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Modifiable risk factors associated with bone deficits in childhood cancer survivors.

Abstract：

BACKGROUND:To determine the prevalence and severity of bone deficits in a cohort of childhood cancer survivors (CCS) compared to a healthy sibling control group, and the modifiable factors associated with bone deficits in CCS. METHODS:Cross-sectional study of bone health in 319 CCS and 208 healthy sibling controls. Bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry (DXA). Generalized estimating equations were used to compare measures between CCS and controls. Among CCS, multivariable logistic regression was used to evaluate odds ratios for BMD Z-score ≤ -1. RESULTS:All subjects were younger than 18 years of age. Average time since treatment was 10.1 years (range 4.3 - 17.8 years). CCS were 3.3 times more likely to have whole body BMD Z-score ≤ -1 than controls (95% CI: 1.4-7.8; p = 0.007) and 1.7 times more likely to have lumbar spine BMD Z-score ≤ -1 than controls (95% CI: 1.0-2.7; p = 0.03). Among CCS, hypogonadism, lower lean body mass, higher daily television/computer screen time, lower physical activity, and higher inflammatory marker IL-6, increased the odds of having a BMD Z-score ≤ -1. CONCLUSIONS:CCS, less than 18 years of age, have bone deficits compared to a healthy control group. Sedentary lifestyle and inflammation may play a role in bone deficits in CCS. Counseling CCS and their caretakers on decreasing television/computer screen time and increasing activity may improve bone health.

journal_name

BMC Pediatr

journal_title

BMC pediatrics

authors

Polgreen LE,Petryk A,Dietz AC,Sinaiko AR,Leisenring W,Goodman P,Steffen LM,Perkins JL,Dengel DR,Baker KS,Steinberger J

doi

10.1186/1471-2431-12-40

subject

Has Abstract

pub_date

2012-03-28 00:00:00

pages

40

issn

1471-2431

pii

1471-2431-12-40

journal_volume

12

pub_type

杂志文章

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