Delivery strategies for malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less than 5 years old in Malawi: a protocol for a cluster randomized trial.

Abstract:

BACKGROUND:Children initially hospitalized with severe anaemia in Africa are at high risk of readmission or death within 6 months after discharge. No intervention strategy specifically protects children during the post-discharge period. Recent evidence from Malawi shows that 3 months of post-discharge malaria chemoprevention (PMC) with monthly treatment with artemether-lumefantrine in children with severe malarial anaemia prevented 31% of deaths and readmissions. While a confirmatory multi-centre trial for PMC with dihydroartemisinin-piperaquine is on going in Kenya and Uganda, there is a need to design and evaluate an effective delivery strategy for this promising intervention. METHODS:This is a cluster-randomized trial with 5 arms, each representing a unique PMC delivery strategy. Convalescent children aged less than 5 years and weighing more than 5 kg admitted with severe anaemia and clinically stable are included. All eligible children will receive dihydroartemisinin-piperaquine at 2, 6 and 10 weeks after discharge either: 1) in the community without an SMS reminder; 2) in the community with an SMS reminder; 3) in the community with a community health worker reminder; 4) at the hospital with an SMS reminder; or 5) at the hospital without an SMS reminder. For community-based strategies (1, 2 and 3), mothers will be given all the PMC doses at the time of discharge while for hospital-based strategies (4 and 5) mothers will be required to visit the hospital each month. Each arm will consist of 25 clusters with an average of 3 children per cluster giving approximately 75 children and will be followed up for 15 weeks. The primary outcome measure is uptake of complete courses of PMC drugs. DISCUSSION:The proposed study will help to identify the most effective, cost-effective, acceptable and feasible strategy for delivering malaria chemoprevention for post-discharge management of severe anaemia in under-five children in the Malawian context. This information is important for policy decision in the quest for new strategies for malaria control in children in similar contexts. TRIAL REGISTRATION:ClinicalTrials.gov: NCT02721420 . Protocol registered on 29 March 2016.The study was not retrospectively registered but there was a delay between date of submission and the date it first became available on the registry.

journal_name

BMC Pediatr

journal_title

BMC pediatrics

authors

Gondwe T,Robberstad B,Mukaka M,Lange S,Blomberg B,Phiri K

doi

10.1186/s12887-018-1199-3

subject

Has Abstract

pub_date

2018-07-20 00:00:00

pages

238

issue

1

issn

1471-2431

pii

10.1186/s12887-018-1199-3

journal_volume

18

pub_type

杂志文章,随机对照试验
  • Changes in hepatitis B virus antibody titers over time among children: a single center study from 2012 to 2015 in an urban of South Korea.

    abstract:BACKGROUND:Hepatitis B virus (HBV) infection is the most common cause of liver disease in endemic areas such as South Korea. After HBV vaccination, hepatitis B surface antibody (HBsAb) titers gradually decrease. Trends in HBsAb titers have not been evaluated among children in South Korea over the past decade. METHODS:...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-017-0924-7

    authors: Lee KH,Shim KS,Lim IS,Chae SA,Yun SW,Lee NM,Choi YB,Yi DY

    更新日期:2017-07-14 00:00:00

  • Causes and differentials of childhood mortality in Iraq.

    abstract:BACKGROUND:Limited information is available in Iraq regarding the causes of under-five mortality. The vital registration system is deficient in its coverage, particularly from rural areas where access to health services is limited and most deaths occur at home, i.e. outside the health system, and hence the cause of dea...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-9-40

    authors: Awqati NA,Ali MM,Al-Ward NJ,Majeed FA,Salman K,Al-Alak M,Al-Gasseer N

    更新日期:2009-06-22 00:00:00

  • Sail sign in neonatal pneumomediastinum: a case report.

    abstract:BACKGROUND:Pneumomediastinum is an uncommon cause of neonatal respiratory distress. Clinical history and examination of the neonate may be uninformative in determining the aetiology of the respiratory distress. Chest x-ray can be diagnostic of pneumomediastinum however is often difficult to interpret. CASE PRESENTATIO...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1397-7

    authors: Teo SSS,Priyadarshi A,Browning Carmo K

    更新日期:2019-01-31 00:00:00

  • Prevalence of underweight, overweight and obesity among Palestinian school-age children and the associated risk factors: a cross sectional study.

    abstract:BACKGROUND:Childhood obesity is rising in developed and developing countries, while childhood underweight is rising mainly in developing countries. Childhood underweight has been shown to increase a child's risk of rapid weight gain. Overweight and obese children are more likely to become obese adults, which increases ...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1842-7

    authors: Al-Lahham S,Jaradat N,Altamimi M,Anabtawi O,Irshid A,AlQub M,Dwikat M,Nafaa F,Badran L,Mohareb R,Haji R,Aqqad T,Jayyab S,Ghosh BA,Taher R,Al Zabadi H

    更新日期:2019-12-09 00:00:00

  • Neonatal tactile stimulation at birth in a low-resource setting.

    abstract:BACKGROUND:Stimulation is the most common intervention during neonatal resuscitation at birth, but scarce information is available on the actual methods, timing and efficacy of this basic step. To evaluate the occurrence, patterns and response to tactile stimulation at birth in a low-resource setting. METHODS:We revie...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-018-1279-4

    authors: Pietravalle A,Cavallin F,Opocher A,Madella S,Cavicchiolo ME,Pizzol D,Putoto G,Trevisanuto D

    更新日期:2018-09-20 00:00:00

  • Feeding and smoking habits as cumulative risk factors for early childhood caries in toddlers, after adjustment for several behavioral determinants: a retrospective study.

    abstract:BACKGROUND:Several maternal health determinants during the first period of life of the child, as feeding practice, smoking habit and socio-economic level, are involved in early childhood health problems, as caries development. The potential associations among early childhood caries, feeding practices, maternal and envi...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-14-45

    authors: Majorana A,Cagetti MG,Bardellini E,Amadori F,Conti G,Strohmenger L,Campus G

    更新日期:2014-02-15 00:00:00

  • Prevalence and factors associated with intestinal parasitic infection among under-five children in and around Haro Dumal Town, Bale Zone, Ethiopia.

    abstract:BACKGROUND:Intestinal parasitic infection is diversified illness and diseases caused millions morbidity among under-five children lives in developing countries particularly vulnerable rural communities. Deworming coverage in such community is low. The aim of this study was to determine the prevalence and associated ris...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1731-0

    authors: Gadisa E,Jote K

    更新日期:2019-10-27 00:00:00

  • Unusual presentation of angiomyomatous hamartoma in an eight-month-old infant: case report and literature review.

    abstract:BACKGROUND:Evaluation of palpable neck masses may be a diagnostic problem in pediatric patients, with differential diagnosis including congenital, inflammatory, tumoral and traumatic lesions. Ultrasonography is usually a satisfactory method to make a correct pre-operative evaluation of neck masses, although diagnosis i...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2431-12-172

    authors: Catania VD,Manzoni C,Novello M,Lauriola L,Coli A

    更新日期:2012-11-06 00:00:00

  • Blood pressure percentiles by age and height for non-overweight Chinese children and adolescents: analysis of the China Health and Nutrition Surveys 1991-2009.

    abstract:BACKGROUND:Hypertension is an important health problem in China and raised blood pressure in children may lead to future hypertension. Accordingly we aimed to provide a reference blood pressure table for age, gender and height in Chinese children. METHODS:A reference sample of subjects was drawn from the Chinese Healt...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-13-195

    authors: Yan W,Liu F,Li X,Wu L,Zhang Y,Cheng Y,Zhou W,Huang G

    更新日期:2013-11-25 00:00:00

  • Baby's first bites: a randomized controlled trial to assess the effects of vegetable-exposure and sensitive feeding on vegetable acceptance, eating behavior and weight gain in infants and toddlers.

    abstract:BACKGROUND:The start of complementary feeding in infancy plays an essential role in promoting healthy eating habits. Evidence shows that it is important what infants are offered during this first introduction of solid foods: e.g. starting exclusively with vegetables is more successful for vegetable acceptance than star...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12887-019-1627-z

    authors: van der Veek SMC,de Graaf C,de Vries JHM,Jager G,Vereijken CMJL,Weenen H,van Winden N,van Vliet MS,Schultink JM,de Wild VWT,Janssen S,Mesman J

    更新日期:2019-08-01 00:00:00

  • Effects of a physical education intervention on cognitive function in young children: randomized controlled pilot study.

    abstract:BACKGROUND:Randomized controlled trials (RCT) are required to test relationships between physical activity and cognition in children, but these must be informed by exploratory studies. This study aimed to inform future RCT by: conducting practical utility and reliability studies to identify appropriate cognitive outcom...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2431-11-97

    authors: Fisher A,Boyle JM,Paton JY,Tomporowski P,Watson C,McColl JH,Reilly JJ

    更新日期:2011-10-28 00:00:00

  • Increase in foreign body and harmful substance ingestion and associated complications in children: a retrospective study of 1199 cases from 2005 to 2017.

    abstract:BACKGROUND:Children with a history of caustic or foreign body ingestion (FBI) seem to be presenting more frequently to emergency departments. This study aims to elucidate the clinical presentation, diagnostic procedures, and complications associated with the ingestion of different object categories over a 13-year time ...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-020-02444-8

    authors: Speidel AJ,Wölfle L,Mayer B,Posovszky C

    更新日期:2020-12-18 00:00:00

  • Exclusive breastfeeding practice during first six months of an infant's life in Bangladesh: a country based cross-sectional study.

    abstract:BACKGROUND:Breastfeeding offers incredible health benefits to both child and mother. It is suggested by World Health Organization that an able mother should practice and maintain exclusive breastfeeding for first six months of her infant's life. The objective of this study was to determine the prevalence and factors as...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-018-1076-0

    authors: Hossain M,Islam A,Kamarul T,Hossain G

    更新日期:2018-03-02 00:00:00

  • White, affluent, educated parents are least likely to choose HPV vaccination for their children: a cross-sectional study of the National Immunization Study - teen.

    abstract:BACKGROUND:Human Papillomavirus (HPV) vaccination coverage is below national goals in the United States. Research is needed to inform strategically designed interventions that target sociodemographic groups with underutilization of HPV vaccination. METHODS:Secondary data analysis of the National Immunization Survey-Te...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-017-0953-2

    authors: Warner EL,Ding Q,Pappas LM,Henry K,Kepka D

    更新日期:2017-12-01 00:00:00

  • Introduction of less invasive surfactant administration (LISA), impact on diagnostic and therapeutic procedures in early life: a historical cohort study.

    abstract:BACKGROUND:In preterm infants with Respiratory Distress Syndrome (RDS), Less Invasive Surfactant Administration (LISA) has been established to reduce the need of mechanical ventilation and might improve survival rates without bronchopulmonary dysplasia. The aim of this study was to investigate whether NICU care has cha...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-020-02325-0

    authors: Bugter IAL,Janssen LCE,Dieleman J,Kramer BW,Andriessen P,Niemarkt HJ

    更新日期:2020-09-03 00:00:00

  • An innovative method for manufacturing the Tuebingen palatal plate for infants with Robin sequence.

    abstract:BACKGROUND:Robin sequence (RS) is characterized by mandibular micro- and retrognathia, glossoptosis, upper airway obstruction and optionally a cleft palate. With an incidence of 1:8000, it belongs to the so-called rare diseases; 30-50% of patients have RS as part of a syndrome. A comparatively well-studied treatment op...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-020-2009-2

    authors: Müller-Hagedorn S,Arand J,Scholz T,Poets CF,Wiechers C

    更新日期:2020-03-04 00:00:00

  • Exploring the usefulness of comprehensive care plans for children with medical complexity (CMC): a qualitative study.

    abstract:BACKGROUND:The Medical Home model recommends that Children with Special Health Care Needs (CSHCN) receive a medical care plan, outlining the child's major medical issues and care needs to assist with care coordination. While care plans are a primary component of effective care coordination, the creation and maintenance...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-13-10

    authors: Adams S,Cohen E,Mahant S,Friedman JN,Macculloch R,Nicholas DB

    更新日期:2013-01-19 00:00:00

  • A qualitative study of the infant feeding beliefs and behaviours of mothers with low educational attainment.

    abstract:BACKGROUND:Infancy is an important period for the promotion of healthy eating, diet and weight. However little is known about how best to engage caregivers of infants in healthy eating programs. This is particularly true for caregivers, infants and children from socioeconomically disadvantaged backgrounds who experienc...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-016-0601-2

    authors: Russell CG,Taki S,Azadi L,Campbell KJ,Laws R,Elliott R,Denney-Wilson E

    更新日期:2016-05-21 00:00:00

  • Online cognitive-behavioral based group interventions for adolescents with chronic illness and parents: study protocol of two multicenter randomized controlled trials.

    abstract:BACKGROUND:Adolescents with chronic illness (CI) and parents of a child with CI are at risk for psychosocial problems. Psychosocial group interventions may prevent these problems. With the use of cognitive-behavioral therapy, active coping strategies can be learned. Offering an intervention online eliminates logistic b...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12887-018-1216-6

    authors: Douma M,Scholten L,Maurice-Stam H,Grootenhuis MA

    更新日期:2018-07-18 00:00:00

  • Do pediatricians manage influenza differently than internists?

    abstract:BACKGROUND:Little is known about how pediatricians or internists manage influenza symptoms. Recent guidelines on antiviral prescribing by the Centers for Disease Control and Prevention (CDC) make almost no distinction between adults and children. Our objective was to describe how pediatricians in two large academic med...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-8-15

    authors: Rothberg MB,Bonner AB,Rajab MH,Stechenberg BW,Rose DN

    更新日期:2008-04-24 00:00:00

  • Systematic review of outcome measures in trials of pediatric anaphylaxis treatment.

    abstract:BACKGROUND:Considerable heterogeneity has been observed in the selection and reporting of disease-specific pediatric outcome measures in randomized controlled trials (RCTs). This makes interpretation of results and comparison across trials challenging. Outcome measures in pediatric anaphylaxis trials have never previou...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2431-14-158

    authors: Rubin T,Clayton J,Adams D,Jou H,Vohra S

    更新日期:2014-06-20 00:00:00

  • Eleven percent intact PGM3 in a severely immunodeficient patient with a novel splice-site mutation, a case report.

    abstract:BACKGROUND:A novel immunodeficiency, frequently accompanied by high serum-IgE, and caused by mutations in the PGM3 gene was described in 2014. To date there are no unique phenotype characteristics for PGM3 deficiency. PGM3 encodes a carbohydrate-modifying enzyme, phosphoglucomutase 3. Null-mutations are quite likely le...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-018-1258-9

    authors: Lundin KE,Wang Q,Hamasy A,Marits P,Uzunel M,Wirta V,Wikström AC,Fasth A,Ekwall O,Smith CIE

    更新日期:2018-08-29 00:00:00

  • Household and family factors related to weight status in first through third graders: a cross-sectional study in Eastern Massachusetts.

    abstract:BACKGROUND:Early environmental influences have been linked to child weight status, however further understanding of associations in diverse populations is needed. METHODS:A cross-sectional analysis of household and family factors associated with overweight was conducted on a culturally diverse, urban dwelling sample o...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-14-167

    authors: Hauser SI,Economos CD,Nelson ME,Goldberg JP,Hyatt RR,Naumova EN,Anderson SE,Must A

    更新日期:2014-07-01 00:00:00

  • Childhood injuries and food stamp benefits: an examination of administrative data in one US state.

    abstract:BACKGROUND:Currently in the United States, childhood injuries are the leading cause of mortality and morbidity, resulting in an estimated 9.2 million emergency department visits and $17 billion annually in medical costs. For preschoolers, it is also the leading cause of disability. METHODS:We use linked administrative...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-020-02084-y

    authors: Heflin CM,Arteaga I,Ndashimye JF,Rabbitt MP

    更新日期:2020-06-17 00:00:00

  • The influence of socioeconomic factors on choice of infant male circumcision provider in rural Ghana; a community level population based study.

    abstract:BACKGROUND:The influence of socio-economic determinants on choice of infant male circumcision provider is not known in areas with high population coverage such as rural Africa. The overall aim of this study was to determine the key socio-economic factors which influence the choice of infant male circumcision provider i...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-017-0937-2

    authors: Gyan T,McAuley K,Strobel N,Newton S,Owusu-Agyei S,Edmond K

    更新日期:2017-08-29 00:00:00

  • End-user perspectives to inform policy and program decisions: a qualitative and quantitative content analysis of lifestyle treatment recommendations by adolescents with obesity.

    abstract:BACKGROUND:Lifestyle modifications represent the first line of treatment in obesity management; however, many adolescents with obesity do not meet lifestyle recommendations. Given that adolescents are rarely consulted during health policy development and in the design of lifestyle interventions, their first-hand experi...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1749-3

    authors: Kebbe M,Perez A,Buchholz A,McHugh TF,Scott SD,Richard C,Dyson MP,Ball GDC

    更新日期:2019-11-08 00:00:00

  • Randomised controlled trial of improvisational music therapy's effectiveness for children with autism spectrum disorders (TIME-A): study protocol.

    abstract:BACKGROUND:Previous research has suggested that music therapy may facilitate skills in areas typically affected by autism spectrum disorders such as social interaction and communication. However, generalisability of previous findings has been restricted, as studies were limited in either methodological accuracy or the ...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-2431-12-2

    authors: Geretsegger M,Holck U,Gold C

    更新日期:2012-01-05 00:00:00

  • Foot length, chest and head circumference measurements in detection of Low birth weight neonates in Mekelle, Ethiopia: a hospital based cross sectional study.

    abstract:BACKGROUND:Low birth weight (Birth weight < 2500 g) is a leading cause of prenatal and neonatal deaths. The early identification of Low birth weight (LBW) neonates is essential for any comprehensive initiative to improve their chance of survival. However, a large proportion of births in developing countries take place ...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-017-0866-0

    authors: Hadush MY,Berhe AH,Medhanyie AA

    更新日期:2017-04-21 00:00:00

  • Undernourished children presenting to an urban emergency department of a tertiary hospital in Tanzania: a prospective descriptive study.

    abstract:BACKGROUND:Childhood undernutrition causes significant morbidity and mortality in low- and middle-income countries (LMICs). In Tanzania, the in-hospital prevalence of undernutrition in children under five years of age is approximated to be 30% with a case fatality rate of 8.8%. In Tanzania, the burden of undernourished...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1706-1

    authors: Bashaka PJ,Sawe HR,Mwafongo V,Mfinanga JA,Runyon MS,Murray BL

    更新日期:2019-09-11 00:00:00

  • Early Check: translational science at the intersection of public health and newborn screening.

    abstract:BACKGROUND:Newborn screening (NBS) occupies a unique space at the intersection of translational science and public health. As the only truly population-based public health program in the United States, NBS offers the promise of making the successes of translational medicine available to every infant with a rare disorde...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1606-4

    authors: Bailey DB Jr,Gehtland LM,Lewis MA,Peay H,Raspa M,Shone SM,Taylor JL,Wheeler AC,Cotten M,King NMP,Powell CM,Biesecker B,Bishop CE,Boyea BL,Duparc M,Harper BA,Kemper AR,Lee SN,Moultrie R,Okoniewski KC,Paquin RS,Pe

    更新日期:2019-07-17 00:00:00