Abstract：
BACKGROUND:Alzheimer's disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy population. Resveratrol and exercise are two treatments that have been linked with attenuation of age-related diseases, including the risk of bone fractures. In this study, we test the hypothesis that these treatments improve fracture resistance in a mouse model representative of the AD condition. METHODS:Three-month-old male 3xTg-AD mice were treated for 4 months with resveratrol or exercise or both combined, and compared with wild type mice. Exercise training was performed on a treadmill at 15 m/min for 45 min/day, 5 days/week. Resveratrol was given at 4 g/kg diet in the form of pellets. Three-point bending, cross-sectional geometric, and fluorescence analyses were conducted on tibias and compared by treatment group. RESULTS:Tibias of 3xTg mice exhibited signs of diminished bone quality and fracture under less force than age-matched wild type mice (P < 0.05). Treatment with both resveratrol and exercise improved indicators of fracture resistance and bone quality in AD mice to levels comparable to that of wild type mice (P < 0.05). CONCLUSIONS:The 3xTg mouse model of AD is at elevated risk for limb bone fracture compared to wild type controls. Treatment with resveratrol, exercise, or both in combination improves fracture resistance and cross-sectional geometric indicators of bone strength.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Alkhouli MF,Hung J,Squire M,Anderson M,Castro M,Babu JR,Al-Nakkash L,Broderick TL,Plochocki JHdoi
10.1186/s12906-019-2451-6subject
Has Abstractpub_date
2019-02-04 00:00:00pages
39issue
1issn
1472-6882pii
10.1186/s12906-019-2451-6journal_volume
19pub_type
杂志文章abstract：BACKGROUND:The use of herbal medicines as complements or alternatives to orthodox medicines has been on the increase. There has been the erroneous belief that these medicines are free from adverse effects. Schefflera barteri is popularly used in the West region of Cameroon for the treatment of various diseases such as ...
journal_title：BMC complementary and alternative medicine
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journal_title：BMC complementary and alternative medicine
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