Changes in hepatitis B virus antibody titers over time among children: a single center study from 2012 to 2015 in an urban of South Korea.

Abstract:

BACKGROUND:Hepatitis B virus (HBV) infection is the most common cause of liver disease in endemic areas such as South Korea. After HBV vaccination, hepatitis B surface antibody (HBsAb) titers gradually decrease. Trends in HBsAb titers have not been evaluated among children in South Korea over the past decade. METHODS:We screened 6155 patients (aged 7 months to 17 years) who underwent HBV antigen/antibody testing at Chung-Ang University Hospital from May 2012 to April 2015. Titer criteria were defined as follows: positive, titer ≥100 IU/L; weakly positive, titer 10-99 IU/L; and negative, titer <10 IU/L. We also compared titers before and 1 month after a single booster vaccination. RESULTS:Of the 5655 patients included, 3016 were male and 5 (0.09%) tested positive for HBV surface antigen. A marked reduction in antibody titer was observed until 4 years of age. Thereafter, the titers showed fluctuating decreases. HBsAb titers reached their lowest levels by 14 years of age. After 7 years of age, 50% of patients tested negative for HBsAb. Simple linear analysis showed that the titer reached levels of <10 IU/L and zero at 12.9 and 13.4 years of age, respectively. 1 month after a single booster vaccination was administered to those who were HBsAb-negative (n = 72), 69 children (96%) had developed antibodies while 3 (4%) remained HBsAb-negative. CONCLUSIONS:In conclusion, the continuous reduction in HBsAb titers over time and in each age group was confirmed. The titer level was shown significant decline until age 4. More than half of the sample had negative titers after age 7 years. After booster vaccination, most of child significantly increase titer level.

journal_name

BMC Pediatr

journal_title

BMC pediatrics

authors

Lee KH,Shim KS,Lim IS,Chae SA,Yun SW,Lee NM,Choi YB,Yi DY

doi

10.1186/s12887-017-0924-7

subject

Has Abstract

pub_date

2017-07-14 00:00:00

pages

164

issue

1

issn

1471-2431

pii

10.1186/s12887-017-0924-7

journal_volume

17

pub_type

杂志文章
  • Barriers to voluntary participation in sport for children: a systematic review.

    abstract:BACKGROUND:Numerous studies have detailed the physical health benefits of children's participation in sport and a growing body of research also highlights the benefits for mental health. Children who participate in sport have also been shown to be advantaged academically. However, despite the benefits there is evidence...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,评审

    doi:10.1186/s12887-018-1014-1

    authors: Somerset S,Hoare DJ

    更新日期:2018-02-09 00:00:00

  • A qualitative study of the infant feeding beliefs and behaviours of mothers with low educational attainment.

    abstract:BACKGROUND:Infancy is an important period for the promotion of healthy eating, diet and weight. However little is known about how best to engage caregivers of infants in healthy eating programs. This is particularly true for caregivers, infants and children from socioeconomically disadvantaged backgrounds who experienc...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-016-0601-2

    authors: Russell CG,Taki S,Azadi L,Campbell KJ,Laws R,Elliott R,Denney-Wilson E

    更新日期:2016-05-21 00:00:00

  • Uncorrected amteropia among children hospitalized for headache evaluation: a clinical descriptive study.

    abstract:BACKGROUND:Headache is a common complaint in children occasionally requiring hospital admission. The purposes of the present study were to analyze the prevalence of uncorrected ametropia in children with headache admitted to the hospital, and evaluate the importance of refraction assessment as part of their evaluation....

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-14-241

    authors: Dotan G,Stolovitch C,Moisseiev E,Cohen S,Kesler A

    更新日期:2014-09-29 00:00:00

  • Cord blood calcium, phosphate, magnesium, and alkaline phosphatase gestational age-specific reference intervals for preterm infants.

    abstract:BACKGROUND:The objective was to determine the influence of gestational age, maternal, and neonatal variables on reference intervals for cord blood bone minerals (calcium, phosphate, magnesium) and related laboratory tests (alkaline phosphatase, and albumin-adjusted calcium), and to develop gestational age specific refe...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-11-76

    authors: Fenton TR,Lyon AW,Rose MS

    更新日期:2011-08-31 00:00:00

  • A multicenter, randomized, open-label, active-comparator trial to determine the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for treatment of fever in hospitalized pediatric patients.

    abstract:BACKGROUND:Oral antipyretics are commonly used to treat pediatric patients who develop fevers. However, patients presenting to the emergency department or undergoing surgery are frequently unable to tolerate oral antipyretics. Rectal formulations are available; however, this route of administration is unpredictable. Th...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12887-017-0795-y

    authors: Khalil SN,Hahn BJ,Chumpitazi CE,Rock AD,Kaelin BA,Macias CG

    更新日期:2017-02-01 00:00:00

  • Eleven percent intact PGM3 in a severely immunodeficient patient with a novel splice-site mutation, a case report.

    abstract:BACKGROUND:A novel immunodeficiency, frequently accompanied by high serum-IgE, and caused by mutations in the PGM3 gene was described in 2014. To date there are no unique phenotype characteristics for PGM3 deficiency. PGM3 encodes a carbohydrate-modifying enzyme, phosphoglucomutase 3. Null-mutations are quite likely le...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-018-1258-9

    authors: Lundin KE,Wang Q,Hamasy A,Marits P,Uzunel M,Wirta V,Wikström AC,Fasth A,Ekwall O,Smith CIE

    更新日期:2018-08-29 00:00:00

  • Improving health, wellbeing and parenting skills in parents of children with special health care needs and medical complexity - a scoping review.

    abstract:BACKGROUND:Parenting children with special health care needs can be challenging particularly if children have complex conditions. Parents may struggle to manage their child's health and their own emotions, contributing to poorer health outcomes for the family. Frequent healthcare contact presents opportunities to inter...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1648-7

    authors: Bradshaw S,Bem D,Shaw K,Taylor B,Chiswell C,Salama M,Bassett E,Kaur G,Cummins C

    更新日期:2019-08-30 00:00:00

  • COVID-19 related reduction in pediatric emergency healthcare utilization - a concerning trend.

    abstract:BACKGROUND:The COVID-19 pandemic has disrupted healthcare systems worldwide. In addition to the direct impact of the virus on patient morbidity and mortality, the effect of lockdown strategies on health and healthcare utilization have become apparent. Little is known on the effect of the pandemic on pediatric and adole...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-020-02303-6

    authors: Dopfer C,Wetzke M,Zychlinsky Scharff A,Mueller F,Dressler F,Baumann U,Sasse M,Hansen G,Jablonka A,Happle C

    更新日期:2020-09-07 00:00:00

  • The N3RO trial: a randomised controlled trial of docosahexaenoic acid to reduce bronchopulmonary dysplasia in preterm infants

    abstract:BACKGROUND:Bronchopulmonary dysplasia (BPD) is a major cause of mortality and long-term respiratory and neurological morbidity in very preterm infants. While survival rates of very preterm infants have increased over the past two decades there has been no decrease in the rate of BPD in surviving infants. Evidence from ...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12887-016-0611-0

    authors: Collins CT,Gibson RA,Makrides M,McPhee AJ,Sullivan TR,Davis PG,Thio M,Simmer K,Rajadurai VS,N3RO Investigative Team.

    更新日期:2016-06-01 00:00:00

  • Immunization coverage of 12-23 months old children and its associated factors in Minjar-Shenkora district, Ethiopia: a community-based study.

    abstract:BACKGROUND:Childhood vaccinations have been shown to be effective in protecting children against vaccine-preventable diseases. The systematic investigation of the causes of incomplete immunization is critical for the full immunization and develop health system interventions to improve immunization coverage. To date, no...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1575-7

    authors: Mekonnen AG,Bayleyegn AD,Ayele ET

    更新日期:2019-06-14 00:00:00

  • Paracetamol use (and/or misuse) in children in Enugu, South-East, Nigeria.

    abstract:BACKGROUND:Paracetamol (also known as acetaminophen) is the commonest available analgesic and anti-pyretic. It is readily accessed from pharmacy, patent medicine and provision shops as over the counter drug making it a potential drug of abuse, especially in children. We sought to find its use and/or misuse in children ...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-12-103

    authors: Obu HA,Chinawa JM,Ubesie AC,Eke CB,Ndu IK

    更新日期:2012-07-19 00:00:00

  • Baby's first bites: a randomized controlled trial to assess the effects of vegetable-exposure and sensitive feeding on vegetable acceptance, eating behavior and weight gain in infants and toddlers.

    abstract:BACKGROUND:The start of complementary feeding in infancy plays an essential role in promoting healthy eating habits. Evidence shows that it is important what infants are offered during this first introduction of solid foods: e.g. starting exclusively with vegetables is more successful for vegetable acceptance than star...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12887-019-1627-z

    authors: van der Veek SMC,de Graaf C,de Vries JHM,Jager G,Vereijken CMJL,Weenen H,van Winden N,van Vliet MS,Schultink JM,de Wild VWT,Janssen S,Mesman J

    更新日期:2019-08-01 00:00:00

  • Burkitts's lymphoma--an atypical presentation.

    abstract:BACKGROUND:In female adolescents and young adults, malignancies of the genital tract are the most frequent type of cancer, closely followed by Hodgkin's and non-Hodgkin's lymphomas. CASE PRESENTATION:We report an unusual case of sporadic Burkitt's lymphoma (BL) presenting with massive bilateral ovarian infiltration, p...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-12-113

    authors: Ziade F,von der Weid N,Beck-Popovic M,Nydegger A

    更新日期:2012-08-06 00:00:00

  • Foot length, chest and head circumference measurements in detection of Low birth weight neonates in Mekelle, Ethiopia: a hospital based cross sectional study.

    abstract:BACKGROUND:Low birth weight (Birth weight < 2500 g) is a leading cause of prenatal and neonatal deaths. The early identification of Low birth weight (LBW) neonates is essential for any comprehensive initiative to improve their chance of survival. However, a large proportion of births in developing countries take place ...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-017-0866-0

    authors: Hadush MY,Berhe AH,Medhanyie AA

    更新日期:2017-04-21 00:00:00

  • Parent-reported sleep problems, symptom ratings, and serum ferritin levels in children with attention-deficit/hyperactivity disorder: a case control study.

    abstract:BACKGROUND:Sleep problems are common among children with attention-deficit/hyperactivity disorder (ADHD). Serum ferritin levels have been associated with the severity of symptoms and sleep disturbances among children with ADHD. This study was conducted to investigate parent-reported sleep problems in a sample of Egypti...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-13-217

    authors: Abou-Khadra MK,Amin OR,Shaker OG,Rabah TM

    更新日期:2013-12-30 00:00:00

  • Randomized, controlled trial comparing laryngeal mask versus endotracheal intubation during neonatal resuscitation---a secondary publication.

    abstract:BACKGROUND:This study aimed to study the feasibility, efficacy and safety of using laryngeal mask (LM) ventilation compared with endotracheal intubation (ETI) during neonatal resuscitation. METHODS:Neonates with a heart rate below 60 beats per minute despite 30 s of face mask ventilation were assigned quasi-randomly (...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12887-016-0553-6

    authors: Yang C,Zhu X,Lin W,Zhang Q,Su J,Lin B,Ye H,Yu R

    更新日期:2016-01-25 00:00:00

  • End-user perspectives to inform policy and program decisions: a qualitative and quantitative content analysis of lifestyle treatment recommendations by adolescents with obesity.

    abstract:BACKGROUND:Lifestyle modifications represent the first line of treatment in obesity management; however, many adolescents with obesity do not meet lifestyle recommendations. Given that adolescents are rarely consulted during health policy development and in the design of lifestyle interventions, their first-hand experi...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1749-3

    authors: Kebbe M,Perez A,Buchholz A,McHugh TF,Scott SD,Richard C,Dyson MP,Ball GDC

    更新日期:2019-11-08 00:00:00

  • Online cognitive-behavioral based group interventions for adolescents with chronic illness and parents: study protocol of two multicenter randomized controlled trials.

    abstract:BACKGROUND:Adolescents with chronic illness (CI) and parents of a child with CI are at risk for psychosocial problems. Psychosocial group interventions may prevent these problems. With the use of cognitive-behavioral therapy, active coping strategies can be learned. Offering an intervention online eliminates logistic b...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12887-018-1216-6

    authors: Douma M,Scholten L,Maurice-Stam H,Grootenhuis MA

    更新日期:2018-07-18 00:00:00

  • Do pediatricians manage influenza differently than internists?

    abstract:BACKGROUND:Little is known about how pediatricians or internists manage influenza symptoms. Recent guidelines on antiviral prescribing by the Centers for Disease Control and Prevention (CDC) make almost no distinction between adults and children. Our objective was to describe how pediatricians in two large academic med...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-8-15

    authors: Rothberg MB,Bonner AB,Rajab MH,Stechenberg BW,Rose DN

    更新日期:2008-04-24 00:00:00

  • Classic Ehlers-Dalnos syndrome presenting as atypical chronic haematoma: a case report with novel frameshift mutation in COL5A1.

    abstract:BACKGROUND:Ehlers-Danlos syndrome (EDS) is a group of inherited connective tissue disorders characterized by skin hyperextensibility, joint hypermobility and soft tissue vulnerable to blunt injury. Early recognition and diagnosis are crucial to patients to provide appropriate treatment, as well as to screen for life-th...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-020-02386-1

    authors: Chiu WC,Chen SH,Lo MC,Kuo YT

    更新日期:2020-10-27 00:00:00

  • Brain research to ameliorate impaired neurodevelopment--home-based intervention trial (BRAIN-HIT).

    abstract:BACKGROUND:This randomized controlled trial aims to evaluate the effects of an early developmental intervention program on the development of young children in low- and low-middle-income countries who are at risk for neurodevelopmental disability because of birth asphyxia. A group of children without perinatal complica...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-2431-10-27

    authors: Wallander JL,McClure E,Biasini F,Goudar SS,Pasha O,Chomba E,Shearer D,Wright L,Thorsten V,Chakraborty H,Dhaded SM,Mahantshetti NS,Bellad RM,Abbasi Z,Carlo W,BRAIN-HIT Investigators.

    更新日期:2010-04-30 00:00:00

  • Arthrogryposis in infancy, multidisciplinary approach: case report.

    abstract:BACKGROUND:Arthrogryposis multiplex congenita is an etiopathogenetically heterogeneous disorder characterised by non-progressive multiple intra-articular contractures, which can be recognised at birth. The frequency is estimated at 1 in 3,000 newborns. Etiopathogenesis of arthrogryposis is multifactorial. CASE PRESENT...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-13-184

    authors: Binkiewicz-Glinska A,Sobierajska-Rek A,Bakula S,Wierzba J,Drewek K,Kowalski IM,Zaborowska-Sapeta K

    更新日期:2013-11-11 00:00:00

  • Population-based study of the incidence of congenital hip dysplasia in preterm infants from the Survey of Neonates in Pomerania (SNiP).

    abstract:BACKGROUND:Some etiological factors involved in developmental dysplasia of the hip (DDH) occur in the last trimester of pregnancy, which could result in a decreased incidence of DDH in preterm infants. The aim of this study was to compare the incidence of DDH between preterm and term infants. METHODS:Ultrasound of the...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-017-0829-5

    authors: Lange AE,Lange J,Ittermann T,Napp M,Krueger PC,Bahlmann H,Kasch R,Heckmann M

    更新日期:2017-03-16 00:00:00

  • Evaluation of the efficacy and safety of olanzapine as an adjunctive treatment for anorexia nervosa in adolescent females: a randomized, double-blind, placebo-controlled trial.

    abstract:BACKGROUND:Anorexia Nervosa (AN) is a serious, debilitating condition that causes significant physical, emotional, and functional impairment. The condition is characterized by destructive weight loss behaviours and a refusal to maintain body weight at or above a minimally normal weight for age and height. AN often deve...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2431-8-4

    authors: Spettigue W,Buchholz A,Henderson K,Feder S,Moher D,Kourad K,Gaboury I,Norris M,Ledoux S

    更新日期:2008-01-31 00:00:00

  • Pilot study of a model-based approach to blood glucose control in very-low-birthweight neonates.

    abstract:BACKGROUND:Hyperglycemia often occurs in premature, very low birthweight infants (VLBW) due to immaturity of endogenous regulatory systems and the stress of their condition. Hyperglycemia in neonates has been linked to increased morbidities and mortality and occurs at increasing rates with decreasing birthweight. In th...

    journal_title:BMC pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-2431-12-117

    authors: Le Compte AJ,Lynn AM,Lin J,Pretty CG,Shaw GM,Chase JG

    更新日期:2012-08-07 00:00:00

  • Pain, motor function and health-related quality of life in children with cerebral palsy as reported by their physiotherapists.

    abstract:BACKGROUND:Children and adolescents with cerebral palsy suffer from higher levels of pain than their peers without disability. The aim of this study was to explore the impact of pain on health-related quality of life and motor function in individuals with cerebral palsy as reported by health professionals. METHODS:Cro...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-14-192

    authors: Badia M,Riquelme I,Orgaz B,Acevedo R,Longo E,Montoya P

    更新日期:2014-07-27 00:00:00

  • An outbreak of Coxsackievirus A6-associated hand, foot, and mouth disease in a kindergarten in Beijing in 2015.

    abstract:BACKGROUND:Coxsackievirus A6 (CVA6) is one of the major agents to cause hand, foot and mouth disease (HFMD) outbreaks globally. The objective of this study is to investigate the epidemiologic and clinical manifestations of CVA6 outbreak, and thus guide the diagnosis and treatment of the disease, as well as disease prev...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-018-1253-1

    authors: Li J,Zhu R,Huo D,Du Y,Yan Y,Liang Z,Luo Y,Yang Y,Jia L,Chen L,Wang Q,He Y

    更新日期:2018-08-21 00:00:00

  • Prevalence of abuse among young children with femur fractures: a systematic review.

    abstract:BACKGROUND:Clinical factors that affect the likelihood of abuse in children with femur fractures have not been well elucidated. Consequently, specifying which children with femur fractures warrant an abuse evaluation is difficult. Therefore the purpose of this study is to estimate the proportion of femur fractures in y...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2431-14-169

    authors: Wood JN,Fakeye O,Mondestin V,Rubin DM,Localio R,Feudtner C

    更新日期:2014-07-02 00:00:00

  • No effect of adding dairy lipids or long chain polyunsaturated fatty acids on formula tolerance and growth in full term infants: a randomized controlled trial.

    abstract:BACKGROUND:When breastfeeding is not possible, infants are fed formulas in which lipids are usually of plant origin. However, the use of dairy fat in combination with plant oils enables a lipid profile in formula closer to breast milk in terms of fatty acid composition, triglyceride structure and cholesterol content. T...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12887-018-0985-2

    authors: Gianni ML,Roggero P,Baudry C,Fressange-Mazda C,le Ruyet P,Mosca F

    更新日期:2018-01-22 00:00:00

  • Children grow and horses race: is the adiposity rebound a critical period for later obesity?

    abstract:BACKGROUND:The adiposity rebound is the second rise in body mass index that occurs between 3 and 7 years. An early age at adiposity rebound is known to be a risk factor for later obesity. The aim here is to clarify the connection between the age at rebound and the corresponding pattern of body mass index change, in cen...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-4-6

    authors: Cole TJ

    更新日期:2004-03-12 00:00:00