Abstract:
BACKGROUND:Premedication before neonatal intubation is heterogeneous and contentious. The combination of a short acting, rapid onset opioid with a muscle relaxant is considered suitable by many experts. The purpose of this study was to describe the tolerance and conditions of intubation following anaesthesia with atropine, sufentanil and atracurium in very premature infants. METHODS:Monocentric, prospective observational study in premature infants born before 32 weeks of gestational age, hospitalised in the NICU and requiring semi-urgent or elective intubation. Intubation conditions, heart rate, pulse oxymetry (SpO2), arterial blood pressure and transcutaneous PCO2 (TcPCO2) were collected in real time during 30 minutes following the first drug injection. Repeated physiological measurements were analysed using mixed linear models. RESULTS:Thirty five intubations were performed in 24 infants with a median post conceptional age of 27.6 weeks and a median weight of 850 g at the time of intubation. The first attempt was successful in 74% and was similar for junior (75%) and senior (74%) operators. The operator rated conditions as "excellent" or "good" in 94% of intubations. A persistent increase in TcPCO2 as compared to baseline was observed whereas other vital parameters showed no significant variations 5, 10, 15 and 30 minutes after the first drug injection. Eighteen (51%) desaturations (SpO2 less than or equal to 80% for more than 60 seconds) and 2 (6%) bradycardia (heart rate less than 100 bpm for more than 60 seconds) were observed. CONCLUSION:This drug combination offers satisfactory success rate for first attempt and intubation conditions for the operator without any significant change in heart rate and blood pressure for the patient. However it is associated with frequent desaturations and a possible persistent hypercapnia. SpO2 and PCO2 can be significantly modified during neonatal intubation and should be cautiously followed in this high-risk population.
journal_name
BMC Pediatrjournal_title
BMC pediatricsauthors
Durrmeyer X,Dahan S,Delorme P,Blary S,Dassieu G,Caeymaex L,Carbajal Rdoi
10.1186/1471-2431-14-120subject
Has Abstractpub_date
2014-05-07 00:00:00pages
120issn
1471-2431pii
1471-2431-14-120journal_volume
14pub_type
杂志文章相关文献
BMC Pediatrics文献大全abstract:BACKGROUND:Although breastfeeding duration in New Zealand's indigenous Māori is shorter than in non-Māori, we know little about barriers or motivators of breastfeeding in this community. The aim of this analysis was to identify predictors for extended duration of breastfeeding amongst participants drawn from predominan...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1274-9
更新日期:2018-09-12 00:00:00
abstract:BACKGROUND:Guidelines for the management of fever in children have been recently published, however "fever phobia" is still spreading. To provide information which may sustain educational interventions tailored to our population we investigated the parental and medical knowledge and management of fever in preschool chi...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-12-97
更新日期:2012-07-13 00:00:00
abstract:BACKGROUND:Between 1998 and 2015, we report on the survival of congenital diaphragmatic hernia (CDH)-infants presenting with symptoms within the first 24 h of life, treated at Odense University Hospital (OUH), a tertiary referral non-extracorporeal membrane oxygenation (ECMO) hospital for paediatric surgery. METHODS:W...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02072-2
更新日期:2020-05-07 00:00:00
abstract:BACKGROUND:Rapid weight gain (RWG) in infants is associated with overweight and obesity in childhood and beyond, highlighting the need for early intervention. METHODS:Data from a birth cohort of Australian Aboriginal and Torres Strait Islander children living in an urban area were analysed to determine the prevalence ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02121-w
更新日期:2020-05-18 00:00:00
abstract:BACKGROUND:Comprehensive data are needed to evaluate the burden of low birthweight. Analysis of routine data on health-care utilization during early childhood were used to test the hypothesis that infants with low birthweight have (i) increased inpatient health-care utilization, (ii) higher hospital costs and (iii) dif...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1424-8
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:To reduce the risk of brain damage children with acute lymphoblastic leukaemia (ALL) are nowadays mainly treated with intrathecal chemotherapy (ITC) instead of central nervous system (CNS) radiation therapy (CRT) to prevent CNS relapse. However, chemotherapy may also lead to cognitive deficits. As growth hor...
journal_title:BMC pediatrics
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2431-8-25
更新日期:2008-06-20 00:00:00
abstract:BACKGROUND:Indigenous infants and children in Australia, especially in remote communities, experience early and chronic otitis media (OM) which is difficult to treat and has lifelong impacts in health and education. The LiTTLe Program (Learning to Talk, Talking to Learn) aimed to increase infants' access to spoken lang...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1081-3
更新日期:2018-03-06 00:00:00
abstract:BACKGROUND:The use of osteopathic manipulative treatment (OMT) in preterm infants has been documented and results from previous studies suggest the association between OMT and length of stay (LOS) reduction, as well as significant improvements in several clinical outcomes. The aim of the present study is to investigate...
journal_title:BMC pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2431-13-65
更新日期:2013-04-26 00:00:00
abstract:BACKGROUND:Children with longstanding use of antiepileptic drugs (AEDs) are susceptible to developing low bone mineral density and an increased fracture risk. However, the literature regarding the effects of AEDs on growth in epileptic children is limited. The aim of this study was to investigate the potential effects ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-016-0597-7
更新日期:2016-05-03 00:00:00
abstract:BACKGROUND:Movement and physical activity is crucial to brain development and has a positive impact on the ability to learn. With children spending a large portion of their time in the school setting, physical activity and the development of motor skills in this environment may not only impact their overall development...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1262-0
更新日期:2018-09-05 00:00:00
abstract:BACKGROUND:In biliary atresia, the disease process of obliterative cholangiopathy may begin in the perinatal period; however, no chronological evidence exists on how the cholangiopathy progresses to biliary obliteration. This is the first acquired case with the final diagnosis of type III cystic biliary atresia with an...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1125-8
更新日期:2018-05-11 00:00:00
abstract:BACKGROUND:Rhabdomyolysis is a potentially life-threatening syndrome that can develop from a variety of causes. The aim of the work is to analyze the clinical spectrum and to evaluate the prevalence of various etiologies in children, who present to the emergency department (ED) with rhabdomyolysis. METHODS:During a 6-...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-13-134
更新日期:2013-09-03 00:00:00
abstract:BACKGROUND:Donor human milk (DHM) is the best alternative for preterm infants when their own mother's milk is unavailable. DHM should be pasteurized to guarantee microbiological safety; however, this process can influence the macronutrient content. The aim of this study was to investigate the effect of Holder pasteuriz...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1427-5
更新日期:2019-02-12 00:00:00
abstract:BACKGROUND:The fundamental treatment for patients with pediatric malignant mediastinal tumors is chemotherapy. Therefore, accurate diagnosis is essential for selecting the appropriate chemotherapeutic regimen. However, malignant mediastinal tumors occasionally cause respiratory distress, and biopsies under general anes...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02183-w
更新日期:2020-06-10 00:00:00
abstract:BACKGROUND:The "Staying Healthy in Child Care" Australian guidelines provide for illness and disease exclusions and encourage vaccination of staff in child care settings, however these requirements are not subject to accreditation and licensing, and their level of implementation is unknown. This study aimed to describe...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-12-98
更新日期:2012-07-13 00:00:00
abstract:BACKGROUND:Maintaining and building healthy bones during the lifetime requires a complicated interaction between a number of physiological and lifestyle factors. Our goal of this study was to analyze the association between hand grip strength and the maximum peak expiratory flow with bone mineral density and content in...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1015-0
更新日期:2018-03-02 00:00:00
abstract:BACKGROUND:Poor sleep contributes to the developmental problems seen in preterm infants. We evaluated sleep problems in preterm infants 6 months of post-gestational age using the subjective Brief Infant Sleep Questionnaire (BISQ) and objective sleep tests. We also compared the sleep of premature infants with that of fu...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-014-0303-6
更新日期:2014-12-16 00:00:00
abstract:BACKGROUND:Several environmental factors favour the occurrence of acute respiratory disease, which is the main reason for paediatric consultations in our country (Colombia). Tobacco smoke is considered a significant environmental pollutant with a great impact on health. The objective of this study is to estimate the pr...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02193-8
更新日期:2020-06-16 00:00:00
abstract:BACKGROUND:DNA ligase IV deficiency is a rare autosomal recessive disorder caused by hypomorphic mutations in the DNA ligase IV (LIG4) gene. DNA ligase IV is an essential protein for the development of a healthy immune system as well as for the protection of genomic integrity. Apart from typical stigmata, patients with...
journal_title:BMC pediatrics
pub_type: 杂志文章,评审
doi:10.1186/s12887-019-1724-z
更新日期:2019-10-11 00:00:00
abstract:BACKGROUND:Oral antipyretics are commonly used to treat pediatric patients who develop fevers. However, patients presenting to the emergency department or undergoing surgery are frequently unable to tolerate oral antipyretics. Rectal formulations are available; however, this route of administration is unpredictable. Th...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12887-017-0795-y
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Existing literature shows that there is an inverse association between socioeconomic position and screen time among adolescents. What is less known is the mechanism behind these differences. The study aimed to explore individual, interpersonal and neighborhood environmental correlates of total screen time (T...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02181-y
更新日期:2020-06-05 00:00:00
abstract:BACKGROUND:To investigate the prevalence and patterns of breastfeeding at discharge and in the first six months of life in a high-risk fetal, neonatal and child referral center. METHODS:Prospective, longitudinal study that included the following three steps: hospital admission, first visit after hospital discharge and...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02272-w
更新日期:2020-08-07 00:00:00
abstract:BACKGROUND:Delayed diagnosis of critical congenital heart disease (CCHD) carries a serious risk of mortality, morbidity, and handicap. As echocardiography is commonly used to diagnose congenital heart disease (CHD), echocardiographic investigations in newborns may be helpful in detecting CCHD earlier and with higher se...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1344-z
更新日期:2018-11-19 00:00:00
abstract:BACKGROUND:Osteomyelitis can be difficult to diagnose and there has previously not been a prospective approach to identify all children in a defined geographic area. The aim of this study was to assess the annual incidence of osteomyelitis in children, describe the patient and disease characteristics in those with acut...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2431-8-45
更新日期:2008-10-20 00:00:00
abstract:BACKGROUND:Several maternal health determinants during the first period of life of the child, as feeding practice, smoking habit and socio-economic level, are involved in early childhood health problems, as caries development. The potential associations among early childhood caries, feeding practices, maternal and envi...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-14-45
更新日期:2014-02-15 00:00:00
abstract:BACKGROUND:Admission to the neonatal intensive care unit (NICU) may disrupt parent-infant interaction with adverse consequences for infants and their families. Several family-centered care programs promote parent-infant interaction in the NICU; however, all of these retain the premise that health-care professionals sho...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12887-015-0527-0
更新日期:2015-12-15 00:00:00
abstract:BACKGROUND:Intramuscular vitamin A supplementation decreases the risk of bronchopulmonary dysplasia (BPD) in very-low-birth-weight preterm infants without significant adverse effects. However, intramuscular vitamin A supplementation is not widely accepted because of the discomfort and risk of trauma associated with rep...
journal_title:BMC pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12887-017-0958-x
更新日期:2017-12-16 00:00:00
abstract:BACKGROUND:The Pediatric Quality of Life Inventory (PedsQL) is a modular instrument, designed to integrate generic and disease specific measures, and includes both self- and proxy-reports. The aim of the study was to assess the reliability and limited validity of the Swedish version of the disease specific Pediatric Qu...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02387-0
更新日期:2020-10-28 00:00:00
abstract:BACKGROUND:Otitis Media (OM) is the most common disease of childhood. Twenty thousand people die each year from otitis media. It is an important cause of preventable hearing loss, affects children's intellectual performance and language development. There are very small numbers of studies done in Ethiopia concerning th...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/s12887-019-1781-3
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The Global Trigger Tool (GTT),which is a method using "triggers" to review medical record retrospectively to identify possible adverse events. Several studies showed that the GTT was effective. However, there were only a few localized trigger tools that had been established to detect pediatric adverse drug e...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02354-9
更新日期:2020-09-29 00:00:00