当前位置： SCI文献检索 > BMC Urology期刊下所有文献 > Prostate cancer outcomes in France: treatments, adverse effects and two-year mortality.

Prostate cancer outcomes in France: treatments, adverse effects and two-year mortality.

Abstract：

BACKGROUND:This very large population-based study investigated outcomes after a diagnosis of prostate cancer (PCa) in terms of mortality rates, treatments and adverse effects. METHODS:Among the 11 million men aged 40 years and over covered by the general national health insurance scheme, those with newly managed PCa in 2009 were followed for two years based on data from the national health insurance information system (SNIIRAM). Patients were identified using hospitalisation diagnoses and specific refunds related to PCa and PCa treatments. Adverse effects of PCa treatments were identified by using hospital diagnoses, specific procedures and drug refunds. RESULTS:The age-standardised two-year all-cause mortality rate among the 43,460 men included in the study was 8.4%, twice that of all men aged 40 years and over. Among the 36,734 two-year survivors, 38% had undergone prostatectomy, 36% had been treated by hormone therapy, 29% by radiotherapy, 3% by brachytherapy and 20% were not treated. The frequency of treatment-related adverse effects varied according to age and type of treatment. Among men between 50 and 69 years of age treated by prostatectomy alone, 61% were treated for erectile dysfunction and 24% were treated for urinary disorders. The frequency of treatment for these disorders decreased during the second year compared to the first year (erectile dysfunction: 41% vs 53%, urinary disorders: 9% vs 20%). The frequencies of these treatments among men treated by external beam radiotherapy alone were 7% and 14%, respectively. Among men between 50 and 69 years with treated PCa, 46% received treatments for erectile dysfunction and 22% for urinary disorders. For controls without PCa but treated surgically for benign prostatic hyperplasia, these frequencies were 1.5% and 6.0%, respectively. CONCLUSIONS:We report high survival rates two years after a diagnosis of PCa, but a high frequency of PCa treatment-related adverse effects. These frequencies remain underestimated, as they are based on treatments for erectile dysfunction and urinary disorders and do not reflect all functional outcomes. These results should help urologists and general practitioners to inform their patients about outcomes at the time of screening and diagnosis, and especially about potential treatment-related adverse effects.

journal_name

BMC Urol

journal_title

BMC urology

authors

Tuppin P,Samson S,Fagot-Campagna A,Lukacs B,Alla F,CNAMTS scientific board members.,Paccaud F,Thalabard JC,Vicaut E,Vidaud M,Millat B

doi

10.1186/1471-2490-14-48

subject

Has Abstract

pub_date

2014-06-13 00:00:00

pages

issn

1471-2490

pii

1471-2490-14-48

journal_volume

pub_type

杂志文章

在线工具

Prostate cancer outcomes in France: treatments, adverse effects and two-year mortality.