Levofloxacin versus ciprofloxacin versus lomefloxacin in acute pyelonephritis.


OBJECTIVES:To evaluate, in two randomized, multicenter trials, levofloxacin compared with ciprofloxacin and lomefloxacin for efficacy and safety in treating acute pyelonephritis. METHODS:We enrolled a total of 186 patients with bacteriologically proved infection. Of these, 89 patients in both trials combined received levofloxacin 250 mg once daily; 58 received ciprofloxacin 500 mg twice daily in the first trial (double blind); and 39 received lomefloxacin 400 mg once daily in the second trial (open label). Microbiologic response of patients evaluable for microbiologic efficacy was the primary efficacy variable, and clinical response of microbiologically evaluable patients was the secondary efficacy variable in both studies. RESULTS:Escherichia coli was the most prevalent pathogen. At 5 to 9 days after the end of treatment, 95% of uropathogens were eradicated in patients who received levofloxacin compared with 94% in the ciprofloxacin-treated group and 95% in the lomefloxacin-treated group. The clinical cure rate was 92% for levofloxacin in both studies combined, 88% for ciprofloxacin, and 80% for lomefloxacin. Drug-related adverse events were reported by 2% of levofloxacin-treated patients, 8% of ciprofloxacin-treated patients, and 5% of lomefloxacin-treated patients. CONCLUSIONS:The once-daily oral administration, proven efficacy, and good tolerability make levofloxacin an excellent choice for empiric treatment of acute pyelonephritis.






Richard GA,Klimberg IN,Fowler CL,Callery-D'Amico S,Kim SS




Has Abstract


1998-07-01 00:00:00
















  • Predictors of short postoperative prostate-specific antigen doubling time for patients diagnosed during PSA era.

    abstract:OBJECTIVES:To determine the preoperative and postoperative predictors of a short prostate-specific antigen (PSA) doubling time (PSADT) after radical prostatectomy for patients diagnosed during the PSA era. METHODS:Between 1989 and 2003, 1785 men underwent radical prostatectomy for 2002 American Joint Committee on Canc...


    pub_type: 杂志文章


    authors: Lin DD,Schultz D,Renshaw AA,Rubin MA,Richie JP,D'Amico AV

    更新日期:2005-03-01 00:00:00

  • Improved detection of renal pathologic features on multiphasic helical CT compared with IVU in patients presenting with microscopic hematuria.

    abstract:OBJECTIVES:To examine the virtues of multiphasic helical computed tomography (CT) in the diagnosis of upper urinary tract lesions refractory to identification by intravenous urography (IVU). METHODS:A total of 86 patients (59 men and 27 women), 27 to 88 years old, with microscopic hematuria and negative IVU findings w...


    pub_type: 杂志文章


    authors: Lang EK,Macchia RJ,Thomas R,Watson RA,Marberger M,Lechner G,Gayle B,Richter F

    更新日期:2003-03-01 00:00:00

  • AZFa Microdeletions: Occurrence in Chinese Infertile Men and Novel Deletions Revealed by Semiconductor Sequencing.

    abstract:OBJECTIVE:To evaluate the frequency of azoospermia factor (AZFa) microdeletions among infertile men and establish a new high-throughput sequencing method to detect novel deletion types. MATERIALS AND METHODS:A total of 3731 infertile men were included. Karyotype analysis was performed using G-band staining of peripher...


    pub_type: 杂志文章


    authors: Liu XY,Zhang HY,Pang DX,Xue LT,Yang X,Li YS,Liu RZ

    更新日期:2017-09-01 00:00:00

  • Type IX Ehlers-Danlos syndrome: bladder diverticula with transitional cell carcinoma.

    abstract::Patients with type IX Ehlers-Danlos syndrome have a tendency for development of diverticulae of the urinary bladder, and these often recur after surgical excision. We report on a patient with this syndrome in whom an extensively infiltrating transitional cell carcinoma developed in a diverticulum. To our knowledge, th...


    pub_type: 杂志文章,评审


    authors: Rabin JM,Hirschfield L,Badlani GH

    更新日期:1991-12-01 00:00:00

  • Human bladder smooth muscle cell damage in disturbed oxygen tension.

    abstract:OBJECTIVE:To characterize human bladder smooth muscle cell reactions to disturbed oxygen tension. Clinical studies have shown a close correlation between bladder ischemia and lower urinary tract symptoms in elderly patients. MATERIALS AND METHODS:Confluent cultured human bladder smooth muscle cells were incubated unde...


    pub_type: 杂志文章


    authors: Azadzoi KM,Yalla SV,Siroky MB

    更新日期:2011-10-01 00:00:00

  • Arterial embolization of bleeding pseudoaneurysm caused by percutaneous renal biopsy.

    abstract::A pseudoaneurysm of a primary branch of the renal artery with massive hemorrhage developed in a patient who underwent percutaneous needle renal biopsy. He was treated successfully by embolization of the artery with gelatin sponge (Gelfoam). ...


    pub_type: 杂志文章


    authors: Uretzky G,Shapiro A,Ring E

    更新日期:1979-09-01 00:00:00

  • Treatment of vesicoureteral reflux in adults by endoscopic injection.

    abstract:OBJECTIVES:To prospectively evaluate the efficacy of endoscopic injection in the adult population with vesicoureteral reflux (VUR). The search for VUR is a part of the standard workup of children with febrile urinary tract infections. However, VUR can present later in life and should be investigated in the case of recu...


    pub_type: 杂志文章


    authors: Moore K,Bolduc S

    更新日期:2011-06-01 00:00:00

  • Tissue expansion of underdeveloped scrotum to accommodate large testicular prosthesis. A technique.

    abstract::A contracted empty scrotum in a young man will not accept an artificial testis satisfactorily using any of the standard techniques. Previous operative scars, as from a failed orchiopexy, have often added to the difficulties. Greatly enlarging the scrotum by gradual distention of a tissue expander implanted in the cont...


    pub_type: 杂志文章


    authors: Lattimer JK,Stalnecker MC

    更新日期:1989-01-01 00:00:00

  • Clinical outcome of Taiwanese men with metastatic prostate cancer compared with other ethnic groups.

    abstract:OBJECTIVES:Prostate cancer incidence varies significantly among different ethnic groups. However, little is known about the survival outcome among groups. We sought to compare the survival outcome in patients with metastatic prostate cancer among different ethnic groups and to identify independent prognostic factors af...


    pub_type: 杂志文章


    authors: Chen CH,Tzai TS,Huang SP,Wu HC,Tai HC,Chang YH,Pu YS

    更新日期:2008-12-01 00:00:00

  • Satisfaction With Testicular Prosthesis After Radical Orchiectomy.

    abstract:OBJECTIVES:To determine patient satisfaction with testicular prostheses (TP) for testicular cancer. Reconstruction represents an important part of surgical oncology, yet placement of TP following orchiectomy is infrequently performed. Improved data on patient satisfaction with TP would help in counseling patients with ...


    pub_type: 杂志文章


    authors: Clifford TG,Burg ML,Hu B,Loh-Doyle J,Hugen CM,Cai J,Djaladat H,Wayne K,Daneshmand S

    更新日期:2018-04-01 00:00:00

  • Transumbilical multiport laparoscopic orchiopexy in children: comparison with standard laparoscopic orchiopexy.

    abstract:OBJECTIVE:To compare the clinical outcomes of transumbilical multiport laparoscopic orchiopexy (TMLO) vs standard laparoscopic orchiopexy (SLO) for 1-stage management of impalpable testes in children. MATERIALS AND METHODS:A total of 30 patients underwent primary TMLO from January 2010 to December 2011. An additional ...


    pub_type: 杂志文章


    authors: Mei H,Pu J,Qi T,Qi M,Li D,Tang S,Zheng L,Tong Q

    更新日期:2012-12-01 00:00:00

  • Development and Validity of a Silicone Renal Tumor Model for Robotic Partial Nephrectomy Training.

    abstract:OBJECTIVE:To provide a training tool to address the technical challenges of robot-assisted laparoscopic partial nephrectomy, we created silicone renal tumor models using 3-dimensional printed molds of a patient's kidney with a mass. In this study, we assessed the face, content, and construct validity of these models. ...


    pub_type: 杂志文章


    authors: Monda SM,Weese JR,Anderson BG,Vetter JM,Venkatesh R,Du K,Andriole GL,Figenshau RS

    更新日期:2018-04-01 00:00:00

  • Nocturia in interstitial cystitis/painful bladder syndrome.

    abstract:OBJECTIVES:To explore the roles of pain and urgency in the nocturia of patients with interstitial cystitis/painful bladder syndrome (IC/PBS). METHODS:In a longitudinal study of incident IC/PBS cases, we assessed the associations of the presence and severity of nocturia with the presence and severity of pain and urgenc...


    pub_type: 杂志文章


    authors: Warren JW,Horne L,Diggs C,Greenberg P,Langenberg PW

    更新日期:2011-06-01 00:00:00

  • Telomere DNA content in prostate biopsies predicts early rise in prostate-specific antigen after radical prostatectomy for prostate cancer.

    abstract:OBJECTIVE:To determine whether measurement of telomere DNA content (TC) in prostate biopsy tissue predicts prostate-specific antigen (PSA) recurrence in men after undergoing radical prostatectomy for prostate cancer. METHODS:Slot blot titration assay was used to quantitate TC in archived diagnostic prostate needle bio...


    pub_type: 杂志文章


    authors: Treat EG,Heaphy CM,Massie LW,Bisoffi M,Smith AY,Davis MS,Griffith JK

    更新日期:2010-03-01 00:00:00

  • Genitourinary injuries in pediatric all-terrain vehicle trauma--a mechanistic relationship?

    abstract:OBJECTIVES:To define and discuss the characteristics of all-terrain vehicle (ATV)-related pediatric (<16 years) genitourinary (GU) trauma. ATV collisions represent a significant and growing portion of trauma cases in rural America. ATV-related renal injuries have been reported in adults but a comprehensive review of AT...


    pub_type: 杂志文章


    authors: Kluemper C,Rogers A,Fallat M,Bernard AC

    更新日期:2010-05-01 00:00:00

  • Serial endoscopy following visual laser ablation of prostate (VLAP)

    abstract::Visual laser ablation of the prostate (VLAP) was evaluated by serial video-endoscopy and six months of clinical correlation in 7 men suffering from advanced prostatism and urinary retention. Images of the prostatic urethra were obtained before and at various intervals from two to nineteen weeks after the procedure. A ...


    pub_type: 杂志文章


    authors: Marks LS

    更新日期:1993-07-01 00:00:00

  • Retroperitoneoscopic living donor nephrectomy: short learning curve and our original hybrid technique.

    abstract:OBJECTIVE:To evaluate the effect of the learning curve for the hybrid technique of retroperitoneoscopic living donor nephrectomy (RDN) on donor and recipient outcomes. METHODS:We retrospectively reviewed 120 consecutive patients who underwent RDN, performed by a laparoscopic surgeon, at Sendai Shakaihoken Hospital bet...


    pub_type: 杂志文章


    authors: Tokodai K,Takayama T,Amada N,Haga I,Nakamura A,Kashiwadate T

    更新日期:2013-11-01 00:00:00

  • Which anatomic structures should be preserved during Aquablation contour planning to optimize ejaculatory function? A case-control study using ultrasound video recordings to identify surgical predictors of postoperative anejaculation.

    abstract:OBJECTIVE:To identify key anatomic structures that should be preserved to decrease postoperative anejaculation after Aquablation. METHODS:We conducted a case-control study design using patient data and operative video logs from Aquablation clinical trials. Cases were sexually active participants with functional baseli...


    pub_type: 杂志文章


    authors: Nguyen DD,Mantri SS,Zorn KC,Misraï V,Elterman D,Bhojani N

    更新日期:2021-01-19 00:00:00

  • Use of effective core volume obtained from transrectal biopsies for predicting target tumor volume.

    abstract:OBJECTIVES:To evaluate, in a retrospective review, whether the concept of effective core volume is useful for predicting the volume of a tumor focus identified by transrectal needle biopsy of the prostate gland. METHODS:The tumor volume range was estimated according to the concept of an effective core volume using the...


    pub_type: 杂志文章


    authors: Kobayashi T,Mitsumori K,Nishizawa K,Kawahara T,Ogura K,Ide Y

    更新日期:2005-10-01 00:00:00

  • Effect of dosing regimen on efficacy and safety of doxazosin in normotensive men with symptomatic prostatism: a pilot study.

    abstract:OBJECTIVES:In this pilot study, the effect of dosing schedule on the efficacy and safety of the long-acting alpha 1-adrenergic blocker doxazosin (DOX) was evaluated in 48 consecutive, normotensive men (mean age, 61.2 years) with symptoms of prostatism. METHODS:In this titration to fixed dose study, patients were rando...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kaplan SA,Soldo KA,Olsson CA

    更新日期:1994-09-01 00:00:00

  • Low-dose instillation therapy with bacille Calmette-Guérin Tokyo 172 strain after transurethral resection: historical cohort study.

    abstract:OBJECTIVES:To evaluate the effectiveness and side effects of prophylactic low-dose bacille Calmette-Guérin (BCG) Tokyo 172 strain. METHODS:We conducted a historical cohort study to compare the clinical usefulness of standard-dose versus low-dose BCG Tokyo 172 strain. A total of 156 patients with superficial bladder ca...


    pub_type: 杂志文章


    authors: Yoneyama T,Ohyama C,Imai A,Ishimura H,Hagisawa S,Iwabuchi I,Mori K,Kamimura N,Koie T,Yamato T,Suzuki T

    更新日期:2008-06-01 00:00:00

  • Robot-assisted radical cystectomy versus open radical cystectomy: a complete cost analysis.

    abstract:OBJECTIVES:To perform a complete cost analysis comparing robot assisted radical cystectomy (RARC) versus open radical cystectomy (ORC). MATERIAL AND METHODS:After institutional review board approval for data collection, we prospectively recorded perioperative outcomes and costs, such as hospital stay, transfusion rate...


    pub_type: 杂志文章


    authors: Martin AD,Nunez RN,Castle EP

    更新日期:2011-03-01 00:00:00

  • Treatment options for patients with stage D1 (T0-3,N1-2,M0) adenocarcinoma of prostate.

    abstract::Three hundred six patients with adenocarcinoma of the prostate underwent pelvic lymphadenectomy and had Stage D1 (T0-3,N1-2,M0) disease; 171 patients underwent radical retropubic prostatectomy with or without immediate adjuvant therapy (hormonal or radiation or both) or conservative (hormonal or radiation or both) tre...


    pub_type: 杂志文章


    authors: Zincke H,Utz DC,Thulé PM,Taylor WF

    更新日期:1987-10-01 00:00:00

  • Variations in use of imaging in a national sample of men with early-stage prostate cancer.

    abstract:OBJECTIVES:To measure the national practice variations in imaging studies performed for men newly diagnosed with clinically localized prostate cancer. METHODS:We created an analytic file from 1991 to 1996 Medicare claims data using files for a random sample of 5% of all Medicare beneficiaries. Among men with newly dia...


    pub_type: 杂志文章


    authors: Saigal CS,Pashos CL,Henning JM,Litwin MS

    更新日期:2002-03-01 00:00:00

  • Testicular recurrence from "primary" retroperitoneal germ cell tumor.

    abstract::Extragonadal germ cell tumors are a rare clinical entity. We present the case of an extragonadal germ cell tumor followed by testicular recurrence more than 4 years later. This presents an interesting dilemma as to whether this was recurrence of the original tumor or a new, primary tumor. The patient's outcome and sur...


    pub_type: 杂志文章


    authors: Mindrup SR,Konety BR

    更新日期:2004-11-01 00:00:00

  • Detection of cell surface antigen in cancer of renal pelvis and ureter.

    abstract::Thirty-five patients with transitional cell carcinoma of the renal pelvis or ureter of all stages and grades were studied for presence or absence of ABO(H) antigens utilizing an improved technique for staining and preserving the slides. Seventy per cent of the grade I tumors retained their antigens. Patients with anti...


    pub_type: 杂志文章


    authors: Lippert M,Bergman S,Walker P,Berger C,Javadpour N

    更新日期:1983-10-01 00:00:00

  • Percutaneous nephrostomy for assessment of functional recovery of obstructed kidneys.

    abstract::The use of percutaneous nephrostomy to evaluate the recoverability of function of the obstructed kidney is described and examined as a practical clinical method. Long-term drainage was used to assess the functional status of four kidneys and found to be of great value. The use of percutaneous nephrostomy to evaluate f...


    pub_type: 杂志文章


    authors: Pode D,Shapiro A,Gordon R,Lebensart P

    更新日期:1982-05-01 00:00:00

  • Impact of robot-assisted radical prostatectomy on lower urinary tract symptoms and predictive factors for symptom changes: a longitudinal study.

    abstract:OBJECTIVE:To investigate the longitudinal changes in lower urinary tract symptoms (LUTS) after robot-assisted radical prostatectomy (RARP). METHODS:Data on 127 patients who underwent RARP and completed the American Urological Association Symptom Score (AUASS) preoperatively and at 3, 6, and 12 months after surgery wer...


    pub_type: 杂志文章


    authors: Kim JH,Ha YS,Jeong SJ,Lee DH,Kim WJ,Kim IY

    更新日期:2013-04-01 00:00:00

  • Frequency and clinicopathologic correlates of ErbB1, ErbB2, and ErbB3 immunoreactivity in urothelial tumors of upper urinary tract.

    abstract:OBJECTIVES:To investigate the frequency and clinicopathologic correlates of ErbB1, ErbB2, and ErbB3 receptor expression in patients with upper urothelial carcinoma. METHODS:Immunohistochemical staining for ErbB1, ErbB2, and ErbB3 was done with serial sections from archival specimens of 94 patients who underwent nephro...


    pub_type: 杂志文章


    authors: Tsai YS,Tzai TS,Chow NH,Wu CL

    更新日期:2005-12-01 00:00:00

  • Adverse impact of sexual dysfunction in chronic prostatitis/chronic pelvic pain syndrome.

    abstract:OBJECTIVES:To examine the prevalence, characteristics, and impact of sexual dysfunction in our primary care referral population. METHODS:Participants seeking treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) were recruited from general urology clinics. The subjects completed the National Institu...


    pub_type: 杂志文章


    authors: Lee SW,Liong ML,Yuen KH,Leong WS,Cheah PY,Khan NA,Krieger JN

    更新日期:2008-01-01 00:00:00