Abstract：
OBJECTIVES:To evaluate the efficacy, safety, and tolerability of sildenafil in men with broad-spectrum erectile dysfunction (ED), with reference to age-matched healthy control subjects. METHODS:One hundred eleven patients were enrolled in a randomized, double-blind, placebo-controlled, parallel-group, 12-week, flexible-dose study. Efficacy assessments included the International Index of Erectile Function (IIEF), a global assessment question, and patient event log data. In a separate, nontreatment study, 109 control subjects also completed the IIEF. RESULTS:Mean IIEF scores at baseline were significantly lower for patients with ED than for control subjects without a history of ED. After treatment, mean IIEF scores for patients receiving sildenafil approached values observed in control subjects and were significantly higher than mean scores for patients receiving placebo (P<0.01). Responses to the global assessment question and patient log data corroborated the IIEF results. Sildenafil was well tolerated, with no discontinuations because of adverse events. CONCLUSIONS:The results indicate that sildenafil, an effective oral therapy for the treatment of broad-spectrum ED, is associated with a near normalization of patient erectile function.
journal_name
Urologyjournal_title
Urologyauthors
Dinsmore WW,Hodges M,Hargreaves C,Osterloh IH,Smith MD,Rosen RCdoi
10.1016/s0090-4295(98)00586-xsubject
Has Abstractpub_date
1999-04-01 00:00:00pages
800-5issue
4eissn
0090-4295issn
1527-9995pii
S009042959800586Xjournal_volume
53pub_type
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