Abstract:
OBJECTIVES:Six random systematic core biopsies (SRSCB) of the prostate is considered by many to represent the standard method of detecting prostate cancer. We sought to evaluate the sensitivity of the transrectal ultrasound (TRU)S-guided needle biopsies in 89 consecutive patients with a history of biopsy-proven prostate cancer. These patients underwent repeat biopsy prior to enrollment in an ongoing, randomized protocol. We also compared the clinical and pathological features of patients with SRSCB-documented prostate carcinoma and negative repeat-sextant biopsy. METHODS:Our study population consisted of 89 patients enrolled in our randomized, prospective study assessing the effect of androgen deprivation therapy in combination with radical prostatectomy for clinically localized prostate cancer. A comparison was made of the patients' rebiopsy results with initial biopsy. Patients having either a positive or negative rebiopsy were analyzed with respect to grade, T stage, prostate-specific antigen (PSA), PSA density (PSAD), organ-confined rate, and final surgical margin status. RESULTS:Repeat sextant biopsy was positive for prostate cancer in 71 (80%) patients and negative in 18 (20%) patients. There was no significant difference between patients with a negative or positive rebiopsy with respect to PSA or PSAD. There was a trend toward greater prostate volumes in the negative-rebiopsy group (P = 0.08) and lower clinical stage in the negative rebiopsy (P = 0.025) group. In patients with a negative repeat biopsy, the organ-confined (OC) rate was 77% (14/18 patients), as compared to the positive-rebiopsy group of 56% (40/71 patients) (P = 0.08). Similarly, the margin-positive rate in the negative-rebiopsy group was 17% (3/18 patients), as compared to the positive-rebiopsy group who had a margin-positive rate of 44% (31/71 patients) (P = 0.03). CONCLUSIONS:In patients with clinically localized disease, the sensitivity of SRSCB in detecting carcinoma is 80%. The results of this study highlight the potential sampling error of the SRSCB and the implication of a negative rebiopsy in patients with clinically significant prostate cancer.
journal_name
Urologyjournal_title
Urologyauthors
Stroumbakis N,Cookson MS,Reuter VE,Fair WRdoi
10.1016/s0090-4295(97)00178-7subject
Has Abstractpub_date
1997-03-01 00:00:00pages
113-8issue
3A Suppleissn
0090-4295issn
1527-9995pii
S0090-4295(97)00178-7journal_volume
49pub_type
临床试验,杂志文章,随机对照试验相关文献
UROLOGY文献大全abstract::This article will discuss the advantages and disadvantages of the various types of optical magnification currently available. The instruments necessary for performing most operations will also be presented. Attention will be focused on the physical properties and technical considerations of microvascular anastomosis. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(84)80013-8
更新日期:1984-05-01 00:00:00
abstract::A case of emphysematous pyelonephritis which was diagnosed by conventional radiology and confirmed by ultrasonography, computed tomography, and surgery is described. The etiology and pathogenesis of this severe infection are discussed, and the usefulness of the various noninvasive radiologic methods for the diagnosis ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(87)90613-3
更新日期:1987-01-01 00:00:00
abstract::A 78-year-old man with coagulopathy and lower urinary tract symptoms secondary to benign prostatic hyperplasia underwent transurethral prostate ethanol gel injection. Six months after the injection, the patient presented with irritative symptoms and hematuria. Ultrasonography revealed a 5-cm intravesical calculus. Cys...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2004.12.007
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the relationship between low prostate-specific antigen (PSA) levels that are considered normal and the long-term risk of prostate cancer. METHODS:The relative risk of, and cumulative probability of freedom from, prostate cancer by PSA level and age decade was evaluated in male participants of a ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(01)01304-8
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVES:To determine whether nadir prostate-specific antigen (PSA) levels within 12 months (nadir PSA12) after completion of radiotherapy (RT) can be used as an early marker of recurrence risk. METHODS:A total of 4839 patients were treated with RT and without hormonal therapy from 1986 to 1995 for Stage T1-T2 prost...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2006.08.1056
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVES:To report our experience with pediatric renal adenocarcinoma. METHODS:We conducted a retrospective review of renal adenocarcinoma cases from 1971 to 2006. RESULTS:We treated 154 patients with renal tumor, 4 (2.6%) of whom had adenocarcinoma. The mean age of presentation was 8.5 years (range, 2-15 years). T...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.03.030
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVES:To review our experience to better define pediatric renal cell carcinoma (RCC). Pediatric RCC is rare, and recent data suggest it may be a unique disease. METHODS:A retrospective review was conducted of hospital and pathology records from 1965 to 2003. Patients with RCC were identified, and the clinical and...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.06.104
更新日期:2005-12-01 00:00:00
abstract::Ninety-three cases of germinal testicular tumors with urinary gonadotropin (HCG) values, estimated by biologic or radioimmunoassay techniques, were reviewed. Preoperative values of HCG and subsequent postoperative values were related to response to treatment and prognosis. Twenty-five patients (26.9 per cent) comprise...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(75)90074-6
更新日期:1975-04-01 00:00:00
abstract:OBJECTIVES:The techniques for hemostasis after renal tumor excision have limited the widespread application of laparoscopic partial nephrectomy (LPN). To improve hemostasis and aid visualization, we report our experience with a novel radiofrequency coagulation (RFC) technique for LPN. METHODS:Ten patients underwent RF...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(01)01086-x
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To increase the diagnostic sensitivity of standard MAG3 diuretic renal scans for ureteropelvic junction obstruction (UPJO) by exploring the utility of an alternative measurement P40, the percentage of maximal tracer counts present at 40 minutes. MATERIALS AND METHODS:Patients with strong clinical and anatomi...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2016.11.049
更新日期:2017-05-01 00:00:00
abstract::Rhabdomyosarcoma is the most common sarcoma diagnosed in childhood and adolescence, arising from the bladder/prostate in only 5%-10% of cases. Treatment-induced cytodifferention of tumor cells into mature rhabdomyoblasts has been reported following chemoradiation and is thought to suggest a more favorable outcome. We ...
journal_title:Urology
pub_type:
doi:10.1016/j.urology.2019.11.050
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To assess stone-free rates following ureteroscopy (URS) for renal calculi at our institution using low-dose renal only computed tomography (CT). METHODS:A retrospective review of patients undergoing flexible URS for renal stones only with subsequent CT scan within 3 months. Meticulous basketing of all stone ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2018.09.005
更新日期:2019-02-01 00:00:00
abstract::We present a clinical imaging question focusing on a patient with a history of gross hematuria and an enhancing mass abutting the left renal collecting system. In patients with nondiagnostic cytology and imaging, upper tract urothelial carcinoma should be explored as a potential etiology prior to definitive surgical m...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.08.042
更新日期:2020-12-01 00:00:00
abstract::Neonatal adrenal hemorrhage presenting as scrotal swelling has been reported in 17 cases, with unnecessary surgical exploration in 7. We report 2 new cases, emphasizing the knowledge of this clinical association and the role of ultrasonography in the differential diagnosis for this specific condition and in all cases ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(01)01610-7
更新日期:2002-04-01 00:00:00
abstract::We present a case of juvenile hemangioma of the testis associated with hemangiomas of the liver and skin. The testicular hemangioma appeared to progress after therapy with interferon alpha-2a (IFN alpha-2a), whereas the liver and skin hemangiomas regressed. Analysis of growth factors responsible for proliferation of h...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/S0090-4295(96)00439-6
更新日期:1997-02-01 00:00:00
abstract::Dedicated portable ultrasound devices generally offer a rapid, noninvasive, largely operator-independent means of assessing post-void residual urine (PVR) volume. In most published series, PVR measured by portable ultrasound correlates well with catheterized urine volume. We report 3 cases in which follow-up of falsel...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/s0090-4295(99)00565-8
更新日期:2000-04-01 00:00:00
abstract::We report an important and unusual cause of an enhancing retroperitoneal paracaval mass. Ten years after vena cava filter (VCF) placement, a 3.5-cm mass was found juxtaposed to the right kidney and vena cava. Open exploration demonstrated a venous variceal mass with perforation of the VCF through the wall of the vena ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2011.06.042
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To assess the ability of daily oral simvastatin administration to reduce the negative urodynamic changes associated with cyclophosphamide (CP)-induced cystitis and to prevent bladder inflammation. Patients undergoing CP chemotherapy frequently develop cystitis, leading to urinary dysfunction and hemorrhage. R...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2012.08.041
更新日期:2013-01-01 00:00:00
abstract::A urinary enzyme pattern and kidney tissue pattern were investigated simultaneously in 117 urologic patients. In contrast to all other renal disorders only the sixteen malignant tumors of the kidney showed a significant drop of gamma-GT in tumor tissue and urine. So far urinary enzymology has been used only as screeni...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(76)90553-7
更新日期:1976-01-01 00:00:00
abstract::A case is reported of the simultaneous occurrence of renal carcinoma with staghorn calculus, perinephric abscess, and xanthogranulomatous pyelonephritis in the same kidney, with subcutaneous abscess of the thigh as the initial presentation. The coexistence of these diseases in the same kidney would seem to be importan...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(83)90213-3
更新日期:1983-06-01 00:00:00
abstract::For clinical practice and research of overactive bladder syndrome, it is essential to evaluate urgency symptoms in daily life. We have developed a portable patient-activated device to record bladder sensations. This electronic device is pocket-size and light, with five grading buttons and another button for cancellati...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.01.036
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:Nephrolithiasis is a recurrent condition with significant associated morbidity and economic impact. Although urologic intervention addresses symptomatic stone episodes, prevention of recurrences with proven medical therapy is indicated. METHODS:This retrospective study examined 97 patients who presented in ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(00)00822-0
更新日期:2000-12-20 00:00:00
abstract::Recurrent transitional cell carcinoma of the bladder is often a locally progressive disease. Regional lymph node metastasis is a frequent finding and may be the first sign of recurrence. Involvement of the gastrointestinal tract is rare, but metastasis to the colon, small intestine, and stomach have been reported. Her...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/S0090-4295(99)80471-3
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the effect of extracorporeal magnetic innervation (ExMI) therapy in children with refractory monosymptomatic nocturnal enuresis (MNE). METHODS:A total of 55 children (34 boys and 21 girls, median age 8.0 years, range 5 to 13) who wetted the bed more than twice per week because of MNE that was re...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/j.urology.2007.05.027
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:To describe our initial experience with the laparoscopic technique of sliding-clip renorrhaphy applied to open surgery for small renal masses. METHODS:Knotless renorrhaphy with the sliding-clip technique is performed by securing suture with Hem-o-lok clips slid under tension against the renal capsule and lo...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2010.10.025
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To report the first performance of simultaneous bilateral percutaneous nephrolithotomy and flexible ureteroscopy carried out in tandem by 2 different surgeons in a patient with bilateral medium-sized renal calculi, describing step-by-step details of the surgical technique. MATERIALS AND METHODS:A 46-year-old...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2016.04.017
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To establish a score threshold that constitutes a clinically relevant change for each domain of the Expanded Prostate Cancer Index Composite (EPIC) Short Form (EPIC-26). Although its use in clinical practice and clinical trials has increased worldwide, the clinical interpretation of this 26-item disease-speci...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2014.08.044
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To address the overarching question whether chemoradiation therapy (CMT) offers overall survival (OS) similar to that of radical cystectomy (RC) in muscle-invasive bladder cancer (MIBC), we performed analyses using the National Cancer Database. MATERIALS AND METHODS:Patients diagnosed with MIBC in 2004-2014 ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2019.05.062
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:To assess the results of jejunal conduit urinary diversion, with particular attention to electrolyte imbalance and long-term renal function. METHODS:From 1976 to 1994, 50 patients underwent urinary diversion using a short jejunal loop (10 to 12 cm) placed transperitoneally. Of these patients, 18 received pe...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/S0090-4295(97)00210-0
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVES:To examine the predictive value of ultrasonic measurements obtained by transrectal ultrasonography for infravesical obstruction as evaluated by pressure flow studies. METHODS:In 85 men with moderate to severe lower urinary tract symptoms, ultrasonic measurements including prostatic volume, transition zone v...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/S0090-4295(97)00310-5
更新日期:1997-10-01 00:00:00