Analysis of anticholinergic and sedative medicine effects on physical function, cognitive function, appetite and frailty: a cross-sectional study in Australia.

abstract：OBJECTIVES:Pharmacoepidemiological studies are an important hypothesis-testing tool in the evaluation of postmarketing drug safety. Despite the potential to produce robust value-added data, interpretation of findings can be hindered due to well-recognised methodological limitations of these studies. Therefore, assessme...

journal_title：BMJ open

authors： Neyarapally GA,Hammad TA,Pinheiro SP,Iyasu S

更新日期：2012-09-25 00:00:00

abstract：OBJECTIVES:Hospitals devoted to maternal and child health represent unique healthcare institutions in China. Healthcare professionals in these hospitals attend to health services for women and children, and also provide technical services and support for district maternal and children's healthcare as well as family pla...

journal_title：BMJ open

authors： Ye J,Wang H,Wu H,Ye L,Li Q,Ma XY,Yu X,Zhang H,Luo X

更新日期：2019-01-25 00:00:00

abstract：INTRODUCTION:Up to 1 in 4 pregnancies and 1 in 20 subsequent pregnancies end in miscarriage. Despite such prevalence the psychosocial effects are often unrecognised and unsupported. In the absence of any biomedical sequelae among men such marginalisation may be intensified. Men living through multiple miscarriages may ...

journal_title：BMJ open

authors： Williams HM,Jones LL,Coomarasamy A,Topping AE

更新日期：2020-05-15 00:00:00

abstract：INTRODUCTION:Obesity is a global epidemic and is a risk factor for developing other comorbidities. Young adulthood is a critical period for body weight change and establishing healthy lifestyle behaviours. The 'Freshman 15' suggests that undergraduate students gain 15 lbs (6.8 kg) during their first year of university,...

journal_title：BMJ open

authors： Morassut RE,Langlois C,Alyass A,Ishola AF,Yazdi FT,Mayhew AJ,Reddon H,MacKillop J,Pigeyre M,Meyre D

更新日期：2017-12-10 00:00:00

abstract：INTRODUCTION:Hamstring injury among athletes often results in significant morbidity. Currently, there are controversies regarding the clinical use of platelet-rich plasma (PRP) for the treatment of acute hamstring injury. METHODS AND ANALYSIS:This study is a single-centre double-blind randomised placebo-controlled tri...

journal_title：BMJ open

authors： A Hamid MS,Hussein KH,Helmi Salim AM,Puji A,Mat Yatim R,Yong CC,Sheng TWY

更新日期：2020-08-20 00:00:00

abstract：OBJECTIVES AND DESIGN:We identified a novel TRIM59 gene, as an early signal transducer in two (SV40Tag and Ras) oncogene pathways in murine prostate cancer (CaP) models. We explore its clinical applications as a multitumour marker detecting early tumorigenesis by immunohistochemistry (IHC). SETTING AND PARTICIPANTS:88...

journal_title：BMJ open

authors： Khatamianfar V,Valiyeva F,Rennie PS,Lu WY,Yang BB,Bauman GS,Moussa M,Xuan JW

更新日期：2012-10-08 00:00:00

abstract：INTRODUCTION:The study 'Mental healthcare provision for adults with intellectual disability and a mental disorder' (MEMENTA) is a cross-sectional epidemiological study carried out in three different regions of Germany. Its main aim is to assess the prevalence of mental disorders in adults with intellectual disability (...

journal_title：BMJ open

authors： Koch A,Vogel A,Holzmann M,Pfennig A,Salize HJ,Puschner B,Schützwohl M

更新日期：2014-05-20 00:00:00

abstract：INTRODUCTION:Maternal and perinatal death surveillance and response (MPDSR), or any related form of audit, is a systematic process used to prevent future maternal and perinatal deaths. While the existence of MPDSR policies is routinely measured, measurement and understanding of policy implementation has lagged behind. ...

journal_title：BMJ open

authors： Kinney MV,Walugembe DR,Wanduru P,Waiswa P,George AS

更新日期：2019-11-27 00:00:00

abstract：INTRODUCTION:With the rapid ageing of the population in Europe, reliable estimates of the future development of the disease and disability burden as well as healthy life years in the older sections of the population are crucial. Meanwhile, the future prospects of the health and functional ability of the working-aged po...

journal_title：BMJ open

authors： Paalanen L,Härkänen T,Tolonen H

更新日期：2019-06-20 00:00:00

abstract：OBJECTIVES:This study aims to provide a comprehensive description of noise levels in operating rooms (ORs) in a tertiary care hospital in China. Additionally, the study aims to examine the deviation in noise levels from international and internal standards as well as the differences in noise levels by category of surge...

journal_title：BMJ open

authors： Wang X,Zeng L,Li G,Xu M,Wei B,Li Y,Li N,Tao L,Zhang H,Guo X,Zhao Y

更新日期：2017-09-18 00:00:00

abstract：INTRODUCTION:Multiple interventions are effective for migraine prophylaxis. However, the comparative effectiveness of these interventions is still not clear. Therefore, the aim of this study is to summarise the direct and indirect evidence for pharmacological and non-pharmacological interventions to prevent migraine at...

journal_title：BMJ open

authors： Zheng H,Chen M,Huang D,Li J,Chen Q,Fang J

更新日期：2015-05-06 00:00:00

abstract：OBJECTIVE:Animal and in vitro studies suggest that viral acute respiratory infection (VARI) can predispose to pneumococcal infection. These findings suggest that the prevention of VARI can yield additional benefits for the control of pneumococcal disease (PD). In population-based studies, however, the evidence is not i...

journal_title：BMJ open

authors： Li Y,Peterson ME,Campbell H,Nair H

更新日期：2018-04-21 00:00:00

abstract：INTRODUCTION:Families in low-income and middle-income countries (LMICs) face multiple challenges (eg, poverty and adverse childhood experiences) that increase the risk for child mental health problems, while the context may provide them with few resources. Existing prevention-oriented parenting programmes have been sho...

journal_title：BMJ open

authors： Frantz I,Foran HM,Lachman JM,Jansen E,Hutchings J,Băban A,Fang X,Gardner F,Lesco G,Raleva M,Ward CL,Williams ME,Heinrichs N

更新日期：2019-01-25 00:00:00

abstract：OBJECTIVES:Transgender women (TW) are highly burdened by HIV infection in the USA. Research is needed into drivers of the HIV epidemic for TW, including longitudinal studies to identify risks for incident HIV infection and optimal intervention targets. This formative research sought to understand TW's experiences with,...

journal_title：BMJ open

authors： Reisner SL,Chaudhry A,Cooney E,Garrison-Desany H,Juarez-Chavez E,Wirtz AL

更新日期：2020-01-19 00:00:00

abstract：OBJECTIVES:Mortality has declined in people with HIV infection, subsequent to the improved access to antiretroviral therapy (ART). We assessed the incidence and determinants of mortality among patients with HIV-1 infection who were started on ART in a referral treatment centre for HIV infection in Yaounde, Cameroon. D...

journal_title：BMJ open

authors： Poka-Mayap V,Pefura-Yone EW,Kengne AP,Kuaban C

更新日期：2013-07-13 00:00:00

abstract：OBJECTIVE:Leptin is a pleiotropic hormone associated with learning and memory via brain receptors. However, elevated plasma leptin levels may impair cognitive and memory functions. Since individual differences in memory performance affect students' ability to learn, we aimed to study the relation between leptin status ...

journal_title：BMJ open

authors： Correa-Burrows P,Blanco E,Reyes M,Castillo M,Peirano P,Algarín C,Lozoff B,Gahagan S,Burrows R

更新日期：2016-10-18 00:00:00

abstract：INTRODUCTION:In patients with large abdominal aortic aneurysm (AAA), open surgical or endovascular aneurysm repair procedures are often used to minimise the risk of aneurysm-related rupture and death; however, aneurysm repair itself carries a high risk. Low cardiopulmonary fitness is associated with an increased risk o...

journal_title：BMJ open

authors： Tew GA,Weston M,Kothmann E,Batterham AM,Gray J,Kerr K,Martin D,Nawaz S,Yates D,Danjoux G

更新日期：2014-01-10 00:00:00

abstract：OBJECTIVES:To investigate an association between fatty liver disease (FLD) and erosive oesophagitis. DESIGN AND SETTING:This was a cross-sectional study of subjects selected from examinees who underwent health check-up, including oesophagogastroduodenoscopy in one hospital between 2004 and 2011. Erosive oesophagitis w...

journal_title：BMJ open

authors： Choi JS,Kim HM,Yang YJ,Lee S,Jeong SH,Han KJ

更新日期：2019-01-30 00:00:00

abstract：OBJECTIVES:This study compared the impact of two different 8-week mindfulness based courses (.b Foundations and Mindfulness-Based Stress Reduction (MBSR)), delivered to school teachers, on quantitative (stress, anxiety and depression) and qualitative (experience, acceptability and implementation) outcomes. DESIGN:A mi...

journal_title：BMJ open

authors： Todd C,Cooksey R,Davies H,McRobbie C,Brophy S

更新日期：2019-07-04 00:00:00

abstract：OBJECTIVES:Hip fracture patients of 65 years and older are a complex patient group who often suffer from complications and difficult rehabilitation with disappointing results. It is unknown to what extent suboptimal hospital care contributes to these poor outcomes. This study reports on the scale, preventability, cause...

journal_title：BMJ open

authors： Merten H,Johannesma PC,Lubberding S,Zegers M,Langelaan M,Jukema GN,Heetveld MJ,Wagner C

更新日期：2015-09-07 00:00:00

abstract：INTRODUCTION:Stroke is among the leading causes of death and disability worldwide. Poststroke cognitive impairment is a common sequela of stroke. The burden of cognitive impairment poststroke has significant impacts on the individual poststroke, their family and wider society. Despite the prevalence and associated burd...

journal_title：BMJ open

authors： O Donoghue M,Boland P,Galvin R,Coote S,Hayes S

更新日期：2019-11-07 00:00:00

abstract：PURPOSE:Despite the growing evidence that physical activity and familial factors play a role in low back pain (LBP), there is a lack of robust longitudinal studies that (1) investigate the types and dosages of physical activity that are protective or harmful for LBP, (2) employ objective measures of physical activity a...

journal_title：BMJ open

authors： Carvalho-E-Silva AP,Pinheiro MB,Ferreira ML,Hübscher M,Calais-Ferreira L,Ferreira PH

更新日期：2020-07-28 00:00:00

abstract：INTRODUCTION:Idiopathic Parkinson's disease (PD) is a progressive neurodegenerative disorder related to α-synuclein misfolding and aggregation. For this reason, it belongs to the family of 'synucleinopathies', which also includes some other neurological diseases. Although imaging and ancillary investigations may be hel...

journal_title：BMJ open

authors： Eusebi P,Hansson O,Paciotti S,Orso M,Chiasserini D,Calabresi P,Blennow K,Parnetti L

更新日期：2017-11-22 00:00:00

abstract：OBJECTIVE:Despite tremendous efforts to scale up key maternal and child health interventions in Zambia, progress has not been uniform across the country. This raises fundamental health system performance questions that require further investigation. Our study investigates technical and scale efficiency (SE) in the deli...

journal_title：BMJ open

authors： Achoki T,Hovels A,Masiye F,Lesego A,Leufkens H,Kinfu Y

更新日期：2017-01-05 00:00:00

abstract：OBJECTIVE:Insomnia is highly prevalent in prisoners and is a risk factor for poor mental well-being, depression, suicidality and aggression, all common concerns in this vulnerable population. Improving sleep management options in prison offers the potential to impact positively on a number of these common risk factors....

journal_title：BMJ open

authors： Dewa LH,Hassan L,Shaw J,Senior J

更新日期：2018-08-29 00:00:00

abstract：INTRODUCTION:Depressive disorders are very common diseases entailing a great burden on affected people. However, comprehensive information on long-term disease course in patients with severe depression is lacking so far. The objectives of the DELTA study are to examine long-term outcomes and their predicting factors, t...

journal_title：BMJ open

authors： Kirchberger I,Maleckar B,Meisinger C,Linseisen J,Schmauss M,Baumgärtner J

更新日期：2019-12-23 00:00:00

abstract：OBJECTIVES:Most studies reporting evidence of adverse effects of lead and cadmium on the ability to balance have been conducted in high-exposure groups or have included adults. The effects of prenatal exposure have not been well studied, nor have the effects in children been directly studied. The aim of the study was t...

journal_title：BMJ open

authors： Taylor CM,Humphriss R,Hall A,Golding J,Emond AM

更新日期：2015-12-30 00:00:00

abstract：OBJECTIVES:Although human factors are important in terms of patient safety, there have been very few reports on the attitudes of healthcare professionals working in acute care settings in South Korea. In the present study, we investigated the attitudes of such professionals, their cultures and their management systems....

journal_title：BMJ open

authors： Kim SE,Kim CW,Lee SJ,Oh JH,Lee DH,Lim TH,Choi HJ,Chung HS,Ryu JY,Jang HY,Choi YH,Kim SJ,Jung JH

更新日期：2015-07-24 00:00:00

abstract：INTRODUCTION:Trauma to the nail bed is the most common surgically treated paediatric hand injury. The majority of surgeons replace the nail plate after repairing the nail bed despite a lack of evidence to do so. Replacing the nail plate may be associated with increased postoperative infection. We will investigate the i...

journal_title：BMJ open

authors： Jain A,Jones A,Gardiner MD,Cooper C,Sierakowski A,Dritsaki M,Png ME,Stokes JR,Shirkey B,Cook J,Beard D,Greig AVH

更新日期：2019-12-04 00:00:00

abstract：INTRODUCTION:Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current lack of understanding of mechanisms of chronic pain. Recently, duloxetine...

journal_title：BMJ open

authors： Reckziegel D,Bailey H,Cottam WJ,Tench CR,Mahajan RP,Walsh DA,Knaggs RD,Auer DP

更新日期：2017-06-26 00:00:00