Diagnosis and management of inhalation injury: an updated review.

Abstract:

:In this article we review recent advances made in the pathophysiology, diagnosis, and treatment of inhalation injury. Historically, the diagnosis of inhalation injury has relied on nonspecific clinical exam findings and bronchoscopic evidence. The development of a grading system and the use of modalities such as chest computed tomography may allow for a more nuanced evaluation of inhalation injury and enhanced ability to prognosticate. Supportive respiratory care remains essential in managing inhalation injury. Adjuncts still lacking definitive evidence of efficacy include bronchodilators, mucolytic agents, inhaled anticoagulants, nonconventional ventilator modes, prone positioning, and extracorporeal membrane oxygenation. Recent research focusing on molecular mechanisms involved in inhalation injury has increased the number of potential therapies.

journal_name

Crit Care

authors

Walker PF,Buehner MF,Wood LA,Boyer NL,Driscoll IR,Lundy JB,Cancio LC,Chung KK

doi

10.1186/s13054-015-1077-4

subject

Has Abstract

pub_date

2015-10-28 00:00:00

pages

351

eissn

1364-8535

issn

1466-609X

pii

10.1186/s13054-015-1077-4

journal_volume

19

pub_type

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