Abstract:
INTRODUCTION:Individuals with Parkinson's disease (PD) have to deal with several aspects of voice and speech decline and thus alteration of communication ability during the course of the disease. Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction and dysprosody, which is linked to the neurodegenerative processes; (2) effects of the pharmacological treatment, which vary according to the disease stage; and (3) particular speech modifications that may be language-specific, that is, dependent on the language spoken by the patients. The main objective of the FraLusoPark project is to provide a thorough evaluation of changes in PD speech as a result of pharmacological treatment and disease duration in 2 different languages (French vs European Portuguese). METHODS AND ANALYSIS:Individuals with PD are enrolled in the study in France (N=60) and Portugal (N=60). Their global motor disability and orofacial motor functions is assessed with specific clinical rating scales, without (OFF) and with (ON) pharmacological treatment. 2 groups of 60 healthy age-matched volunteers provide the reference for between-group comparisons. Along with the clinical examinations, several speech tasks are recorded to obtain acoustic and perceptual measures. Patient-reported outcome measures are used to assess the psychosocial impact of dysarthria on quality of life. ETHICS AND DISSEMINATION:The study has been approved by the local responsible committees on human experimentation and is conducted in accordance with the ethical standards. A valuable large-scale database of speech recordings and metadata from patients with PD in France and Portugal will be constructed. Results will be disseminated in several articles in peer-reviewed journals and in conference presentations. Recommendations on how to assess speech and voice disorders in individuals with PD to monitor the progression and management of symptoms will be provided. TRIAL REGISTRATION NUMBER:NCT02753192, Pre-results.
journal_name
BMJ Openjournal_title
BMJ openauthors
Pinto S,Cardoso R,Sadat J,Guimarães I,Mercier C,Santos H,Atkinson-Clement C,Carvalho J,Welby P,Oliveira P,D'Imperio M,Frota S,Letanneux A,Vigario M,Cruz M,Martins IP,Viallet F,Ferreira JJdoi
10.1136/bmjopen-2016-012885subject
Has Abstractpub_date
2016-11-17 00:00:00pages
e012885issue
11issn
2044-6055pii
bmjopen-2016-012885journal_volume
6pub_type
杂志文章,多中心研究相关文献
BMJ Open文献大全abstract:OBJECTIVES:To compare days on sick leave and assess predictors of return to work following shoulder surgery. DESIGN:A secondary analysis of a randomised controlled trial. SETTING:Orthopaedic department. PARTICIPANTS:114 patients with type II superior labral tear from anterior to posterior of the shoulder. INTERVENT...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035259
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:Patients with atrial fibrillation (AF) are at increased risk of many adverse events, notably stroke. To prevent all adverse outcomes, integrated AF care is advocated though the potential domain for such multidisciplinary management is still unclear. Therefore, insight in the systemic nature of AF and identif...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-021681
更新日期:2018-08-23 00:00:00
abstract:INTRODUCTION:Parkinson's disease is the second most common chronic neurodegenerative condition with bladder dysfunction affecting up to 71%. Symptoms affect quality of life and include urgency, frequency, hesitancy, nocturia and incontinence. Addressing urinary dysfunction is one of the top 10 priority research areas i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034887
更新日期:2020-02-17 00:00:00
abstract:OBJECTIVES:To compare the clinical, socioeconomic and demographic characteristics of individuals diagnosed with Neisseria gonorrhoeae (NG) in the community using a concomitant nucleic acid amplification test (NAAT, AptimaCombo2) as part of the (community-based) UK Chlamydia Screening Programme (CSP), with those diagnos...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-004862
更新日期:2014-03-14 00:00:00
abstract:OBJECTIVES:We examined the patterns of total and domain-specific physical activity (PA) by sex, socioeconomic status and maternal education level in adolescents from Sao Paulo city, Brazil. DESIGN:Cross-sectional study. PARTICIPANTS:We included a representative sample of 2682 (52.2% boys) adolescents aged 14-15 years...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037290
更新日期:2020-09-02 00:00:00
abstract:OBJECTIVES:To identify effective interventions to increase organ donor registration and improve knowledge about organ donation among ethnic minorities in North America and the UK. DESIGN:Systematic review. DATA SOURCES:MEDLINE, EMBASE, PsycINFO, CINAHL and Cochrane Central searched up to November 2012, together with ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003453
更新日期:2013-12-20 00:00:00
abstract:INTRODUCTION:Multiple interventions are effective for migraine prophylaxis. However, the comparative effectiveness of these interventions is still not clear. Therefore, the aim of this study is to summarise the direct and indirect evidence for pharmacological and non-pharmacological interventions to prevent migraine at...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2015-007594
更新日期:2015-05-06 00:00:00
abstract:OBJECTIVES:Ethiopia is a developing country striving to achieve universal health coverage using the health extension programme. There is limited evidence about Ethiopian women's satisfaction with their urban health extension programme. Thus, this study was aimed at assessing the level of women's satisfaction with their...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-039390
更新日期:2020-12-13 00:00:00
abstract:OBJECTIVE:Whether low-intensity telephone-counselling interventions can improve cardiometabolic risk factors in screen-detected people with metabolic syndrome (MetS) is unclear. The aim of this study was to evaluate the effectiveness of a low-intensity, telephone-counselling programme on MetS implemented by the Nationa...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-007603
更新日期:2015-07-10 00:00:00
abstract:OBJECTIVE:We aimed to epidemiologically assess rubella herd immunity as a function of time, age and gender in Japan, with reference to the recent 2012-2014 rubella epidemic. DESIGN:This study is a retrospective seroepidemiological analysis. MAIN OUTCOME MEASURES:The susceptible fraction of the population was examined...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009928
更新日期:2016-01-27 00:00:00
abstract:OBJECTIVES:Malignant melanoma has high morbidity and mortality rates. Early diagnosis improves prognosis. Clinical prediction rules (CPRs) can be used to stratify patients with symptoms of suspected malignant melanoma to improve early diagnosis. We conducted a systematic review of CPRs for melanoma diagnosis in ambulat...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2016-014096
更新日期:2017-03-06 00:00:00
abstract:INTRODUCTION:Providing smoking cessation treatment is an important intervention for tuberculosis (TB) patients. Mobile technologies, such as smartphone applications, have shown promising potential. However, there are few effective applications that could support TB patients in their efforts to quit smoking. To address ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031204
更新日期:2019-12-02 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the relationship between birth order and stereoacuity among Chinese children aged 60-72 months. DESIGN:Cross-sectional. PARTICIPANTS:1342 children with complete data on the questionnaire, stereoacuity and refraction were included. RESULTS:The mean stereoacuity was 53.2±1.7, ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-032833
更新日期:2020-10-12 00:00:00
abstract:INTRODUCTION:Overtreatment of localised prostate cancer is substantial despite increased use of active surveillance. No randomised trials help define how to monitor patients or when to initiate treatment with curative intent. METHODS AND ANALYSIS:A randomised, multicentre, intervention trial designed to evaluate the s...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027860
更新日期:2019-08-22 00:00:00
abstract:OBJECTIVES:To evaluate health inequity on access to services in the ethnic regions of Northeastern Myanmar from three points of analysis: geographic barrier, gender-based disparity and financial burden of health services. SETTING:A multistage-stratified random cluster survey was conducted in Shan State Special Region ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-017770
更新日期:2017-12-14 00:00:00
abstract:BACKGROUND:Mild traumatic brain injury (mTBI) is a common injury among military personnel serving in Iraq or Afghanistan. The impact of repeated episodes of combat mTBI is unknown. OBJECTIVE:To evaluate relationships among mTBI, post-traumatic stress disorder (PTSD) and neurological deficits (NDs) in US veterans who s...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000312
更新日期:2012-03-18 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the implementation of the Ohio Emergency and Acute Care Facility Opioids and Other Controlled Substances Prescribing Guidelines and their perceived impact on local policies and practice. METHODS:The study design was a cross-sectional survey of emergency department (ED) medical directors, or...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020477
更新日期:2018-06-30 00:00:00
abstract:OBJECTIVE:Cardiac disease in pregnancy is a leading cause of maternal death in high-income countries. Evidence-based guidelines to assist in planning and managing the healthcare of affected women is lacking. The objective of this research was to produce the first qualitative metasynthesis of the experiences of pregnant...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2018-022755
更新日期:2018-09-28 00:00:00
abstract:INTRODUCTION:The proportion of elderly people is steadily rising worldwide, especially in low-income and middle-income countries, including China. Chronic kidney disease (CKD) is a common disorder in older people. However, little is known about the epidemiology of CKD and its consequences among the elderly. Improvement...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-019457
更新日期:2018-02-24 00:00:00
abstract:OBJECTIVES:The current COVID-19 pandemic, as well as the measures taken to control it, have a profound impact on healthcare. This study was set up to gain insights into the consequences of the COVID-19 outbreak on the core competencies of general practice, as they are experienced by general practitioners (GPs) on the f...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-039674
更新日期:2020-06-17 00:00:00
abstract:OBJECTIVE:This study aims to test a Chinese cross-cultural adaptation of the English version of the Person-Centred Care Assessment Tool (P-CAT) and evaluate its psychometric properties. DESIGN:P-CAT was translated/back-translated using established procedures before the psychometric evaluation of the Chinese version wa...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031580
更新日期:2020-07-13 00:00:00
abstract:INTRODUCTION:Current perspectives present feedback as a dynamic, dialogic process. It is widely accepted that feedback can have an impact on workplace performance, however, how dialogic feedback is enacted with the learner in authentic healthcare settings is less apparent. This paper seeks to describe the design and de...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034945
更新日期:2020-06-08 00:00:00
abstract:OBJECTIVE:The human leucocyte antigen-DO (HLA-DO) gene located in the HLA non-classical class-II region may play a role in treatment response to hepatitis C virus (HCV). This study was conducted to explore the role of single nucleotide polymorphisms (SNPs) in HLA-DO in responding to HCV therapy. SETTING:All patients w...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-019406
更新日期:2018-04-12 00:00:00
abstract:OBJECTIVE:Conduct an economic evaluation based on best currently available evidence comparing alternative treatments levonorgestrel-releasing intrauterine system, depot-medroxyprogesterone acetate, combined oral contraceptive pill (COCP) and 'no treatment' to prevent recurrence of endometriosis after conservative surge...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010580
更新日期:2016-04-15 00:00:00
abstract:INTRODUCTION:Although a great majority of patients with cervical radiculopathy syndrome can successfully be treated non-operatively, a considerable proportion experience persistent symptoms, severe enough to require neurosurgical intervention. During the past decade, cervical spine procedures have increasingly been per...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2019-032575
更新日期:2019-11-26 00:00:00
abstract:INTRODUCTION:To advance person- and family-centred healthcare, government initiatives have supported the engagement of patients and family caregivers in decision-making in healthcare systems. There is, however, no consensus on how to define success for such initiatives. This scoping review aims to identify the key elem...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-032788
更新日期:2019-11-06 00:00:00
abstract:INTRODUCTION:Evidence from animal studies suggest that the rate of ageing may be influenced not only by genetic and lifestyle factors, but also by the prenatal environment. We have previously shown that people who were exposed to famine during early gestation performed worse on a selective attention task, which may be ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003167
更新日期:2013-06-20 00:00:00
abstract:OBJECTIVE:To investigate the association of living in foster care (FC) with substance use and subjective well-being in a sample of secondary school students (11-16 years) in Wales in 2015/16, and to examine whether these associations are attenuated by the perceived quality of interpersonal relationships. DESIGN:Cross-...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-014198
更新日期:2017-02-20 00:00:00
abstract:OBJECTIVE:Whether areas affected by Q fever during a large outbreak (2008-2010) had higher rates of adverse pregnancy outcomes than areas not affected by Q fever. DESIGN:Nationwide registry-based ecological study. SETTING:Pregnant women in areas affected and not affected by Q fever in the Netherlands, 2003-2004 and 2...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006821
更新日期:2015-04-10 00:00:00
abstract:OBJECTIVES:The aim of the study was to examine the level of patient satisfaction with nursing care and identify the factors affecting satisfaction from the inpatient's perspective in a backward region of China. DESIGN:This was a cross-sectional study. SETTING:The study was conducted at a tertiary hospital located in ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034196
更新日期:2020-09-09 00:00:00