Cytotoxic activity and DNA-binding properties of isoeuxanthone derivatives.


:In this study, the interactions of different groups substituted isoeuxanthone derivatives with calf thymus DNA (ct DNA) were investigated by spectrophotometric methods and viscosity measurements. Results indicated that the xanthone derivatives could intercalate into the DNA base pairs by the plane of xanthone ring and the various substituents may influence the binding affinity with DNA according to the calculated quenching constant values. Furthermore, two tumor cell lines including the human cervical cancer cell line (HeLa) and human hepatocellular liver carcinoma cell line (HepG2) were used to evaluate the cytotoxic activities of xanthone derivatives by acid phosphatase assay. Analyses showed that the oxiranylmethoxy substituted xanthone exhibited more effective cytotoxic activity against the cancer cells than the other substituted xanthones. The effects on the inhibition of tumor cells in vitro agreed with the studies of DNA-binding.


Wang HF,Yan H,Gao X,Niu B,Guo R,Wei L,Xu B,Tang N




Has Abstract


2014-01-01 00:00:00














  • Light irradiation is a factor in the bactericidal activity of silver-loaded zeolite.

    abstract::Silver loaded zeolite (Ag-Z) was previously found to have effective bactericidal activity against Escherichia coli. To understand the mechanisms of bactericidal activity of Ag-Z, role of light irradiation was focused and investigated in this study. In this study, we focused on light irradiation. Antibacterial assay an...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Inoue Y,Kogure M,Matsumoto K,Hamashima H,Tsukada M,Endo K,Tanaka T

    更新日期:2008-05-01 00:00:00

  • Synthesis of dibenzofurans directly from aryl halides and ortho-bromophenols via one-pot consecutive SNAr and intramolecular palladium-catalyzed aryl-aryl coupling reactions.

    abstract::A series of dibenzofurans were efficiently and conveniently synthesized via one-pot consecutive C(sp(2))-O bond formation reaction (SNAr) in the presence of anhydrous K(2)CO(3), followed by C(sp(2))-C(sp(2)) bond formation reaction (intramolecular palladium-catalyzed aryl-aryl coupling reaction) between aryl halides a...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Xu H,Fan LL

    更新日期:2008-10-01 00:00:00

  • Selective allylic hydroxylation of octahydronaphthalene derivatives with a bridgehead double bond using electrochemical method with iron picolinate complexes.

    abstract::The combination of electrolysis and the Fe(III)(PA)3/O2/CH3CN system was investigated for allylic hydroxylation of octahydronaphthalene derivatives. Substrates with a bridgehead double bond gave the allylic alcohol with alpha-preference, while non-bridgehead olefin did not react smoothly. This system is a useful tool ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Okamoto I,Funaki W,Nobuchika S,Sawamura M,Kotani E,Takeya T

    更新日期:2005-02-01 00:00:00

  • Analysis of the phase solubility diagram of a phenacetin/competitor/beta-cyclodextrin ternary system, involving competitive inclusion complexation.

    abstract::The competitive inclusion complexations in the ternary phenacetin/competitors/beta-cyclodextrin (beta-CyD) systems were investigated by the solubility method, where m-bromobenzoic acid (m-BBA) and o-toluic acid (o-TA) were used as competitors. The solubility changes of the drug and competitors as a function of beta-Cy...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ono N,Hirayama F,Arima H,Uekama K

    更新日期:2001-01-01 00:00:00

  • Microbial metabolites of harman alkaloids.

    abstract::Several microorganisms showed the ability to transform the harman alkaloids, harmaline (1), harmalol (2) and harman (5). Harmaline (1) and harmalol (2) were converted by Rhodotorula rubra ATCC 20129 into the tryptamines, 2-acetyl-3-(2-acetamidoethyl)-7-methoxyindole (3) and 2-acetyl-3-(2-acetamidoethyl)-7-hydroxyindol...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Herath W,Mikell JR,Ferreira D,Khan IA

    更新日期:2003-06-01 00:00:00

  • Synthesis of (±)-8-deisopropyladunctin B.

    abstract::(±)-8-Deisopropyladunctin B, the deisopropyl form of adunctin B, which was isolated from the leaves of Piper aduncum (Piperaceae) collected in Papua New Guinea, was synthesized in 0.77% overall yield in 17 steps from 5,7-dimethoxycoumarin-3-carboxylate. The key step was our original stereoconvergent skeleton transform...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nomura S,Arimitsu K,Yamaguchi S,Kosuga Y,Kakimoto Y,Komai T,Hasegawa K,Nakanishi A,Miyoshi T,Iwasaki H,Ozeki M,Kawasaki I,Kurume A,Ohta S,Yamashita M

    更新日期:2012-01-01 00:00:00

  • Prediction of color changes using the time-temperature superposition principle in liquid formulations.

    abstract::This study reports the results of applying the time-temperature superposition principle (TTSP) to the prediction of color changes in liquid formulations. A sample solution consisting of L-tryptophan and glucose was used as the model liquid formulation for the Maillard reaction. After accelerated aging treatment at ele...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Mochizuki K,Takayama K

    更新日期:2014-01-01 00:00:00

  • Studies on the constituents of Mikania hirsutissima (Compositae).

    abstract::Two novel norhumulene-type sesquiterpenes, named mikaniahumulene I (1) and II (2) were isolated along with nine known compounds, seven kaurenic acid-type diterpenes (3-9), a coumarin (10) and a flavone (11), from the aerial parts of Mikania hirsutissima DC (Compositae). The structures of new norhumulenes were determin...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ohkoshi E,Makino M,Fujimoto Y

    更新日期:1999-10-01 00:00:00

  • Studies on cardiotonic agents. II. Synthesis of novel phthalazine and 1,2,3-benzotriazine derivatives.

    abstract::A series of phthalazine and 1,2,3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested for cardiotonic activity in anesthetized dogs. Several 6,7-dimethoxyphthalazine derivatives showed relatively potent cardiotonic activity comparable to that of amrinone. ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nomoto Y,Obase H,Takai H,Teranishi M,Nakamura J,Kubo K

    更新日期:1990-08-01 00:00:00

  • Antiproliferative constituents from umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica.

    abstract::The CHCl3 extract of the root of Angelica japonica showed high inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. From this extract, a new furanocoumarin named japoangelone and four furanocoumarin ethers of falcarindiol, named japoangelols A-D, were isolated together with caffeic acid methyl ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Fujioka T,Furumi K,Fujii H,Okabe H,Mihashi K,Nakano Y,Matsunaga H,Katano M,Mori M

    更新日期:1999-01-01 00:00:00

  • Conversion of Ginsenoside Rb1 into Six Types of Highly Bioactive Ginsenoside Rg3 and Its Derivatives by FeCl3 Catalysis.

    abstract::Ginsenoside Rb1 is an important saponin of ginseng(s); however, Rb1, with 3-O- and 20-O-sugar moieties, has low bioavailability. Here, we report the derivatization of ginsenoside Rb1 to completely generate six types of highly bioactive minor ginsenoside Rg3 and its derivatives by FeCl3 catalysis, the reaction conditio...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Yu H,Wang Y,Liu C,Yang J,Xu L,Li G,Song J,Jin F

    更新日期:2018-01-01 00:00:00

  • Synthesis and antifungal activity of novel 14-membered benzomacrolides, as galbonolide analogues.

    abstract::Asymmetric total synthesis of benzene analogues of galbonolide, a 14-membered antifungal macrolide, possessing a benzene ring instead of a conjugated diene structure, was achieved starting from chiral 1-aryl-1-propanol obtained by enzyme-catalyzed kinetic resolution with high enantioselectivity. Representatively, a me...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Sakoh H,Sakuraba S,Sugimoto Y,Imamura H,Jona H,Yamada K,Bamba-Nagano R,Hashizume T,Morishima H

    更新日期:2004-01-01 00:00:00

  • Synthetic studies of vitamin D analogs. XXIV. Synthesis of active vitamin D3 analogs substituted at the 2 beta-position and their preventive effects on bone mineral loss in ovariectomized rats.

    abstract::Analogs related to 1 alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D3 (ED-71) (4), oxa-type and carba-type analogs of vitamin D3 bearing substituents at the 2 beta-position of 1 alpha,25-dihydroxyvitamin D3 (1), were synthesized from the alpha-epoxides (6 and 13). Three analogs, ED-71 (4) and two carba-type anal...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ono Y,Watanabe H,Shiraishi A,Takeda S,Higuchi Y,Sato K,Tsugawa N,Okano T,Kobayashi T,Kubodera N

    更新日期:1997-10-01 00:00:00

  • Naturally occurring 5-lipoxygenase inhibitor. II. Structures and syntheses of ardisianones A and B, and maesanin, alkenyl-1,4-benzoquinones from the rhizome of Ardisia japonica.

    abstract::New alkenyl-1,4-benzoquinones, ardisianones A (1) and B (2), and the known maesanin (3) as 5-lipoxygenase inhibitors have been isolated from the rhizome of Ardisia japonica. Their structures have been elucidated as 2-methoxy-6-[(Z)-10'-pentadecenyl]-1,4-benzoquinone and 5-hydroxy-2-methoxy-6-[(Z)-8'-tridecenyl]-1,4-be...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Fukuyama Y,Kiriyama Y,Okino J,Kodama M,Iwaki H,Hosozawa S,Matsui K

    更新日期:1993-03-01 00:00:00

  • Flavonol triglycosides from the leaves of Hammada scoparia (POMEL) ILJIN.

    abstract::A new flavonol triglycoside, isorhamnetin 3-O-beta-D-xylopyranosyl-(1"-->3)-alpha-L-rhamnopyranosyl-(1'''-->6")-beta-D-galactopyranoside, has been isolated from the leaves of Hammada scoparia together with two known compounds, isorhamnetin 3-O-beta-D-apiofuranosyl-(1'''-->2")[alpha-L-rhamnopyranosyl-(1"-->6")]-beta-D-...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ben Salah H,Jarraya R,Martin MT,Veitch NC,Grayer RJ,Simmonds MS,Damak M

    更新日期:2002-09-01 00:00:00

  • Cytotoxic evaluation of phenolic compounds from lichens against melanoma cells.

    abstract::Atranorin, lichexanthone, and the (+)-usnic, diffractaic, divaricatic, perlatolic, psoromic, protocetraric, and norstictic acids isolated from the lichens Parmotrema dilatatum (VAIN.) HALE, Usnea subcavata MOTYKA, Usnea sp., Ramalina sp., Cladina confusa (SANT.) FOLMM. & AHTI, Dirinaria aspera HÄSÄNEN, and Parmotrema ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Brandão LF,Alcantara GB,Matos Mde F,Bogo D,Freitas Ddos S,Oyama NM,Honda NK

    更新日期:2013-01-01 00:00:00

  • Synthesis and anticancer evaluation of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and Mannich bases.

    abstract::A series of 5-(pyridin-4-yl)-N-substituted-1,3,4-oxadiazol-2-amines (3a-d), 5-(pyridin-4-yl)-N-substituted-1,3,4-thiadiazol-2-amines (4a-d) and 5-(pyridin-4-yl)-4-substituted-1,2,4-triazole-3-thiones (5a-d) were obtained by the cyclization of hydrazinecarbothioamide derivatives 2a-d derived from isonicotinic acid hydr...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Megally Abdo NY,Kamel MM

    更新日期:2015-01-01 00:00:00

  • Novel bile acids from bear bile powder and bile of geese.

    abstract::Two new bile acids, tauroselocholic acid (1) and tauroansocholic acid (2), a new natural bile acid, cygnocholic acid (3) were respectively isolated from bear bile powder Selenaretos thibetanus CUVIER and bile of geese Anser anser domesticus, together with seven known compounds. By spectrum analysis of MS, 1D and 2D NM...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Bi D,Chai XY,Song YL,Lei Y,Tu PF

    更新日期:2009-05-01 00:00:00

  • Scale-Up of Lubricant Mixing Process by Using V-Type Blender Based on Discrete Element Method.

    abstract::A method for scale-up of a lubricant mixing process in a V-type blender was proposed. Magnesium stearate was used for the lubricant, and the lubricant mixing experiment was conducted using three scales of V-type blenders (1.45, 21 and 130 L) under the same fill level and Froude (Fr) number. However, the properties of ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Horibe M,Sonoda R,Watano S

    更新日期:2018-01-01 00:00:00

  • Synthesis and SAR Study of the Novel Thiadiazole-Imidazole Derivatives as a New Anticancer Agents.

    abstract::In the present study, a novel series of 2-(2-(3-aryl-5-substituted-1,3,4-thiadiazol-2(3H)-ylidene)hydrazinyl)-4,4-diphenyl-1H-imidazol-5(4H)-one derivatives were designed and prepared via the reaction of the most versatile, hitherto unreported 2-(5-oxo-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-yl)-N-phenylhydrazinecarbot...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Gomha SM,Abdel-Aziz HM,Khalil KD

    更新日期:2016-01-01 00:00:00

  • Synthesis of 2-phenylbenzofuran derivatives and selective binding activities on estrogen receptor.

    abstract::An improved chemical reaction protocol with short time and easy work-up was described here for 2-phenylbenzofuran derivatives. The final purified products, 2-phenylbenzofuran derivatives 5a-g and the intermediate diols 4a-g, were evaluated for their estrogen receptor (ER) binding affinity and selective activity in vit...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Zhang P,Yang Y,Zheng X,Huang W,Ma Z,Shen Z

    更新日期:2012-01-01 00:00:00

  • A 3D-QSAR Analysis of CDK2 Inhibitors Using FMO Calculations and PLS Regression.

    abstract::We report a three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis of CDK2 inhibitors using fragment molecular orbital (FMO) calculations and partial least squares (PLS) regression. In our analysis, fragment binding energies of individual amino acids and fragment binding energy of a single l...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Yoshida T,Hirono S

    更新日期:2019-01-01 00:00:00

  • Interaction characteristics with bovine serum albumin and retarded nitric oxide release of ZCVI₄-2, a new nitric oxide-releasing derivative of oleanolic acid.

    abstract::ZCVI₄-2 is a newly developed furoxan-based nitric oxide-releasing derivative of oleanolic acid. It exhibited strong cytotoxicity against human hepatocellular carcinoma (HCC) in vitro and significantly inhibited the growth of HCC tumors in vivo. However, its low aqueous solubility and toxicity due to the fast release o...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Zhang J,Gao Y,Su F,Gong Z,Zhang Y

    更新日期:2011-01-01 00:00:00

  • Preparation of benzo[b]furans having five-membered heterocycles at the 2-position and 2-(4-Alkylcarbamoylbuta-1,3-dienyl)benzo[b]furans, and their cysteinyl leukotriene receptor (cysLT1, cysLT2) inhibitory activity.

    abstract::A series of benzo[b]furan derivatives having a five-membered heterocyclic substituent at the 2-position were prepared from 2-(1-chloro-2-formylvinyl)benzo[b]furans (2) and 2-(4-alkylcarbamoylbuta-1,3-dienyl)benzo[b]furans. These 2-heterocyclic benzo[b]furans were evaluated for their cysteinyl leukotriene receptor (cys...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Akai Y,Tabuchi Y,Ando K,Ito A,Sakata Y,Kawasaki I,Ohishi T,Yamashita M,Ohta S,Nishide K,Ohishi Y

    更新日期:2012-01-01 00:00:00

  • Transformation of metastable forms of acetaminophen studied by thermal Fourier transform infrared (FT-IR) microspectroscopy.

    abstract::A novel Fourier transform infrared (FT-IR) microspectroscopy equipped with a micro hot stage (thermal FT-IR microscopic system) was used to quickly study the phase transformation of acetaminophen polymorphs by a one-step process. Acetaminophen was sealed in KBr disc on the first and second heating processes under this...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Wang SL,Lin SY,Wei YS

    更新日期:2002-02-01 00:00:00

  • Acacia concinna saponins. I. Structures of prosapogenols, concinnosides A-F, isolated from the alkaline hydrolysate of the highly polar saponin fraction.

    abstract::A highly polar saponin mixture from pods of Acacia concinna (Leguminosae) was hydrolyzed with alkali to yield five new triterpenoidal prosapogenols named concinnosides A (6), B (3), C (7), D (4), and E (8), together with four known glycosides, acaciaside, (2), julibroside A1 (10) julibroside A3 (9), albiziasaponin C (...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Abul Gafur M,Obata T,Kiuchi F,Tsuda Y

    更新日期:1997-04-01 00:00:00

  • Formulation and physicochemical characterization of imwitor 308 based self microemulsifying drug delivery systems.

    abstract::Self Microemulsifying Drug Delivery Systems (SMEDDS) are a novel alternative to the conventional transdermal delivery systems. SMEDDS are water-free systems, made up of oils and surfactants that can readily form a microemulsion upon dilution within an aqueous medium. Before SMEDDS can be used as a drug delivery system...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Zargar-Shoshtari S,Wen J,Alany RG

    更新日期:2010-10-01 00:00:00

  • Taxiphyllin 6'-O-gallate, actinidioionoside 6'-O-gallate and myricetrin 2″-O-sulfate from the leaves of Syzygium samarangense and their biological activities.

    abstract::Three new compounds were isolated from a MeOH extract of the leaves of Syzygium samarangense, one new cyanogenic glucoside, taxiphyllin 6'-O-gallate (1), one new megastigmane glucoside, actinidioionoside 6'-O-gallate (2), and one new sulfated flavonoid rhamnoside, myricetrin 2″-O-sulfate (3), together with 14 known co...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Samy MN,Sugimoto S,Matsunami K,Otsuka H,Kamel MS

    更新日期:2014-01-01 00:00:00

  • NF-κB inhibitory activities of glycosides and alkaloids from Zanthoxylum schinifolium stems.

    abstract::Zanthoxylum schinifolium is an aromatic shrub, the pericarp and leaves of which are widely used in culinary applications in East Asian countries. In the present study, one new neolignan glycoside, zanthoxyloside A (1) together with 16 known glycosides (2-12) and alkaloids (13-17), were isolated from methanol extract o...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Li W,Yang SY,Yan XT,Sun YN,Song SB,Kang HK,Kim YH

    更新日期:2014-01-01 00:00:00

  • Prediction of the stability of octreotide in a mixed infusion.

    abstract::The purpose of this study was to predict the stability of octreotide in a mixed infusion containing sodium bisulfite (SBS). In aqueous solution the hydrolysis of octreotide was found to be accelerated by pH, and by increasing concentrations of SBS. Equations for the degradation rate constants (kobs) of pH and SBS were...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Takasu Y,Yoshida M,Shimizu K,Asahara K,Tange M,Uchida T

    更新日期:2014-01-01 00:00:00