Temporal changes in ART initiation in adults with high CD4 counts in Latin America: a cohort study.

abstract：INTRODUCTION:Global guidelines emphasize the ethical obligation of investigators to help participants in HIV-endpoint trials reduce HIV risk by offering an optimal HIV prevention package. Oral pre-exposure prophylaxis (PrEP) has increasingly become part of state-of-the-art HIV prevention. Here we describe the process o...

journal_title：Journal of the International AIDS Society

authors： Beesham I,Welch JD,Heffron R,Pleaner M,Kidoguchi L,Palanee-Phillips T,Ahmed K,Baron D,Bukusi EA,Louw C,Mastro TD,Smit J,Batting JR,Malahleha M,Bailey VC,Beksinska M,Donnell D,Baeten JM,ECHO Trial Consortium.

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP) for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to ...

journal_title：Journal of the International AIDS Society

authors： Cowan FM,Delany-Moretlwe S,Sanders EJ,Mugo NR,Guedou FA,Alary M,Behanzin L,Mugurungi O,Bekker LG

更新日期：2016-10-18 00:00:00

abstract：:Prevention of HIV infection has recently acquired new effective tools, based on the provision of antiretrovirals, to both decrease the "source" of HIV infection and/or to decrease host susceptibility to HIV infection. The milestone concept of using antiretrovirals for prevention has been tested already in the 1990s, t...

journal_title：Journal of the International AIDS Society

authors： Vella S

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:The majority of new HIV infections occur through mucosal transmission. The availability of readily applicable and accessible platforms for anti-retroviral (ARV) delivery is critical for the prevention of HIV acquisition through sexual transmission in both women and men. There is a compelling need for devel...

journal_title：Journal of the International AIDS Society

authors： Crakes KR,Herrera C,Morgan JL,Olstad K,Hessell AJ,Ziprin P,LiWang PJ,Dandekar S

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:WHO recommends assisted partner notification (APN) for people living with HIV (PLHIV). These services have not been widely scaled in Central Asia. We describe the results from an APN intervention implemented within a programme focused on PLHIV and people who inject drugs in Kazakhstan, the Kyrgyz Republic ...

journal_title：Journal of the International AIDS Society

authors： Little KM,Kan M,Samoylova O,Rsaldinova A,Saliev D,Ishokov F,Gray R,Hasen NS

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:Although individual HIV rapid diagnostic tests (RDTs) show good performance in evaluations conducted by WHO, reports from several African countries highlight potentially significant performance issues. Despite widespread use of RDTs for HIV diagnosis in resource-constrained settings, there has been no syst...

journal_title：Journal of the International AIDS Society

authors： Kosack CS,Page AL,Beelaert G,Benson T,Savane A,Ng'ang'a A,Andre B,Zahinda JB,Shanks L,Fransen K

更新日期：2017-03-24 00:00:00

abstract：INTRODUCTION:Men who have sex with men (MSM) and transgender women (TGW) are two key populations (KPs) in Thailand at high risk for HIV. Uptake and scale-up of pre-exposure prophylaxis (PrEP) among them has been slow. We used data from Princess PrEP, Thailand's largest KP-led PrEP programme, to operationalize PrEP serv...

journal_title：Journal of the International AIDS Society

authors： Ramautarsing RA,Meksena R,Sungsing T,Chinbunchorn T,Sangprasert T,Fungfoosri O,Meekrua D,Sumalu S,Pasansai T,Bunainso W,Wongsri T,Mainoy N,Colby D,Avery M,Mills S,Vannakit R,Phanuphak P,Phanuphak N

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:This retrospective survey describes types of cancers diagnosed in HIV-infected subjects in Asia, and assesses risk factors for cancer in HIV-infected subjects using contemporaneous HIV-infected controls without cancer. METHODS:TREAT Asia HIV Observational Database (TAHOD) sites retrospectively reviewed clin...

journal_title：Journal of the International AIDS Society

authors： Petoumenos K,Hui E,Kumarasamy N,Kerr SJ,Choi JY,Chen YM,Merati T,Zhang F,Lim PL,Sungkanuparph S,Pujari S,Ponnampalavanar S,Ditangco R,Lee CK,Grulich A,Law MG,TREAT Asia HIV Observational Database.

更新日期：2010-12-10 00:00:00

abstract：INTRODUCTION:We compared the effectiveness of tenofovir/emtricitabine (TDF/FTC) combined with either lopinavir/r (LPV/r) or another recommended third drug in the 2010 French guidelines in antiretroviral-naïve patients starting combination antiretroviral therapy in 2004-2008 in the French Hospital Database on HIV. METH...

journal_title：Journal of the International AIDS Society

authors： Potard V,Rey D,Poizot-Martin I,Mokhtari S,Pradier C,Rozenbaum W,Brun-Vezinet F,Costagliola D,FHDH ANRS CO4 (French Hospital Database on HIV, Agence Nationale de Recherches sur le Sida, cohort 4).

更新日期：2014-09-25 00:00:00

abstract：INTRODUCTION:The Robert Koch Institute (RKI) aimed to assess a molecular surveillance strategy based on filter-dried serum spots (DSS) of all newly diagnosed HIV infections in Germany. In 2013, diagnostic laboratories sent DSS to the RKI representing 55% of the newly diagnosed HIV infections reported to the RKI (protec...

journal_title：Journal of the International AIDS Society

authors： Andrea H,Alexandra H,Claudia SH,Ruth Z,Osamah H,Norbert B,Claudia K

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:The clinical value of monitoring CD4 counts in immune reconstituted, virologically suppressed HIV-infected patients is limited. We investigated if absolute lymphocyte counts (ALC) from an automated blood counting machine could accurately estimate CD4 counts. MATERIALS AND METHODS:CD4 counts, ALC and HIV v...

journal_title：Journal of the International AIDS Society

authors： Young B,Lye D,Ng OT,Leo YS

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Critical technological advances have yielded a toolkit of HIV prevention strategies. This literature review sought to provide contextual and historical reflection needed to bridge the conceptual gap between clinical efficacy and community effectiveness (i.e. knowledge and usage) of existing HIV prevention ...

journal_title：Journal of the International AIDS Society

authors： Parker RG,Perez-Brumer A,Garcia J,Gavigan K,Ramirez A,Milnor J,Terto V Jr

更新日期：2016-09-30 00:00:00

abstract：:Improved knowledge, better programmes and policies, effective treatment and other scientific developments have reduced levels of new HIV infections globally. Evidence shows that programmes that prevent HIV among sex workers and their clients are most successful when all aspects of vulnerability are addressed and when ...

journal_title：Journal of the International AIDS Society

authors： Overs C,Loff B

更新日期：2013-08-29 00:00:00

abstract：INTRODUCTION:Cenicriviroc (CVC), a once-daily, dual CCR5/CCR2 co-receptor antagonist, has completed Phase 2b development. CVC demonstrated favourable safety and similar efficacy compared with efavirenz (EFV) in Study 202 (NCT01338883); an ex vivo sub-analysis evaluated treatment effects on HIV entry, measured by intrac...

journal_title：Journal of the International AIDS Society

authors： Kramer V,Hassounah S,Colby-Germinario S,Mesplède T,Lefebvre E,Wainberg M

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Although RTS as HIV Diagnosis was considered cost effectiveness [1], overall budget may be unaffordable for some countries. We explore Incremental cost per NDHI associated with different TS. MATERIALS AND METHODS:From a health care perspective, using direct costs and Euros currency, we calculated budget a...

journal_title：Journal of the International AIDS Society

authors： Gomez-Ayerbe C,Elías MJ,Muriel A,Elías PP,Cano A,Diaz A,Moreno A,Casado JL,Santos C,Martinez-Colubi M,Uranga A,Dronda F,Moreno S

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Routes of transmission and reasons for HIV testing are important epidemiologic data to analyze the epidemic and to tailor the response to AIDS. The aim of this study was to analyze reasons for testing and transmission ways of HIV among recently diagnosed HIV patients registered in the multicenter HIV-TR co...

journal_title：Journal of the International AIDS Society

authors： Dokuzoguz B,Korten V,Gökengin D,Fincanci M,Yildirmak T,Kes UN,Tasdelen Fisgin N,Inan D,Eraksoy H,Akalin H

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:As adolescents transition from childhood to adulthood, they experience major physical, social and psychological changes, and are at heightened risk for developing mental health conditions and engaging in health-related risk behaviours. For adolescents living with HIV (ALHIV), these risks may be even more p...

journal_title：Journal of the International AIDS Society

authors： Laurenzi CA,Skeen S,Gordon S,Akin-Olugbade O,Abrahams N,Bradshaw M,Brand A,du Toit S,Melendez-Torres GJ,Tomlinson M,Servili C,Dua T,Ross DA

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:Although hepatitis C virus (HCV) screening is recommended for all HIV-infected patients initiating antiretroviral therapy, data on epidemiologic characteristics of HCV infection in resource-limited settings are scarce. METHODS:We searched PubMed and EMBASE for studies assessing the prevalence of HCV infec...

journal_title：Journal of the International AIDS Society

authors： Azevedo TC,Zwahlen M,Rauch A,Egger M,Wandeler G

更新日期：2016-06-09 00:00:00

abstract：INTRODUCTION:Women in sub-Saharan Africa spend a substantial portion of their reproductive lives pregnant and/or breastfeeding (P/BF), yet they have limited options to prevent HIV during these maternal stages. In preparation for phase 3b prevention trials in P/BF women, we explored attitudes about using a vaginal ring ...

journal_title：Journal of the International AIDS Society

authors： van der Straten A,Ryan JH,Reddy K,Etima J,Taulo F,Mutero P,Taylor J,Piper J,Musara P,MTN-041\/MAMMA Study Team.

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Infection with HIV subtype A has been associated with poorer neurocognitive outcomes compared to HIV subtype D in Ugandan children not eligible for antiretroviral therapy (ART). In this study, we sought to determine whether subtype-specific differences are also observed among children receiving ART. MATER...

journal_title：Journal of the International AIDS Society

authors： Bangirana P,Ruel TD,Boivin MJ,Pillai SK,Giron LB,Sikorskii A,Banik A,Achan J

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:Recent debates on how to achieve an optimal HIV response are dominated by intervention strategies that fail to recognize children's role in the community response to HIV. Whilst formal responses are key to the HIV response, they must recognize and build on indigenous community resources. This study examine...

journal_title：Journal of the International AIDS Society

authors： Skovdal M,Magutshwa-Zitha S,Campbell C,Nyamukapa C,Gregson S

更新日期：2013-02-04 00:00:00

abstract：INTRODUCTION:Changes in combination antiretroviral therapy (cART) throughout childhood challenge the continuity of paediatric HIV treatment. This study aimed to evaluate the prevalence of treatment interruption (TI), including lamivudine (3TC) monotherapy, and the relationship of TI to virologic and immunologic paramet...

journal_title：Journal of the International AIDS Society

authors： Rakhmanina N,Lam KS,Hern J,Young HA,Walters A,Castel AD

更新日期：2016-10-27 00:00:00

abstract：INTRODUCTION:This was a descriptive non-interventional study in HIV-1-infected patients treated with DRV/r conducted in the clinical setting, with a single-arm prospective design. The primary objective was to collect data on utilization of darunavir/ritonavir (DRV/r) under the conditions described in the marketing auth...

journal_title：Journal of the International AIDS Society

authors： Antinori A,Galli M,Gianotti N,Mussini C,Quirino T,Sterrantino K,Mancusi D,Termini R

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Transactional sex is a structural driver of HIV for women and girls in sub-Saharan Africa. In transactional relationships, sexual and economic obligations intertwine and may have positive and negative effects on women's financial standing and social status. We conducted a clinic-based survey with pregnant ...

journal_title：Journal of the International AIDS Society

authors： Fielding-Miller R,Dunkle KL,Hadley C,Cooper HL,Windle M

更新日期：2017-07-18 00:00:00

abstract：INTRODUCTION:Rilpivirine (RPV) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) that was recently approved for the treatment of antiretroviral-naïve individuals with HIV-1 viral load of <100,000 copies/ml. As transmission of the drug resistance mutations to this NNRTI may affect treatment o...

journal_title：Journal of the International AIDS Society

authors： Parczewski M,Urbańska A,Maciejewska K,Witak-Jȩdra M,Leszczyszyn-Pynka M

更新日期：2014-04-17 00:00:00

abstract：INTRODUCTION:Globally, young gay, bisexual and other men who have sex with men (gbMSM) continue to experience disproportionately high rates of HIV and other sexually transmitted and blood-borne infections (STBBIs). As such, there are strong public health imperatives to evaluate innovative prevention, treatment and care...

journal_title：Journal of the International AIDS Society

authors： Knight R,Karamouzian M,Salway T,Gilbert M,Shoveller J

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Global HIV-1 prevalence is 35.3 million [1]; women comprise >50% of those infected. The majority of women may lack regular care and only one-fourth are virologically suppressed [2]. ELLA is a cross-sectional, non-interventional study conducted across Europe, Latin America, Canada and Asia that describes ba...

journal_title：Journal of the International AIDS Society

authors： Baran R,Mulcahy F,Krznaric I,Monforte Ad,Samarina A,Xi H,Cassetti I,Madruga JV,Zachry W,van Wyk J,Martinez M

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:In the Microbicide Trial Network MTN-003 (VOICE) study, a Phase IIB pre-exposure prophylaxis trial of daily oral or vaginal tenofovir (TFV), product adherence was poor based on pharmacokinetic (PK) drug detection in a random subsample. Here, we sought to compare behavioural and PK measures of adherence and...

journal_title：Journal of the International AIDS Society

authors： van der Straten A,Brown ER,Marrazzo JM,Chirenje MZ,Liu K,Gomez K,Marzinke MA,Piper JM,Hendrix CW,MTN-003 VOICE Protocol Team for Microbicide Trials Network.

更新日期：2016-02-04 00:00:00

abstract：INTRODUCTION:It is estimated that over half of newly diagnosed HIV infections in Europe present late. An HIV positive individual presenting late to care represents a missed opportunity to benefit from treatment, increasing the risk of morbidity and mortality at an individual level, and onward disease transmission at po...

journal_title：Journal of the International AIDS Society

authors： Shivaji T,Diniz A,Cortes-Martins H

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:T cell immunoglobulin and mucin domain (Tim) 3 and programmed death 1 (PD-1) are co-inhibitory receptors involved in the so-called T cell exhaustion, and in vivo blockade of these molecules restores T cell dysfunction. High expression of Tim-3 and PD-1 is induced after chronic antigen-specific stimulation ...

journal_title：Journal of the International AIDS Society

authors： Sada-Ovalle I,Ocaña-Guzman R,Pérez-Patrigeón S,Chávez-Galán L,Sierra-Madero J,Torre-Bouscoulet L,Addo MM

更新日期：2015-10-19 00:00:00