Abstract：
OBJECTIVE:To assess the qualitative and quantitative changes on prostate multiparametric magnetic resonance imaging (mpMRI) following partial gland ablation (PGA) with cryotherapy and correlate with histopathology. METHODS:We used 3D Slicer to generate prostate models and segment ipsilateral (treated) and contralateral peripheral and transition zones in 10 men who underwent MRI/transrectal ultrasound fusion-guided PGA during 2017-2018. Pre- and post-PGA volumes of prostate segments were compared. Post-PGA mpMRI were categorized according to PI-RADS v2 and treatment response on mpMRI was assessed in a manner similar to the radiology evaluation framework following liver lesion ablation. RESULTS:Median volume of ipsilateral peripheral and transition zones decreased from 10.9 mL and 13.0 mL to 7.2 mL and 10.8 mL (P = .005), respectively. Median volume of contralateral peripheral and transition zones also decreased from 12.1 mL and 12.5 mL to 9.9 mL to 10.4 mL (P = .005), respectively. Five men had clinically significant disease (Grade group ≥2) on post-PGA biopsy (3 within treatment field and 2 outside). Of the men with clinically significant prostate cancer, mpMRI revealed PI-RADS 3 lesions in 2. However, the treatment response framework did not detect residual disease. CONCLUSION:PGA results in asymmetrical and significant reductions in prostate volume. Our results highlight the need for a separate assessment framework to enable standardization of the interpretation and reporting of post-PGA surveillance mpMRI. Moreover, our findings have significant implications for MRI-targeted surveillance biopsy following PGA with cryotherapy.
journal_name
Urologyjournal_title
Urologyauthors
Al Hussein Al Awamlh B,Margolis DJ,Gross MD,Natarajan S,Priester A,Hectors S,Ma X,Mosquera JM,Liao J,Hu JCdoi
10.1016/j.urology.2020.01.005subject
Has Abstractpub_date
2020-04-01 00:00:00pages
98-105eissn
0090-4295issn
1527-9995pii
S0090-4295(20)30022-4journal_volume
138pub_type
杂志文章相关文献
UROLOGY文献大全abstract：:Between March, 1978, and July, 1981, 86 patients with polychronotopic superficial papillary bladder tumors and concurrent carcinoma in situ were randomized to receive either transurethral resection alone (43) or TUR plus BCG (43). The results indicate that BCG is not only active in preventing recurrences of new tumors...
journal_title：Urology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0090-4295(85)90525-4
更新日期：1985-02-01 00:00:00
abstract：OBJECTIVES:To evaluate the prevalence of abnormal voiding and bowel habits in healthy children, and to identify possible relationships between personal and familial factors and voiding and/or bowel habits. METHODS:A randomly selected cross-sectional study was conducted in 19,240 children (5-13 years old) nationwide in...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.urology.2009.12.022
更新日期：2010-07-01 00:00:00
abstract：:Nuclear DNA content of paraffin-embedded tissue from 19 clinically benign adrenal pheochromocytomas and 18 control adrenal glands was analyzed using flow cytometry. All control adrenal glands and 6 pheochromocytomas were diploid. Four tumors were tetraploid. Nine were aneuploid with relative DNA indices in the near di...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(87)90171-3
更新日期：1987-08-01 00:00:00
abstract：:A technique utilizing a combined thoracoabdominal-median sternotomy approach is described for stimulatenous resection of a large adrenal cancer occluding the inferior vena cava and extending into the left hepatic vein. This technique is useful in removint an extensive extension of a renal or adrenal cancer into the in...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(78)90419-3
更新日期：1978-12-01 00:00:00
abstract：OBJECTIVES:To investigate whether there is an oxytocinergic neurotransmission at the hippocampus involved in the central regulation of penile erection in the rat. METHODS:Male adult Sprague-Dawley (n = 27) rats anesthetized with pentobarbital were used. A 26-gauge needle was inserted into the corpus cavernosum to meas...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(01)01000-7
更新日期：2001-07-01 00:00:00
abstract：OBJECTIVES:The treatment of patients with asymptomatic prostate cancer with biochemical failure (BF) remains controversial. The early introduction of hormonal therapy causes important secondary effects and increases costs. Our general policy has been to follow-up patients with low prostate-specific antigen (PSA) levels...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.07.019
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:To assess the safety and efficacy of holmium laser resection for primary, clinically nonmuscle-invasive, bladder cancer (HoLRBT) compared with standard transurethral resection of bladder tumor (TURBT). METHODS:The data from a total of 212 consecutive patients with primary nonmuscle-invasive bladder cancer w...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.05.028
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the association of male lower urinary tract symptoms (LUTS) with metabolic syndrome (MetS) and androgenetic alopecia in a Latin American population. METHODS:We enrolled 907 patients for prospective evaluation at a single institution. LUTS were evaluated with the International Prostate Symptom Sco...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.03.001
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVE:To investigate whether antitumor activity of sunitinib is enhanced by silencing Akt1 in a human castration-resistant prostate cancer PC3 model. MATERIALS AND METHODS:We initially established PC3 in which the expression vector containing a short hairpin ribonucleic acid targeting Akt1 was introduced (PC3/sh-A...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.02.016
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVES:To assess serum creatinine as a putative marker for staging/prognosis in localized prostate cancer. Although clinical stage, tumor grade, serum prostate-specific antigen (PSA), and tumor volume assessment by biopsy positivity are established prognostic markers in prostate cancer, the need for additional seru...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(01)01370-x
更新日期：2001-11-01 00:00:00
abstract：OBJECTIVES:To compare the prevalence, symptoms, and pathologic changes related to chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) with significant prostatitis-like symptoms between 2 altitude areas in northwest China. METHODS:From October 2009 to March 2010 community male residents at 3000 m (Delingha) and ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.04.066
更新日期：2011-11-01 00:00:00
abstract：:This report presents the results of 40 salvage cystectomies performed after failure of radiation therapy to control the disease in patients with bladder cancer. All patients had failure or recurrence after 7,000 rad. The time between end of radiation therapy and cystectomy was three to six months in 11 patients, seven...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(83)90227-3
更新日期：1983-11-01 00:00:00
abstract：:Using cultured HeLa S3 cells an ID50 of 2.5 micrograms/ml was found after a twenty-four-hour incubation with estradiol-17 beta- 3N -bis-(2-chloroethyl) carbamate (estramustine). Similar ID90 values were found in two Walker 256 rat carcinoma cell lines which were either sensitive or resistant to nitrogen mustards. Alka...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(84)80094-1
更新日期：1984-06-01 00:00:00
abstract：OBJECTIVE:To describe total and component radical prostatectomy (RP) episode costs across a diverse set of hospitals in Michigan, and examine drivers of variation in such payments. METHODS:We identified Medicare and private payer patients undergoing RP from 2012 to 2014 from the claims-based registry maintained by the...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2016.05.071
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVES:Recent studies have shown that growth factors may play a role in the etiology of benign prostatic hyperplasia (BPH) and prostatic carcinoma. Several growth factors have been reported to be expressed by prostatic tissues, but these growth factors have never been examined in human fetal prostate and compared w...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(96)00376-7
更新日期：1996-12-01 00:00:00
abstract：:This paper is one-half of a 2 part review on minimally-invasive procedures in pediatric urology. This article focuses on lower tract procedures, including ureteroureterostomy, anti-reflux surgeries, creation of continent catheterizable channels, and augmentation cystoplasty. We note important articles on pure laparosc...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2009.11.073
更新日期：2010-07-01 00:00:00
abstract：:A fifty-five-year-old man was seen with anuria. Retrograde pyelograms demonstrated bilateral ureteral obstruction subsequently shown to have resulted from sloughed renal papillae. A twenty-year history of phenacetin was obtained. Treatment included bilateral ureteral intubation, then ureterotomy on one side. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(75)90353-2
更新日期：1975-06-01 00:00:00
abstract：OBJECTIVES:To evaluate, in a cross-sectional study, the relationships among physical activity, sexual functioning, and treatment type for 111 men who had undergone radiotherapy for localized prostate cancer within the past 18 months. Physical activity preserves the sexual functioning capacity of older men. However, lit...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2004.11.029
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVES:Robotic-assisted surgery using the da Vinci Surgical System is gaining popularity among urologists. However, training residents to use this system presents new challenges for surgical educators. We describe a method for training residents to perform robotic-assisted radical prostatectomy. METHODS:Residents ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.01.057
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of 3-dimensionally (3D) printed physical renal models with enhancing masses on medical trainee characterization, localization, and understanding of renal malignancy. METHODS:Proprietary software was used to import standard computed tomography (CT) cross-sectional imaging into 3D printe...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.02.053
更新日期：2015-06-01 00:00:00
abstract：:In a retrospective study the data of 428 patients with primary superficial transitional cell carcinoma of the bladder were evaluated. The histologic slides were reviewed for presence of a tumor-associated tissue inflammatory reaction, especially tumor-associated eosinophilia. Tumor-associated cell infiltration was fou...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(92)90524-z
更新日期：1992-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the trends in the American diet over the last 40 years (1974-2010), during which time the National Health and Nutrition Examination Survey data set has documented an increase in stone prevalence from 3.8% to 8.8%. MATERIALS AND METHODS:We used the National Health and Nutrition Examination Survey ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.06.037
更新日期：2014-11-01 00:00:00
abstract：:Vesicourethral suspension operations fail (1) when preoperative evaluation is insuffcient, leading to improper selection of patients; and (2) for technical reasons when anatomy is uncorrected (suture malplacement, suture breakage, and failure to release adhesions) or when anatomy is corrected (periurethral fibrosis, f...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(79)90149-3
更新日期：1979-08-01 00:00:00
abstract：OBJECTIVE:To explore the margin, ischemia, and complications (MIC) system achievement rate within a population of patients who were treated with robotic partial nephrectomy (RAPN), at 3 different tertiary care centers, and to determine the factors predicting MIC achievement. METHODS:The study population consisted of 3...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.urology.2014.09.068
更新日期：2015-03-01 00:00:00
abstract：:CD20-negative diffuse large B-cell lymphoma (DLBCL) is a very uncommon neoplasm, and very rare unclassifiable cases that did not meet the criteria for well-established subtypes of CD20-negative DLBCLs have been reported. CD20-negative DLBCLs often present an aggressive clinical course with important chemoresistance an...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2018.04.019
更新日期：2018-07-01 00:00:00
abstract：:A randomized prospective study was set up to assess the role of postoperative catheter drainage and the value of hydraulic self-dilatation of the urethra after internal urethrotomy. Sixty-two patients were admitted into the study and followed-up for two years. The results support the use of a no-catheter posturethroto...
journal_title：Urology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0090-4295(85)90178-5
更新日期：1985-10-01 00:00:00
abstract：OBJECTIVE:Sacrocolpopexy is considered the gold standard for the treatment of pelvic organ prolapse (POP). This procedure was the first technique used to treat POP with robotic assistance and has gone a long way since the open procedure was introduced. Originally, 5 trocars were inserted and there remained issues in te...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2016.11.023
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVES:To investigate the clinical efficacy of SS-cream, the topical agent made from the extracts of nine natural products for the treatment of premature ejaculation, we performed a double-blind, randomized, placebo-controlled Phase III clinical study of patients with lifelong premature ejaculation in three medical...
journal_title：Urology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0090-4295(99)00415-x
更新日期：2000-02-01 00:00:00
abstract：:A 32-week estimated gestational age female infant had elevated systolic blood pressure at birth and a palpable left abdominal mass. Radiologic evaluation revealed a left upper pole renal mass. The renin level was significantly elevated. Left nephrectomy confirmed a diagnosis of congenital mesoblastic nephroma. The pos...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/s0090-4295(00)00497-0
更新日期：2000-05-01 00:00:00
abstract：:Current methods to evaluate renovascular hypertension in the pediatric population often requires a general anesthetic. Saralasin, an angiotensin II competitive inhibitor, is a safe, noninvasive technique which can be utilized at the bedside in a salt-depleted child off antihypertensive medication. Two illustrative cas...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(80)90593-2
更新日期：1980-11-01 00:00:00
