Abstract:
BACKGROUND:This study was designed to investigate the efficacy of alteplase double-bolus dosing compared with the front-loaded 90-minute infusion regimen in patients with acute myocardial infarction. Recent pilot studies have suggested that bolus dosing may provide improved efficacy in establishing early, complete, and sustained patency of the infarct-related artery in the thrombolytic treatment of acute myocardial infarction. METHODS AND RESULTS:In this multicenter, randomized, open-label trial, 461 patients with acute myocardial infarction received 100 mg alteplase as a front-loaded 90-minute infusion (15 mg bolus, then 50 mg over a 30-minute period, then 35 mg over a 60-minute period) or double bolus (two 50 mg bolus injections 30 minutes apart). All patients also received intravenous heparin and oral aspirin during and after alteplase treatment. The 90-minute angiographic patency rates were 74.5% in the double-bolus group and 81.4% in the infusion group (p = 0.08). Patency rates were also comparable for the two groups at 60 minutes (76.8% vs 77.5%) and 24 hours (95.5% vs 93.5%) after initiation of treatment. In-hospital mortality rates were 4.5% in the bolus group and 1.3% in the infusion group (p = 0.04); 30-day mortality rates were 4.5% and 1.7%, respectively (p = NS). The two-groups were comparable in frequency of all other adverse events. CONCLUSIONS:Double-bolus alteplase administration produced reperfusion rates comparable to front-loaded infusion, but in-hospital and 30-day mortality rates were higher in the double-bolus group. These findings are in agreement with those of the COBALT megatrial, which also reported a trend to higher mortality rates with double-bolus dosing.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Bleich SD,Adgey AA,McMechan SR,Love TWdoi
10.1016/s0002-8703(98)70024-9subject
Has Abstractpub_date
1998-10-01 00:00:00pages
741-8issue
4 Pt 1eissn
0002-8703issn
1097-6744pii
S0002870398000829journal_volume
136pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract::The incremental advantage of transesophageal echocardiography was determined by comparing results of paired transthoracic and transesophageal echocardiographic examinations performed in 61 patients for evaluation of suspected infective endocarditis. According to clinical and pathologic data, 31 of 61 (51%) patients ha...
journal_title:American heart journal
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journal_title:American heart journal
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journal_title:American heart journal
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journal_title:American heart journal
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journal_title:American heart journal
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journal_title:American heart journal
pub_type: 杂志文章
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abstract:BACKGROUND:It is unclear whether fibrinogen predicts cardiovascular events independently of echocardiographic cardiovascular abnormalities and traditional risk factors. METHODS:We studied 2671 American Indians who participated in the second Strong Heart Study examination (1993-1995) and were observed for an average of...
journal_title:American heart journal
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journal_title:American heart journal
pub_type: 杂志文章
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journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究
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doi:10.1067/mhj.2001.112487
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-12-01 00:00:00
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更新日期:2009-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0002-8703(95)90143-4
更新日期:1995-12-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1991-06-01 00:00:00
abstract::The development of ECG Minnesota Q-QS codes and their subsequent evolution were studied in the first 692 subjects to enter the POSCH program who had had one MI. The mean interval from MI to entry into the study was 2.2 years. Sixty-three percent of the subjects developed the most significant code with the infarction. ...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1985-08-01 00:00:00
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journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:1999-07-01 00:00:00
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更新日期:1989-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Recent studies suggest that class III antiarrhythmic agents may have enhanced efficacy in the treatment of ventricular tachycardia. This study describes the first clinical assessment of the new class III agent ibutilide to suppress inducible monomorphic ventricular tachycardia (VT) in human beings. METHODS ...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:1998-06-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2009.07.020
更新日期:2009-10-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2006-04-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,评审
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更新日期:2015-07-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2013.08.026
更新日期:2013-11-01 00:00:00
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journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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