End of life care in Brazil: the long and winding road.

abstract：BACKGROUND:The aim of life-support measures in brain-dead donors is to preserve the functional value of their organs. In renal transplantation, serum creatinine level is one of the criteria for graft harvest. The aim of this study was to assess the impact of intensive care on donor renal function through two criteria: ...

journal_title：Critical care (London, England)

authors： Blasco V,Leone M,Bouvenot J,Geissler A,Albanèse J,Martin C

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, it plays pivotal roles in the pathogenesis of sepsis in several ways. Our previous study showed that rs1800625 (-429T/C) revealed a strong clinical relevance with sepsis morbidity rate and...

journal_title：Critical care (London, England)

authors： Zeng L,Du J,Gu W,Zhang AQ,Wang HY,Wen DL,Qiu L,Yang XT,Sun JH,Zhang M,Hao J,Jiang JX

更新日期：2015-01-09 00:00:00

abstract：INTRODUCTION:Although activation of A3 adenosine receptors attenuates reperfusion lung injury and associated apoptosis, the signaling pathway that mediates this protection remains unclear. Adenosine agonists activate mitogen-activated protein kinases, and these kinases have been implicated in ischemia/reperfusion injur...

journal_title：Critical care (London, England)

authors： Matot I,Weiniger CF,Zeira E,Galun E,Joshi BV,Jacobson KA

更新日期：2006-01-01 00:00:00

abstract：:In this article we review recent advances made in the pathophysiology, diagnosis, and treatment of inhalation injury. Historically, the diagnosis of inhalation injury has relied on nonspecific clinical exam findings and bronchoscopic evidence. The development of a grading system and the use of modalities such as chest...

journal_title：Critical care (London, England)

authors： Walker PF,Buehner MF,Wood LA,Boyer NL,Driscoll IR,Lundy JB,Cancio LC,Chung KK

更新日期：2015-10-28 00:00:00

abstract：:Women are generally under-represented in many academic medical settings. Through a brief commentary on this issue, the present article discusses possible explanations for this under-representation as well as potential solutions. Issues examined include women in leadership positions, attrition out of academic medicine,...

journal_title：Critical care (London, England)

authors： Weinacker A,Stapleton RD

更新日期：2013-01-29 00:00:00

abstract：:Characteristic patterns of variation over time, namely rhythms, represent a defining feature of complex systems, one that is synonymous with life. Despite the intrinsic dynamic, interdependent and nonlinear relationships of their parts, complex biological systems exhibit robust systemic stability. Applied to critical ...

journal_title：Critical care (London, England)

authors： Seely AJ,Macklem PT

更新日期：2004-12-01 00:00:00

abstract：:Many aspects of left ventricular function are explained by considering ventricular pressure-volume characteristics. Contractility is best measured by the slope, Emax, of the end-systolic pressure-volume relationship. Ventricular systole is usefully characterized by a time-varying elastance (ΔP/ΔV). An extended area, t...

journal_title：Critical care (London, England)

authors： Walley KR

更新日期：2016-09-10 00:00:00

abstract：INTRODUCTION:Many patients experience 'relocation stress' when they are transferred from an intensive care unit (ICU) to step-down (high dependency) or general ward care, and much has been written about the psychological causes. This qualitative analysis of in-depth, narrative interviews with former ICU patients explor...

journal_title：Critical care (London, England)

authors： Field K,Prinjha S,Rowan K

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:ICU-acquired weakness (ICUAW) complicates the disease course of critically ill patients. Inflammation and acute-phase response occur directly within myocytes and contribute to ICUAW. We observed that tripartite motif-containing 62 (TRIM62), an E3 ubiquitin ligase and modifier of inflammation, is increased ...

journal_title：Critical care (London, England)

authors： Schmidt F,Kny M,Zhu X,Wollersheim T,Persicke K,Langhans C,Lodka D,Kleber C,Weber-Carstens S,Fielitz J

更新日期：2014-09-29 00:00:00

abstract：BACKGROUND:Clinical team composition for prehospital paediatric intubation may affect success and complication rates. We performed a systematic review and meta-analysis to determine the success and complication rates by type of clinical team. METHODS:We searched MEDLINE, EMBASE, and CINAHL for interventional and obser...

journal_title：Critical care (London, England)

authors： Garner AA,Bennett N,Weatherall A,Lee A

更新日期：2020-04-15 00:00:00

abstract：INTRODUCTION:The choice of invasive systemic haemodynamic monitoring in critically ill patients remains controversial as no multicentre comparative clinical data exist. Accordingly, we sought to study and compare the features and outcomes of patients who receive haemodynamic monitoring with either the pulmonary artery ...

journal_title：Critical care (London, England)

authors： Uchino S,Bellomo R,Morimatsu H,Sugihara M,French C,Stephens D,Wendon J,Honore P,Mulder J,Turner A,PAC\/PiCCO Use and Likelihood of Success Evaluation PULSE Study Group.

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The association between isolated admission heart rate (HR) and prognosis has been discussed, but not that between gross HR change and neurological outcome in patients with severe traumatic brain injury (TBI). In the acute phase of severe TBI, HR is influenced by several factors (e.g., pain, sympathetic activ...

journal_title：Critical care (London, England)

authors： Inoue A,Hifumi T,Kuroda Y,Nishimoto N,Kawakita K,Yamashita S,Oda Y,Dohi K,Kobata H,Suehiro E,Maekawa T,Brain Hypothermia (B-HYPO) Study Group in Japan.

更新日期：2018-12-19 00:00:00

abstract：:Those involved in the airway management of COVID-19 patients are particularly at risk. Here, we describe a practical, stepwise protocol for safe in-hospital airway management in patients with suspected or confirmed COVID-19 infection. ...

journal_title：Critical care (London, England)

authors： Sullivan EH,Gibson LE,Berra L,Chang MG,Bittner EA

更新日期：2020-06-05 00:00:00

abstract：INTRODUCTION:Cardio-renal syndromes are characterized by the impairment of cardiac and renal functions. Plasma and urinary neutrophil gelatinase-associated lipocalin (NGAL), and plasma B-type natriuretic peptide (BNP) are markers of acute kidney injury (AKI) and heart failure (HF), respectively. METHODS:GFR (99mTc-DTP...

journal_title：Critical care (London, England)

authors： Donadio C

更新日期：2014-02-28 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is common among intensive care unit (ICU) patients. AKI is highly heterogeneous, with variable links to poor outcomes. Current approaches to classify AKI severity and identify patients at highest risk for poor outcomes focus on the maximum change in serum creatinine (SCr) values. Ho...

journal_title：Critical care (London, England)

authors： Bhatraju PK,Mukherjee P,Robinson-Cohen C,O'Keefe GE,Frank AJ,Christie JD,Meyer NJ,Liu KD,Matthay MA,Calfee CS,Christiani DC,Himmelfarb J,Wurfel MM

更新日期：2016-11-17 00:00:00

abstract：:Antithrombotic prophylaxis in critically ill patients frequently fails. Venous thromboembolism is associated with adverse clinical outcomes, including a prolonged intensive care unit stay and death. A potential mechanism by which critically ill patients may be predisposed to antithrombotic failure is the inability to ...

journal_title：Critical care (London, England)

authors： Crowther M,Lim W

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:This prospective, randomized, controlled, experimental animal study looks at the effects of recombinant human activated protein C (rhAPC) on global hemodynamics and microcirculation in ovine acute lung injury (ALI) and septic shock, resulting from smoke inhalation injury. METHODS:Twenty-one sheep (37 ± 2 ...

journal_title：Critical care (London, England)

authors： Maybauer MO,Maybauer DM,Fraser JF,Szabo C,Westphal M,Kiss L,Horvath EM,Nakano Y,Herndon DN,Traber LD,Traber DL

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Transthoracic echocardiography (TTE) is a useful tool for minimally invasive hemodynamic monitoring in the ICU. Dynamic indices (such as the inferior vena cava distensibility index (dIVC)) can be used to predict fluid responsiveness in mechanically ventilated patients. Although quantitative use of the dIVC...

journal_title：Critical care (London, England)

authors： Duwat A,Zogheib E,Guinot P,Levy F,Trojette F,Diouf M,Slama M,Dupont H

更新日期：2014-01-14 00:00:00

abstract：INTRODUCTION:In intensive care unit patients we assessed, using bispectral index (BIS) monitoring, whether the addition of magnesium sulphate infusion could decrease the sufentanil infusion required to maintain sedation. PATIENTS AND METHODS:A total of 30 adult patients who were expected to require mechanical ventilat...

journal_title：Critical care (London, England)

authors： Memiş D,Turan A,Karamanlioglu B,Oguzhan N,Pamukçu Z

更新日期：2003-10-01 00:00:00

abstract：:Acute pancreatitis results from a sequence of events that involve the systemic inflammatory response. Activated C has multiple anti-inflammatory activities and may attenuate the degree of pancreatic injury and systemic organ dysfunction when infused early in pancreatitis. ...

journal_title：Critical care (London, England)

authors： Kirschenbaum L,Astiz M

更新日期：2005-06-01 00:00:00

abstract：:Several papers are discussed including the CARP (Coronary Artery Revascularisation Prophylaxis) trial, examining the role, if any, of preoperative coronary revascularisation and a study examining the heart rate in the intensive care unit (ICU) population. We also take a look at infections in the ICU with particular re...

journal_title：Critical care (London, England)

authors： Tomlinson LA,Forni LG

更新日期：2005-04-01 00:00:00

abstract：INTRODUCTION:The present study was conducted to assess the value of serum concentration of lipopolysaccharide-binding protein (LBP) in patients with systemic inflammatory response syndrome (SIRS), sepsis and septic shock with respect to its ability to differentiate between infectious and noninfectious etiologies in SIR...

journal_title：Critical care (London, England)

authors： Prucha M,Herold I,Zazula R,Dubska L,Dostal M,Hildebrand T,Hyanek J

更新日期：2003-12-01 00:00:00

abstract：INTRODUCTION:Passive leg raising (PLR) is a simple reversible maneuver that mimics rapid fluid loading and increases cardiac preload. The effects of this endogenous volume expansion on stroke volume enable the testing of fluid responsiveness with accuracy in spontaneously breathing patients. However, this maneuver requ...

journal_title：Critical care (London, England)

authors： Biais M,Vidil L,Sarrabay P,Cottenceau V,Revel P,Sztark F

更新日期：2009-01-01 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available ...

journal_title：Critical care (London, England)

authors： Bassetti M,Bandera A,Gori A

更新日期：2020-03-24 00:00:00

abstract：:Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequ...

journal_title：Critical care (London, England)

authors： Rudd KE,Kissoon N,Limmathurotsakul D,Bory S,Mutahunga B,Seymour CW,Angus DC,West TE

更新日期：2018-09-23 00:00:00

abstract：BACKGROUND:Renal perfusion status remains poorly studied at the bedside during septic shock. We sought to measure cortical renal perfusion in patients with septic shock during their first 3 days of care using renal contrast enhanced ultrasound (CEUS). METHODS:We prospectively included 20 ICU patients with septic shock...

journal_title：Critical care (London, England)

authors： Harrois A,Grillot N,Figueiredo S,Duranteau J

更新日期：2018-06-15 00:00:00

abstract：:Large quantitaties of inflammatory mediators are released during the course of endotoxaemia. These mediators in turn can stimulate the sympathetic nervous system (SNS) to release catecholamines, which ultimately regulate inflammation-associated impairment in tissue perfusion, myocardial impairment and vasodilatation. ...

journal_title：Critical care (London, England)

authors： Beck GCh,Brinkkoetter P,Hanusch C,Schulte J,van Ackern K,van der Woude FJ,Yard BA

更新日期：2004-12-01 00:00:00

abstract：INTRODUCTION:The mortality benefit of whole-body computed tomography (CT) in early trauma management remains controversial and poorly understood. The objective of this study was to assess the impact of whole-body CT compared with selective CT on mortality and management of patients with severe blunt trauma. METHODS:Th...

journal_title：Critical care (London, England)

authors： Yeguiayan JM,Yap A,Freysz M,Garrigue D,Jacquot C,Martin C,Binquet C,Riou B,Bonithon-Kopp C,FIRST Study Group.

更新日期：2012-06-11 00:00:00

abstract：INTRODUCTION:Unawareness of an asymmetry between the right and left internal jugular vein (IJV) and methodological pitfalls in previous studies raise concerns about such asymmetry. Hence the aim of this prospective non-interventional study was to validate the hypothesis that right IJV diameter is greater than those of ...

journal_title：Critical care (London, England)

authors： Tartière D,Seguin P,Juhel C,Laviolle B,Mallédant Y

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:In transgenic animal models of sepsis, members of the Bcl-2 family of proteins regulate lymphocyte apoptosis and survival of sepsis. This study investigates the gene regulation of pro-apoptotic and anti-apoptotic members of the Bcl-2 family of proteins in patients with early stage severe sepsis. METHODS:I...

journal_title：Critical care (London, England)

authors： Weber SU,Schewe JC,Lehmann LE,Müller S,Book M,Klaschik S,Hoeft A,Stüber F

更新日期：2008-01-01 00:00:00