当前位置： SCI文献检索 > BMJ Open期刊下所有文献 > Pharmaceutical treatments to prevent recurrence of endometriosis following surgery: a model-based economic evaluation.

Pharmaceutical treatments to prevent recurrence of endometriosis following surgery: a model-based economic evaluation.

Abstract：

OBJECTIVE:Conduct an economic evaluation based on best currently available evidence comparing alternative treatments levonorgestrel-releasing intrauterine system, depot-medroxyprogesterone acetate, combined oral contraceptive pill (COCP) and 'no treatment' to prevent recurrence of endometriosis after conservative surgery in primary care, and to inform the design of a planned trial-based economic evaluation. METHODS:We developed a state transition (Markov) model with a 36-month follow-up. The model structure was informed by a pragmatic review and clinical experts. The economic evaluation adopted a UK National Health Service perspective and was based on an outcome of incremental cost per quality-adjusted life year (QALY). As available data were limited, intentionally wide distributions were assigned around model inputs, and the average costs and outcome of the probabilistic sensitivity analyses were reported. RESULTS:On average, all strategies were more expensive and generated fewer QALYs compared to no treatment. However, uncertainty attributing to the transition probabilities affected the results. Inputs relating to effectiveness, changes in treatment and the time at which the change is made were the main causes of uncertainty, illustrating areas where robust and specific data collection is required. CONCLUSIONS:There is currently no evidence to support any treatment being recommended to prevent the recurrence of endometriosis following conservative surgery. The study highlights the importance of developing decision models at the outset of a trial to identify data requirements to conduct a robust post-trial analysis.

journal_name

BMJ Open

journal_title

BMJ open

authors

Sanghera S,Barton P,Bhattacharya S,Horne AW,Roberts TE,PRE-EMPT research group.

doi

10.1136/bmjopen-2015-010580

subject

Has Abstract

pub_date

2016-04-15 00:00:00

pages

e010580

issue

4

issn

2044-6055

pii

bmjopen-2015-010580

journal_volume

6

pub_type

杂志文章

相关文献

BMJ Open文献大全