Abstract：
BACKGROUND:Endophytes, which reside in plant tissues, have the potential to produce novel metabolites with immense benefits for health industry. Cytotoxic and antimicrobial activities of endophytic fungi isolated from Bacopa monnieri (L.) Pennell were investigated. METHODS:Endophytic fungi were isolated from the Bacopa monnieri. Extracts from liquid cultures were tested for cytotoxicity against a number of cancer cell lines using the MTT assay. Antimicrobial activity was determined using the micro dilution method. RESULTS:22% of the examined extracts showed potent (IC50 of <20 μg/ml) cytotoxic activity against HCT-116 cell line. 5.5%, 11%, 11% of the extracts were found to be cytotoxic for MCF-7, PC-3, and A-549 cell lines respectively. 33% extracts displayed antimicrobial activity against at least one test organism with MIC value 10-100 μg/ml. The isolate B9_Pink showed the most potent cytotoxic activity for all the cell lines examined and maximum antimicrobial activity against the four pathogens examined which was followed by B19. CONCLUSIONS:Results indicated the potential for production of bioactive agents from endophytes of Bacopa monnieri.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Katoch M,Singh G,Sharma S,Gupta N,Sangwan PL,Saxena AKdoi
10.1186/1472-6882-14-52subject
Has Abstractpub_date
2014-02-11 00:00:00pages
52issn
1472-6882pii
1472-6882-14-52journal_volume
14pub_type
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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abstract：BACKGROUND:Lysophosphatidylcholine (lysoPC), a metabolite from membrane phospholipids, accumulates in the ischemic myocardium and plays an important role in the development of myocardial dysfunction ventricular arrhythmia. In this study, we investigated if baicalein, a major component of Huang Qui, can protect against ...
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journal_title：BMC complementary and alternative medicine
pub_type： 杂志文章
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journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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