Abstract:
:The complexations of sulfasalazine (H3Suz) with some of transition metals have been investigated. Three types of complexes, [Mn(HSuz)-2(H2O)4] x 2H2O, [M(HSuz)-2(H2O)2] x xH2O (M=Hg(II), ZrO(II) and VO(II), x=4, 8 and 6, respectively) and [M(HSuz)-2(Cl)(H2O)3] x xH2O (M=Cr(III) and Y(III), x=5 and 6, respectively) were obtained and characterized by physicochemical and spectroscopic methods. The IR spectra of the complexes suggest that the H3Suz behaves as a bidentate ligand. The thermal decomposition of the complexes as well as thermodynamic parameters (DeltaE*, DeltaH*, DeltaS* and DeltaG*) were estimated using Coats-Redfern and Horowitz-Metzger equations. In vitro antimicrobial activities of the H3Suz and the complexes were tested.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
El-Wahed MG,Refat MS,El-Megharbel SMdoi
10.1248/cpb.56.1585subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1585-91issue
11eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/56.1585journal_volume
56pub_type
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