Abstract：
:Animal research has shown that anxiety may inhibit pain through the release of endogenous opioids. On the other hand, anxiety is often believed to exacerbate pain in clinical situations, and anxiety reduction has been shown to attenuate the affective component of pain. In the present study phobic anxiety was induced by confronting forty-eight spider phobic subjects with a spider, after which they received two mildly painful electrical stimuli at two different current levels. The benzodiazepine alprazolam (1 mg) was administered to investigate the influence on pain of a reduction in anxiety, while the role of endogenous opioids was studied by administering the opioid antagonist naltrexone (50 mg). Alprazolam resulted in lower anxiety and pain ratings during pain stimulation, supporting the idea that (presumably pain-related) anxiety may increase the experience of pain. Naltrexone did not influence pain and anxiety ratings, nor was there a significant interaction between the two pharmacological manipulations. These findings confirm previous evidence that phobic fear does not necessarily induce an endogenous opioid-mediated analgesia.
journal_name
Behav Res Therjournal_title
Behaviour research and therapyauthors
Janssen SA,Arntz Adoi
10.1016/s0005-7967(98)00100-4subject
Has Abstractpub_date
1999-01-01 00:00:00pages
77-86issue
1eissn
0005-7967issn
1873-622Xpii
S0005-7967(98)00100-4journal_volume
37pub_type
临床试验,杂志文章abstract：:The psychological consequences of traumatic stress may last even into old age. In persons in their 60s and 70s who had been victims of political detention and torture four decades ago, we compared the outcome of narrative exposure therapy (NET) to that of psychoeducation (PED) only. From a group of 59 former political...
journal_title：Behaviour research and therapy
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journal_title：Behaviour research and therapy
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更新日期：2017-10-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 杂志文章
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journal_title：Behaviour research and therapy
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更新日期：2012-11-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Behaviour research and therapy
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journal_title：Behaviour research and therapy
pub_type： 杂志文章
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更新日期：2010-03-01 00:00:00
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journal_title：Behaviour research and therapy
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journal_title：Behaviour research and therapy
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1996-05-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 临床试验,杂志文章
doi：10.1016/0005-7967(90)90078-w
更新日期：1990-01-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2004.05.006
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pub_type： 杂志文章
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journal_title：Behaviour research and therapy
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journal_title：Behaviour research and therapy
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更新日期：2013-07-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Behaviour research and therapy
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1999-09-01 00:00:00
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journal_title：Behaviour research and therapy
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journal_title：Behaviour research and therapy
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journal_title：Behaviour research and therapy
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journal_title：Behaviour research and therapy
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更新日期：2005-12-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2007.04.013
更新日期：2007-10-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Behaviour research and therapy
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journal_title：Behaviour research and therapy
pub_type： 杂志文章
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journal_title：Behaviour research and therapy
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journal_title：Behaviour research and therapy
pub_type： 杂志文章
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journal_title：Behaviour research and therapy
pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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journal_title：Behaviour research and therapy
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