Combination of Anandron with orchiectomy in treatment of metastatic prostate cancer. Results of a double-blind study.

Abstract:

:A multicenter, randomized double-blind study was carried out in 203 patients with metastatic prostate cancer, in order to compare the efficacy of complete suppression of androgens achieved with surgical castration and nilutamide (Anandron), 100 mg t.i.d. The combined therapy was well-tolerated by patients, and they noted a better relief of bone pain after six months than those in the control group. There was a greater number of favorable responses in the combined treatment group. In addition, despite a similar median progression-free actuarial rate, the combined treatment (nilutamide plus orchiectomy) offered an improved survival time over orchiectomy alone.

journal_name

Urology

journal_title

Urology

authors

Beland G

doi

10.1016/0090-4295(91)80098-r

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

25-9

issue

2 Suppl

eissn

0090-4295

issn

1527-9995

journal_volume

37

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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