Abstract:
BACKGROUND:Increasing evidences have documented that microRNAs (miRNAs) act as oncogenes or tumor suppressors in a variety types of cancer. The discovery of tumor associated miRNAs in serum of patients gives rise to extensive investigation of circulating miRNAs in many human cancers which support the use of plasma/serum miRNAs as noninvasive means of cancer detection. However, the aberrant expression of miRNAs and the circulating miRNAs in bladder cancer are less reported. METHODS:We used Taqman probe stem-loop real-time PCR to accurately measure the levels of miR-99a in bladder cancer cell lines, 100 pairs of bladder cancer tissues, the adjacent non-neoplastic tissues and plasma collected from bladder cancer patients or control patients. miR-99a mimics were re-introduced into bladder cancer cells to investigate its role on regulating cell proliferation which was measured by CCK-8 assay and cell cycle analysis. RESULTS:miR-99a was significantly down-regulated in bladder cancer tissues, and even the lower expression of miR-99a was correlative with the more aggressive phenotypes of bladder cancer. Meanwhile, enforced expression of miR-99a can inhibit the cell proliferation of bladder cancer cells. Furthermore, investigation of the expression of miR-99a in plasma of bladder cancer patients showed that miR-99a was also decreased in plasma of bladder cancer patients. The results strongly supported miR-99a as the potential diagnostic marker of bladder cancer. CONCLUSIONS:Our data indicated that miR-99a might act as a tumor suppressor in bladder cancer and was significantly down-regulated in development of bladder cancer.
journal_name
BMC Uroljournal_title
BMC urologyauthors
Feng Y,Kang Y,He Y,Liu J,Liang B,Yang P,Yu Zdoi
10.1186/1471-2490-14-50subject
Has Abstractpub_date
2014-06-23 00:00:00pages
50issn
1471-2490pii
1471-2490-14-50journal_volume
14pub_type
杂志文章相关文献
BMC Urology文献大全abstract:BACKGROUND:Chronic indwelling catheters may induce histologic changes within the bladder, and these changes are sometimes pre-malignant. There are many documented cases of squamous cell carcinoma associated with indwelling catheters, but only three cases of catheter-associated adenocarcinoma have been reported. In this...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-015-0112-8
更新日期:2015-12-03 00:00:00
abstract:BACKGROUND:Carcinoma of urinary bladder is one of the leading causes of death in India. Successful treatment of bladder cancer depends on the early detection & specific diagnostic approaches. In the present study, microsatellite instability (MSI) has been evaluated as a prognostic marker in patients with superficial ur...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-5-2
更新日期:2005-01-12 00:00:00
abstract:BACKGROUND:Site-dependent and interindividual histological differences in Denonvilliers' fascia (DF) are not well understood. This study aimed to examine site-dependent and interindividual differences in DF and to determine whether changes in the current approach to radical prostatectomy are warranted in light of these...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-015-0034-5
更新日期:2015-05-12 00:00:00
abstract:BACKGROUND:The objective of this population-based study was to assess patient, physician and tumour determinants associated with positive surgical margins after prostatectomy, and to assess the effects of positive surgical margins on prostate cancer-specific survival. METHODS:We included 1'254 prostate cancer patients...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-14-86
更新日期:2014-11-05 00:00:00
abstract:BACKGROUND:Intravesical Mitomycin-C (MMC) following transurethral resection of bladder tumor (TURBT), while efficacious, is associated with side effects and poor utilization. Continuous saline bladder irrigation (CSBI) has been examined as an alternative. In this study we sought to compare the rates of recurrence and/o...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-018-0408-6
更新日期:2018-10-24 00:00:00
abstract:BACKGROUND:Vasitis or inflammation of the vas deferens is a rare condition, and few case reports with computed tomography images have been published since 1980. CASE PRESENTATION:A 50-year-old man presented with severe right inguinal and lower abdominal pain. Initial diagnosis at the emergency department was incarcera...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-019-0460-x
更新日期:2019-04-29 00:00:00
abstract:BACKGROUND:Obstetric fistula although virtually eliminated in high income countries, still remains a prevalent and debilitating condition in many parts of the developing world. It occurs in areas where access to care at childbirth is limited, or of poor quality and where few hospitals offer the necessary corrective sur...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-11-23
更新日期:2011-12-07 00:00:00
abstract:BACKGROUND:Upper urinary tract stones is the most common diseases in urology. Percutaneous nephrolithotomy (PCNL) and ureteroscopic lithotripsy (fURL) are common treatment, but both their efficacy and safety are controversial. Thus we aim to evaluate the efficacy and safety of PCNL and fURL in the treatment of upper ur...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-020-00677-4
更新日期:2020-07-25 00:00:00
abstract:BACKGROUND:Clear cell sarcoma of the kidney (CCSK) in adults is extremely rare. Optimal treatment of adult patients with CCSK remains unclear. CASE PRESENTATION:A 22-year-old man presented with a 2-month history of left flank pain. A color duplex sonography revealed a hypervascular, heterogeneous renal mass. Abdominal...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-6-11
更新日期:2006-04-03 00:00:00
abstract:BACKGROUND:Renal cell carcinoma can cause various paraneoplastic syndromes including metabolic and hematologic disturbances. Paraneoplastic hypereosinophilia has been reported in a variety of hematologic and solid tumors. We present the first case in the literature of severe paraneoplastic hypereosinophilia in a patien...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-12-7
更新日期:2012-03-21 00:00:00
abstract:BACKGROUND:Our purpose was to study the relationship of the 3 different types of endoscopic calcifications of the renal papilla (Randall's plaque, intratubular calcification, papillary crater) with the type of stone and urine analysis. METHODS:This prospective study examined 41 patients (age range: 18 to 80 years) who...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-020-00615-4
更新日期:2020-04-25 00:00:00
abstract:BACKGROUND:To evaluate the role of free-hand transperineal targeted prostate biopsy using multiparametric magnetic resonance imaging-transrectal ultrasound (mpMRI-TRUS) fusion in Chinese men with repeated biopsy. METHODS:A total of 101 consecutive patients suspicious of prostate cancer (PCa) at the mpMRI scan and with...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-017-0241-3
更新日期:2017-07-05 00:00:00
abstract:BACKGROUND:The presence of lymph nodes (LN) within the prostatic anterior fat pad (PAFP) has been reported in several recent reports. These PAFP LNs rarely harbor metastatic disease, and the characteristics of patients with PAFP LN metastasis are not well-described in the literature. Our previous study suggested that m...
journal_title:BMC urology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12894-015-0070-1
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:This very large population-based study investigated outcomes after a diagnosis of prostate cancer (PCa) in terms of mortality rates, treatments and adverse effects. METHODS:Among the 11 million men aged 40 years and over covered by the general national health insurance scheme, those with newly managed PCa i...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-14-48
更新日期:2014-06-13 00:00:00
abstract:BACKGROUND:To conduct an accurate evaluation of patients presenting with posttraumatic penoscrotal injuries, and to formulate a treatment algorithm based on this assessment. METHODS:We conducted a retrospective chart review study. Patients with penoscrotal defects admitted to our level I trauma center from 2017 to 201...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-020-00763-7
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Although there is growing evidence of relationship between obesity and some specific stone compositions, results were inconsistent. Due to a greater relationship between metabolic syndrome and some specific stone type, obesity measured by body mass index (BMI) has limitation in determining relationship betwe...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-015-0013-x
更新日期:2015-03-14 00:00:00
abstract:BACKGROUND:Gene expression profiling has recently shown that the mRNA for CD24 is overexpressed in prostate carcinomas (Pca) compared to benign or normal prostate epithelial tissues. Immunohistochemical studies have reported the usefulness of anti-CD24 for detecting prostate cancer over the full range of prostate speci...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-6-7
更新日期:2006-03-15 00:00:00
abstract:BACKGROUND:The control of the lower urinary tract is a complex, multilevel process involving both the peripheral and central nervous system. Due to lesions of the neuraxis, most spinal cord injury patients suffer from neurogenic lower urinary tract dysfunction, which may jeopardise upper urinary tract function and has ...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-14-68
更新日期:2014-08-18 00:00:00
abstract:BACKGROUND:Urologists frequently encounter malignant ureteral obstruction (MUO) caused by advanced urological or non-urological malignant disease, but the treatment policy is unclear. The present study examined the risk factors for predicting ureteral stent failure in patients with MUO after ureteral stent insertion an...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-018-0346-3
更新日期:2018-05-08 00:00:00
abstract:BACKGROUND:Previous studies have suggested a greater benefit for various outcomes in men diagnosed with benign prostatic hyperplasia (BPH) who are treated with dutasteride than for men treated with finasteride. This study investigates whether the rates of BPH-related prostate surgery and acute urinary retention (AUR) d...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-016-0170-6
更新日期:2016-08-31 00:00:00
abstract:BACKGROUND:It is well recognized that the presence of positive surgical margins (PSM) after radical prostatectomy (RP) adversely affects cancer specific outcomes and recent evidence from randomized trials supports the use of adjuvant radiotherapy in these cases. However, not all of the patients with PSM develop disease...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-14-79
更新日期:2014-10-02 00:00:00
abstract:BACKGROUND:Renal artery aneurysm is a rare disorder with a high mortality rate in the event of rupture, the most frequent complication, which can also occur in lesions smaller than those indicated for treatment by current criteria. Surgery is still the first-line treatment, although a growing trend toward endovascular ...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-14-42
更新日期:2014-05-28 00:00:00
abstract:BACKGROUND:Bladder spasm is a common side effect of urological surgery. Main treatment modalities include opioids or anticholinergic medication; however, bladder spasms still occur even after these interventions. Recent studies indicate that transcutaneous stimulation of the foot can result in 50% increase in bladder c...
journal_title:BMC urology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12894-017-0248-9
更新日期:2017-07-13 00:00:00
abstract:BACKGROUND:The aim of the present study is to investigate the clinical relevance of aortic calcification in urolithiasis patients. METHODS:Between January 2010 and September 2014, 1221 patients with urolithiasis were treated in Oyokyo Kidney Research Institute and Hirosaki University Hospital. Among these, 287 patient...
journal_title:BMC urology
pub_type: 临床试验,杂志文章
doi:10.1186/s12894-017-0218-2
更新日期:2017-04-04 00:00:00
abstract:BACKGROUND:Polyorchidism is a congenital anomaly of the urogenital system and means more than two testes. It is a rare phenomenon, where there are no more than 200 reported cases in the literature. In this case, we report a 13-month year's old case with five testicles. CASE PRESENTATION:We report a rare five testicles...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-020-00681-8
更新日期:2020-08-20 00:00:00
abstract:BACKGROUND:Urinary tract infection (UTI) is very common in patients with urolithiasis, which makes the treatment of urolithiasis complicated, even dangerous. The objective of this study was to determine the risk factors for UTI in patients with urolithiasis. METHODS:Eight hundred six patients with urolithiasis were re...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-018-0359-y
更新日期:2018-05-21 00:00:00
abstract:BACKGROUND:Urinary incontinence (UI) is highly prevalent and affects the lives of many men and women. We aimed to conduct a qualitative evidence synthesis (QES) to explore the experience of living with UI and to develop a conceptual model that can help us to understand this experience, and the potential barriers to app...
journal_title:BMC urology
pub_type: 杂志文章,meta分析
doi:10.1186/s12894-019-0555-4
更新日期:2020-01-16 00:00:00
abstract:BACKGROUND:PSA-directed prostate cancer screening leads to a high rate of false positive identifications and an unnecessary biopsy burden. Epigenetic biomarkers have proven useful, exhibiting frequent and abundant inactivation of tumor suppressor genes through such mechanisms. An epigenetic, multiplex PCR test for pros...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/1471-2490-12-16
更新日期:2012-06-06 00:00:00
abstract:BACKGROUND:Continuous bladder irrigation (CBI) and proper adjustment of saline irrigation speed are important to avoid CBI failure in hemorrhagic cystitis (HC) patients after allogeneic hematopoietic stem cell transplantation (HSCT). Nevertheless, too fast irrigation speed could take away the patient's much heat, contr...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-020-00757-5
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:In Ethiopia, about 9000 fistula cases are estimated to occur every year with an incidence of 2.2/1000 women. This study was aimed to determine obstetric fistula characteristics and surgical repair outcomes among patients with fistula surgical repair. METHODS:A Hospital based cross sectional study design was...
journal_title:BMC urology
pub_type: 杂志文章
doi:10.1186/s12894-016-0152-8
更新日期:2016-07-12 00:00:00