High levels of anti-Nef antibodies may prevent AIDS disease progression in vertically HIV-1-infected infants.

Abstract:

INTRODUCTION:HIV-1-associated CD4+ T-cell depletion is a consequence of uninfected cell death. Nef is one of the viral factors that trigger apoptosis on bystander cells, though the plasma Nef levels do not correlate with Th lymphocytes counts. The aim of our study was to evaluate whether anti-Nef antibodies were involved in paediatric AIDS development and whether they can prevent the CD4+ T-cell depletion in vertically infected children. METHODS:Two hundred and seventy three HIV-1 vertically infected children seen at Garrahan Paediatric Hospital were randomly included in the study, adding 13 selected cases: seven LTNP (long-term non-progressors) and six RP (rapid progressors) children (n(total)=286). Specific anti-HIV-1-Nef antibodies were titrated by indirect ELISA and compared between groups. The plasma blocking effect on Nef-dependent cytotoxicity was evaluated in Jurkat cells using recombinant Nef as apoptotic stimulus and patient plasmas as blockers, measuring the apoptotic levels using Annexin-V stain and flow cytometry. RESULTS:Only 63.4% of the patients had specific anti-Nef antibodies, and the levels of anti-Nef antibodies found in the selected LTNPs plasmas were always significantly higher (p=1.55×10(-4)) than those in RPs or general HIV-1+ paediatric populations. The LTNPs' plasma had a strong inhibitory effect on Nef-dependent cytotoxicity even at high dilutions, while RP plasmas had little or no effect on Nef-induced apoptosis. DISCUSSION AND CONCLUSIONS:High anti-Nef antibody levels are associated and predict slow or non-progression to AIDS in vertically HIV-1-infected children. They could be an efficient tool in preventing Nef-associated bystander effect, preserving CD4+ T-cells and the immune function in the context of paediatric HIV-1 infection.

journal_name

J Int AIDS Soc

authors

Corró G,Crudeli CM,Rocco CA,Marino SA,Sen L

doi

10.7448/IAS.17.1.18790

subject

Has Abstract

pub_date

2014-02-14 00:00:00

pages

18790

issn

1758-2652

pii

18790

journal_volume

17

pub_type

杂志文章
  • Treatment advocate tactics to expand access to antiviral therapy for HIV and viral hepatitis C in low- to high-income settings: making sure no one is left behind.

    abstract:INTRODUCTION:Worldwide, 71 million people are infected with hepatitis C virus (HCV), which, without treatment, can lead to liver failure or hepatocellular carcinoma. HCV co-infection increases liver- and AIDS-related morbidity and mortality among HIV-positive people, despite ART. A 12-week course of HCV direct-acting a...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25060

    authors: Grillon C,Krishtel PR,Mellouk O,Basenko A,Freeman J,Mendão L,Andrieux-Meyer I,Morin S

    更新日期:2018-04-01 00:00:00

  • Safety of darunavir/ritonavir (DRV/r) in HIV-1-infected DRV/r-experienced and -naïve patients: analysis of data in the real-world setting in Italy.

    abstract:INTRODUCTION:This descriptive, non-interventional study on HIV-1-infected patients treated with DRV/r in the usual clinical setting, with a single-arm prospective observational design, collected data on utilization of darunavir/ritonavir (DRV/r) under the conditions described in marketing authorization in usual clinica...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.17.4.19573

    authors: Antinori A,Borderi M,Cauda R,Bini T,Chirianni A,Squillace N,Mancusi D,Termini R

    更新日期:2014-11-02 00:00:00

  • Transactional sex and risk for HIV infection in sub-Saharan Africa: a systematic review and meta-analysis.

    abstract:INTRODUCTION:Young women aged 15 to 24 years in sub-Saharan Africa continue to be disproportionately affected by HIV. A growing number of studies have suggested that the practice of transactional sex may in part explain women's heightened risk, but evidence on the association between transactional sex and HIV has not y...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,meta分析,评审

    doi:10.7448/IAS.19.1.20992

    authors: Wamoyi J,Stobeanau K,Bobrova N,Abramsky T,Watts C

    更新日期:2016-11-02 00:00:00

  • The effects of educational curricula and training on LGBT-specific health issues for healthcare students and professionals: a mixed-method systematic review.

    abstract:INTRODUCTION:Poor access of lesbian, gay, bisexual and transgender (LGBT) people to healthcare providers with clinical and cultural competency contributes to health inequalities between heterosexual/cisgender and LGBT people. This systematic review assesses the effect of educational curricula and training for healthcar...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,评审

    doi:10.7448/IAS.20.1.21624

    authors: Sekoni AO,Gale NK,Manga-Atangana B,Bhadhuri A,Jolly K

    更新日期:2017-07-19 00:00:00

  • Agency as a mediator in the pathway from transactional sex to HIV among pregnant women in Swaziland: a multigroup path analysis.

    abstract:INTRODUCTION:Transactional sex is a structural driver of HIV for women and girls in sub-Saharan Africa. In transactional relationships, sexual and economic obligations intertwine and may have positive and negative effects on women's financial standing and social status. We conducted a clinic-based survey with pregnant ...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.20.1.21554

    authors: Fielding-Miller R,Dunkle KL,Hadley C,Cooper HL,Windle M

    更新日期:2017-07-18 00:00:00

  • Neurocognitive impairment among HIV-positive individuals in Botswana: a pilot study.

    abstract:BACKGROUND:The primary objective of this study was to determine the prevalence of neurocognitive impairment among HIV-positive individuals in Botswana, using the International HIV Dementia Scale (IHDS). We also compared performance on the IHDS with performance on tests of verbal learning/memory and processing speed, an...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1186/1758-2652-13-15

    authors: Lawler K,Mosepele M,Ratcliffe S,Seloilwe E,Steele K,Nthobatsang R,Steenhoff A

    更新日期:2010-04-20 00:00:00

  • Temporal changes in ART initiation in adults with high CD4 counts in Latin America: a cohort study.

    abstract:INTRODUCTION:In 2013, the World Health Organization (WHO) recommended initiating combination ART (cART) in all adults with HIV and CD4+ lymphocyte counts (CD4) <500 cells/mm3 . In 2015, this was updated to recommend cART initiation in all patients with HIV, regardless of CD4 count. Implementation of these guidelines in...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25413

    authors: Crabtree-Ramírez BE,Caro-Vega Y,Belaunzarán-Zamudio PF,Shepherd BE,Rebeiro PF,Veloso V,Cortes CP,Padgett D,Gotuzzo E,Sierra-Madero J,McGowan CC,Person AK,Caribbean, Central, South America Network for HIV Epidemiology (CCASAnet).

    更新日期:2019-12-01 00:00:00

  • Fostering successful and sustainable collaborations to advance implementation science: the adolescent HIV prevention and treatment implementation science alliance.

    abstract:INTRODUCTION:HIV continues to devastate the adolescent population in sub-Saharan Africa (SSA). The complex array of interpersonal, social, structural and system-level obstacles specific to adolescents have slowed progress in prevention and treatment of HIV in this population. The field of implementation science holds p...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25572

    authors: Sturke R,Vorkoper S,Bekker LG,Ameyan W,Luo C,Allison S,Walker D,Kapogiannis B,Guay L

    更新日期:2020-09-01 00:00:00

  • Cancers in the TREAT Asia HIV Observational Database (TAHOD): a retrospective analysis of risk factors.

    abstract:BACKGROUND:This retrospective survey describes types of cancers diagnosed in HIV-infected subjects in Asia, and assesses risk factors for cancer in HIV-infected subjects using contemporaneous HIV-infected controls without cancer. METHODS:TREAT Asia HIV Observational Database (TAHOD) sites retrospectively reviewed clin...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1186/1758-2652-13-51

    authors: Petoumenos K,Hui E,Kumarasamy N,Kerr SJ,Choi JY,Chen YM,Merati T,Zhang F,Lim PL,Sungkanuparph S,Pujari S,Ponnampalavanar S,Ditangco R,Lee CK,Grulich A,Law MG,TREAT Asia HIV Observational Database.

    更新日期:2010-12-10 00:00:00

  • The changing face of HIV vaccine research.

    abstract::While there has been remarkable progress in understanding the biology of HIV-1 and its recognition by the human immune system, we have not yet developed an efficacious HIV-1 vaccine. Vaccine challenges include the genetic diversity and mutability of HIV-1 which create a plethora of constantly changing antigens, the st...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,评审

    doi:10.7448/IAS.15.2.17407

    authors: Kwong PD,Mascola JR,Nabel GJ

    更新日期:2012-07-05 00:00:00

  • Acute retroviral syndrome and high baseline viral load are predictors of rapid HIV progression among untreated Argentinean seroconverters.

    abstract:BACKGROUND:Diagnosis of primary HIV infection (PHI) has important clinical and public health implications. HAART initiation at this stage remains controversial. METHODS:Our objective was to identify predictors of disease progression among Argentinean seroconverters during the first year of infection, within a multicen...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1186/1758-2652-14-40

    authors: Socías ME,Sued O,Laufer N,Lázaro ME,Mingrone H,Pryluka D,Remondegui C,Figueroa MI,Cesar C,Gun A,Turk G,Bouzas MB,Kavasery R,Krolewiecki A,Pérez H,Salomón H,Cahn P,Grupo Argentino de Seroconversión Study Group.

    更新日期:2011-08-10 00:00:00

  • "Telling my husband I have HIV is too heavy to come out of my mouth": pregnant women's disclosure experiences and support needs following antenatal HIV testing in eastern Uganda.

    abstract:INTRODUCTION:Disclosure of HIV serostatus by women to their sexual partners is critical for the success of the prevention of mother-to-child transmission of HIV (PMTCT) programme as an integrated service in antenatal care. We explored pregnant HIV-positive and HIV-negative women's partner disclosure experiences and sup...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/ias.15.2.17429

    authors: Rujumba J,Neema S,Byamugisha R,Tylleskär T,Tumwine JK,Heggenhougen HK

    更新日期:2012-01-01 00:00:00

  • Adolescents with HIV and transition to adult care in the Caribbean, Central America and South America, Eastern Europe and Asia and Pacific regions.

    abstract:INTRODUCTION:The HIV epidemics in the Caribbean, Central America and South America (CCASA), Eastern Europe (EE) and Asia and Pacific (AP) regions are diverse epidemics affecting different key populations in predominantly middle-income countries. This narrative review describes the populations of HIV-positive youth appr...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.20.4.21475

    authors: Bailey H,Cruz MLS,Songtaweesin WN,Puthanakit T

    更新日期:2017-05-16 00:00:00

  • Interruptions of antiretroviral therapy in children and adolescents with HIV infection in clinical practice: a retrospective cohort study in the USA.

    abstract:INTRODUCTION:Changes in combination antiretroviral therapy (cART) throughout childhood challenge the continuity of paediatric HIV treatment. This study aimed to evaluate the prevalence of treatment interruption (TI), including lamivudine (3TC) monotherapy, and the relationship of TI to virologic and immunologic paramet...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.19.1.20936

    authors: Rakhmanina N,Lam KS,Hern J,Young HA,Walters A,Castel AD

    更新日期:2016-10-27 00:00:00

  • The HIV drug optimization agenda: promoting standards for earlier investigation and approvals of antiretroviral drugs for use in adolescents living with HIV.

    abstract:INTRODUCTION:Most clinical trials for new antiretroviral (ARV) agents are conducted among narrowly defined adult populations. Only after safety and efficacy have been clearly demonstrated among adults living with HIV are trials including adolescents, children and infants conducted. This approach contributes to signific...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25576

    authors: Rojo P,Carpenter D,Venter F,Turkova A,Penazzato M

    更新日期:2020-09-01 00:00:00

  • How should HIV resources be allocated? Lessons learnt from applying Optima HIV in 23 countries.

    abstract:INTRODUCTION:With limited funds available, meeting global health targets requires countries to both mobilize and prioritize their health spending. Within this context, countries have recognized the importance of allocating funds for HIV as efficiently as possible to maximize impact. Over the past six years, the governm...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,评审

    doi:10.1002/jia2.25097

    authors: Stuart RM,Grobicki L,Haghparast-Bidgoli H,Panovska-Griffiths J,Skordis J,Keiser O,Estill J,Baranczuk Z,Kelly SL,Reporter I,Kedziora DJ,Shattock AJ,Petravic J,Hussain SA,Grantham KL,Gray RT,Yap XF,Martin-Hughes R,Bened

    更新日期:2018-04-01 00:00:00

  • Collateral benefits: how the practical application of Good Participatory Practice can strengthen HIV research in sub-Saharan Africa.

    abstract:INTRODUCTION:The Good Participatory Practice (GPP): Guidelines for Biomedical HIV Prevention Trials, second edition (2011) were developed to provide clinical trial sponsors and implementers with a formal stakeholder engagement framework. As one of the largest African research institutes, Wits Reproductive Health and HI...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25175

    authors: Baron D,Essien T,Pato S,Magongo M,Mbandazayo N,Scorgie F,Rees H,Delany-Moretlwe S

    更新日期:2018-10-01 00:00:00

  • Factors associated with loss to follow-up among women in Option B+ PMTCT programme in northeast Ethiopia: a retrospective cohort study.

    abstract:INTRODUCTION:Ethiopia has recently adopted lifelong antiretroviral therapy (ART) for all HIV-positive pregnant and breastfeeding women (Option B+ strategy), regardless of CD4 count or clinical stage. However, the exact timing and predictors of loss to follow-up (LFU) are unknown. Thus, we examined the levels and determ...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.19.1.20662

    authors: Mitiku I,Arefayne M,Mesfin Y,Gizaw M

    更新日期:2016-03-21 00:00:00

  • Corrigendum.

    abstract::[This corrects the article DOI: 10.7448/IAS.20.01/21317.]. ...

    journal_title:Journal of the International AIDS Society

    pub_type: 已发布勘误

    doi:10.7448/IAS.20.1.22066

    authors:

    更新日期:2017-06-02 00:00:00

  • PrEP implementation research in Africa: what is new?

    abstract:INTRODUCTION:Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP) for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to ...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.19.7.21101

    authors: Cowan FM,Delany-Moretlwe S,Sanders EJ,Mugo NR,Guedou FA,Alary M,Behanzin L,Mugurungi O,Bekker LG

    更新日期:2016-10-18 00:00:00

  • Influences on willingness to use vaginal or oral HIV PrEP during pregnancy and breastfeeding in Africa: the multisite MAMMA study.

    abstract:INTRODUCTION:Women in sub-Saharan Africa spend a substantial portion of their reproductive lives pregnant and/or breastfeeding (P/BF), yet they have limited options to prevent HIV during these maternal stages. In preparation for phase 3b prevention trials in P/BF women, we explored attitudes about using a vaginal ring ...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25536

    authors: van der Straten A,Ryan JH,Reddy K,Etima J,Taulo F,Mutero P,Taylor J,Piper J,Musara P,MTN-041\/MAMMA Study Team.

    更新日期:2020-06-01 00:00:00

  • PrEP uptake preferences among men who have sex with men in China: results from a National Internet Survey.

    abstract:INTRODUCTION:HIV incidence among men who have sex with men (MSM) is high in China. Pre-exposure prophylaxis (PrEP) is a promising mean to prevent HIV transmission but it is not widely available in China. We conducted a large Internet-based online survey to assess the willingness of Chinese MSM to take PrEP and associat...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25242

    authors: Han J,Bouey JZ,Wang L,Mi G,Chen Z,He Y,Viviani T,Zhang F

    更新日期:2019-02-01 00:00:00

  • Addressing treatment and care needs of older adults living with HIV who use drugs.

    abstract:INTRODUCTION:Older adults living with HIV (OALHIV; ≥50 years) who use drugs face unique needs and challenges that compromise their health and wellbeing due to the structural and environmental barriers they experience, in addition to being disproportionately affected by comorbidities. Nevertheless, research on this popu...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25577

    authors: Chayama KL,Ng C,McNeil R

    更新日期:2020-08-01 00:00:00

  • Liver Fibrosis progression using Fibroscan in HIV/HCV coinfected patients with undetectable HIV viral load.

    abstract:INTRODUCTION:Several factors such as duration of infection, age, male gender, consumption of alcohol, HIV infection and low CD4 count have been associated with fibrosis progression rate. However, it is relatively scarce, the knowledge about the liver fibrosis progression rate in HIV-infected patients with undetectable ...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.17.4.19636

    authors: Perez-Martinez L,Sanjoaquin I,Rivero M,Gil-Pérez D,Letona S,Olaiz CI,Arazo P,Blanco JR

    更新日期:2014-11-02 00:00:00

  • Dynamics in HIV-DNA levels over time in HIV controllers.

    abstract:INTRODUCTION:HIV controllers (HIC) maintain viraemia at low levels without antiretroviral treatment and have small HIV reservoirs. Nevertheless, they are heterogeneous regarding their risk of infection progression. The study of reservoirs can help elucidate this control. This study aimed to explore the factors implicat...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jia2.25221

    authors: Avettand-Fenoel V,Bayan T,Gardiennet E,Boufassa F,Lopez P,Lecuroux C,Noel N,Trémeaux P,Monceaux V,Autran B,Meyer L,Saez-Cirion A,Lambotte O,Rouzioux C,CODEX ANRS Cohort Study Group.

    更新日期:2019-01-01 00:00:00

  • Adherence to antiretroviral therapy for HIV/AIDS in Latin America and the Caribbean: Systematic review and meta-analysis.

    abstract:INTRODUCTION:Optimal adherence to antiretroviral therapy is closely related with suppression of the HIV viral load in plasma, slowing disease progression and decreasing HIV transmission rates. Despite its importance, the estimated proportion of people living with HIV in Latin America and the Caribbean with optimal adhe...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,meta分析

    doi:10.1002/jia2.25066

    authors: Costa JM,Torres TS,Coelho LE,Luz PM

    更新日期:2018-01-01 00:00:00

  • Using a HIV registry to develop accurate estimates for the HIV care cascade - the Singapore experience.

    abstract:INTRODUCTION:Achieving UNAIDS 90-90-90 targets is a crucial step towards ending the AIDS epidemic. Many countries have published estimates of care cascades, although often with methodological limitations. We describe an approach that used the national HIV registry as a starting-point to determine the HIV care cascade a...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1002/jia2.25356

    authors: Ho ZJM,Huang F,Wong CS,Chua L,Ma S,Chen MI,Lee VJ

    更新日期:2019-07-01 00:00:00

  • The cost and impact of male circumcision on HIV/AIDS in Botswana.

    abstract:: The HIV/AIDS epidemic continues to be a major issue facing Botswana, with overall adult HIV prevalence estimated to be 25.7 percent in 2007. This paper estimates the cost and impact of the draft Ministry of Health male circumcision strategy using the UNAIDS/WHO Decision-Makers' Programme Planning Tool (DMPPT). Demogr...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.1186/1758-2652-12-7

    authors: Bollinger LA,Stover J,Musuka G,Fidzani B,Moeti T,Busang L

    更新日期:2009-05-27 00:00:00

  • Concurrent partnerships and HIV: an inconvenient truth.

    abstract::The strength of the evidence linking concurrency to HIV epidemic severity in southern and eastern Africa led the Joint United Nations Programme on HIV/AIDS and the Southern African Development Community in 2006 to conclude that high rates of concurrent sexual partnerships, combined with low rates of male circumcision ...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章,评审

    doi:10.1186/1758-2652-14-13

    authors: Epstein H,Morris M

    更新日期:2011-03-15 00:00:00

  • Time trends and correlates of late presentation for HIV care in Northern Greece during the decade 2000 to 2010.

    abstract:BACKGROUND:The aim of our study was to assess the extent of late presentation for HIV care in Northern Greece during the period 2000 to 2010 and to explore correlations aiming to provide guidance for future interventions. METHODS:HIV-positive patients with no prior history of HIV care at presentation and with a CD4 T ...

    journal_title:Journal of the International AIDS Society

    pub_type: 杂志文章

    doi:10.7448/IAS.15.2.17395

    authors: Metallidis S,Pilalas D,Skoura L,Haidich AB,Tsachouridou O,Papaioannou M,Chrysanthidis T,Bakaimi I,Antoniadou ZA,Margariti A,Malisiovas N,Nikolaidis P

    更新日期:2012-10-11 00:00:00