Eubaric hyperoxia: controversies in the management of acute traumatic brain injury.

abstract：:Great white sharks are responsible for about 10 cases of death annually worldwide, as compared with millions of deaths caused by sepsis. However, the basic principles of avoiding shark attacks and fighting sepsis seem to be similar: avoidance, attention, and speed, if necessary. The present review discusses the curren...

journal_title：Critical care (London, England)

authors： Westphal M,Kampmeier T

更新日期：2015-01-01 00:00:00

abstract：:Women are generally under-represented in many academic medical settings. Through a brief commentary on this issue, the present article discusses possible explanations for this under-representation as well as potential solutions. Issues examined include women in leadership positions, attrition out of academic medicine,...

journal_title：Critical care (London, England)

authors： Weinacker A,Stapleton RD

更新日期：2013-01-29 00:00:00

abstract：:Sepsis, despite recent therapeutic progress, still carries unacceptably high mortality rates. The adrenergic system, a key modulator of organ function and cardiovascular homeostasis, could be an interesting new therapeutic target for septic shock. Beta-adrenergic regulation of the immune function in sepsis is complex ...

journal_title：Critical care (London, England)

authors： de Montmollin E,Aboab J,Mansart A,Annane D

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Multiple organ dysfunction syndrome (MODS) is a common complication of sepsis in mechanically ventilated patients with acute respiratory distress syndrome, but the links between mechanical ventilation and MODS are unclear. Our goal was to determine whether a minimally injurious mechanical ventilation strat...

journal_title：Critical care (London, England)

authors： O'Mahony DS,Liles WC,Altemeier WA,Dhanireddy S,Frevert CW,Liggitt D,Martin TR,Matute-Bello G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been shown to protect against such illness-induced muscle wasting and weakness. Here, we hypothesized that this protection was due to increased lipid and ket...

journal_title：Critical care (London, England)

authors： Goossens C,Weckx R,Derde S,Dufour T,Vander Perre S,Pauwels L,Thiessen SE,Van Veldhoven PP,Van den Berghe G,Langouche L

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Sepsis remains a complex medical problem and a major challenge in healthcare. Diagnostics and outcome predictions are focused on physiological parameters with less consideration given to patients' medical background. Given the aging population, not only are diseases becoming increasingly prevalent but occur ...

journal_title：Critical care (London, England)

authors： Zador Z,Landry A,Cusimano MD,Geifman N

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:The dysregulated host immune response that defines sepsis varies as a function of both the immune status of the host and the distinct nature of the pathogen. The degree to which immunocompromising comorbidities or immunosuppressive medications affect the immune response to infection is poorly understood beca...

journal_title：Critical care (London, England)

authors： Greenberg JA,Hrusch CL,Jaffery MR,David MZ,Daum RS,Hall JB,Kress JP,Sperling AI,Verhoef PA

更新日期：2018-04-25 00:00:00

abstract：INTRODUCTION:Pre-hospital triage is a key element in a trauma system that aims to admit patients to the most suitable trauma center, and may decrease intra-hospital mortality. We evaluated the performance of a pre-hospital procedure in a regional trauma system through measurements of the quality of pre-hospital medical...

journal_title：Critical care (London, England)

authors： Bouzat P,Ageron FX,Brun J,Levrat A,Berthet M,Rancurel E,Thouret JM,Thony F,Arvieux C,Payen JF,TRENAU group.

更新日期：2015-03-18 00:00:00

abstract：IMPORTANCE:The optimal approach to airway management during in-hospital cardiac arrest is unknown. OBJECTIVE:To describe hospital-level variation in endotracheal intubation during cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest and the association between hospital use of endotracheal intubation and ...

journal_title：Critical care (London, England)

authors： Bradley SM,Zhou Y,Ramachandran SK,Engoren M,Donnino M,Girotra S

更新日期：2019-05-06 00:00:00

abstract：INTRODUCTION:Dysbiosis of intestinal microbiota likely plays an important role in the development of gut-derived infections, making it a potential therapeutic target against sepsis. However, experience with fecal microbiota transplantation (FMT) in the treatment of sepsis and knowledge of the underlying mechanisms are ...

journal_title：Critical care (London, England)

authors： Li Q,Wang C,Tang C,He Q,Zhao X,Li N,Li J

更新日期：2015-02-09 00:00:00

abstract：INTRODUCTION:Staphylococcus (S.) aureus has emerged as an important cause of necrotizing pneumonia. Lung injury during S. aureus pneumonia may be enhanced by local release of damage associated molecular patterns such as high-mobility group box 1 (HMGB1). In the current study we sought to determine the functional role o...

journal_title：Critical care (London, England)

authors： Achouiti A,van der Meer AJ,Florquin S,Yang H,Tracey KJ,van 't Veer C,de Vos AF,van der Poll T

更新日期：2013-12-16 00:00:00

abstract：:Thromboelastography and thromboelastometry represent viscoelastic diagnostic methodologies with promising application to diseases of altered coagulation. Their use in trauma-induced coagulopathy as a means of assessing the real-time status of the patient's functional coagulation profile in addition to its impact on ef...

journal_title：Critical care (London, England)

authors： Bluth MH,Kashuk JL

更新日期：2011-01-01 00:00:00

abstract：:The early recognition and management of sepsis remain the greatest challenges in the field of critical care medicine. Endothelial injury is one of the hallmarks of sepsis, leading to capillary leak, microcirculatory dysfunction, organ failure, and eventual death in many critically ill patients. The angiogenic growth f...

journal_title：Critical care (London, England)

authors： Giuliano JS Jr,Wheeler DS

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Dysregulation of the host immune response is a pathognomonic feature of sepsis. Abnormal physiological conditions are understood to shift efficient linear splicing of protein-coding RNA towards non-canonical splicing, characterized by the accumulation of non-coding circularized (circ)RNA. CircRNAs remain une...

journal_title：Critical care (London, England)

authors： Khan HN,Brands X,Aufiero S,Hoogendijk AJ,Klarenbeek AM,van Engelen TSR,Haak BW,van Vught LA,Horn J,Schultz MJ,Zwinderman AH,van der Poll T,Scicluna BP

更新日期：2020-07-13 00:00:00

abstract：:Disagreements between the perceptions of nurses and physicians regarding end-of-life (EOL) decisions are frequent. In a survey carried out in 13 Brazilian ICUs, Fumis and Deheinzelin reported that the majority of nurses, physicians and family members are in favor of limiting life-sustaining therapies in terminally ill...

journal_title：Critical care (London, England)

authors： Soares M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Mottling around the knee, reflecting a reduced skin blood flow, is predictive of mortality in patients with septic shock. However, the causative pathophysiology of mottling remains unknown. We hypothesized that the cutaneous hypoperfusion observed in the mottled area is related to regional endothelial dysfun...

journal_title：Critical care (London, England)

authors： Bourcier S,Joffre J,Dubée V,Preda G,Baudel JL,Bigé N,Leblanc G,Levy BI,Guidet B,Maury E,Ait-Oufella H

更新日期：2017-06-23 00:00:00

abstract：INTRODUCTION:During septic shock, resistance to the haemodynamic effects of catecholamine vasopressors and inotropes is a well-recognised marker of mortality risk. However, the specific cardiovascular or metabolic response elements that are most closely associated with outcome have not been well defined. The objective ...

journal_title：Critical care (London, England)

authors： Kumar A,Schupp E,Bunnell E,Ali A,Milcarek B,Parrillo JE

更新日期：2008-01-01 00:00:00

abstract：:Coronavirus disease (COVID-19) is an emerging viral infection that is rapidly spreading across the globe. SARS-CoV-2 belongs to the same coronavirus class that caused respiratory illnesses such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). During the SARS and MERS outbreaks, ...

journal_title：Critical care (London, England)

authors： Kaur R,Weiss TT,Perez A,Fink JB,Chen R,Luo F,Liang Z,Mirza S,Li J

更新日期：2020-09-23 00:00:00

abstract：INTRODUCTION:Acute kidney injury (AKI) is a common complication in intensive care unit (ICU) patients and is associated with increased morbidity and mortality. We compared long-term outcome and quality of life (QOL) in ICU patients with AKI treated with renal replacement therapy (RRT) with matched non-AKI-RRT patients....

journal_title：Critical care (London, England)

authors： Oeyen S,De Corte W,Benoit D,Annemans L,Dhondt A,Vanholder R,Decruyenaere J,Hoste E

更新日期：2015-08-06 00:00:00

abstract：INTRODUCTION:Activation of the sympathetic nervous system has beneficial cardiovascular effects in sepsis, but there is also evidence that sympatholytics have beneficial actions in sepsis. We therefore determined the effect of selective β1-adrenoceptor blockade on cardiac and renal function and cytokine release in ovin...

journal_title：Critical care (London, England)

authors： Calzavacca P,Lankadeva YR,Bailey SR,Bailey M,Bellomo R,May CN

更新日期：2014-11-21 00:00:00

abstract：BACKGROUND:The association between isolated admission heart rate (HR) and prognosis has been discussed, but not that between gross HR change and neurological outcome in patients with severe traumatic brain injury (TBI). In the acute phase of severe TBI, HR is influenced by several factors (e.g., pain, sympathetic activ...

journal_title：Critical care (London, England)

authors： Inoue A,Hifumi T,Kuroda Y,Nishimoto N,Kawakita K,Yamashita S,Oda Y,Dohi K,Kobata H,Suehiro E,Maekawa T,Brain Hypothermia (B-HYPO) Study Group in Japan.

更新日期：2018-12-19 00:00:00

abstract：:The advent of biologic agents has provided a more specific and targeted approach to the treatment of various hematological malignancies and other autoimmune disorders. Such biologic agents have been relatively well tolerated with fewer adverse events reported as compared with many other chemotherapeutic agents. Rituxi...

journal_title：Critical care (London, England)

authors： Kasi PM,Tawbi HA,Oddis CV,Kulkarni HS

更新日期：2012-08-31 00:00:00

abstract：:Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is an increasingly adopted life-saving mechanical circulatory support for a number of potentially reversible or treatable cardiac diseases. It is also started as a bridge-to-transplantation/ventricular assist device in the case of unrecoverable cardiac or ca...

journal_title：Critical care (London, England)

authors： Bonicolini E,Martucci G,Simons J,Raffa GM,Spina C,Coco VL,Arcadipane A,Pilato M,Lorusso R

更新日期：2019-07-30 00:00:00

abstract：:There is persuasive evidence, including the present report by Dubin and colleagues, of a dissociation between increases in arterial pressure produced by vasopressor agents and improvement in microvascular perfusion and delivery of vital substrates. Especially in settings of septic shock, the current routine administra...

journal_title：Critical care (London, England)

authors： Weil MH,Tang W

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Enteral nutrition (EN) with eicosapentaenoic acid (EPA)/γ-linolenic acid (GLA) is recommended for mechanically ventilated patients with severe lung injury. EPA/GLA has anti-inflammatory benefits, as evidenced by its association with reduction in pulmonary inflammation, improvement in oxygenation and improv...

journal_title：Critical care (London, England)

authors： Pontes-Arruda A,Martins LF,de Lima SM,Isola AM,Toledo D,Rezende E,Maia M,Magnan GB,Investigating Nutritional Therapy with EPA, GLA and Antioxidants Role in Sepsis Treatment (INTERSEPT) Study Group.

更新日期：2011-06-09 00:00:00

abstract：BACKGROUND:Prognostication in out-of-hospital cardiac arrest (OHCA) survivors is often difficult. Recent studies have shown the predictive ability of bispectral index (BIS) monitoring to assist with early neuroprognostication. The aim of this study was to investigate whether characteristics of BIS values equal to zero ...

journal_title：Critical care (London, England)

authors： Eertmans W,Genbrugge C,Haesevoets G,Dens J,Boer W,Jans F,De Deyne C

更新日期：2017-08-22 00:00:00

abstract：INTRODUCTION:The diagnostic and prognostic value of arterial blood gas analysis (ABGA) parameters in unselected patients presenting with acute dyspnea to the Emergency Department (ED) is largely unknown. METHODS:We performed a post-hoc analysis of two different prospective studies to investigate the diagnostic and pro...

journal_title：Critical care (London, England)

authors： Burri E,Potocki M,Drexler B,Schuetz P,Mebazaa A,Ahlfeld U,Balmelli C,Heinisch C,Noveanu M,Breidthardt T,Schaub N,Reichlin T,Mueller C

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Data on the epidemiology and management of anorexia nervosa (AN) in the intensive care unit (ICU) are scarce. The aim of this study was to evaluate the prevalence and associated morbidity and mortality of AN in French ICUs. METHODS:We randomly selected 30 ICUs throughout France. Thereafter, we retrospecti...

journal_title：Critical care (London, England)

authors： Vignaud M,Constantin JM,Ruivard M,Villemeyre-Plane M,Futier E,Bazin JE,Annane D,AZUREA group (AnorexieRea Study Group).

更新日期：2010-01-01 00:00:00

abstract：:Storage time and residual leukocytes in red blood cell (RBC) units may be deleterious by increasing the accumulation of leukocyte-derived cytokines and by raising the adhesion of RBCs to endothelium. Leukodepleted RBC transfusion may reduce the incidence of infection and organ dysfunction. However, the influence of le...

journal_title：Critical care (London, England)

authors： Tanaka S,Harrois A,Duranteau J

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:Despite recent interest in measurement of central venous oxygen saturation (ScvO2), there are no published data describing the pattern of ScvO2 changes after major general surgery or any relationship with outcome. METHODS:ScvO2 and other biochemical, physiological and demographic data were prospectively m...

journal_title：Critical care (London, England)

authors： Pearse R,Dawson D,Fawcett J,Rhodes A,Grounds RM,Bennett ED

更新日期：2005-01-01 00:00:00