Abstract:
:A variety of 5,4'-disubstituted flavones, which are anticipated to be androgen receptor antagonists to treat diseases mediated by the androgen receptor, were synthesized. It was found that an intramolecular ipso-substitution reaction via cesium enolate using 2-fluoro-6-hydroxyacetophenone and various benzoyl chlorides was effective in the preparation of 5-hydroxy-4'-alkylflavones.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Matsugi M,Takeda M,Takahashi A,Tazaki T,Tamura H,Shioiri Tdoi
10.1248/cpb.58.1107subject
Has Abstractpub_date
2010-08-01 00:00:00pages
1107-10issue
8eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/58.1107journal_volume
58pub_type
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