Dynamics of the TOM complex of mitochondria during binding and translocation of preproteins.

abstract：:Extinction of phosphoenolpyruvate carboxykinase (PCK) gene expression in hepatoma x fibroblast hybrids is mediated by a trans-acting genetic locus designated tissue-specific extinguisher 1 (TSE1). To identify PCK gene sequences required for extinction, hepatoma transfectants expressing PCK-thymidine kinase (TK) chimer...

journal_title：Molecular and cellular biology

authors： Thayer MJ,Lugo TG,Leach RJ,Fournier RE

更新日期：1990-06-01 00:00:00

abstract：:We show that the nuclear genes for the cytoplasmic and mitochondrial leucyl-tRNA synthetase (LeuRS) of Neurospora crassa are distinct in their encoded proteins, codon usage, mRNA levels, and regulation. The 4.2-kilobase-pair region representing the structural gene for cytoplasmic LeuRS and flanking regions has been se...

journal_title：Molecular and cellular biology

authors： Chow CM,Rajbhandary UL

更新日期：1989-11-01 00:00:00

abstract：:The genes that encode the variable regions of immunoglobulin (Ig) heavy chains are encoded by three DNA segments: VH, D, and JH. During B-cell development these segments are brought together by a pair of site-specific DNA rearrangements. The first of these joins a D segment to a JH segment; the second brings a VH segm...

journal_title：Molecular and cellular biology

authors： Alessandrini A,Desiderio SV

更新日期：1991-04-01 00:00:00

abstract：:Preadipocyte factor 1 (Pref-1/Dlk1) inhibits in vitro adipocyte differentiation and has been recently reported to be a paternally expressed imprinted gene at human chromosome 14q32. Studies on human chromosome 14 deletions and maternal uniparental disomy (mUPD) 14 suggest that misexpression of a yet-to-be-identified i...

journal_title：Molecular and cellular biology

authors： Moon YS,Smas CM,Lee K,Villena JA,Kim KH,Yun EJ,Sul HS

更新日期：2002-08-01 00:00:00

abstract：:Filopodia are dynamic structures found at the leading edges of most migrating cells. IRSp53 plays a role in filopodium dynamics by coupling actin elongation with membrane protrusion. IRSp53 is a Cdc42 effector protein that contains an N-terminal inverse-BAR (Bin-amphipysin-Rvs) domain (IRSp53/MIM homology domain [IMD]...

journal_title：Molecular and cellular biology

authors： Robens JM,Yeow-Fong L,Ng E,Hall C,Manser E

更新日期：2010-02-01 00:00:00

abstract：:The production of tumor necrosis factor alpha (TNF-alpha), a key proinflammatory cytokine essential for the function of the immune system, is regulated at both the transcriptional and posttranscriptional levels. In this report, we focus on the interaction of TNF-alpha mRNA with macrophage proteins, likely mediators of...

journal_title：Molecular and cellular biology

authors： Hel Z,Skamene E,Radzioch D

更新日期：1996-10-01 00:00:00

abstract：:Ribonucleotide reductase (RNR), which catalyzes the rate-limiting step for deoxyribonucleotide production required for DNA synthesis, is an alpha2beta2 tetramer consisting of two large and two small subunits. RNR2 encodes a small subunit and is essential for mitotic viability in Saccharomyces cerevisiae. We have clone...

journal_title：Molecular and cellular biology

authors： Huang M,Elledge SJ

更新日期：1997-10-01 00:00:00

abstract：:Mdm2 and MdmX are structurally related p53-binding proteins that function as critical negative regulators of p53 activity in embryonic and adult tissue. The overexpression of Mdm2 or MdmX inhibits p53 tumor suppressor functions in vitro, and the amplification of Mdm2 or MdmX is observed in human cancers retaining wild...

journal_title：Molecular and cellular biology

authors： Matijasevic Z,Steinman HA,Hoover K,Jones SN

更新日期：2008-02-01 00:00:00

abstract：:Activation of oncogenes or inhibition of WEE1 kinase deregulates cyclin-dependent kinase (CDK) activity and leads to replication stress; however, the underlying mechanism is not understood. We now show that elevation of CDK activity by inhibition of WEE1 kinase rapidly increases initiation of replication. This leads t...

journal_title：Molecular and cellular biology

authors： Beck H,Nähse-Kumpf V,Larsen MS,O'Hanlon KA,Patzke S,Holmberg C,Mejlvang J,Groth A,Nielsen O,Syljuåsen RG,Sørensen CS

更新日期：2012-10-01 00:00:00

abstract：:Insulin gene transcription relies on enhancer and promoter elements which are active in pancreatic beta cells. We showed that adenovirus type 5 infection of HIT T-15 cells, a transformed hamster beta cell line, represses insulin gene transcription and mRNA levels. Using expression plasmids transiently introduced into ...

journal_title：Molecular and cellular biology

authors： Stein RW,Ziff EB

更新日期：1987-03-01 00:00:00

abstract：:We demonstrate that ATF3, a member of the ATF/CREB family of transcription factors, is induced in a variety of stressed tissues: mechanically injured liver, toxin-injured liver, blood-deprived heart, and postseizure brain. We also demonstrate that an ATF3-interacting protein, gadd153/Chop10, forms a nonfunctional hete...

journal_title：Molecular and cellular biology

authors： Chen BP,Wolfgang CD,Hai T

更新日期：1996-03-01 00:00:00

abstract：:We have previously proposed that IQGAP1, an effector of Rac1 and Cdc42, negatively regulates cadherin-mediated cell-cell adhesion by interacting with beta-catenin and by causing the dissociation of alpha-catenin from cadherin-beta-catenin-alpha-catenin complexes and that activated Rac1 and Cdc42 positively regulate ca...

journal_title：Molecular and cellular biology

authors： Fukata M,Nakagawa M,Itoh N,Kawajiri A,Yamaga M,Kuroda S,Kaibuchi K

更新日期：2001-03-01 00:00:00

abstract：:Yeast cells containing the recessive mas3 mutation display temperature-sensitive defects in both mitochondrial protein import and the cell division cycle. The import defect is characterized by two pools of mitochondrial precursors and a dramatically slower rate of posttranslational import. The effect of mas3 on cell c...

journal_title：Molecular and cellular biology

authors： Smith BJ,Yaffe MP

更新日期：1991-05-01 00:00:00

abstract：:Several factors that mediate activation by nuclear receptors also modify the chemical and structural composition of chromatin. Prominent in this diverse group is the steroid receptor coactivator 1 (SRC-1) family, which interact with agonist-bound nuclear receptors, thereby coupling them to multifunctional transcriptio...

journal_title：Molecular and cellular biology

authors： DiRenzo J,Shang Y,Phelan M,Sif S,Myers M,Kingston R,Brown M

更新日期：2000-10-01 00:00:00

abstract：:We have studied the patterns of expression of four B-type cyclins (Clbs), Clb1, Clb2, Clb3, and Clb4, and their ability to activate p34cdc28 during the mitotic and meiotic cell cycles of Saccharomyces cerevisiae. During the mitotic cell cycle, Clb3 and Clb4 were expressed and induced a kinase activity in association w...

journal_title：Molecular and cellular biology

authors： Grandin N,Reed SI

更新日期：1993-04-01 00:00:00

abstract：:Histone acetylation plays an important role in regulating chromatin structure and thus gene expression. Here we describe the functional characterization of HDAC4, a human histone deacetylase whose C-terminal part displays significant sequence similarity to the deacetylase domain of yeast HDA1. HDAC4 is expressed in va...

journal_title：Molecular and cellular biology

authors： Wang AH,Bertos NR,Vezmar M,Pelletier N,Crosato M,Heng HH,Th'ng J,Han J,Yang XJ

更新日期：1999-11-01 00:00:00

abstract：:The family of p21-activated protein kinases (PAKs) appear to be present in all organisms that have Cdc42-like GTPases. In mammalian cells, PAKs have been implicated in the activation of mitogen-activated protein kinase cascades, but there are no reported effects of these kinases on the cytoskeleton. Recently we have s...

journal_title：Molecular and cellular biology

authors： Manser E,Huang HY,Loo TH,Chen XQ,Dong JM,Leung T,Lim L

更新日期：1997-03-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) is the name of a group of closely related polypeptides characterized by a multiplicity of effects, including regulation of extracellular proteolysis and turnover of the extracellular matrix. Its cellular mechanism of action is largely unknown. TGF-beta 1 is a strong and fast ...

journal_title：Molecular and cellular biology

authors： Riccio A,Pedone PV,Lund LR,Olesen T,Olsen HS,Andreasen PA

更新日期：1992-04-01 00:00:00

abstract：:Brain disturbances, like injuries or aberrant protein deposits, evoke nucleotide release or leakage from cells, leading to microglial chemotaxis and ingestion. Recent studies have identified P2Y12 purinergic receptors as triggers for microglial chemotaxis and P2Y6 receptors as mediators for phagocytosis. However, pino...

journal_title：Molecular and cellular biology

authors： Li HQ,Chen C,Dou Y,Wu HJ,Liu YJ,Lou HF,Zhang JM,Li XM,Wang H,Duan S

更新日期：2013-11-01 00:00:00

abstract：:An enzyme was isolated from a eucaryotic, Chlorella-like green alga infected with the virus PBCV-1 which exhibits type II restriction endonuclease activity. The enzyme recognized the sequence GATC and cleaved DNA 5' to the G. Methylation of deoxyadenosine in the GATC sequence inhibited enzyme activity. In vitro the en...

journal_title：Molecular and cellular biology

authors： Xia YN,Burbank DE,Uher L,Rabussay D,Van Etten JL

更新日期：1986-05-01 00:00:00

abstract：:It is well established that cell survival signals stimulated by growth factors, cytokines, and oncoproteins are initiated by phosphoinositide 3-kinase (PI3K)- and Akt-dependent signal transduction pathways. Oncogenic Ras, an upstream activator of Akt, requires NF-kappaB to initiate transformation, at least partially t...

journal_title：Molecular and cellular biology

authors： Madrid LV,Wang CY,Guttridge DC,Schottelius AJ,Baldwin AS Jr,Mayo MW

更新日期：2000-03-01 00:00:00

abstract：:Saccharomyces cerevisiae mutant E124 was selected in a visual screen based on elongated cell shape. Genetic analysis showed that E124 contains two separate mutations, pps1-1 and elm4-1, each causing a distinct phenotype inherited as a single-gene trait. In rich medium, pps1-1 by itself causes increased doubling time b...

journal_title：Molecular and cellular biology

authors： Blacketer MJ,Madaule P,Myers AM

更新日期：1994-07-01 00:00:00

abstract：:Cell fate specification requires precise coordination of transcription factors and their regulators to achieve fidelity and flexibility in lineage allocation. The transcriptional repressor growth factor independence 1 (GFI1) is comprised of conserved Snail/Slug/Gfi1 (SNAG) and zinc finger motifs separated by a linker ...

journal_title：Molecular and cellular biology

authors： Andrade D,Velinder M,Singer J,Maese L,Bareyan D,Nguyen H,Chandrasekharan MB,Lucente H,McClellan D,Jones D,Sharma S,Liu F,Engel ME

更新日期：2016-05-02 00:00:00

abstract：:SH2 (src homology region 2) domains are implicated in protein-protein interactions involved in signal transduction pathways. Isolated SH2 domains bind proteins that are tyrosine phosphorylated. A novel, phosphotyrosine-independent binding interaction between BCR, the Philadelphia chromosome breakpoint cluster region g...

journal_title：Molecular and cellular biology

authors： Muller AJ,Pendergast AM,Havlik MH,Puil L,Pawson T,Witte ON

更新日期：1992-11-01 00:00:00

abstract：:mRNA in the yeast Saccharomyces cerevisiae is primarily degraded through a pathway that is stimulated by removal of the mRNA cap structure. Here we report that a mutation in the SPB8 (YJL124c) gene, initially identified as a suppressor mutation of a poly(A)-binding protein (PAB1) gene deletion, stabilizes the mRNA cap...

journal_title：Molecular and cellular biology

authors： Boeck R,Lapeyre B,Brown CE,Sachs AB

更新日期：1998-09-01 00:00:00

abstract：:Infection of mouse fibroblasts by wild-type polyomavirus results in increased phosphorylation of ribosomal protein S6 (D.A. Talmage, J. Blenis, and T.L. Benjamin, Mol. Cell. Biol. 8:2309-2315, 1988). Here we identify pp70 S6 kinase (pp70S6K) as a target for signal transduction events leading from polyomavirus middle t...

journal_title：Molecular and cellular biology

authors： Dahl J,Freund R,Blenis J,Benjamin TL

更新日期：1996-06-01 00:00:00

abstract：:The yeast nuclear gene YME1 was one of six genes recently identified in a screen for mutations that elevate the rate at which DNA escapes from mitochondria and migrates to the nucleus. yme1 mutations, including a deletion, cause four known recessive phenotypes: an elevation in the rate at which copies of TRP1 and ARS1...

journal_title：Molecular and cellular biology

authors： Thorsness PE,White KH,Fox TD

更新日期：1993-09-01 00:00:00

abstract：:In Drosophila and several other metazoan organisms, there are two genes that encode related but distinct homologs of ADA2-type transcriptional adaptors. Here we describe mutations of the two Ada2 genes of Drosophila melanogaster. By using mutant Drosophila lines, which allow the functional study of individual ADA2s, w...

journal_title：Molecular and cellular biology

authors： Pankotai T,Komonyi O,Bodai L,Ujfaludi Z,Muratoglu S,Ciurciu A,Tora L,Szabad J,Boros I

更新日期：2005-09-01 00:00:00

abstract：:The human 4F2 cell surface antigen is a 120-kilodalton (kDa) disulfide-linked heterodimer which is composed of an 80- to 90-kDa glycosylated heavy chain (4F2HC) and a 35- to 40-kDa nonglycosylated light chain (4F2LC). 4F2 belongs to a family of inducible cell surface molecules which are involved in T-lymphocyte activa...

journal_title：Molecular and cellular biology

authors： Gottesdiener KM,Karpinski BA,Lindsten T,Strominger JL,Jones NH,Thompson CB,Leiden JM

更新日期：1988-09-01 00:00:00

abstract：:3-Methyl adenine (3meA), a minor-groove DNA lesion, presents a strong block to synthesis by replicative DNA polymerases (Pols). To elucidate the means by which replication through this DNA lesion is mediated in eukaryotic cells, here we carry out genetic studies in the yeast Saccharomyces cerevisiae treated with the a...

journal_title：Molecular and cellular biology

authors： Johnson RE,Yu SL,Prakash S,Prakash L

更新日期：2007-10-01 00:00:00