Abstract:
:N-1 and N-2 substituted pyrazolo[4,5-g]pyrido[1,2-a]benzimidazoles were prepared regioselectively, and cytotoxicities evaluated in vitro against K562 and HL60 cells. All compounds displayed weaker activity than doxorubicin against sensitive lines, but showed the same activity against resistant cell lines (multidrug resistance+, (MDR+); K562R and HL60R) indicating no resistance phenomena.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Dupuy M,Pinguet F,Blache Y,Chavignon O,Teulade JC,Chapat JPdoi
10.1248/cpb.46.1820subject
Has Abstractpub_date
1998-11-01 00:00:00pages
1820-3issue
11eissn
0009-2363issn
1347-5223journal_volume
46pub_type
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更新日期:2008-02-01 00:00:00