Abstract:
:Myocardial pH has been shown in animal models to be a sensitive indicator of ischemia. In vivo measurement in humans using 31p magnetic resonance spectroscopy is complicated by the overlap of blood 2,3-diphosphoglycerate peaks with the P(i) peak used for pH measurement. A "saturation transfer" method combined with spatial presaturation of skeletal muscle signal is presented which can obtain spectra from the heart free of contamination of 2,3-DPG signal in which intracellular P(i) resonance can be clearly observed. Application to a group of six normal subjects found that the chemical shift of the intracellular inorganic phosphate peak was 4.95+/-0.06 relative to the phosphocreatine peak. This is equivalent to a pH of 7.11+/-0.05.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Blamire AM,Rajagopalan B,Radda GKdoi
10.1002/(sici)1522-2594(199901)41:1<198::aid-mrm28subject
Has Abstractpub_date
1999-01-01 00:00:00pages
198-203issue
1eissn
0740-3194issn
1522-2594pii
10.1002/(SICI)1522-2594(199901)41:1<198::AID-MRM28journal_volume
41pub_type
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