Abstract:
:The pH-dependence of the ability of coproporphyrin (CP) and uroporphyrin (UP) to photogenerate hydrogen peroxide (H2O2) in aqueous solution was investigated, with special attention to the structure-activity relationship related to the aggregation of the porphyrins. It was found that the efficiency was strongly dependent on the aggregation of CP and UP mediated by changes in the pH of the solution, and a dimeric form had a weak ability to produce H2O2, while a highly aggregated form had a good ability. The increased efficiency of the highly aggregated porphyrin to produce H2O2 was further demonstrated using a different type of aggregate formed by the electrostatic interaction of cationic tetrakis-5,10,15,20-(N-methyl-4-pyridyl)porphin (TMPyP) with anionic tetrakis-5,10,15,20-(4-sulfonatophenyl)porphin (TSPP). The present results demonstrated the importance of the state of aggregation of porphyrin to photogenerate H2O2, and the results may help to develop a new type of medicine for photodynamic therapy.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Komagoe K,Tamagake K,Katsu Tdoi
10.1248/cpb.54.1004subject
Has Abstractpub_date
2006-07-01 00:00:00pages
1004-9issue
7eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/54.1004journal_volume
54pub_type
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