Abstract:
BACKGROUND:Intravenous immunoglobulin (IVIG) is commonly used to improve the immunomodulatory effects, although its regulatory effect on premature Treg cells is unclear. The purpose of this study is to study the effect of high dose of IVIG (HD-IVIG) on Treg cells expression and cytokine profile in premature birth. METHODS:Fifty-two premature infants were enrolled in this study and thirty-one premature infants who were suspected to have intrauterine infection received HD-IVIG (1-2 g/kg) at the first day of birth; the remaining 21 premature infants were assigned as the control group. The peripheral blood CD4 + T and foxp3+ Treg cells were checked by flow cytometry, and cytokine concentrations were detected by cytometric bead array. RESULTS:With the gestational age growth, peripheral blood CD4 + T and foxp3+ Treg cells of prematurity gradually declined from 50% to 35% and from 8% to 6%, respectively. Meanwhile, HD-IVIG increased the percentage of CD4 + T and foxp3+ Treg cells compared with their baseline levels (p < 0.001). HD-IVIG demonstrated different regulating effects on cytokines secretion, increased IL-17 and TGF-β, and inhibited IL-6 secretion. CONCLUSION:Our results demonstrated that HD-IVIG not only enhanced the premature immune tolerance, but also suppressed the excessive inflammation response mediated by IL-6. TRIAL REGISTRATION:This study was under the clinical study registration (ChiCTR-ORC-16008872, date of registration, 2016-07-21).
journal_name
BMC Pediatrjournal_title
BMC pediatricsauthors
Liu P,Li L,Fan P,Zheng J,Zhao Ddoi
10.1186/s12887-018-1055-5subject
Has Abstractpub_date
2018-02-21 00:00:00pages
74issue
1issn
1471-2431pii
10.1186/s12887-018-1055-5journal_volume
18pub_type
杂志文章相关文献
BMC Pediatrics文献大全abstract:BACKGROUND:Tympanic thermometry has come as a suitable alternative to traditional thermometry because of its safety and ease of use. However, it is still yet to gain wide acceptance in African settings due to conflicting results on its accuracy, thus rectal thermometry remains the gold standard in the newborn. The aim ...
journal_title:BMC pediatrics
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2431-12-86
更新日期:2012-06-25 00:00:00
abstract:BACKGROUND:In 2006, a new rotavirus vaccine (RotaTeq) was licensed in the US and recommended for routine immunization of all US infants. Because a previously licensed vaccine (Rotashield) was withdrawn from the US for safety concerns, identifying barriers to uptake of RotaTeq will help develop strategies to broaden vac...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2431-7-32
更新日期:2007-10-18 00:00:00
abstract:BACKGROUND:In spite of surplus food production, in Amhara region, a significant number of children had under-nutrition. Investigating factors associated with under-nutrition in food secured households is crucial to design preventive measures. Therefore, the objective of this study was to assess under-nutrition and asso...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1386-2
更新日期:2019-01-07 00:00:00
abstract::After publication of the original article [1] it was brought to our attention that author Bouchra Ouled Amar Bencheikh was incorrectly included as Bouchra Oulad Amar Bencheikh. ...
journal_title:BMC pediatrics
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12887-018-1114-y
更新日期:2018-04-17 00:00:00
abstract:BACKGROUND:Poisoning in toddlers and infants is almost always unintentional due to their exploratory behavior, which is different from adults. The prevalence and background of childhood poisoning in Qatar is still unknown. The aim of this study is to explore the extent of childhood poisoning in Qatar and, specifically,...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-015-0423-7
更新日期:2015-08-28 00:00:00
abstract:BACKGROUND:As many preschoolers are not able to cooperate with health-related invasive procedures, sedation can help with the child's comfort and allow the intervention to be done. It is scarcely known how parents affect children's behavior during dental treatment under conscious sedation. The aim of this exploratory s...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-016-0743-2
更新日期:2016-12-03 00:00:00
abstract:BACKGROUND:Global childhood mortality rates remain high. Millennium Development Goal 4 focused efforts on reducing rates by two-thirds between 1990 and 2015. In Ethiopia, child mortality rates dropped 71 % from 1990 to 2015, however it is estimated that 184,000 Ethiopian children die each year. There is limited informa...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-016-0709-4
更新日期:2016-10-21 00:00:00
abstract:BACKGROUND:Intrapartum-related hypoxic events are a major cause of morbidity and mortality in low resource countries. Neonates who receive proper resuscitation may go on to live otherwise healthy lives. However, even when a birth attendant is present, these babies frequently receive suboptimal ventilation with poor out...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-1925-5
更新日期:2020-01-30 00:00:00
abstract:BACKGROUND:Children with traumatic brain injury (TBI) are frequently at risk of long-term impairments of attention and executive functioning but these problems are difficult to predict. Although deficits have been reported to vary with injury severity, age at injury and sex, prognostication of outcome remains imperfect...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/s12887-017-0925-6
更新日期:2017-07-24 00:00:00
abstract:BACKGROUND:Hypertension is an important health problem in China and raised blood pressure in children may lead to future hypertension. Accordingly we aimed to provide a reference blood pressure table for age, gender and height in Chinese children. METHODS:A reference sample of subjects was drawn from the Chinese Healt...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-13-195
更新日期:2013-11-25 00:00:00
abstract:BACKGROUND:The mental health and quality of life in children with asthma have attracted widespread attention. This study focused on the evaluation of mental health conditions and their clinical characteristics in Chinese children with asthma. METHODS:A total of 261 children with asthma aged 6 to 16 years old and 261 a...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1834-7
更新日期:2019-11-22 00:00:00
abstract:BACKGROUND:The aim of this study was to revise the 2003 Fenton Preterm Growth Chart, specifically to: a) harmonize the preterm growth chart with the new World Health Organization (WHO) Growth Standard, b) smooth the data between the preterm and WHO estimates, informed by the Preterm Multicentre Growth (PreM Growth) stu...
journal_title:BMC pediatrics
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2431-13-59
更新日期:2013-04-20 00:00:00
abstract:BACKGROUND:Well baby visits (WBVs) are a cornerstone of early childhood health, but few studies have examined the correlates of WBVs for socioeconomically vulnerable infants. The study objective was to identify factors related to the number of WBVs received by Medicaid-enrolled infants in the first three years of life ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-13-158
更新日期:2013-10-05 00:00:00
abstract:BACKGROUND:Children and adolescents dying from complex chronic conditions require paediatric palliative care. One aim of palliative care is to enable a home death if desired and well supported. However, there is little data to inform care, particularly from countries without paediatric palliative care, which constitute...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-017-0970-1
更新日期:2017-12-22 00:00:00
abstract:BACKGROUND:Severe acute malnutrition affects around 17 million under-five children in the world, of which the highest burden is accounted by Sub-Saharan Africa where Ethiopia is found. Though there are few individual, inconsistent and inconclusive studies, there is no nationally representative study on treatment outcom...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02188-5
更新日期:2020-07-07 00:00:00
abstract:BACKGROUND:Seeking healthcare in children is unique since parents decide upon the type and frequency of healthcare services accessed. Mothers/caregivers lower healthcare seeking behavior is one of the major reason for increased morbidity and mortality from childhood illness in developing countries. Hence, this study ai...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1588-2
更新日期:2019-07-03 00:00:00
abstract:BACKGROUND:Neonatal near miss cases occur more often than neonatal deaths and could enable a more comprehensive analysis of risk factors, short-term outcomes and prognostic factors in neonates born to mothers with severe obstetric complications. The objective was to assess the incidence, presentation and perinatal outc...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-015-0362-3
更新日期:2015-04-17 00:00:00
abstract:BACKGROUND:Although numerous evidence-based and feasible interventions are available to treat pain from childhood vaccine injections, evidence indicates that children are not benefitting from this knowledge. Unrelieved vaccination pain puts children at risk for significant long-term harms including the development of n...
journal_title:BMC pediatrics
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2431-13-23
更新日期:2013-02-08 00:00:00
abstract:BACKGROUND:Although adolescent spinal pain increases the risk for chronic back pain in adulthood, most adolescents can be regarded as healthy. The aim of the present study was to provide data on localization, intensity and frequency of adolescent spinal pain and to investigate which physical and psycho-social parameter...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-015-0344-5
更新日期:2015-04-17 00:00:00
abstract:BACKGROUND:The Pediatric Quality of Life Inventory (PedsQL) is a modular instrument, designed to integrate generic and disease specific measures, and includes both self- and proxy-reports. The aim of the study was to assess the reliability and limited validity of the Swedish version of the disease specific Pediatric Qu...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02387-0
更新日期:2020-10-28 00:00:00
abstract:BACKGROUND:The influence of socio-economic determinants on choice of infant male circumcision provider is not known in areas with high population coverage such as rural Africa. The overall aim of this study was to determine the key socio-economic factors which influence the choice of infant male circumcision provider i...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-017-0937-2
更新日期:2017-08-29 00:00:00
abstract:BACKGROUND:Acute mountain sickness (AMS) is commonly found among people traveling above 2500 m. We investigated whether the occurrence of AMS is related to differences in individual physical fitness and BMI in subjects 11-13 years of age. METHODS:This study was conducted at Xue Mountain, Taiwan (elevation of 3886 m) b...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-015-0373-0
更新日期:2015-05-08 00:00:00
abstract:BACKGROUND:Early environmental influences have been linked to child weight status, however further understanding of associations in diverse populations is needed. METHODS:A cross-sectional analysis of household and family factors associated with overweight was conducted on a culturally diverse, urban dwelling sample o...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-14-167
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:13q33-q34 microdeletions are rare chromosomal aberrations associated with a high risk of developmental disability, facial dysmorphism, cardiac defects and other malformation of organs. It is necessary to collect and report evidence of this rare chromosome mutation to improve the prognosis of this rare diseas...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02205-7
更新日期:2020-07-02 00:00:00
abstract:BACKGROUND:Alcohol intoxicated adolescents (AIA) in emergency department are an important target group for prevention and valid information on their familial risk and protective factors (RPF) is crucial for implementing customized family-based counseling in hospitals. We therefore, examined the psychometric characteris...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-015-0471-z
更新日期:2015-11-19 00:00:00
abstract:BACKGROUND:Numerous studies have detailed the physical health benefits of children's participation in sport and a growing body of research also highlights the benefits for mental health. Children who participate in sport have also been shown to be advantaged academically. However, despite the benefits there is evidence...
journal_title:BMC pediatrics
pub_type: 杂志文章,评审
doi:10.1186/s12887-018-1014-1
更新日期:2018-02-09 00:00:00
abstract:BACKGROUND:Premedication before neonatal intubation is heterogeneous and contentious. The combination of a short acting, rapid onset opioid with a muscle relaxant is considered suitable by many experts. The purpose of this study was to describe the tolerance and conditions of intubation following anaesthesia with atrop...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-14-120
更新日期:2014-05-07 00:00:00
abstract:BACKGROUND:The fundamental treatment for patients with pediatric malignant mediastinal tumors is chemotherapy. Therefore, accurate diagnosis is essential for selecting the appropriate chemotherapeutic regimen. However, malignant mediastinal tumors occasionally cause respiratory distress, and biopsies under general anes...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02183-w
更新日期:2020-06-10 00:00:00
abstract:BACKGROUND:Hyperglycemia often occurs in premature, very low birthweight infants (VLBW) due to immaturity of endogenous regulatory systems and the stress of their condition. Hyperglycemia in neonates has been linked to increased morbidities and mortality and occurs at increasing rates with decreasing birthweight. In th...
journal_title:BMC pediatrics
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2431-12-117
更新日期:2012-08-07 00:00:00
abstract:BACKGROUND:In order for infants and toddlers to meet recommended movement guidelines, their caregivers need to encourage play daily. This study used a qualitative approach to understand how mothers perceive and promote play and physical activity during the first 2 years of life. METHODS:Mothers with children between 0...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02321-4
更新日期:2020-09-09 00:00:00