Huachansu injection inhibits metastasis of pancreatic cancer in mice model of human tumor xenograft.

Abstract:

BACKGROUND:Huachansu injection (HCS) is a water-soluble preparation made from Bufo gargarizans's skin, which has been widely used in clinics for tumor therapy in China. Though the anti-cancer activity of HCS has been verified through studies in vitro and in vivo, there is little research about its potential anti-metastasis effect. The primary objective of this study was to assess the effects of HCS on both the invasion of pancreatic cancer cells in vitro and on the progression of liver metastasis in vivo in this study. METHODS:HCS anti-metastasis potential was accessed using both assay of Cell viability and invasion in vitro, and then further Establishing xenograft model in nude mice. In the cell-based assay, mRNA and protein expression of MMP-2, MMP-9 and VEGF was detected by semi-quantitative RT-PCR and western blotting. In animal experiment, liver metastasis nodules and change of liver-body ratio was observed. Meanwhile, correlation of the CA19-9 and CEA content in serum with the progression of liver metastasis was analyzed. RESULT:We observed that HCS prevented the invasion of cancer cells, with inhibiting the expressions of MMP-2 and MMP-9, and reduced not only the number of metastasis nodules but the ratio of liver-body weight as well. Furthermore, HCS decreased the expression of MMP-2, MMP-9 and VEGF in liver metastasis, while also reducing CA19-9 contents in serum. In addition, correlation analysis indicated that the level of CA19-9 in serum was closely related to the number of liver metastasis nodules. CONCLUSION:Our experimental results suggest that HCS has some anti-metastasis potential to suppress the growth of liver metastasis by decreasing the expression of MMP-2 and MMP-9 as well as VEGF.

authors

Yin JH,Zhu XY,Shi WD,Liu LM

doi

10.1186/1472-6882-14-483

subject

Has Abstract

pub_date

2014-12-13 00:00:00

pages

483

issn

1472-6882

pii

1472-6882-14-483

journal_volume

14

pub_type

杂志文章
  • Evaluation of the medicinal properties of Cyrtocarpa procera Kunth fruit extracts.

    abstract:BACKGROUND:The fruit of Cyrtocarpa procera is used to treat stomach diseases by people living in San Rafael, Coxcatlan, Puebla. This work investigated the antibacterial, antioxidant, cytotoxic and anti-inflammatory activities of the fruit produced by this species. METHODS:Methanol extract was obtained by maceration. A...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0602-y

    authors: Martinez-Elizalde KS,Jimenez-Estrada M,Flores CM,Hernandez LB,Rosas-Lopez R,Duran-Diaz A,Nieto-Yañez OJ,Barbosa E,Rodriguez-Monroy MA,Canales-Martinez M

    更新日期:2015-03-21 00:00:00

  • Effects of Gelam and Acacia honey acute administration on some biochemical parameters of Sprague Dawley rats.

    abstract:BACKGROUND:Since ancient times, honey has been used for medicinal purposes in many cultures; it is one of the oldest and most enduring substances used in wound management. Scientific evidence for its efficacy is widely studied, but systemic safety studies are still lacking. It is essential to study the impact of consum...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-146

    authors: Samat S,Nor NA,Nor Hussein F,Ismail WI

    更新日期:2014-05-04 00:00:00

  • An in vitro study on the risk of non-allergic type-I like hypersensitivity to Momordica charantia.

    abstract:BACKGROUND:Momordica charantia (MC) is a tropical plant that is extensively used in folk medicine. However, the knowledge about side effects of this plant is relatively little according to knowledge about its therapeutic effects. The aim of this study is to reveal the effects of non-allergic type-I like hypersensitivit...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-284

    authors: Sagkan RI

    更新日期:2013-10-26 00:00:00

  • Prevalence of and factors associated with utilization of herbal medicines among outpatients in primary health centers in Cambodia.

    abstract:BACKGROUND:Traditional, complementary and alternative medicine (TCAM) is seen as a way to provide healthcare in both developed and developing countries across the world. In Cambodia, there is a long tradition of using TCAM. However, scant studies have been conducted on the extent of Cambodian TCAM use and how it intera...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2181-1

    authors: Pearson H,Fleming T,Chhoun P,Tuot S,Brody C,Yi S

    更新日期:2018-04-02 00:00:00

  • Development and evaluation of an instrument for the critical appraisal of randomized controlled trials of natural products.

    abstract:BACKGROUND:The efficacy of natural products (NPs) is being evaluated using randomized controlled trials (RCTs) with increasing frequency, yet a search of the literature did not identify a widely accepted critical appraisal instrument developed specifically for use with NPs. The purpose of this project was to develop an...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-9-11

    authors: Jurgens T,Whelan AM,MacDonald M,Lord L

    更新日期:2009-04-23 00:00:00

  • Cannabinoid-deficient Benin republic hemp (Cannabis sativa L.) improves semen parameters by reducing prolactin and enhancing anti-oxidant status.

    abstract:BACKGROUND:Nigerian Cannabis sativa (hemp) causes male gonadotoxicity by inducing hyperprolactinemia, down-regulation of hypothalamic-pituitary-testicular axis, and oxidative stress. Benin republic hemp has been preferred by illicit users in Nigeria but its effect on male fertility is not understood. This study determi...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2541-5

    authors: Alagbonsi AI,Olayaki LA,Abdulrahim HA,Adetona TS,Akinyemi GT

    更新日期:2019-06-17 00:00:00

  • The Chinese medicine JC-001 enhances the chemosensitivity of Lewis lung tumors to cisplatin by modulating the immune response.

    abstract:BACKGROUND:JC-001 is a Chinese medicine that can modulate the immunity in Hepa 1-6 tumor-bearing mice, and we questioned whether JC-001 can serve as efficient adjuvant chemotherapy. We aimed to identify a novel approach for enhancing cis-diamminedichloroplatinum (II) (CDDP)-based chemotherapy by immunomodulation. METH...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1728-x

    authors: Chuang MH,Jan MS,Chang JT,Lu FJ

    更新日期:2017-04-11 00:00:00

  • Is 'mainstreaming AYUSH' the right policy for Meghalaya, northeast India?

    abstract:BACKGROUND:National policy on medical pluralism in India encourages the mainstreaming of AYUSH (Ayurveda, Yoga, Unani, Siddha, and Homeopathy) systems and the revitalization of local health traditions (LHT). In Meghalaya state in the northeast, the main LHT is its indigenous tribal traditional medicine. This paper pres...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-015-0818-x

    authors: Albert S,Porter J

    更新日期:2015-08-18 00:00:00

  • Preliminary study of the antioxidant properties of flowers and roots of Pyrostegia venusta (Ker Gawl) Miers.

    abstract:BACKGROUND:Free radical stress leads to tissue injury and can eventually to arthritis, atherosclerosis, diabetes mellitus, neurodegenerative diseases and carcinogenesis. Several studies are ongoing worldwide to find natural antioxidants of plant origin. We assessed the in-vitro antioxidant activities and screened the p...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-11-69

    authors: Roy P,Amdekar S,Kumar A,Singh V

    更新日期:2011-08-23 00:00:00

  • Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer's disease.

    abstract:BACKGROUND:Alzheimer's disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy population. Resveratrol and exercise are two treatments that have been linked with attenuation of age-related...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2451-6

    authors: Alkhouli MF,Hung J,Squire M,Anderson M,Castro M,Babu JR,Al-Nakkash L,Broderick TL,Plochocki JH

    更新日期:2019-02-04 00:00:00

  • A nebulized complex traditional Chinese medicine inhibits Histamine and IL-4 production by ovalbumin in guinea pigs and can stabilize mast cells in vitro.

    abstract:BACKGROUND:Traditional Chinese medicines have been used for anti-asthma treatment for several centuries in many Asian countries, and have been shown to effectively relieve symptoms. Our previous study demonstrated that a complex traditional Chinese medicine (CTCM) administered in nebulized form through the intratrachea...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-174

    authors: Chang HC,Gong CC,Chan CL,Mak OT

    更新日期:2013-07-13 00:00:00

  • Carrageenan delays cell cycle progression in human cancer cells in vitro demonstrated by FUCCI imaging.

    abstract:BACKGROUND:Carrageenan is a sulfated polysaccharide that exists in red seaweeds recently shown to have anticancer properties. Previous findings show various effects of carrageenan suppressing tumor cell growth. One of the hallmarks of cancer is uncontrolled proliferation, a consequence of loss of normal cell-cycle cont...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1199-5

    authors: Prasedya ES,Miyake M,Kobayashi D,Hazama A

    更新日期:2016-08-04 00:00:00

  • Wenyang Huazhuo Tongluo formula, a Chinese herbal decoction, improves skin fibrosis by promoting apoptosis and inhibiting proliferation through down-regulation of survivin and cyclin D1 in systemic sclerosis.

    abstract:BACKGROUND:Fibrosis is a major contributor to systemic sclerosis (SSc)-related morbidity, and rapid, progressive skin involvement predicts later mortality. Western medicine therapies for SSc cannot produce satisfactory effects currently, while Traditional Chinese Medicine (TCM), such as the Wenyang Huazhuo Tongluo (WYH...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1056-6

    authors: Han L,Bian H,Ouyang J,Bi Y,Yang L,Ye S

    更新日期:2016-02-20 00:00:00

  • The effects of the court-type Thai traditional massage on anatomical relations, blood flow, and skin temperature of the neck, shoulder, and arm.

    abstract:BACKGROUND:Court-type Thai traditional massage (CTTM) has specific major signal points (MaSP) for treating musculoskeletal conditions. The objectives of this study are to investigate the anatomical surfaces and structures of MaSPs, and to examine blood flow (BF) and skin temperature (ST) changes after applying pressure...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1282-y

    authors: Plakornkul V,Vannabhum M,Viravud Y,Roongruangchai J,Mutirangura P,Akarasereenont P,Laohapand T

    更新日期:2016-09-15 00:00:00

  • Anti-inflammatory activities of astringent persimmons (Diospyros kaki Thunb.) stalks of various cultivar types based on the stages of maturity in the Gyeongnam province.

    abstract:BACKGROUND:Natural products play a significant role in human health in relation to the prevention and treatment of inflammatory conditions. One of the plants with great medicinal potentials is Diospyros kaki which is mainly cultivated in Asian countries including Korea, Japan, and China. Astringent D. kaki is a wild sp...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2659-5

    authors: Choi J,Kim MJ,Komakech R,Jung H,Kang Y

    更新日期:2019-09-23 00:00:00

  • The use of herbal medicines during breastfeeding: a population-based survey in Western Australia.

    abstract:BACKGROUND:Main concerns for lactating women about medications include the safety of their breastfed infants and the potential effects of medication on quantity and quality of breast milk. While medicine treatments include conventional and complementary medicines, most studies to date have focused on evaluating the saf...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-13-317

    authors: Sim TF,Sherriff J,Hattingh HL,Parsons R,Tee LB

    更新日期:2013-11-13 00:00:00

  • Assessment of free radical scavenging and anti-proliferative activities of Tinospora cordifolia Miers (Willd).

    abstract:BACKGROUND:Tinospora cordifolia (Guduchi or Amrita) is an important drug of Ayurvedic System of Medicine and found mention in various classical texts for the treatment of diseases such as jaundice, fever, diabetes, cancer and skin disease etc. In view of its traditional claims, antioxidant and anti-proliferative activi...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1953-3

    authors: Polu PR,Nayanbhirama U,Khan S,Maheswari R

    更新日期:2017-09-11 00:00:00

  • Inhibitory effects of berberine on proinflammatory M1 macrophage polarization through interfering with the interaction between TLR4 and MyD88.

    abstract:BACKGROUNDS:Inflammation is recognized as the key pathological mechanism of type 2 diabetes. The hypoglyceamic effects of berberine (BBR) are related to the inhibition of the inflammatory response, but the mechanism is not completely clear. METHODS:The inflammatory polarization of Raw264.7 cells and primary peritoneal...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2710-6

    authors: Gong J,Li J,Dong H,Chen G,Qin X,Hu M,Yuan F,Fang K,Wang D,Jiang S,Zhao Y,Huang W,Huang Z,Lu F

    更新日期:2019-11-19 00:00:00

  • Anti-inflammatory effects of Sanguisorbae Radix water extract on the suppression of mast cell degranulation and STAT-1/Jak-2 activation in BMMCs and HaCaT keratinocytes.

    abstract:BACKGROUND:Sanguisorbae Radix (SR) is a well-known herbal medicine used to treat inflammatory disease and skin burns in Asia. In addition, it is used to treat many types of allergic skin diseases, including urticaria, eczema, and allergic dermatitis. SR has been reported to exhibit anti-wrinkle, anti-oxidant, and anti-...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1317-4

    authors: Yang JH,Yoo JM,Cho WK,Ma JY

    更新日期:2016-09-06 00:00:00

  • Neuroprotective effect of Aronia melanocarpa extract against glutamate-induced oxidative stress in HT22 cells.

    abstract:BACKGROUND:Glutamate (an endogenous excitatory neurotransmitter) at high concentrations contributes to the development of neurodegenerative diseases. Aronia melanocarpa (A. melanocarpa) berries contain anthocyanins and have high antioxidant activities. In this study, we evaluated whether A. melanocarpa berries could pr...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-1716-1

    authors: Lee HY,Weon JB,Ryu G,Yang WS,Kim NY,Kim MK,Ma CJ

    更新日期:2017-04-11 00:00:00

  • Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat.

    abstract:BACKGROUND:Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we inves...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-019-2611-8

    authors: Lee KY,Kim JH,Kim EY,Yeom M,Jung HS,Sohn Y

    更新日期:2019-08-09 00:00:00

  • Central-stimulating and analgesic activity of the ethanolic extract of Alternanthera sessilis in mice.

    abstract:BACKGROUND:Alternanthera sessilis is a popular vegetable and used in traditional medicinal practice of Bangladesh and other parts of Asia to relive tiredness, laziness, and sleeps as well as pain and inflammation. However, no report was found on the neuropharmacological and analgesic activity of this plant to-date. Pre...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-398

    authors: Mondal H,Saha S,Awang K,Hossain H,Ablat A,Islam MK,Jahan IA,Sadhu SK,Hossain MG,Shilpi JA,Uddin SJ

    更新日期:2014-10-15 00:00:00

  • The effects of freeze-dried Ganoderma lucidum mycelia on a recurrent oral ulceration rat model.

    abstract:BACKGROUND:Conventional scientific studies had supported the use of polysaccharides and β-glucans from a number of fungi, including Ganoderma lucidum for the treatment of recurrent oral ulceration (ROU). Our aim of the present study was to evaluate whether freeze-dried powder from G. lucidum mycelia (FDPGLM) prevents R...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-2021-8

    authors: Xie L,Zhong X,Liu D,Liu L,Xia Z

    更新日期:2017-12-01 00:00:00

  • Fisetin and polymeric micelles encapsulating fisetin exhibit potent cytotoxic effects towards ovarian cancer cells.

    abstract:BACKGROUND:The anti-tumor activities of Natural compounds and their derivatives are of great interest to pharmaceutical industries. Fisetin is one of prospective natural compounds in this regard but unfortunately with poor hydrophilicity. METHODS:The effects of unmodified and modified fisetin in cultured ovarian cance...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-018-2127-7

    authors: Xiao X,Zou J,Fang Y,Meng Y,Xiao C,Fu J,Liu S,Bai P,Yao Y

    更新日期:2018-03-15 00:00:00

  • Anti-adipogenic effects of the traditional herbal formula Dohongsamul-tang in 3T3-L1 adipocytes.

    abstract:BACKGROUND:Blood stasis syndrome (BSS) is a general pattern identification and refers to pathological stagnation of blood circulation, dysfunction of endothelial cells or metabolic disorder in traditional Korean medicine (TKM). Dohongsamul-Tang (DHSMT) is a well-known traditional herbal formula which used for treatment...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-017-2038-z

    authors: Shim EH,Lee H,Lee MS,You S

    更新日期:2017-12-19 00:00:00

  • Garlic extracts prevent oxidative stress, hypertrophy and apoptosis in cardiomyocytes: a role for nitric oxide and hydrogen sulfide.

    abstract:BACKGROUND:In ancient times, plants were recognized for their medicinal properties. Later, the arrival of synthetic drugs pushed it to the backstage. However, from being merely used for food, plants are now been widely explored for their therapeutic value. The current study explores the potential of skin and flesh extr...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-12-140

    authors: Louis XL,Murphy R,Thandapilly SJ,Yu L,Netticadan T

    更新日期:2012-08-29 00:00:00

  • Transcendental Meditation for the improvement of health and wellbeing in community-dwelling dementia caregivers [TRANSCENDENT]: a randomised wait-list controlled trial.

    abstract:BACKGROUND:Dementia is a prevalent neurodegenerative disorder affecting an estimated 24.3 million people across the globe. The burden on those caring for people with dementia is substantial, with widespread implications for the caregiver, the care recipient and the community. Relaxation techniques, such as Transcendent...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12906-015-0666-8

    authors: Leach MJ,Francis A,Ziaian T

    更新日期:2015-05-08 00:00:00

  • Sub-MICs of Carum copticum and Thymus vulgaris influence virulence factors and biofilm formation in Candida spp.

    abstract:BACKGROUND:Emergence of drug-resistant strains of Candida and inefficiency of conventional antifungal therapy has necessitated the search for alternative and new antifungal agents. Inhibition of virulence and biofilm are the potential drug targets. In this study, the oils of Carum copticum, Thymus vulgaris and their ma...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-14-337

    authors: Khan MS,Ahmad I,Cameotra SS,Botha F

    更新日期:2014-09-15 00:00:00

  • The use of CAM by women suffering from nausea and vomiting during pregnancy.

    abstract:BACKGROUND:Nausea and vomiting during pregnancy (NVP) affects two-thirds of pregnant women to varying degrees and over the years many modalities have been used to try to alleviate this often debilitating condition. There is a paucity of information in the literature about the use or efficacy of complementary and altern...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/1472-6882-2-5

    authors: Hollyer T,Boon H,Georgousis A,Smith M,Einarson A

    更新日期:2002-05-17 00:00:00

  • Anti-platelet activity of panaxatriol saponins is mediated by suppression of intracellular calcium mobilization and ERK2/p38 activation.

    abstract:BACKGROUND:Increased platelet aggregation is implicated in the pathogenesis of ischemic stroke and anti-platelet strategy may contribute to its therapy. Panaxatriol saponin (PTS), the main components extracted from Panax notoginseng, has been shown to be efficacious in the prevention and treatment of ischemic stroke in...

    journal_title:BMC complementary and alternative medicine

    pub_type: 杂志文章

    doi:10.1186/s12906-016-1160-7

    authors: Qi H,Huang Y,Yang Y,Dou G,Wan F,Zhang W,Yang H,Wang L,Wu C,Li L

    更新日期:2016-06-08 00:00:00