Influence of FCGR3A genotype on the therapeutic response to rituximab in rheumatoid arthritis: an observational cohort study.

abstract：OBJECTIVES:Identifying the issues and concerns that matter most to burns survivors can be challenging. For a number of reasons, but mainly relating to patient empowerment, some of the most pressing concerns patients may have during a clinical encounter may not naturally be the focal point of that encounter. The Patient...

journal_title：BMJ open

authors： Gibson JAG,Yarrow J,Brown L,Evans J,Rogers SN,Spencer S,Shokrollahi K

更新日期：2019-12-30 00:00:00

abstract：PURPOSE:The goal of the Pregnancy, Race, Environment, Genes study was to understand how social and environmental determinants of health (SEDH), pregnancy-specific environments (PSE) and biological processes influence the timing of birth and account for the racial disparity in preterm birth. The study followed a raciall...

journal_title：BMJ open

authors： Lapato DM,Moyer S,Olivares E,Amstadter AB,Kinser PA,Latendresse SJ,Jackson-Cook C,Roberson-Nay R,Strauss JF,York TP

更新日期：2018-05-09 00:00:00

abstract：INTRODUCTION:Individuals with Parkinson's disease (PD) have to deal with several aspects of voice and speech decline and thus alteration of communication ability during the course of the disease. Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction...

journal_title：BMJ open

authors： Pinto S,Cardoso R,Sadat J,Guimarães I,Mercier C,Santos H,Atkinson-Clement C,Carvalho J,Welby P,Oliveira P,D'Imperio M,Frota S,Letanneux A,Vigario M,Cruz M,Martins IP,Viallet F,Ferreira JJ

更新日期：2016-11-17 00:00:00

abstract：OBJECTIVES:The microscopic evaluation of slides has been gradually moving towards all digital in recent years, leading to the possibility for computer-aided diagnosis. It is worthwhile to know the similarities between deep learning models and pathologists before we put them into practical scenarios. The simple criteria...

journal_title：BMJ open

authors： Song Z,Yu C,Zou S,Wang W,Huang Y,Ding X,Liu J,Shao L,Yuan J,Gou X,Jin W,Wang Z,Chen X,Chen H,Liu C,Xu G,Sun Z,Ku C,Zhang Y,Dong X,Wang S,Xu W,Lv N,Shi H

更新日期：2020-09-10 00:00:00

abstract：INTRODUCTION:Previous studies have showed association between smoking and central fat distribution. However, the impact of smoking on whole body fat distribution, particularly peripheral fat distribution remains unclear. METHODS:Nicotine dependence was assessed in a total of 1264 male adults aged 18-80 years using the...

journal_title：BMJ open

authors： Wei C,Ye S,Sheng JR,Ma X,Ru Y,Zhang L,Guo H,Zhu S

更新日期：2019-03-12 00:00:00

abstract：OBJECTIVES:Physically demanding work increases the risk of developing musculoskeletal disorders during working life, with low back pain (LBP) as the most prevalent and debilitating musculoskeletal disorder worldwide. However, a lack of knowledge exists about the role of early working years on musculoskeletal health lat...

journal_title：BMJ open

authors： Bláfoss R,Skovlund SV,López-Bueno R,Calatayud J,Sundstrup E,Andersen LL

更新日期：2020-12-07 00:00:00

abstract：OBJECTIVE:To examine whether confidence in primary healthcare (PHC) differs among ethnic-linguistic groups and which PHC experiences are associated with confidence. DESIGN:A cross-sectional study where patient surveys were administered using random digit dialling. Regression models identify whether ethnic-linguistic g...

journal_title：BMJ open

authors： Wong ST,Black C,Cutler F,Brooke R,Haggerty JL,Levesque JF

更新日期：2014-02-25 00:00:00

abstract：OBJECTIVES:An increasing number of studies had shown that air pollution exposure may aggravate blood glucose control in patients with diabetes, an independent risk factor for colorectal cancer (CRC) proposed by some researchers. This study aimed to investigate the impact of exposure to ambient particulate matter with a...

journal_title：BMJ open

authors： Ma JW,Lai TJ,Hu SY,Lin TC,Ho WC,Tsan YT

更新日期：2020-10-28 00:00:00

abstract：OBJECTIVE/DESIGN:It remains unclear as to the efficacy of readiness for change measurements in child and adolescent obesity intervention programmes. This observational study aimed to determine whether the caregiver's stage of change could predict outcome and adherence to treatment in an intensive intervention programme...

journal_title：BMJ open

authors： Anderson YC,Dolan GMS,Wynter LE,Treves KF,Wouldes TA,Grant CC,Cave TL,Smiley AJ,Derraik JGB,Cutfield WS,Hofman PL

更新日期：2019-03-27 00:00:00

abstract：OBJECTIVE:To investigate the long-term effectiveness of a school-based intervention to improve physical activity and diet in children. DESIGN:Cluster-randomised controlled trial. SETTING:60 primary schools in the southwest of England. PARTICIPANTS:Primary school children who were aged 8-9 years at recruitment, 9-10 ...

journal_title：BMJ open

authors： Anderson EL,Howe LD,Kipping RR,Campbell R,Jago R,Noble SM,Wells S,Chittleborough C,Peters TJ,Lawlor DA

更新日期：2016-11-24 00:00:00

abstract：OBJECTIVES AND DESIGN:We identified a novel TRIM59 gene, as an early signal transducer in two (SV40Tag and Ras) oncogene pathways in murine prostate cancer (CaP) models. We explore its clinical applications as a multitumour marker detecting early tumorigenesis by immunohistochemistry (IHC). SETTING AND PARTICIPANTS:88...

journal_title：BMJ open

authors： Khatamianfar V,Valiyeva F,Rennie PS,Lu WY,Yang BB,Bauman GS,Moussa M,Xuan JW

更新日期：2012-10-08 00:00:00

abstract：OBJECTIVE:Legislation to safeguard children from maltreatment by carers or violence by others was advanced in England and Scotland around 2004-2005 and resulted in different policies and services. We examined whether subsequent trends in injury admissions to hospital related to maltreatment or violence varied between t...

journal_title：BMJ open

authors： Gonzalez-Izquierdo A,Cortina-Borja M,Woodman J,Mok J,McGhee J,Taylor J,Parkin C,Gilbert R

更新日期：2014-04-22 00:00:00

abstract：INTRODUCTION:It is estimated that Iran accounted for about 1% of hip fracture burden of the world in 2007, but these data are based on incomplete evidence. As the country's population is ageing, it is expected that a dramatic rise in hip fracture incidence will result. There is no single national study that accurately ...

journal_title：BMJ open

authors： Maghbooli Z,Hossein-Nezhad A,Jafarpour M,Noursaadat S,Ramezani M,Hashemian R,Moattari S

更新日期：2017-04-11 00:00:00

abstract：INTRODUCTION:Current perspectives present feedback as a dynamic, dialogic process. It is widely accepted that feedback can have an impact on workplace performance, however, how dialogic feedback is enacted with the learner in authentic healthcare settings is less apparent. This paper seeks to describe the design and de...

journal_title：BMJ open

authors： Ossenberg C,Mitchell M,Henderson A

更新日期：2020-06-08 00:00:00

abstract：INTRODUCTION:Community-based interventions have been found to effectively increase the implementation of alcohol management practices and reduce excessive alcohol use and alcohol-related harm at sports clubs. However, once implementation support ceases there may be a reduction in such intervention effects. Thus, ongoin...

journal_title：BMJ open

authors： McFadyen T,Wolfenden L,Kingsland M,Tindall J,Rowland B,Sherker S,Gillham K,Heaton R,Clinton-McHarg T,Lecathelinais C,Brooke D,Wiggers J

更新日期：2018-01-23 00:00:00

abstract：OBJECTIVES:This article summarises all the available evidence on the impact of introducing blood-based point-of-care panel testing (POCT) in ambulatory care on patient outcomes and healthcare processes. DESIGN:Systematic review and meta-analysis of randomised-controlled trials and before-after studies. DATA SOURCES:O...

journal_title：BMJ open

authors： Goyder C,Tan PS,Verbakel J,Ananthakumar T,Lee JJ,Hayward G,Turner PJ,Van Den Bruel A

更新日期：2020-02-27 00:00:00

abstract：INTRODUCTION:Controlled trials support the efficacy of exercise as a treatment modality for chronic conditions, yet effectiveness of real-world Exercise Physiology services is yet to be determined. This study will investigate the efficacy and cost-effectiveness of services provided by Accredited Exercise Physiologists ...

journal_title：BMJ open

authors： Kitic CM,Selig S,Davison K,Best TLB,Parmenter B,Pumpa K,Furzer B,Rice V,Hardcastle S,Cheney M,Palmer AJ,Fraser S,Williams AD

更新日期：2019-08-21 00:00:00

abstract：OBJECTIVE:The global research group, DIPLOMATIC (Using eviDence, Implementation science, and a clinical trial PLatform to Optimise MATernal and newborn health in low Income Countries), aims to reduce stillbirths and preterm births and optimise outcomes for babies born preterm. Minimum datasets for routine data collecti...

journal_title：BMJ open

authors： von Wissmann B,Wastnedge E,Waters D,Gadama LA,Dube Q,Masesa C,Chodzaza E,Stock SJ,Reynolds RM,Norrie J,Makwakwa E,Freyne B,Campbell H,Norman JE,Wood R,DIPLOMATIC collaboration.

更新日期：2020-11-24 00:00:00

abstract：INTRODUCTION:Current pharmacological treatment options for hyperemesis gravidarum have been introduced based on scarce evidence and are often not sufficiently effective. Several case reports suggest that mirtazapine, an antidepressant, may be an effective treatment for hyperemesis gravidarum, but so far there are no co...

journal_title：BMJ open

authors： Ostenfeld A,Petersen TS,Futtrup TB,Andersen JT,Jensen AK,Westergaard HB,Pedersen LH,Løkkegaard ECL

更新日期：2020-03-24 00:00:00

abstract：INTRODUCTION:Expectant mothers in low-income and middle-income countries often lack access to vital information about pregnancy, preparation for birth and best practices when caring for their newborn. Innovative solutions are needed to bridge this knowledge gap and dramatically improve maternal and neonatal health in t...

journal_title：BMJ open

authors： Su Y,Yuan C,Zhou Z,Heitner J,Campbell B

更新日期：2016-08-10 00:00:00

abstract：INTRODUCTION:Reported adherence to urate-lowering therapy (ULT) in gout varies widely (17%-83.5%). Variability may partly be due to different adherence measurement methods. This review aimed to quantify ULT adherence in adult patients with gout. METHODS:This analysis examined studies in PubMed, Web of Science, CNKI Sc...

journal_title：BMJ open

authors： Yin R,Li L,Zhang G,Cui Y,Zhang L,Zhang Q,Fu T,Cao H,Li L,Gu Z

更新日期：2018-04-10 00:00:00

abstract：INTRODUCTION:Complex coronary artery disease (left main and three-vessel disease) carries high risks of adverse events and cost burden. However, in China, little is known about which patients are directed toward which treatment strategies and what outcomes are being achieved. METHODS AND ANALYSIS:Using the China PEACE...

journal_title：BMJ open

authors： Rao C,Bongiovanni T,Li X,Gao H,Zhang H,Li J,Zhao Y,Yuan X,Hua K,Hu S,Krumholz HM,Jiang L,Zheng Z,China PEACE Collaborative Group.

更新日期：2016-02-15 00:00:00

abstract：OBJECTIVE:To test the association between use of medicines with anticholinergic or sedative properties and physical function, cognitive function, appetite and frailty. DESIGN, SETTING AND PARTICIPANTS:This cross-sectional study analysed baseline data collected as part of the Australian Longitudinal Study of Ageing, a ...

journal_title：BMJ open

authors： Lim R,Kalisch Ellett LM,Widagdo IS,Pratt NL,Roughead EE

更新日期：2019-09-04 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the risk of injuries among children exposed to a stressful life exposure (defined as bereavement) before conception or during fetal life. DESIGN:Population-based cohort study. SETTING:Denmark. PARTICIPANTS:All singleton births in Denmark between 1 January 1995 and 31 De...

journal_title：BMJ open

authors： Virk J,Li J,Lauritsen J,Olsen J

更新日期：2013-04-22 00:00:00

abstract：OBJECTIVES:Evidence comparing the effectiveness of surgical and conservative treatment of symptomatic lumbar disc herniation is controversial. We sought to compare short-term and long-term effectiveness of surgical and conservative treatment in sciatica symptom severity and quality of life in patients with lumbar disc ...

journal_title：BMJ open

authors： Gugliotta M,da Costa BR,Dabis E,Theiler R,Jüni P,Reichenbach S,Landolt H,Hasler P

更新日期：2016-12-21 00:00:00

abstract：OBJECTIVES:To identify and evaluate interventions aimed at increasing uptake of, or access to, physical health screening by adults with severe mental illness; to examine why interventions might work. DESIGN:Realist review. SETTING:Primary, secondary and tertiary care. RESULTS:A systematic search identified 1448 stud...

journal_title：BMJ open

authors： Lamontagne-Godwin F,Burgess C,Clement S,Gasston-Hales M,Greene C,Manyande A,Taylor D,Walters P,Barley E

更新日期：2018-02-10 00:00:00

abstract：OBJECTIVE:To determine the association of the Martin Luther King Jr Hospital (MLK) closure on the distribution of admissions on adjacent trauma centres, and injury mortality rates in these centres and within the county. DESIGN:Observational, retrospective study. SETTING:Non-public patient-level data from the state of...

journal_title：BMJ open

authors： Crandall M,Sharp D,Wei X,Nathens A,Hsia RY

更新日期：2016-05-10 00:00:00

abstract：OBJECTIVE:To investigate the gap between real-world data and clinical research initiated by doctors in China, explore the potential reasons for this gap and collect different stakeholders' suggestions. DESIGN:This qualitative study involved three types of hospital personnel based on three interview outlines. The data ...

journal_title：BMJ open

authors： Jin F,Yao C,Yan X,Dong C,Lai J,Li L,Wang B,Tan Y,Zhu S

更新日期：2020-12-29 00:00:00

abstract：OBJECTIVE:Administering medication to hospitalised infants and children is a complex process at high risk of error. Failure mode and effect analysis (FMEA) is a proactive tool used to analyse risks, identify failures before they happen and prioritise remedial measures. To examine the hazards associated with the process...

journal_title：BMJ open

authors： Lago P,Bizzarri G,Scalzotto F,Parpaiola A,Amigoni A,Putoto G,Perilongo G

更新日期：2012-12-18 00:00:00

abstract：OBJECTIVE:We assessed the impact of political conflict (Boko Haram) on tuberculosis (TB) case notifications in Adamawa State in North-east Nigeria. DESIGN:A retrospective analysis of TB case notifications from TB registers (2010-2016) to describe changes in TB notification, sex and age ratios by the degree of conflict ...

journal_title：BMJ open

authors： Pembi E,John S,Dumre SP,Ahmadu BU,Vuong NL,Ebied A,Mizukami S,Huy NT,Cuevas LE,Hirayama K

更新日期：2020-09-16 00:00:00