Abstract:
:This paper describes syntheses and doxorubicin-inclusion abilities of beta-cyclodextrin (CyD) derivatives with a hydroquinone alpha-glycoside residue attached at the primary side. The hydroquinone glycoside having an alpha-D-glucosidic or 2-acetamido-2-deoxy-alpha-D-glucosidic linkage became a useful component for providing an alpha-D-glucose- or 2-acetamido-2-deoxy-alpha-D-glucose-beta-CyD conjugate. The surface plasmon resonance analyses of these beta-CyD derivatives for the anticancer agent, doxorubicin, indicated that they had excellent inclusion associations on the order of 10(5 m)-1 for the immobilized doxorubicin.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Oda Y,Miura M,Hattori K,Yamanoi Tdoi
10.1248/cpb.57.74subject
Has Abstractpub_date
2009-01-01 00:00:00pages
74-8issue
1eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/57.74journal_volume
57pub_type
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pub_type: 杂志文章
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