Flow cytometric determination of nuclear DNA content in benign adrenal pheochromocytomas.

Abstract:

:Nuclear DNA content of paraffin-embedded tissue from 19 clinically benign adrenal pheochromocytomas and 18 control adrenal glands was analyzed using flow cytometry. All control adrenal glands and 6 pheochromocytomas were diploid. Four tumors were tetraploid. Nine were aneuploid with relative DNA indices in the near diploid range in 2, in the peritriploid range in 5, and in the near tetraploid range in 2. These results indicate that aneuploid DNA content is a frequent occurrence in benign adrenal pheochromocytomas. Aneuploidy per se is not a specific marker of malignancy in these tumors as has been suggested by previous reports.

journal_name

Urology

journal_title

Urology

authors

Amberson JB,Vaughan ED Jr,Gray GF,Naus GJ

doi

10.1016/0090-4295(87)90171-3

subject

Has Abstract

pub_date

1987-08-01 00:00:00

pages

102-4

issue

2

eissn

0090-4295

issn

1527-9995

pii

0090-4295(87)90171-3

journal_volume

30

pub_type

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