Drug use, HIV, HCV and TB: major interlinked challenges in Eastern Europe and Central Asia.

abstract：: The question of whether to initiate ART at higher CD4+ cell counts than currently recommended by World Health Organization (WHO) treatment guidelines received much attention at the XVII International AIDS Conference (AIDS 2008). If studies presented at the conference ultimately lead to a revision of WHO treatment gui...

journal_title：Journal of the International AIDS Society

authors： Mascolini M,Kort R,Gilden D

更新日期：2009-10-06 00:00:00

abstract：INTRODUCTION:While there is a global consensus on monitoring Human Immunodeficiency Virus (HIV) treatment progress, there has been less attention to the degree of consistency of the measurement of HIV prevention programmes-and the global prevention response is not on-track to achieve 2020 goals. In this paper, we asses...

journal_title：Journal of the International AIDS Society

authors： Sekimitsu S,DePasse J,Morrison M,Mahy M,Rice B,Earle K,Daley K,Larson J,Carter A,Garnett GP,Holmes CB

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Lopinavir/ritonavir-based antiretroviral therapy (ART) is recommended for all HIV-infected children less than three years. However, little is known about its field implementation and effectiveness in West Africa. We assessed the 12-month response to lopinavir/ritonavir-based antiretroviral therapy in a coh...

journal_title：Journal of the International AIDS Society

authors： Amani-Bosse C,Dahourou DL,Malateste K,Amorissani-Folquet M,Coulibaly M,Dattez S,Emieme A,Barry M,Rouzioux C,N'gbeche S,Yonaba C,Timité-Konan M,Mea V,Ouédraogo S,Blanche S,Meda N,Seguin-Devaux C,Leroy V

更新日期：2017-04-25 00:00:00

abstract：INTRODUCTION:Dolutegravir (DTG) is an HIV integrase strand transfer inhibitor approved for use in combination with other antiretrovirals for the treatment of HIV-infection in adults and adolescents. Metformin is a drug frequently used in diabetic HIV-infected patients, which requires titration to optimize dosing. In vi...

journal_title：Journal of the International AIDS Society

authors： Zong J,Borland J,Jerva F,Wynne B,Choukour M,Song I

更新日期：2014-11-02 00:00:00

abstract：BACKGROUND:Diagnosis of primary HIV infection (PHI) has important clinical and public health implications. HAART initiation at this stage remains controversial. METHODS:Our objective was to identify predictors of disease progression among Argentinean seroconverters during the first year of infection, within a multicen...

journal_title：Journal of the International AIDS Society

authors： Socías ME,Sued O,Laufer N,Lázaro ME,Mingrone H,Pryluka D,Remondegui C,Figueroa MI,Cesar C,Gun A,Turk G,Bouzas MB,Kavasery R,Krolewiecki A,Pérez H,Salomón H,Cahn P,Grupo Argentino de Seroconversión Study Group.

更新日期：2011-08-10 00:00:00

abstract：INTRODUCTION:Disclosure of HIV serostatus by women to their sexual partners is critical for the success of the prevention of mother-to-child transmission of HIV (PMTCT) programme as an integrated service in antenatal care. We explored pregnant HIV-positive and HIV-negative women's partner disclosure experiences and sup...

journal_title：Journal of the International AIDS Society

authors： Rujumba J,Neema S,Byamugisha R,Tylleskär T,Tumwine JK,Heggenhougen HK

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Viral load testing is essential to manage HIV disease, especially in infants and children. Early infant diagnosis is performed using nucleic-acid testing in children under 18 months. Resource-limited health systems face severe challenges to scale-up both viral load and early infant diagnosis to unprecedent...

journal_title：Journal of the International AIDS Society

authors： Vubil A,Nhachigule C,Loquiha O,Meggi B,Mabunda N,Bollinger T,Sacks JA,Jani I,Vojnov L

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Young women aged 15 to 24 years in sub-Saharan Africa continue to be disproportionately affected by HIV. A growing number of studies have suggested that the practice of transactional sex may in part explain women's heightened risk, but evidence on the association between transactional sex and HIV has not y...

journal_title：Journal of the International AIDS Society

authors： Wamoyi J,Stobeanau K,Bobrova N,Abramsky T,Watts C

更新日期：2016-11-02 00:00:00

abstract：:The strength of the evidence linking concurrency to HIV epidemic severity in southern and eastern Africa led the Joint United Nations Programme on HIV/AIDS and the Southern African Development Community in 2006 to conclude that high rates of concurrent sexual partnerships, combined with low rates of male circumcision ...

journal_title：Journal of the International AIDS Society

authors： Epstein H,Morris M

更新日期：2011-03-15 00:00:00

abstract：BACKGROUND:Traditional medication adherence measures do not account for the pharmacokinetic (PK) properties of the drugs, potentially misrepresenting true therapeutic exposure. METHODS:In a population of HIV-infected Kenyan children on antiretroviral therapy including nevirapine (NVP), we used a one-compartment model ...

journal_title：Journal of the International AIDS Society

authors： Tu W,Nyandiko WM,Liu H,Slaven JE,Scanlon ML,Ayaya SO,Vreeman RC

更新日期：2017-06-15 00:00:00

abstract：INTRODUCTION:Guidelines regarding antiretroviral therapy (ART) initiation in HIV infection have varied over time, with the 2015 World Health Organization recommendation suggesting ART initiation at the time of diagnosis regardless of CD4 T-cell counts. Herein, we investigated the influence of socio-demographic and clin...

journal_title：Journal of the International AIDS Society

authors： Mehraj V,Cox J,Lebouché B,Costiniuk C,Cao W,Li T,Ponte R,Thomas R,Szabo J,Baril JG,Trottier B,Côté P,LeBlanc R,Bruneau J,Tremblay C,Routy JP,Montreal Primary HIV-Infection Study Group.

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:High levels of HIV seroconcordance at the population level reduce the potential for effective HIV transmission. However, the level of HIV seroconcordance is largely unknown among heterosexual couples in sub-Saharan Africa. We aimed to quantify the population level HIV seroconcordance in stable heterosexual...

journal_title：Journal of the International AIDS Society

authors： Kim HY,Harling G,Vandormael A,Tomita A,Cuadros DF,Bärnighausen T,Tanser F

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Transgender women are the population most vulnerable to HIV in Latin America, with prevalence between 18 and 38%. Although the region has improved antiretroviral coverage, there is an urgent need to strengthen HIV prevention for key populations to meet regional targets set by governments. We conducted an a...

journal_title：Journal of the International AIDS Society

authors： Silva-Santisteban A,Eng S,de la Iglesia G,Falistocco C,Mazin R

更新日期：2016-07-17 00:00:00

abstract：INTRODUCTION:Numerous barriers to optimal uptake of prevention of mother to child transmission (PMTCT) services occur at community level (i.e., outside the healthcare setting). To achieve elimination of paediatric HIV, therefore, interventions must also work within communities to address these barriers and increase ser...

journal_title：Journal of the International AIDS Society

authors： Busza J,Walker D,Hairston A,Gable A,Pitter C,Lee S,Katirayi L,Simiyu R,Mpofu D

更新日期：2012-07-11 00:00:00

abstract：BACKGROUND:The primary objective of this study was to determine the prevalence of neurocognitive impairment among HIV-positive individuals in Botswana, using the International HIV Dementia Scale (IHDS). We also compared performance on the IHDS with performance on tests of verbal learning/memory and processing speed, an...

journal_title：Journal of the International AIDS Society

authors： Lawler K,Mosepele M,Ratcliffe S,Seloilwe E,Steele K,Nthobatsang R,Steenhoff A

更新日期：2010-04-20 00:00:00

abstract：INTRODUCTION:HIV continues to devastate the adolescent population in sub-Saharan Africa (SSA). The complex array of interpersonal, social, structural and system-level obstacles specific to adolescents have slowed progress in prevention and treatment of HIV in this population. The field of implementation science holds p...

journal_title：Journal of the International AIDS Society

authors： Sturke R,Vorkoper S,Bekker LG,Ameyan W,Luo C,Allison S,Walker D,Kapogiannis B,Guay L

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:HIV testing is a cornerstone of efforts to combat the HIV epidemic, and testing conducted as part of surveillance provides invaluable data on the spread of infection and the effectiveness of campaigns to reduce the transmission of HIV. However, participation in HIV testing can be low, and if respondents sy...

journal_title：Journal of the International AIDS Society

authors： McGovern ME,Marra G,Radice R,Canning D,Newell ML,Bärnighausen T

更新日期：2015-11-26 00:00:00

abstract：INTRODUCTION:Infection with HIV subtype A has been associated with poorer neurocognitive outcomes compared to HIV subtype D in Ugandan children not eligible for antiretroviral therapy (ART). In this study, we sought to determine whether subtype-specific differences are also observed among children receiving ART. MATER...

journal_title：Journal of the International AIDS Society

authors： Bangirana P,Ruel TD,Boivin MJ,Pillai SK,Giron LB,Sikorskii A,Banik A,Achan J

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:The universal test and treat strategy (UTT) was developed to maximize the proportion of all HIV-positive individuals on antiretroviral treatment (ART) and virally suppressed, assuming that it will lead to a reduction in HIV incidence at the population level. The evolution over time of the cross-sectional H...

journal_title：Journal of the International AIDS Society

authors： Larmarange J,Diallo MH,McGrath N,Iwuji C,Plazy M,Thiébaut R,Tanser F,Bärnighausen T,Pillay D,Dabis F,Orne-Gliemann J,ANRS 12249 TasP Study Group.

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:Although individual HIV rapid diagnostic tests (RDTs) show good performance in evaluations conducted by WHO, reports from several African countries highlight potentially significant performance issues. Despite widespread use of RDTs for HIV diagnosis in resource-constrained settings, there has been no syst...

journal_title：Journal of the International AIDS Society

authors： Kosack CS,Page AL,Beelaert G,Benson T,Savane A,Ng'ang'a A,Andre B,Zahinda JB,Shanks L,Fransen K

更新日期：2017-03-24 00:00:00

abstract：INTRODUCTION:This was a descriptive non-interventional study in HIV-1-infected patients treated with DRV/r conducted in the clinical setting, with a single-arm prospective design. The primary objective was to collect data on utilization of darunavir/ritonavir (DRV/r) under the conditions described in the marketing auth...

journal_title：Journal of the International AIDS Society

authors： Antinori A,Galli M,Gianotti N,Mussini C,Quirino T,Sterrantino K,Mancusi D,Termini R

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:HIV incidence among men who have sex with men (MSM) is high in China. Pre-exposure prophylaxis (PrEP) is a promising mean to prevent HIV transmission but it is not widely available in China. We conducted a large Internet-based online survey to assess the willingness of Chinese MSM to take PrEP and associat...

journal_title：Journal of the International AIDS Society

authors： Han J,Bouey JZ,Wang L,Mi G,Chen Z,He Y,Viviani T,Zhang F

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:Since 2003, US government funding to address the HIV and AIDS pandemic has been subject to an anti-prostitution clause. Simultaneously, the efficacy of some HIV prevention efforts for sex work in areas receiving US government funding has diminished. This article seeks to explain why. METHODS:This analysis...

journal_title：Journal of the International AIDS Society

authors： Ditmore MH,Allman D

更新日期：2013-03-28 00:00:00

abstract：INTRODUCTION:International investment in the response to HIV and AIDS has plateaued and its future level is uncertain. With many countries committed to ending the epidemic, it is essential to allocate available resources efficiently over different response periods to maximize impact. The objective of this study is to p...

journal_title：Journal of the International AIDS Society

authors： Shattock AJ,Kerr CC,Stuart RM,Masaki E,Fraser N,Benedikt C,Gorgens M,Wilson DP,Gray RT

更新日期：2016-02-23 00:00:00

abstract：:While there has been remarkable progress in understanding the biology of HIV-1 and its recognition by the human immune system, we have not yet developed an efficacious HIV-1 vaccine. Vaccine challenges include the genetic diversity and mutability of HIV-1 which create a plethora of constantly changing antigens, the st...

journal_title：Journal of the International AIDS Society

authors： Kwong PD,Mascola JR,Nabel GJ

更新日期：2012-07-05 00:00:00

abstract：INTRODUCTION:Clinicians often do not have the time and possibilities to read all scientific evidence necessary to maintain high quality patient care. They rely on guidelines made by experts to help them in their daily work. METHODS:We compared the 2012 recommendations and the arguments of the IAS-USA Panel with the da...

journal_title：Journal of the International AIDS Society

authors： Piso RJ

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:The success of HIV treatment programmes globally has resulted in children with perinatally acquired HIV reaching adolescence in large numbers. The number of adolescents living with HIV is growing further due to persisting high HIV incidence rates among adolescents in low- and middle-income settings, partic...

journal_title：Journal of the International AIDS Society

authors： Marcus R,Ferrand RA,Kranzer K,Bekker LG

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Despite recent advances in the management of HIV infection and increased access to treatment, prevention, care and support, the HIV/AIDS epidemic continues to be a major global health problem, with sub-Saharan Africa suffering by far the greatest humanitarian, demographic and socio-economic burden of the e...

journal_title：Journal of the International AIDS Society

authors： Divaris K,Newman J,Hemingway-Foday J,Akam W,Balimba A,Dusengamungu C,Kalenga L,Mbaya M,Molu BM,Mugisha V,Mukumbi H,Mushingantahe J,Nash D,Niyongabo T,Atibu J,Azinyue I,Kiumbu M,Woelk G

更新日期：2012-11-21 00:00:00

abstract：INTRODUCTION:Rilpivirine (RPV) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) that was recently approved for the treatment of antiretroviral-naïve individuals with HIV-1 viral load of <100,000 copies/ml. As transmission of the drug resistance mutations to this NNRTI may affect treatment o...

journal_title：Journal of the International AIDS Society

authors： Parczewski M,Urbańska A,Maciejewska K,Witak-Jȩdra M,Leszczyszyn-Pynka M

更新日期：2014-04-17 00:00:00

abstract：INTRODUCTION:The Robert Koch Institute (RKI) aimed to assess a molecular surveillance strategy based on filter-dried serum spots (DSS) of all newly diagnosed HIV infections in Germany. In 2013, diagnostic laboratories sent DSS to the RKI representing 55% of the newly diagnosed HIV infections reported to the RKI (protec...

journal_title：Journal of the International AIDS Society

authors： Andrea H,Alexandra H,Claudia SH,Ruth Z,Osamah H,Norbert B,Claudia K

更新日期：2014-11-02 00:00:00