Plasma natriuretic peptides in children and adolescents with obstructive sleep apnea and their changes following intervention.

Abstract:

OBJECTIVE:This study aimed to evaluate circulating natriuretic peptides (NP) concentration in obese and non-obese children and adolescents with and without obstructive sleep apnea (OSA), and their levels following OSA treatment. METHODS:Subjects with habitual snoring and symptoms suggestive of OSA were recruited. They underwent physical examination and overnight polysomnography (PSG). OSA was diagnosed if obstructive apnea-hypopnea index (OAHI) was ≥1/h. Fasting serum atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were taken after overnight PSG. The subjects were divided into obese, non-obese, with and without OSA groups for comparisons. RESULTS:One hundred fourteen children (77 were boys) with a median [interquartile range (IQR)] age of 10.8 (8.3-12.7) years (range: 2.4-11.8 years) were recruited. Sixty-eight subjects were found to have OSA. NP levels did not differ between subjects with and without OSA in both obese and non-obese groups. Stepwise multiple linear regressions revealed that body mass index (BMI) z-score was the only independent factor associated with NP concentrations. Fifteen children with moderate-to-severe OSA (OAHI >5/h) underwent treatment and there were no significant changes in both ANP and BNP levels after intervention. CONCLUSION:Body mass index rather than OSA was the main determinant of NP levels in school-aged children and adolescents.

journal_name

Front Pediatr

journal_title

Frontiers in pediatrics

authors

Li AM,Au CT,Zhu JY,Chan KC,Chan MH,Lee DL,Wing YK

doi

10.3389/fped.2014.00022

subject

Has Abstract

pub_date

2014-03-24 00:00:00

pages

22

issn

2296-2360

journal_volume

2

pub_type

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