliferative activi...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-017-1953-3
更新日期：2017-09-11 00:00:00
abstract：BACKGROUND:The effect and safety of catgut implantation at acupoints o treat allergic rhinitis (ICD-10 code J30.4) remain controversial. Here, we used a sham catgut implantation group to determine whether catgut implantation at acupoints is an effective and safe treatment for allergic rhinitis. METHODS:A randomized do...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12906-016-1400-x
更新日期：2016-11-10 00:00:00
abstract：BACKGROUND:Nuna Kadugu (NK), a Siddha medicine prepared from leaves and fruits of Morinda Pubescens, used for the treatment of various skin diseases. Though NK has been widely used for several decades, no scientific report was available on its safety. Present study was undertaken to demonstrate the oral toxicity of NK ...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-12-190
更新日期：2012-10-22 00:00:00
abstract：BACKGROUND:Inverse docking technology has been a trend of drug discovery, and bioinformatics approaches have been used to predict target proteins, biological activities, signal pathways and molecular regulating networks affected by drugs for further pharmacodynamic and mechanism studies. METHODS:In the present paper, ...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-015-0579-6
更新日期：2015-03-05 00:00:00
abstract：BACKGROUND:The present investigation was aimed at evaluating the hypoglycemic and hypolipidemic properties of the aqueous and methanolic extracts from Bersama engleriana leaves in streptozotocin/nicotinamide (STZ-NA)-induced type 2 diabetic rats. METHODS:Animals were orally treated for 4 consecutive weeks with Bersama...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-12-264
更新日期：2012-12-26 00:00:00
abstract：BACKGROUND:Uncomplicated chronic rachialgia is a highly prevalent complaint, and one for which therapeutic results are contradictory. The aim of the present study is to evaluate the effectiveness and safety of treatment with auriculopressure, in the primary healthcare sector, carried out by trained healthcare professio...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/1472-6882-8-36
更新日期：2008-07-06 00:00:00
abstract：BACKGROUND:Metabolic syndrome may lead to many complications, such as nonalcoholic fatty liver disease (NAFLD). A natural and effective therapeutic agent for patients with NAFLD is urgently needed. In a previous study, we showed that Rhodiola crenulata root extract (RCE) regulated hepatic gluconeogenesis through activa...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-016-1108-y
更新日期：2016-05-17 00:00:00
abstract：BACKGROUND:The anti-tumor activities of Natural compounds and their derivatives are of great interest to pharmaceutical industries. Fisetin is one of prospective natural compounds in this regard but unfortunately with poor hydrophilicity. METHODS:The effects of unmodified and modified fisetin in cultured ovarian cance...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-018-2127-7
更新日期：2018-03-15 00:00:00
abstract：BACKGROUND:Decision-making during pregnancy regarding different options of care can be difficult, particularly when risks of intervention versus no intervention for mother and baby are unclear. Unbiased information and support for decision making may be beneficial in these situations. The management of normal pregnanci...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章,评审
doi：10.1186/s12906-015-0663-y
更新日期：2015-05-07 00:00:00
abstract：BACKGROUND:Juglans regia has been found to exhibit significant anticancer activity against various human cancer cell lines. This study was undertaken to isolate the active chemical constituent (Juglone) and to investigate its cytotoxic activity along with its various analogs against different human cancer cell lines. ...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-015-0920-0
更新日期：2015-11-03 00:00:00
abstract：BACKGROUND:The young shoots of Rubus idaeus are traditionally used as a herbal remedy in common cold, fever and flu-like infections yet there is no research concerning this plant material. The aim of the study was to evaluate the chemical composition and biological properties of raspberry shoots from 11 cultivar variet...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-14-480
更新日期：2014-12-12 00:00:00
abstract：BACKGROUND:Paclitaxel induced fatigue still remains underrecognized and undertreated, partly because of limited understanding of its pathophysiology and lack of effective treatments. This study is aim to evaluate the anti-fatigue effects and mechanism of Bu-Zhong-Yi-Qi pill in murine 4 T1 breast cancer mice were treate...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-14-497
更新日期：2014-12-15 00:00:00
abstract：BACKGROUND:Weight gain is common after breast cancer (BC) treatment and may increase the risk of disease recurrence. Complementary medicine (CM) use is high amongst BC patients. This paper describes the use of CM from a cross-sectional self-administered survey on prevalence and management of weight after BC. METHODS:U...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-019-2747-6
更新日期：2019-11-21 00:00:00
abstract：BACKGROUND:In Vitro Fertilisation (IVF) is now an accepted and effective treatment for infertility, however IVF is acknowledged as contributing to, rather than lessening, the overall psychosocial effects of infertility. Psychological and counselling interventions have previously been widely recommended in parallel with...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-9-50
更新日期：2009-12-12 00:00:00
abstract：BACKGROUND:Our preliminary studies indicated that electroacupuncture (EA) at the ST36 and Ashi acupoints could promote regeneration of the rabbit gastrocnemius (GM) by improving microcirculation perfusion, promoting the recovery of myofiber structures, and inhibiting excessive fibrosis. However, the effects of EA on re...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-015-0601-z
更新日期：2015-03-19 00:00:00
abstract：BACKGROUND:In Pakistan Fagonia olivieri (Zygophyllaceae) is commonly used in the indigenous system of medicine for treatment of conditions like diabetes, cancer, fever, asthma, toothache, stomach troubles and kidney disorders. This study evaluated the crude methanol extract of F. olivieri (FOM) and its derived fraction...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/1472-6882-13-167
更新日期：2013-07-10 00:00:00
abstract：BACKGROUND:Previous study showed that extracts from Croton macrostachyus (Euphorbiaceae) exhibit analgesic effects in acute pain models. The present study evaluates the antinociceptive properties of the methanol/methylene chloride extract (MECM) of the stem bark of this plant using mice models of persistent inflammator...
journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
doi：10.1186/s12906-015-0816-z
更新日期：2015-08-25 00:00:00
