Abstract:
:4-(2-Pyridinylamino)-1,1,1-trifluoro-3-penten-2-ones 3, obtained from the reaction of commercially available 2-aminopyridine derivatives and 4-methoxy-1,1,1-trifluoro-3-penten-2-one 2, were converted to 6-(dimethylamino)-4-(2-pyridinylamino)-3,5-hexadien-2-ones 4 by treatment with dimethylformamide dimethyl acetal. Azannulation of hexadienones 4 afforded 4-(2-pyridinylamino)-2-trifluoromethylpyridines 5 and 2-(trifluoroacetylmethylene)pyrido[1,2-a]pyrimidines 6, classes of compounds particularly interesting from a chemical and biological point of view.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Cocco MT,Conglu C,Onnis Vdoi
10.1248/cpb.49.703subject
Has Abstractpub_date
2001-06-01 00:00:00pages
703-6issue
6eissn
0009-2363issn
1347-5223journal_volume
49pub_type
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