Abstract：
OBJECTIVES:To investigate the possible correlations of apoptosis and apoptosis-associated factors, including the apoptotic index (AI), proliferation index (PI), and expression of Bcl-2 and caspase 3, with the percent area density of epithelium and stroma in benign prostatic hyperplasia (BPH). METHODS:A total of 60 patients with histologically determined BPH were investigated. The percent area density of epithelium and stroma was determined using a computerized image analysis system after Masson's trichrome staining. Apoptosis was detected using the AI through the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling assay. Cell proliferation was determined using the PI through Ki-67 immunostaining. The expression of Bcl-2 and caspase 3 was immunohistochemically examined. Double-label immunofluorescent staining was performed to assess co-localization of Bcl-2 and caspase 3. RESULTS:The stroma/epithelium ratio ranged from 4.6 to 6.3 (average 5.2) in BPH. A greater stromal PI was closely related to the percent area density of stroma (P <0.01), and a greater epithelial AI was reversely related to the percent area density of the epithelium (P <0.05). Bcl-2 and caspase 3 expression was detected in 50 (80%) and 48 (75%) of 60 BPH samples, respectively. The expression of Bcl-2 and caspase 3 was not related to PI, AI, or the percent area density of the BPH components (P >0.05). Immunofluorescence analysis revealed co-localization of Bcl-2 and caspase 3 in the serial sections of BPH specimens that already showed either Bcl-2 or caspase 3 expression. CONCLUSIONS:The development of BPH may be associated with both stromal growth due to active stromal cell proliferation and epithelial growth due to reduced glandular apoptosis.
journal_name
Urologyjournal_title
Urologyauthors
Zhang X,Zhang Q,Zhang Z,Na Y,Guo Ydoi
10.1016/j.urology.2006.05.013subject
Has Abstractpub_date
2006-10-01 00:00:00pages
905-10issue
4eissn
0090-4295issn
1527-9995pii
S0090-4295(06)00647-9journal_volume
68pub_type
杂志文章相关文献
UROLOGY文献大全abstract：OBJECTIVES:To investigate the mechanism of gefitinib resistance in renal cell carcinoma (RCC) cells. Although epidermal growth factor receptor (EGFR) is frequently overexpressed in RCC, gefitinib, a tyrosine kinase inhibitor of EGFR, has only a limited antitumor effect on RCC. METHODS:The effects of gefitinib on the a...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.12.058
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVES:To examine the safety, efficacy, and tolerability of tolterodine in four randomized, double-blind, parallel, multicenter, 12-week studies of patients with overactive bladder. METHODS:Two of the four studies compared tolterodine (2 mg twice daily) to oxybutynin (5 mg three times daily) and placebo, one study...
journal_title：Urology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0090-4295(97)00599-2
更新日期：1997-12-01 00:00:00
abstract：:The experience gained from the implantation of 763 Flexirod Prosthesis is described. Special features of this design include a tapered distal tip which provides for better glans stability, a soft hinge which allows for improved penile concealment, and a trimmable tail which, together with preoperative measurement of t...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(84)90247-4
更新日期：1984-05-01 00:00:00
abstract：OBJECTIVE:To establish a score threshold that constitutes a clinically relevant change for each domain of the Expanded Prostate Cancer Index Composite (EPIC) Short Form (EPIC-26). Although its use in clinical practice and clinical trials has increased worldwide, the clinical interpretation of this 26-item disease-speci...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.08.044
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:To investigate the effects of terazosin and melatonin on isolated rabbit bladder strips after partial bladder outlet obstruction and determine responses to agonist-induced contractility and changes in oxidant-antioxidant system. METHODS:We created partial bladder outlet obstruction in 5 groups of rabbits, e...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.02.053
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the statistical association between routine home health use after prostatectomy, short-term surgical outcomes, and payments. METHODS:We identified all men who underwent a robotic radical prostatectomy from April 1, 2014, to October 31, 2015, in the Michigan Urological Surgery Improvement Collabor...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.11.004
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:To compare the clinical outcomes of transumbilical multiport laparoscopic orchiopexy (TMLO) vs standard laparoscopic orchiopexy (SLO) for 1-stage management of impalpable testes in children. MATERIALS AND METHODS:A total of 30 patients underwent primary TMLO from January 2010 to December 2011. An additional ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2012.07.076
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:To assess whether donor kidney Mayo Adhesive probability (MAP) score is associated with (total operative time) ORT in patients undergoing hand-assisted laparoscopic donor nephrectomy (HALDN). METHODS:Three hundred and thirty-one patients undergoing HALDN were reviewed. Donor kidney MAP scores were recorded b...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2018.10.041
更新日期：2019-02-01 00:00:00
abstract：:Percutaneous drainage has rapidly become the initial procedure of choice in the treatment of most intra-abdominal abscesses. The retroperitoneal location of the urinary tract facilitates a percutaneous approach and has been found to be highly effective, with surgical intervention required in a minority of cases. Nonin...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(84)90242-5
更新日期：1984-05-01 00:00:00
abstract：OBJECTIVES:To investigate whether the incidence of urethral stricture is different according to the primary mode of management, we retrospectively reviewed the record of patients with bulbous urethral disruption by external blunt trauma. METHODS:A total of 95 patients with blunt bulbous urethral injuries were included...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)01834-4
更新日期：2002-10-01 00:00:00
abstract：:We present a rare case of classic seminoma in an 86-year-old man. Combined mitotic count, the presence or absence of intravascular invasion, and the expression of PCNA, Ki67, and p53 were compared between this octogenarian and the tumors of four randomly selected standard younger men. These histologic features were ch...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.08.006
更新日期：2007-11-01 00:00:00
abstract：:Ectopic positioning of the kidney is a relatively common event, with the thoracic location of the ectopic kidney the most unusual. At least 140 cases of thoracic kidney have been described, with no consistent anomalies reported in association with the superior location. The vast majority of patients with thoracic kidn...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)01665-5
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVES:Epididymovasostomy is commonly performed at the most distal site of the epididymis where whole sperm are present within the lumen, regardless of their motility status. Although more fresh and motile sperm can be found more proximally within the epididymis, it is believed that the outcome of epididymovasostom...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(97)80001-5
更新日期：1997-04-01 00:00:00
abstract：OBJECTIVES:To evaluate, in two randomized, multicenter trials, levofloxacin compared with ciprofloxacin and lomefloxacin for efficacy and safety in treating acute pyelonephritis. METHODS:We enrolled a total of 186 patients with bacteriologically proved infection. Of these, 89 patients in both trials combined received ...
journal_title：Urology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0090-4295(98)00160-5
更新日期：1998-07-01 00:00:00
abstract：OBJECTIVE:To assess the effect of transrectal radiofrequency hyperthermia (TRFH) in 159 patients with chronic prostatitis (CP) and explore the changes of reactive oxygen species in CP patients pretreatment and posttreatment. METHODS:Patients diagnosed with CP were randomized to 6 weeks of tamsulosin plus clarithromyci...
journal_title：Urology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.urology.2011.08.046
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVES:To estimate the differences in symptoms, prostate volume, and urodynamic variables of symptom-free elderly volunteers, volunteers with lower urinary tract symptoms (LUTS), and urologic patients with LUTS suggestive of benign prostatic hyperplasia. METHODS:The study included 14 male volunteers without LUTS, ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(01)01413-3
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVES:To present patterns of failure and hazard rates for failure that support the concept of cure for patients with prostate cancer treated with external beam radiation (RT). METHODS:Two patient groups are reported: 408 patients treated with RT alone and 63 patients treated with RT and short-term androgen depriv...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(99)00605-6
更新日期：2000-05-01 00:00:00
abstract：:A total of 152 patients had cytology and cystoscopy performed for either initial or recurrent bladder tumors and postoperative control examinations. Positive cytology was found in 97 per cent of patients with pathologically proved bladder tumors. However, 23 per cent of the patients with negative cytology had positive...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(79)90024-4
更新日期：1979-01-01 00:00:00
abstract：OBJECTIVES:Laparoscopic examination of the contralateral inguinal ring has recently been advocated to exclude contralateral hernia in young children. We report a modification using nondisposable cystoscopic equipment, which is quick and reliable. METHODS:Either an 8 or 10 F soft straight catheter or a cystoscope sheat...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(99)80497-x
更新日期：1996-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the relationship of the glomerular filtration rate (GFR) and lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia measures in middle-aged men. METHODS:A total of 1400 male police officers with moderate and severe LUTS (international prostate symptoms score [IPSS] >7) and aged 40-59 ye...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.07.049
更新日期：2013-12-01 00:00:00
abstract：:The clinical necessities of replacing all or part of the diseased or destroyed ureter have plagued surgeons for many years. In the past seventy years more than 100 surgical techniques have been described for ureteral replacement. Methods of replacement have fallen into four categories; nonbiologic substitutes, pedicle...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/0090-4295(75)90001-1
更新日期：1975-02-01 00:00:00
abstract：INTRODUCTION:To describe the otherwise heretical technique of "blind" nonureteroscopic extraction of calculi from the intramural ureter using a 7-mm-diameter tapered coil called the "Stone Cone." TECHNICAL CONSIDERATIONS:After bypassing the stone and deploying the Stone Cone, slow traction was exerted. The Stone Cone'...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.02.007
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVE:To investigate the differences on clinical efficacy, complications, and safety profile between transurethral resection of the prostate (TURP) and bipolar plasmakinetic resection of the prostate (PKRP) for benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:Six hundred ninety patients of BPH were recruit...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.02.006
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVES:To identify the cost components of laparoscopic nephrectomy (LN) that could be targeted to reduce the cost of the procedure. LN is typically more costly than open nephrectomy (ON) because of longer operative times and the use of disposable equipment. METHODS:We compared the overall cost and individual cost ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)01611-4
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVE:To validate the Martini staging system for postoperative rectourethral fistula (RUF) utilizing data from previous studies to determine whether it can accurately predict postoperative success rate. METHODS:A systematic search of peer-reviewed studies was conducted through January, 2020. The primary inclusion ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.08.047
更新日期：2021-01-01 00:00:00
abstract：:We present an unusual case of recurrent reflux on the right side after bilateral vesicoureteroplasty with modified Hutch I technique. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(81)90266-1
更新日期：1981-04-01 00:00:00
abstract：:Complete eversion and prolapse of the urinary bladder is rare. We report a case occurring in an eighty-two-year-old female. We believe only 3 previous cases have been reported, and only 1 of these occurred in an adult. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(83)90310-2
更新日期：1983-12-01 00:00:00
abstract：OBJECTIVES:Quantitative cytology (Quanticyt) provides an objective reproducible alternative for routine cytology. To increase the sensitivity of cytology, we studied the application of consecutive cytology in patients in follow-up for superficial bladder cancer. METHODS:Between 1991 and 1998, a set of five or more bla...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(00)00726-3
更新日期：2000-10-01 00:00:00
abstract：:We report 2 cases of concordant prune belly syndrome occurring in monozygotic twins. In addition to suggesting a genetic basis for this disease, our 12-year follow-up of these cases illustrates that these patients with an otherwise poor prognosis can have normal growth, development, and renal function with appropriate...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(00)00452-0
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVE:To assess the effect of the intravesical protrusion of the prostate (IPP) on the response to medical treatment with tamsulosin for a 3 month period. MATERIALS AND METHODS:The study, which was conducted between 2009 and 2011 in the ambulatory clinic of an academic hospital, divided 183 patients with lower uri...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2012.12.007
更新日期：2013-04-01 00:00:00
